Roger Stupp

  • 41118 Citations
1990 …2023
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Research Output 1990 2020

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Review article
2019
3 Citations (Scopus)

Are integrins still practicable targets for anti-cancer therapy?

Alday-Parejo, B., Stupp, R. & Rüegg, C., Jul 2019, In : Cancers. 11, 7, 978.

Research output: Contribution to journalReview article

Open Access
Integrins
Neoplasms
Tumor Microenvironment
Therapeutics
Clinical Trials
4 Citations (Scopus)

Newly diagnosed glioblastoma: A review on clinical management

Lukas, R. V., Wainwright, D. A., Ladomersky, E., Sachdev, S., Sonabend Worthalter, A. M. & Stupp, R., Jan 1 2019, In : ONCOLOGY (United States). 33, 3, p. 91-100 10 p.

Research output: Contribution to journalReview article

Glioblastoma
Central Nervous System Neoplasms
Standard of Care
Cations
Radiotherapy
2018
28 Citations (Scopus)

CAR T-cell therapies in glioblastoma: A first look

Migliorini, D., Dietrich, P. Y., Stupp, R., Linette, G. P., Posey, A. D. & June, C. H., Feb 1 2018, In : Clinical Cancer Research. 24, 3, p. 535-540 6 p.

Research output: Contribution to journalReview article

Antigen Receptors
Glioblastoma
Cell- and Tissue-Based Therapy
temozolomide
T-Cell Antigen Receptor
2017
209 Citations (Scopus)

European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas

Weller, M., van den Bent, M., Tonn, J. C., Stupp, R., Preusser, M., Cohen-Jonathan-Moyal, E., Henriksson, R., Rhun, E. L., Balana, C., Chinot, O., Bendszus, M., Reijneveld, J. C., Dhermain, F., French, P., Marosi, C., Watts, C., Oberg, I., Pilkington, G., Baumert, B. G., Taphoorn, M. J. B. & 5 others, Hegi, M., Westphal, M., Reifenberger, G., Soffietti, R. & Wick, W., Jun 2017, In : The Lancet Oncology. 18, 6, p. e315-e329

Research output: Contribution to journalReview article

Astrocytoma
Guidelines
Therapeutics
Central Nervous System Neoplasms
Glioblastoma
59 Citations (Scopus)

Toxicity of concurrent stereotactic radiotherapy and targeted therapy or immunotherapy: A systematic review

Kroeze, S. G. C., Fritz, C., Hoyer, M., Lo, S. S., Ricardi, U., Sahgal, A., Stahel, R., Stupp, R. & Guckenberger, M., Feb 1 2017, In : Cancer Treatment Reviews. 53, p. 25-37 13 p.

Research output: Contribution to journalReview article

Immunotherapy
Radiotherapy
Therapeutics
Play Therapy
Literature
2016

Gliome - Was ich wissen muss in zehn Fragen

Translated title of the contribution: Gliomas - What i Have to Know in ten QuestionsGulden-Sala, W., Roth, P., Brown, M., Andratschke, N., Weller, M. & Stupp, R., Mar 2016, In : Praxis. 105, 6, p. 330-337 8 p.

Research output: Contribution to journalReview article

Glioma
Anticonvulsants
Central Nervous System Neoplasms
Intracranial Pressure
Therapeutics
51 Citations (Scopus)

Tumor treating fields: A novel treatment modality and its use in brain tumors

Hottinger, A. F., Pacheco, P. & Stupp, R., Oct 1 2016, In : Neuro-oncology. 18, 10, p. 1338-1349 12 p.

Research output: Contribution to journalReview article

Brain Neoplasms
temozolomide
Glioblastoma
Neoplasms
Maintenance Chemotherapy
2015
98 Citations (Scopus)

Glioma

Weller, M., Wick, W., Aldape, K., Brada, M., Berger, M., Pfister, S. M., Nishikawa, R., Rosenthal, M., Wen, P. Y., Stupp, R. & Reifenberger, G., Jul 16 2015, In : Nature Reviews Disease Primers. 1, 15017.

Research output: Contribution to journalReview article

Glioma
Isocitrate Dehydrogenase
Neoplasms
Astrocytoma
Epigenomics
2014
330 Citations (Scopus)

EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma

Weller, M., van den Bent, M., Hopkins, K., Tonn, J. C., Stupp, R., Falini, A., Cohen-Jonathan-Moyal, E., Frappaz, D., Henriksson, R., Balana, C., Chinot, O., Ram, Z., Reifenberger, G., Soffietti, R. & Wick, W., Aug 2014, In : The Lancet Oncology. 15, 9, p. e395-e403

Research output: Contribution to journalReview article

Glioblastoma
Glioma
Guidelines
Patient Care
Insurance
34 Citations (Scopus)

European perspective for effective cancer drug development

Lacombe, D., Tejpar, S., Salgado, R., Cardoso, F., Golfinopoulos, V., Aust, D., Folprecht, G., Roth, A. & Stupp, R., Jan 1 2014, In : Nature Reviews Clinical Oncology. 11, 8, p. 492-498 7 p.

