Roger Stupp

  • 41274 Citations
1990 …2023
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1990 2020

Filter
Article
2020

Ultrasound-mediated delivery of paclitaxel for glioma: A comparative study of distribution, toxicity, and efficacy of albumin-bound versus cremophor formulations

Zhang, D. Y., Dmello, C., Chen, L., Arrieta, V. A., Gonzalez-Buendia, E., Robert Kane, J., Magnusson, L. P., Baran, A., David James, C., Horbinski, C., Carpentier, A., Desseaux, C., Canney, M., Muzzio, M., Stupp, R. & Sonabend, A. M., Jan 15 2020, In : Clinical Cancer Research. 26, 2, p. 477-486 10 p.

Research output: Contribution to journalArticle

Paclitaxel
Glioma
Albumins
Blood-Brain Barrier
Heterografts
2 Citations (Scopus)

Use of metformin and outcome of patients with newly diagnosed glioblastoma: Pooled analysis

for the EORTC Brain Tumor Group, Feb 1 2020, In : International Journal of Cancer. 146, 3, p. 803-809 7 p.

Research output: Contribution to journalArticle

Metformin
Glioblastoma
Survival
Disease-Free Survival
Confidence Intervals
2019

Changing Paradigms in the Treatment of Brain Metastases

Stupp, R., Nov 1 2019, In : Journal of oncology practice. 15, 11, p. 573-574 2 p.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Brain
5 Citations (Scopus)

Imaging tryptophan uptake with positron emission tomography in glioblastoma patients treated with indoximod

Lukas, R. V., Juhász, C., Wainwright, D. A., James, C. D., Kennedy, E., Stupp, R. & Lesniak, M. S., Jan 15 2019, In : Journal of Neuro-Oncology. 141, 1, p. 111-120 10 p.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Glioblastoma
Tryptophan
Positron-Emission Tomography
temozolomide
2 Citations (Scopus)

Impact of Radiation Target Volume on Health-Related Quality of Life in Patients With Low-Grade Glioma in the 2-Year Period Post Treatment: A Secondary Analysis of the EORTC 22033-26033

Dirven, L., Reijneveld, J. C., Taphoorn, M. J. B., Coens, C., El-Badawy, S. A., Tzuk-Shina, T., Bravo-Marques, J., Back, M., Stalpers, L. J. A., Stupp, R., Baumert, B. G. & Seidel, C., May 1 2019, In : International Journal of Radiation Oncology Biology Physics. 104, 1, p. 90-100 11 p.

Research output: Contribution to journalArticle

Glioma
health
grade
cancer
Quality of Life
8 Citations (Scopus)

MGMT promoter methylation cutoff with safety margin for selecting glioblastoma patients into trials omitting temozolomide: A pooled analysis of four clinical trials

Hegi, M. E., Genbrugge, E., Gorlia, T., Stupp, R., Gilbert, M. R., Chinot, O. L., Burt Nabors, L., Jones, G., Van Criekinge, W., Straub, J. & Weller, M., Jan 1 2019, In : Clinical Cancer Research. 25, 6, p. 1809-1816 8 p.

Research output: Contribution to journalArticle

temozolomide
Methyltransferases
Glioblastoma
Methylation
Clinical Trials
10 Citations (Scopus)

MGMT promoter methylation status testing to guide therapy for glioblastoma: Refining the approach based on emerging evidence and current challenges

Mansouri, A., Hachem, L. D., Mansouri, S., Nassiri, F., Laperriere, N. J., Xia, D., Lindeman, N. I., Wen, P. Y., Chakravarti, A., Mehta, M. P., Hegi, M. E., Stupp, R., Aldape, K. D. & Zadeh, G., Feb 14 2019, In : Neuro-oncology. 21, 2, p. 167-178 12 p.

Research output: Contribution to journalArticle

Glioblastoma
Transferases
Methylation
DNA
Biomarkers

Multimodal Treatment in Operable Stage III NSCLC: A Pooled Analysis on Long-Term Results of Three SAKK trials (SAKK 16/96, 16/00, and 16/01)

Swiss Group for Clinical Cancer Research (SAKK), Jan 2019, In : Journal of Thoracic Oncology. 14, 1, p. 115-123 9 p.

Research output: Contribution to journalArticle

Combined Modality Therapy
Neoplasm Staging
Confidence Intervals
Survival Rate
Survival
1 Citation (Scopus)

Overcoming the blood-brain barrier with an implantable ultrasound device

Sonabend, A. M. & Stupp, R., Jan 1 2019, In : Clinical Cancer Research. 25, 13, p. 3750-3752 3 p.