Research output: Contribution to journalReview article

Pharmaceutical Preparations
Neoplasms
Cost Sharing
Drug Costs
Drug Discovery
26 Citations (Scopus)

Health-related quality of life in small-cell lung cancer: A systematic review on reporting of methods and clinical issues in randomised controlled trials

Zikos, E., Ghislain, I., Coens, C., Ediebah, D. E., Sloan, E., Quinten, C., Koller, M., van Meerbeeck, J. P., Flechtner, H. H., Stupp, R., Pallis, A., Czimbalmos, A., Sprangers, M. A. G. & Bottomley, A., Feb 2014, In : The Lancet Oncology. 15, 2, p. e78-89

Research output: Contribution to journalReview article

Small Cell Lung Carcinoma
Randomized Controlled Trials
Quality of Life
Lung Neoplasms
60 Citations (Scopus)

Standards of care and novel approaches in the management of glioblastoma multiforme

Hottinger, A. F., Stupp, R. & Homicsko, K., Jan 10 2014, In : Chinese Journal of Cancer. 33, 1, p. 32-39 8 p.

Research output: Contribution to journalReview article

Glioblastoma
Standard of Care
Therapeutics
Brain Neoplasms
Immunotherapy
1 Citation (Scopus)
Organizations
Research
Pharmaceutical Preparations
Incentive Reimbursement
Delivery of Health Care
30 Citations (Scopus)

The level of patient-reported outcome reporting in randomised controlled trials of brain tumour patients: A systematic review

Dirven, L., Taphoorn, M. J. B., Reijneveld, J. C., Blazeby, J., Jacobs, M., Pusic, A., Sala, E. L., Stupp, R., Fayers, P. & Efficace, F., Jan 1 2014, In : European Journal of Cancer. 50, 14, p. 2432-2448 17 p.

Research output: Contribution to journalReview article

Brain Neoplasms
Randomized Controlled Trials
Patient Reported Outcome Measures
Glioma
Research Personnel
2013
9 Citations (Scopus)

Brain cancer in 2012: Molecular characterization leads the way

Stupp, R. & Hegi, M. E., Feb 1 2013, In : Nature Reviews Clinical Oncology. 10, 2, p. 69-70 2 p.

Research output: Contribution to journalReview article

Molecular Targeted Therapy
Gene Expression Profiling
Brain Neoplasms
3 Citations (Scopus)

Malignant astrocytoma in elderly patients: Where do we stand?

Tabatabai, G., Stupp, R., Wick, W. & Weller, M., Dec 1 2013, In : Current Opinion in Neurology. 26, 6, p. 693-700 8 p.

Research output: Contribution to journalReview article

Astrocytoma
Radiotherapy
Standard of Care
Methylation
Vascular Endothelial Growth Factor A
12 Citations (Scopus)

Molecular imaging in the development of a novel treatment paradigm for glioblastoma (GBM): An integrated multidisciplinary commentary

Jarzabek, M. A., Sweeney, K. J., Evans, R. L., Jacobs, A. H., Stupp, R., O'Brien, D., Berger, M. S., Prehn, J. H. M. & Byrne, A. T., Nov 1 2013, In : Drug Discovery Today. 18, 21-22, p. 1052-1066 15 p.

Research output: Contribution to journalReview article

Molecular Imaging
Glioblastoma
Traction
Therapeutics
Disease Progression
126 Citations (Scopus)

Molecular neuro-oncology in clinical practice: A new horizon

Weller, M., Pfister, S. M., Wick, W., Hegi, M. E., Reifenberger, G. & Stupp, R., Aug 1 2013, In : The Lancet Oncology. 14, 9, p. e370-e379

Research output: Contribution to journalReview article

Medical Oncology
Brain Neoplasms
Glioma
Medulloblastoma
Glioblastoma
85 Citations (Scopus)

Optimal management of elderly patients with glioblastoma

Laperriere, N., Weller, M., Stupp, R., Perry, J. R., Brandes, A. A., Wick, W. & van den Bent, M. J., Jun 1 2013, In : Cancer Treatment Reviews. 39, 4, p. 350-357 8 p.

Research output: Contribution to journalReview article

Glioblastoma
temozolomide
Radiotherapy
Therapeutics
Survival
3 Citations (Scopus)

PET imaging in glioma: The neuro-oncologist's expectations

Hottinger, A. F., Levivier, M., Negretti, L., Homicsko, K. & Stupp, R., Apr 2013, In : PET Clinics. 8, 2, p. 117-128 12 p.

Research output: Contribution to journalReview article

Glioma
evaluation
imaging techniques
half life
tracers
2012
19 Citations (Scopus)

Brain metastasis: Opportunity for drug development?

Preusser, M., Berghoff, A. S., Schadendorf, D., Lin, N. U. & Stupp, R., Dec 1 2012, In : Current Opinion in Neurology. 25, 6, p. 786-794 9 p.

Research output: Contribution to journalReview article

Neoplasm Metastasis
Brain
Pharmaceutical Preparations
Breast Neoplasms
Melanoma
24 Citations (Scopus)

Clinical implications of molecular neuropathology and biomarkers for malignant glioma

Tabatabai, G., Hegi, M., Stupp, R. & Weller, M., Jun 1 2012, In : Current neurology and neuroscience reports. 12, 3, p. 302-307 6 p.

Research output: Contribution to journalReview article

Glioma
Biomarkers
Radiotherapy
Oligodendroglioma
Drug Therapy
78 Citations (Scopus)

Epilepsy meets cancer: When, why, and what to do about it?

Weller, M., Stupp, R. & Wick, W., Sep 1 2012, In : The Lancet Oncology. 13, 9, p. e375-e382

Research output: Contribution to journalReview article

Epilepsy
Neoplasms
Brain Neoplasms
Drug Interactions
Anticonvulsants
53 Citations (Scopus)

Individualized targeted therapy for glioblastoma: Fact or fiction?

Weller, M., Stupp, R., Hegi, M. & Wick, W., Jan 1 2012, In : Cancer Journal. 18, 1, p. 40-44 5 p.

Research output: Contribution to journalReview article

Glioblastoma
Karnofsky Performance Status
Biomarkers
Therapeutics
Alkylating Agents
63 Citations (Scopus)

Presence of an oligodendroglioma-like component in newly diagnosed glioblastoma identifies a pathogenetically heterogeneous subgroup and lacks prognostic value: Central pathology review of the EORTC-26981/NCIC-CE.3 trial

Hegi, M. E., Janzer, R. C., Lambiv, W. L., Gorlia, T., Kouwenhoven, M. C. M., Hartmann, C., Von Deimling, A., Martinet, D., Schmutz, N. B., Diserens, A. C., Hamou, M. F., Bady, P., Weller, M., Van Den Bent, M. J., Mason, W. P., Mirimanoff, R. O., Stupp, R., Mokhtari, K. & Wesseling, P., Jun 1 2012, In : Acta Neuropathologica. 123, 6, p. 841-852 12 p.

Research output: Contribution to journalReview article

Oligodendroglioma
Glioblastoma
Pathology
Necrosis
temozolomide
2011
286 Citations (Scopus)

Current concepts and management of glioblastoma

Preusser, M., De Ribaupierre, S., Wöhrer, A., Erridge, S. C., Hegi, M., Weller, M. & Stupp, R., Jul 1 2011, In : Annals of neurology. 70, 1, p. 9-21 13 p.

Research output: Contribution to journalReview article

Glioblastoma
Patient Care
Quality of Life
Life Expectancy
Brain Neoplasms
18 Citations (Scopus)

Medulloblastomas in adults: Prognostic factors and lessons from paediatrics

Fellay, C. N., Frappaz, D., Sunyach, M. P., Franceschi, E., Brandes, A. A. & Stupp, R., Dec 1 2011, In : Current Opinion in Neurology. 24, 6, p. 626-632 7 p.

Research output: Contribution to journalReview article

Medulloblastoma
Pediatrics
Histology
Therapeutics
Genes
31 Citations (Scopus)

The role of integrins in glioma biology and anti-glioma therapies

Tabatabai, G., Tonn, J. C., Stupp, R. & Weller, M., Aug 2011, In : Current Pharmaceutical Design. 17, 23, p. 2402-2410 9 p.

Research output: Contribution to journalReview article

Integrins
Glioma
Methyltransferases
Glioblastoma
Methylation
2010
56 Citations (Scopus)

Epilepsy in brain tumor patients

Rossetti, A. O. & Stupp, R., Dec 1 2010, In : Current Opinion in Neurology. 23, 6, p. 603-609 7 p.