Research output: Contribution to journalArticle

Blood-Brain Barrier
Equipment and Supplies
Pharmaceutical Preparations
Skull
1 Citation (Scopus)

Symptom clusters in newly diagnosed glioma patients: Which symptom clusters are independently associated with functioning and global health status?

Coomans, M. B., Dirven, L., Aaronson, N. K., Baumert, B. G., Van Den Bent, M., Bottomley, A., Brandes, A. A., Chinot, O., Coens, C., Gorlia, T., Herrlinger, U., Keime-Guibert, F., Malmström, A., Martinelli, F., Stupp, R., Talacchi, A., Weller, M., Wick, W., Reijneveld, J. C. & Taphoorn, M. J. B., Nov 4 2019, In : Neuro-oncology. 21, 11, p. 1447-1457 11 p.

Research output: Contribution to journalArticle

Glioma
Health Status
Fatigue
Self Report
Randomized Controlled Trials
3 Citations (Scopus)
Glioma
Disease-Free Survival
Meta-Analysis
Randomized Controlled Trials
Quality of Life

The medical necessity of advanced molecular testing in the diagnosis and treatment of brain tumor patients

Horbinski, C., Ligon, K. L., Brastianos, P., Huse, J. T., Venere, M., Chang, S., Buckner, J., Cloughesy, T., Jenkins, R. B., Giannini, C., Stupp, R., Nabors, L. B., Wen, P. Y., Aldape, K. J., Lukas, R. V., Galanis, E., Eberhart, C. G., Brat, D. J. & Sarkaria, J. N., Dec 17 2019, In : Neuro-oncology. 21, 12, p. 1498-1508 11 p.

Research output: Contribution to journalArticle

Open Access
Brain Neoplasms
Therapeutics
Central Nervous System Neoplasms
Molecular Pathology
Epigenomics
2018
6 Citations (Scopus)

Aberrant Lck signal via CD28 Costimulation augments antigen-specific functionality and tumor control by redirected T cells with PD-1 blockade in humanized mice

Gulati, P., Ruhl, J., Kannan, A., Pircher, M., Schuberth, P., Nytko, K. J., Pruschy, M., Sulser, S., Haefner, M., Jensen, S., Soltermann, A., Jungraithmayr, W., Eisenring, M., Winder, T., Samaras, P., Tabor, A., Stenger, R., Stupp, R., Weder, W., Renner, C. & 2 others, Munz, C. & Petrausch, U., Aug 15 2018, In : Clinical Cancer Research. 24, 16, p. 3981-3993 13 p.

Research output: Contribution to journalArticle

Antigen Receptors
CD28 Antigens
T-Lymphocytes
Antigens
Neoplasms
5 Citations (Scopus)

Adjuvant treatment of resectable biliary tract cancer with cisplatin plus gemcitabine: A prospective single center phase II study

Siebenhüner, A. R., Seifert, H., Bachmann, H., Seifert, B., Winder, T., Feilchenfeldt, J., Breitenstein, S., Clavien, P. A., Stupp, R., Knuth, A., Pestalozzi, B. & Samaras, P., Jan 11 2018, In : BMC cancer. 18, 1, 72.

Research output: Contribution to journalArticle

gemcitabine
Biliary Tract Neoplasms
Cisplatin
Disease-Free Survival
Survival
4 Citations (Scopus)

Associations of anticoagulant use with outcome in newly diagnosed glioblastoma

Le Rhun, E., Genbrugge, E., Stupp, R., Chinot, O. L., Nabors, L. B., Cloughesy, T., Reardon, D. A., Wick, W., Gorlia, T. & Weller, M., Sep 2018, In : European Journal of Cancer. 101, p. 95-104 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Anticoagulants
Survival
Blood Platelets
temozolomide

B cell-rich non-neoplastic sentinel lesion preceding primary central nervous system lymphoma

Javier, R., Shaikh, N., Lesniak, M. S., Sonabend, A., Stupp, R., Behdad, A. & Horbinski, C., Jun 5 2018, In : Diagnostic pathology. 13, 1, 37.

Research output: Contribution to journalArticle

Lymphoma
B-Lymphocytes
Central Nervous System
Lymphoma, Large B-Cell, Diffuse
Brain Neoplasms
1 Citation (Scopus)

Developing an Integrative Treatment Program for Cancer-Related Fatigue Using Stakeholder Engagement – A Qualitative Study

Canella, C., Mikolasek, M., Rostock, M., Beyer, J., Guckenberger, M., Jenewein, J., Linka, E., Six, C., Stoll, S., Stupp, R. & Witt, C. M., Sep 1 2018, In : Integrative Cancer Therapies. 17, 3, p. 762-773 12 p.

Research output: Contribution to journalArticle

Second Primary Neoplasms
Fatigue
Complementary Therapies
Neoplasms
Nurses
4 Citations (Scopus)

Diagnostic value of 18F-fluordesoxyglucose positron emission tomography for patients with brain metastasis from unknown primary site

Wolpert, F., Weller, M., Berghoff, A. S., Rushing, E., Füreder, L. M., Petyt, G., Leske, H., Andratschke, N., Regli, L., Neidert, M. C., Stupp, R., Stahel, R., Dummer, R., Frauenfelder, T., Roth, P., Reyns, N., Kaufmann, P. A., Preusser, M. & Le Rhun, E., Jun 2018, In : European Journal of Cancer. 96, p. 64-72 9 p.

Research output: Contribution to journalArticle

Positron-Emission Tomography
Tomography
Neoplasm Metastasis
Brain
Brain Neoplasms
8 Citations (Scopus)

Do statins, ACE inhibitors or sartans improve outcome in primary glioblastoma?

For the EORTC Brain Tumor Group and on behalf of the CENTRIC and CORE Clinical Trial Groups, May 1 2018, In : Journal of Neuro-Oncology. 138, 1, p. 163-171 9 p.

Research output: Contribution to journalArticle

Angiotensin II Type 1 Receptor Blockers
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Glioblastoma
Angiotensin-Converting Enzyme Inhibitors
Disease-Free Survival
4 Citations (Scopus)

Expression-based intrinsic glioma subtypes are prognostic in low-grade gliomas of the EORTC22033-26033 clinical trial

Gao, Y., Weenink, B., van den Bent, M. J., Erdem-Eraslan, L., Kros, J. M., Sillevis Smitt, P. A. E., Hoang-Xuan, K., Brandes, A. A., Vos, M., Dhermain, F., Enting, R., Ryan, G. F., Chinot, O., Ben Hassel, M., van Linde, M. E., Mason, W. P., Gijtenbeek, J. M. M., Balana, C., von Deimling, A., Gorlia, T. & 4 others, Stupp, R., Hegi, M. E., Baumert, B. G. & French, P. J., May 2018, In : European Journal of Cancer. 94, p. 168-178 11 p.

Research output: Contribution to journalArticle

temozolomide
Glioma
Disease-Free Survival
Clinical Trials
Gene Expression Profiling
21 Citations (Scopus)

IDO1 inhibition synergizes with radiation and PD-1 blockade to durably increase survival against advanced glioblastoma

Ladomersky, E., Zhai, L., Lenzen, A., Lauing, K. L., Qian, J., Scholtens, D. M., Gritsina, G., Sun, X., Liu, Y., Yu, F., Gong, W., Liu, Y., Jiang, B., Tang, T., Patel, R., Platanias, L. C., David James, C., Stupp, R., Lukas, R. V., Binder, D. C. & 1 others, Wainwright, D. A., Jun 1 2018, In : Clinical Cancer Research. 24, 11, p. 2559-2573 15 p.

Research output: Contribution to journalArticle

Glioblastoma
Radiation
Survival
T-Lymphocytes
Therapeutics
23 Citations (Scopus)

Influence of treatment with tumor-treating fields on health-related quality of life of patients with newly diagnosed glioblastoma a secondary analysis of a randomized clinical trial

Taphoorn, M. J. B., Dirven, L., Kanner, A. A., Lavy-Shahaf, G., Weinberg, U., Taillibert, S., Toms, S. A., Honnorat, J., Chen, T. C., Sroubek, J., David, C., Idbaih, A., Easaw, J. C., Kim, C. Y., Bruna, J., Hottinger, A. F., Kew, Y., Roth, P., Desai, R., Villano, J. L. & 3 others, Kirson, E. D., Ram, Z. & Stupp, R., Apr 2018, In : JAMA Oncology. 4, 4, p. 495-504 10 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Randomized Controlled Trials
Quality of Life
Neoplasms
6 Citations (Scopus)

Ipilimumab and early signs of pulmonary toxicity in patients with metastastic melanoma: a prospective observational study

Franzen, D., Schad, K., Kowalski, B., Clarenbach, C. F., Stupp, R., Dummer, R. & Kohler, M., Jan 1 2018, In : Cancer Immunology, Immunotherapy. 67, 1, p. 127-134 8 p.