Research output: Contribution to journalReview article

Brain Neoplasms
Anticonvulsants
Epilepsy
etiracetam
Seizures
320 Citations (Scopus)

Guidelines on management of low-grade gliomas: Report of an EFNS-EANO Task Force

Soffietti, R., Baumert, B. G., Bello, L., Von Deimling, A., Duffau, H., Frénay, M., Grisold, W., Grant, R., Graus, F., Hoang-Xuan, K., Klein, M., Melin, B., Rees, J., Siegal, T., Smits, A., Stupp, R. & Wick, W., Sep 1 2010, In : European Journal of Neurology. 17, 9, p. 1124-1133 10 p.

Research output: Contribution to journalReview article

Advisory Committees
Glioma
Radiotherapy
Guidelines
Oligodendroglioma
14 Citations (Scopus)

Is there a place for radiotherapy in low-grade gliomas?

Baumert, B. G. & Stupp, R., Jan 1 2010, In : Advances and technical standards in neurosurgery. 35, p. 159-182 24 p.

Research output: Contribution to journalReview article

Glioma
Radiotherapy
Neoplasms
temozolomide
Therapeutics
444 Citations (Scopus)

MGMT promoter methylation in malignant gliomas: Ready for personalized medicine?

Weller, M., Stupp, R., Reifenberger, G., Brandes, A. A., Van Den Bent, M. J., Wick, W. & Hegi, M. E., Jan 1 2010, In : Nature Reviews Neurology. 6, 1, p. 39-51 13 p.

Research output: Contribution to journalReview article

Precision Medicine
Methyltransferases
Glioma
Methylation
DNA
83 Citations (Scopus)

Molecular diagnostics of gliomas: The clinical perspective

Tabatabai, G., Stupp, R., Van Den Bent, M. J., Hegi, M. E., Tonn, J. C., Wick, W. & Weller, M., Nov 1 2010, In : Acta Neuropathologica. 120, 5, p. 585-592 8 p.

Research output: Contribution to journalReview article

Molecular Pathology
Glioma
Isocitrate Dehydrogenase
Glioblastoma
Methylation
17 Citations (Scopus)

Should biomarkers be used to design personalized medicine for the treatment of glioblastoma?

Weller, M., Wick, W., Hegi, M. E., Stupp, R. & Tabatabai, G., Sep 1 2010, In : Future Oncology. 6, 9, p. 1407-1414 8 p.

Research output: Contribution to journalReview article

Precision Medicine
temozolomide
Methyltransferases
Glioblastoma
Methylation
65 Citations (Scopus)

Targeting integrins in malignant glioma

Tabatabai, G., Weller, M., Nabors, B., Picard, M., Reardon, D., Mikkelsen, T., Ruegg, C. & Stupp, R., Sep 1 2010, In : Targeted Oncology. 5, 3, p. 175-181 7 p.

Research output: Contribution to journalReview article

Glioblastoma
Integrins
Glioma
Integrin alpha Chains
Chemoradiotherapy
1843 Citations (Scopus)

Updated response assessment criteria for high-grade gliomas: Response assessment in neuro-oncology working group

Wen, P. Y., Macdonald, D. R., Reardon, D. A., Cloughesy, T. F., Sorensen, A. G., Galanis, E., DeGroot, J., Wick, W., Gilbert, M. R., Lassman, A. B., Tsien, C., Mikkelsen, T., Wong, E. T., Chamberlain, M. C., Stupp, R., Lamborn, K. R., Vogelbaum, M. A., Van Den Bent, M. J. & Chang, S. M., Apr 10 2010, In : Journal of Clinical Oncology. 28, 11, p. 1963-1972 10 p.

Research output: Contribution to journalReview article

Glioma
Neoplasms
Angiogenesis Inhibitors
Tomography
Magnetic Resonance Imaging
2009
43 Citations (Scopus)

Epigenetic deregulation of DNA repair and its potential for therapy

Hegi, M. E., Sciuscio, D., Murat, A., Levivier, M. & Stupp, R., Aug 15 2009, In : Clinical Cancer Research. 15, 16, p. 5026-5031 6 p.

Research output: Contribution to journalReview article

Epigenomics
DNA Repair
DNA
Neoplasms
Werner Syndrome
9 Citations (Scopus)

Primetime for antiangiogenic therapy

Tabatabai, G. & Stupp, R., Nov 1 2009, In : Current Opinion in Neurology. 22, 6, p. 639-644 6 p.