Research output: Contribution to journalArticle

Observational Studies
Melanoma
Prospective Studies
Lung
Pneumonia
14 Citations (Scopus)

Maturation of tertiary lymphoid structures and recurrence of stage II and III colorectal cancer

Posch, F., Silina, K., Leibl, S., Mündlein, A., Moch, H., Siebenhüner, A., Samaras, P., Riedl, J., Stotz, M., Szkandera, J., Stöger, H., Pichler, M., Stupp, R., van den Broek, M., Schraml, P., Gerger, A., Petrausch, U. & Winder, T., Feb 1 2018, In : OncoImmunology. 7, 2, e1378844.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Recurrence
Germinal Center
Tertiary Lymphoid Structures
Follicular Dendritic Cells

Mobilization of Hematopoietic Progenitor Cells with Standard- or Reduced-Dose Filgrastim after Vinorelbine in Multiple Myeloma Patients: A Randomized Prospective Single-Center Phase II Study

Samaras, P., Rütti, M. F., Seifert, B., Bachmann, H., Schanz, U., Eisenring, M., Renner, C., Susanne Müller, A. M., Schmidt, A., Mischo, A., Fuchs, I., Bargetzi, M., Manz, M. G., Stupp, R., Petrausch, U. & Stenner-Liewen, F., Apr 2018, In : Biology of Blood and Marrow Transplantation. 24, 4, p. 694-699 6 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Multiple Myeloma
Leukapheresis
Body Weight
Pain
39 Citations (Scopus)

Novel, improved grading system(s) for IDH-mutant astrocytic gliomas

Shirahata, M., Ono, T., Stichel, D., Schrimpf, D., Reuss, D. E., Sahm, F., Koelsche, C., Wefers, A., Reinhardt, A., Huang, K., Sievers, P., Shimizu, H., Nanjo, H., Kobayashi, Y., Miyake, Y., Suzuki, T., Adachi, J. I., Mishima, K., Sasaki, A., Nishikawa, R. & 26 others, Bewerunge-Hudler, M., Ryzhova, M., Absalyamova, O., Golanov, A., Sinn, P., Platten, M., Jungk, C., Winkler, F., Wick, A., Hänggi, D., Unterberg, A., Pfister, S. M., Jones, D. T. W., van Den Bent, M., Hegi, M., French, P., Baumert, B. G., Stupp, R., Gorlia, T., Weller, M., Capper, D., Korshunov, A., Herold-Mende, C., Wick, W., Louis, D. N. & von Deimling, A., Apr 23 2018, In : Acta Neuropathologica. p. 1-14 14 p.

Research output: Contribution to journalArticle

Astrocytoma
Neoplasm Grading
Neoplasms
Glioblastoma
Central Nervous System Neoplasms
1 Citation (Scopus)

Primary central nervous system lymphoma: Part 2: Modern therapeutic management and future directions

Lukas, R. V., Gondi, V., Stupp, R. & Raizer, J. J., Jan 1 2018, In : ONCOLOGY (United States). 32, 2, p. e11-e19

Research output: Contribution to journalArticle

Lymphoma
Central Nervous System
Central Nervous System Neoplasms
Therapeutics
Methotrexate
6 Citations (Scopus)

Primary central nervous system lymphoma: Part 1: Epidemiology, diagnosis, staging, and prognosis

Lukas, R. V., Stupp, R., Gondi, V. & Raizer, J. J., Jan 1 2018, In : ONCOLOGY (United States). 32, 1, p. 17-27 11 p.

Research output: Contribution to journalArticle

Lymphoma
Epidemiology
Central Nervous System
Central Nervous System Neoplasms
Central Nervous System Diseases
21 Citations (Scopus)

The DNA methylome of DDR genes and benefit from RT or TMZ in IDH mutant low-grade glioma treated in EORTC 22033

Bady, P., Kurscheid, S., Delorenzi, M., Gorlia, T., van Den Bent, M. J., Hoang-Xuan, K., Vauléon, É., Gijtenbeek, A., Enting, R., Thiessen, B., Chinot, O., Dhermain, F., Brandes, A. A., Reijneveld, J. C., Marosi, C., Taphoorn, M. J. B., Wick, W., von Deimling, A., French, P., Stupp, R. & 2 others, Baumert, B. G. & Hegi, M. E., Apr 1 2018, In : Acta Neuropathologica. 135, 4, p. 601-615 15 p.

Research output: Contribution to journalArticle

temozolomide
Glioma
DNA Damage
Radiotherapy
DNA
2017
22 Citations (Scopus)

Biological activity of tumor-Treating fields in preclinical glioma models

Silginer, M., Weller, M., Stupp, R. & Roth, P., Apr 20 2017, In : Cell Death and Disease. 8, 4, e2753.

Research output: Contribution to journalArticle

Glioma
temozolomide
Neoplasms
Cell Death
Autophagy
221 Citations (Scopus)

Effect of tumor-treating fields plus maintenance temozolomide vs maintenance temozolomide alone on survival in patients with glioblastoma a randomized clinical trial

Stupp, R., Taillibert, S., Kanner, A., Read, W., Steinberg, D. M., Lhermitte, B., Toms, S., Idbaih, A., Ahluwalia, M. S., Fink, K., Di Meco, F., Lieberman, F., Zhu, J. J., Stragliotto, G., Tran, D. D., Brem, S., Hottinger, A. F., Kirson, E. D., Lavy-Shahaf, G., Weinberg, U. & 9 others, Kim, C. Y., Paek, S. H., Nicholas, G., Burna, J., Hirte, H., Weller, M., Palti, Y., Hegi, M. E. & Ram, Z., Dec 19 2017, In : JAMA - Journal of the American Medical Association. 318, 23, p. 2306-2316 11 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Randomized Controlled Trials
Maintenance
Survival
8 Citations (Scopus)

Efficacious and save use of biosimilar filgrastim for hematopoietic progenitor cell chemo-mobilization with vinorelbine in multiple myeloma patients

Maul, J. T., Stenner-Liewen, F., Seifert, B., Pfrommer, S., Petrausch, U., Kiessling, M. K., Schanz, U., Nair, G., Mischo, A., Taverna, C., Schmidt, A., Bargetzi, M., Stupp, R., Renner, C. & Samaras, P., Feb 1 2017, In : Journal of Clinical Apheresis. 32, 1, p. 21-26 6 p.

Research output: Contribution to journalArticle

Biosimilar Pharmaceuticals
Hematopoietic Stem Cells
Multiple Myeloma
Leukapheresis
Body Weight
25 Citations (Scopus)

Infiltrating T cells increase IDO1 expression in glioblastoma and contribute to decreased patient survival

Zhai, L., Ladomersky, E., Lauing, K. L., Wu, M., Genet, M., Gritsina, G., Győrffy, B., Brastianos, P. K., Binder, D. C., Sosman, J. A., Giles, F. J., James, C. D., Horbinski, C., Stupp, R. & Wainwright, D. A., Nov 1 2017, In : Clinical Cancer Research. 23, 21, p. 6650-6660 11 p.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Glioblastoma
T-Lymphocytes
Survival
Neoplasms
100 Citations (Scopus)

Interim results from the CATNON trial (EORTC study 26053-22054) of treatment with concurrent and adjuvant temozolomide for 1p/19q non-co-deleted anaplastic glioma: a phase 3, randomised, open-label intergroup study

van den Bent, M. J., Baumert, B., Erridge, S. C., Vogelbaum, M. A., Nowak, A. K., Sanson, M., Brandes, A. A., Clement, P. M., Baurain, J. F., Mason, W. P., Wheeler, H., Chinot, O. L., Gill, S., Griffin, M., Brachman, D. G., Taal, W., Rudà, R., Weller, M., McBain, C., Reijneveld, J. & 21 others, Enting, R. H., Weber, D. C., Lesimple, T., Clenton, S., Gijtenbeek, A., Pascoe, S., Herrlinger, U., Hau, P., Dhermain, F., van Heuvel, I., Stupp, R., Aldape, K., Jenkins, R. B., Dubbink, H. J., Dinjens, W. N. M., Wesseling, P., Nuyens, S., Golfinopoulos, V., Gorlia, T., Wick, W. & Kros, J. M., Oct 7 2017, In : The Lancet. 390, 10103, p. 1645-1653 9 p.

Research output: Contribution to journalArticle

temozolomide
Glioma
Therapeutics
Radiotherapy
Survival
21 Citations (Scopus)

Is more better? the impact of extended adjuvant temozolomide in newly diagnosed glioblastoma: A secondary analysis of EORTC and NRG Oncology/RTOG

Blumenthal, D. T., Gorlia, T., Gilbert, M. R., Kim, M. M., Burt Nabors, L., Mason, W. P., Hegi, M. E., Zhang, P., Golfinopoulos, V., Perry, J. R., Hyun Nam, D., Erridge, S. C., Corn, B. W., Mirimanoff, R. O., Brown, P. D., Baumert, B. G., Mehta, M. P., Van Den Bent, M. J., Reardon, D. A., Weller, M. & 1 others, Stupp, R., Aug 1 2017, In : Neuro-oncology. 19, 8, p. 1119-1126 8 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Disease-Free Survival
Background Radiation
Survival
148 Citations (Scopus)

Lomustine and bevacizumab in progressive glioblastoma

Wick, W., Gorlia, T., Bendszus, M., Taphoorn, M., Sahm, F., Harting, I., Brandes, A. A., Taal, W., Domont, J., Idbaih, A., Campone, M., Clement, P. M., Stupp, R., Fabbro, M., Le Rhun, E., Dubois, F., Weller, M., Von Deimling, A., Golfinopoulos, V., Bromberg, J. C. & 3 others, Platten, M., Klein, M. & Van Den Bent, M. J., Nov 16 2017, In : New England Journal of Medicine. 377, 20, p. 1954-1963 10 p.

Research output: Contribution to journalArticle

Lomustine
Glioblastoma
Survival
Confidence Intervals
Quality of Life
26 Citations (Scopus)

Molecular-based recursive partitioning analysis model for glioblastoma in the temozolomide era a correlative analysis based on nrg oncology RTOG 0525

Bell, E. H., Pugh, S. L., McElroy, J. P., Gilbert, M. R., Mehta, M., Klimowicz, A. C., Magliocco, A., Bredel, M., Robe, P., Grosu, A. L., Stupp, R., Curran, W., Becker, A. P., Salavaggione, A. L., Barnholtz-Sloan, J. S., Aldape, K., Blumenthal, D. T., Brown, P. D., Glass, J., Souhami, L. & 5 others, Lee, R. J., Brachman, D., Flickinger, J., Won, M. & Chakravarti, A., Jun 2017, In : JAMA Oncology. 3, 6, p. 784-792 9 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Methylation
Proteins
Karnofsky Performance Status
43 Citations (Scopus)

MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma

Huang, T., Kim, C. K., Alvarez, A. A., Pangeni, R. P., Wan, X., Song, X., Shi, T., Yang, Y., Sastry, N., Horbinski, C. M., Lu, S., Stupp, R., Kessler, J. A., Nishikawa, R., Nakano, I., Sulman, E. P., Lu, X., James, C. D., Yin, X. M., Hu, B. & 1 others, Cheng, S. Y., Dec 11 2017, In : Cancer Cell. 32, 6, p. 840-855.e8

Research output: Contribution to journalArticle

Autophagy
Glioblastoma
Phosphorylation
Radiotherapy
Serine
177 Citations (Scopus)

Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial

Weller, M., Butowski, N., Tran, D. D., Recht, L. D., Lim, M., Hirte, H., Ashby, L., Mechtler, L., Goldlust, S. A., Iwamoto, F., Drappatz, J., O'Rourke, D. M., Wong, M., Hamilton, M. G., Finocchiaro, G., Perry, J., Wick, W., Green, J., He, Y., Turner, C. D. & 32 others, Yellin, M. J., Keler, T., Davis, T. A., Stupp, R., Sampson, J. H., Butowski, N., Campian, J., Recht, L., Lim, M., Ashby, L., Drappatz, J., Hirte, H., Iwamoto, F., Mechtler, L., Goldlust, S., Becker, K., Barnett, G., Nicholas, G., Desjardins, A., Benkers, T., Wagle, N., Groves, M., Kesari, S., Horvath, Z., Merrell, R., Curry, R., O'Rourke, J., Schuster, D., Raizer, J., Lesniak, M., ACT IV trial investigators & ACT IV trial investigators, Oct 2017, In : The Lancet Oncology. 18, 10, p. 1373-1385 13 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Survival
Brain Edema
Control Groups
25 Citations (Scopus)

The Neurologic Assessment in Neuro-Oncology (NANO) scale: A tool to assess neurologic function for integration into the Response Assessment in Neuro-Oncology (RANO) criteria

Nayak, L., Deangelis, L. M., Brandes, A. A., Peereboom, D. M., Galanis, E., Lin, N. U., Soffietti, R., MacDonald, D. R., Chamberlain, M., Perry, J., Jaeckle, K., Mehta, M., Stupp, R., Muzikansky, A., Pentsova, E., Cloughesy, T., Iwamoto, F. M., Tonn, J. C., Vogelbaum, M. A., Wen, P. Y. & 2 others, Van Den Bent, M. J. & Reardon, D. A., May 1 2017, In : Neuro-oncology. 19, 5, p. 625-635 11 p.

Research output: Contribution to journalArticle

Nervous System
Outcome Assessment (Health Care)
Observer Variation
Brain Neoplasms
Glioma
2 Citations (Scopus)

Treatment strategies and outcome of surgery for synchronous colorectal liver metastases

Reding, D., Pestalozzi, B. C., Breitenstein, S., Stupp, R., Clavien, P. A., Slankamenac, K. & Samaras, P., Aug 15 2017, In : Swiss Medical Weekly. 147, w14486.

Research output: Contribution to journalArticle

Colorectal Surgery
Neoplasm Metastasis
Liver
Survival
Confidence Intervals
2016
24 Citations (Scopus)

Cilengitide in newly diagnosed glioblastoma: Biomarker expression and outcome

Weller, M., Nabors, L. B., Gorlia, T., Leske, H., Rushing, E., Bady, P., Hicking, C., Perry, J., Hong, Y. K., Roth, P., Wick, W., Goodman, S. L., Hegi, M. E., Picard, M., Moch, H., Straub, J. & Stupp, R., Mar 22 2016, In : Oncotarget. 7, 12, p. 15018-15032 15 p.

Research output: Contribution to journalArticle

Glioblastoma
Integrins
Biomarkers
Methyltransferases
Transforming Growth Factors
92 Citations (Scopus)

Corticosteroids compromise survival in glioblastoma

Pitter, K. L., Tamagno, I., Alikhanyan, K., Hosni-Ahmed, A., Pattwell, S. S., Donnola, S., Dai, C., Ozawa, T., Chang, M., Chan, T. A., Beal, K., Bishop, A. J., Barker, C. A., Jones, T. S., Hentschel, B., Gorlia, T., Schlegel, U., Stupp, R., Weller, M., Holland, E. C. & 1 others, Hambardzumyan, D., May 1 2016, In : Brain. 139, 5, p. 1458-1471 14 p.

Research output: Contribution to journalArticle

Glioblastoma
Dexamethasone
Adrenal Cortex Hormones
Radiotherapy
Survival
7 Citations (Scopus)

Development of OXY111A, a novel hypoxia-modifier as a potential antitumor agent in patients with hepato-pancreato-biliary neoplasms - Protocol of a first Ib/IIa clinical trial

Limani, P., Linecker, M., Kron, P., Samaras, P., Pestalozzi, B., Stupp, R., Jetter, A., Dutkowski, P., Müllhaupt, B., Schlegel, A., Nicolau, C., Lehn, J. M., Petrowsky, H., Humar, B., Graf, R. & Clavien, P. A., Oct 19 2016, In : BMC cancer. 16, 1, 812.

Research output: Contribution to journalArticle

Antineoplastic Agents
Clinical Trials
Neoplasms
Biliary Tract Neoplasms
Epithelial-Mesenchymal Transition
55 Citations (Scopus)

Does valproic acid or levetiracetam improve survival in glioblastoma? A pooled analysis of prospective clinical trials in newly diagnosed glioblastoma

Happold, C., Gorlia, T., Chinot, O., Gilbert, M. R., Nabors, L. B., Wick, W., Pugh, S. L., Hegi, M., Cloughesy, T., Roth, P., Reardon, D. A., Perry, J. R., Mehta, M. P., Stupp, R. & Weller, M., Mar 1 2016, In : Journal of Clinical Oncology. 34, 7, p. 731-739 9 p.

Research output: Contribution to journalArticle

etiracetam
temozolomide
Valproic Acid
Glioblastoma
Clinical Trials
42 Citations (Scopus)

Health-related quality of life in patients with high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study

Reijneveld, J. C., Taphoorn, M. J. B., Coens, C., Bromberg, J. E. C., Mason, W. P., Hoang-Xuan, K., Ryan, G., Hassel, M. B., Enting, R. H., Brandes, A. A., Wick, A., Chinot, O., Reni, M., Kantor, G., Thiessen, B., Klein, M., Verger, E., Borchers, C., Hau, P., Back, M. & 6 others, Smits, A., Golfinopoulos, V., Gorlia, T., Bottomley, A., Stupp, R. & Baumert, B. G., Nov 1 2016, In : The Lancet Oncology. 17, 11, p. 1533-1542 10 p.

Research output: Contribution to journalArticle

temozolomide
Glioma
Quality of Life
Organizations
Radiotherapy
45 Citations (Scopus)

Phase II study of radiotherapy and temsirolimus versus radiochemotherapy with temozolomide in patients with newly diagnosed glioblastoma without MGMT promoter hypermethylation (EORTC 26082)

Wick, W., Gorlia, T., Bady, P., Platten, M., Van Den Bent, M. J., Taphoorn, M. J. B., Steuve, J., Brandes, A. A., Hamou, M. F., Wick, A., Kosch, M., Weller, M., Stupp, R., Roth, P., Golfinopoulos, V., Frene, J. S., Campone, M., Ricard, D., Marosi, C., Villa, S. & 6 others, Weyerbrock, A., Hopkins, K., Homicsko, K., Lhermitte, B., Pesce, G. & Hegi, M. E., Oct 1 2016, In : Clinical Cancer Research. 22, 19, p. 4797-4806 10 p.

Research output: Contribution to journalArticle

temozolomide
Methyltransferases
Chemoradiotherapy
Glioblastoma
Radiotherapy
11 Citations (Scopus)

Preoperative versus postoperative docetaxel-cisplatin- fluorouracil (TCF) chemotherapy in locally advanced resectable gastric carcinoma: 10-year follow-up of the SAKK 43/99 phase III trial

Fazio, N., Biffi, R., Maibach, R., Hayoz, S., Thierstein, S., Brauchli, P., Bernhard, J., Stupp, R., Andreoni, B., Renne, G., Crosta, C., Morant, R., Chiappa, A., Luca, F., Zampino, M. G., Huber, O., Goldhirsch, A., de Braud, F., Roth, A. D., Pace, U. & 15 others, Cenciarelli, S., Pozzi, S., Bertani, E., Mura, S., Lorizzo, K., Di Meglio, G., Ravizza, D., Boselli, S., Matter, M., Richter, M., Monfardini, S., Dittrich, C., Häfner, M., Clemens, M. & Crowe, S., Apr 1 2016, In : Annals of Oncology. 27, 4, p. 668-673 6 p., mdv620.

Research output: Contribution to journalArticle

docetaxel
Fluorouracil
Cisplatin
Stomach
Carcinoma
4 Citations (Scopus)

PROX1 is a novel pathway-specific prognostic biomarker for high-grade astrocytomas; results from independent glioblastoma cohorts stratified by age and IDH mutation status

Roodakker, K. R., Elsir, T., Edqvist, P. H. D., Hägerstrand, D., Carlson, J., Lysiak, M., Henriksson, R., Pontén, F., Rosell, J., Söderkvist, P., Stupp, R., Tchougounova, E., Nistér, M., Malmström, A. & Smits, A., Jan 1 2016, In : Oncotarget. 7, 45, p. 72431-72442 12 p.

Research output: Contribution to journalArticle

Astrocytoma
Glioblastoma
Biomarkers
Mutation
Brain Neoplasms
142 Citations (Scopus)

Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study

Baumert, B. G., Hegi, M. E., van den Bent, M. J., von Deimling, A., Gorlia, T., Hoang-Xuan, K., Brandes, A. A., Kantor, G., Taphoorn, M. J. B., Hassel, M. B., Hartmann, C., Ryan, G., Capper, D., Kros, J. M., Kurscheid, S., Wick, W., Enting, R., Reni, M., Thiessen, B., Dhermain, F. & 17 others, Bromberg, J. E., Feuvret, L., Reijneveld, J. C., Chinot, O., Gijtenbeek, J. M. M., Rossiter, J. P., Dif, N., Balana, C., Bravo-Marques, J., Clement, P. M., Marosi, C., Tzuk-Shina, T., Nordal, R. A., Rees, J., Lacombe, D., Mason, W. P. & Stupp, R., Nov 1 2016, In : The Lancet Oncology. 17, 11, p. 1521-1532 12 p.

Research output: Contribution to journalArticle

temozolomide
Glioma
Radiotherapy
Drug Therapy
Disease-Free Survival