Research output: Contribution to journalReview article

Glioma
Phenotype
Angiogenesis Inhibitors
Therapeutics
Glioblastoma
2008
149 Citations (Scopus)

Cilengitide: An integrin-targeting arginine-glycine-aspartic acid peptide with promising activity for glioblastoma multiforme

Reardon, D. A., Nabors, L. B., Stupp, R. & Mikkelsen, T., Aug 1 2008, In : Expert Opinion on Investigational Drugs. 17, 8, p. 1225-1235 11 p.

Research output: Contribution to journalReview article

Glioblastoma
Aspartic Acid
Integrins
Glycine
Arginine
7 Citations (Scopus)

Comparison of the safety and efficacy of paclitaxel plus gemcitabine combination in young and elderly patients with locally advanced or metastatic non-small cell lung cancer. A retrospective analysis of the Southern Italy Cooperative Oncology Group trials

Comella, P., Gambardella, A., Frasci, G., Avallone, A., Costanzo, R., Gridelli, C., Stupp, R., Scagliotti, G. V., Comella, P., Frasci, G., Avallone, A., Costanzo, R., Gambardella, A., Bianco, M., Bilancia, D., Buzzi, F., Bartolucci, R., Cioffi, R., Messina, V., Carnicelli, P. & 30 others, De Cataldis, G., Del Gaizo, F., Del Prete, S., Di Lullo, L., Farris, A., Putzu, C., Filippelli, G., Olivito, V., Dima, G., Guida, M., Iannelli, A., Condemi, G., Mancarella, S., Maiorino, L., Musicò, M., Massidda, B., Ionta, M. T., Mereu, E., Masullo, P., Muci, D., Paccagnella, A., Panza, N., Palmeri, S., Vaglica, M., Roselli, M., Mariotti, S., Milia, V., Natale, D., Ghiani, M. & Barbato, E., Feb 1 2008, In : Critical Reviews in Oncology/Hematology. 65, 2, p. 164-171 8 p.

Research output: Contribution to journalReview article

gemcitabine
Paclitaxel
Non-Small Cell Lung Carcinoma
Italy
Safety
511 Citations (Scopus)

Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity

Hegi, M. E., Liu, L., Herman, J. G., Stupp, R., Wick, W., Weller, M., Mehta, M. P. & Gilbert, M. R., Sep 18 2008, In : Journal of Clinical Oncology. 26, 25, p. 4189-4199 11 p.

Research output: Contribution to journalReview article

Methyltransferases
Glioblastoma
Methylation
Alkylating Agents
Glioma
94 Citations (Scopus)

Epidermal growth factor receptor inhibitors in neuro-oncology: Hopes and disappointments

Brandes, A. A., Franceschi, E., Tosoni, A., Hegi, M. E. & Stupp, R., Feb 15 2008, In : Clinical Cancer Research. 14, 4, p. 957-960 4 p.

Research output: Contribution to journalReview article

Epidermal Growth Factor Receptor
Glioma
Adenosine Triphosphate
erbB-1 Genes
Antineoplastic Agents
6 Citations (Scopus)

Stratégies thérapeutiques pour le traitement des gliomes

Translated title of the contribution: Therapeutic strategies for the management of gliomasHottinger, A. F. & Stupp, R., Jun 1 2008, In : Revue Neurologique. 164, 6-7, p. 523-530 8 p.

Research output: Contribution to journalReview article

Glioma
Oligodendroglioma
temozolomide
Glioblastoma
Survival
2007
50 Citations (Scopus)

Anaplastic astrocytoma in adults

Stupp, R., Reni, M., Gatta, G., Mazza, E. & Vecht, C., Jul 1 2007, In : Critical Reviews in Oncology/Hematology. 63, 1, p. 72-80 9 p.

Research output: Contribution to journalReview article

Astrocytoma
temozolomide
Drug Therapy
Karnofsky Performance Status
Meta-Analysis
338 Citations (Scopus)

Chemoradiotherapy in malignant glioma: Standard of care and future directions

Stupp, R., Hegi, M. E., Gilbert, M. R. & Chakravarti, A., Sep 10 2007, In : Journal of Clinical Oncology. 25, 26, p. 4127-4136 10 p.

Research output: Contribution to journalReview article

temozolomide
Methyltransferases
Chemoradiotherapy
Standard of Care
Glioma
34 Citations (Scopus)

MGMT methylation status: The advent of stratified therapy in glioblastoma?

Hau, P., Stupp, R. & Hegi, M. E., Jan 1 2007, In : Disease Markers. 23, 1-2, p. 97-104 8 p.

Research output: Contribution to journalReview article

Methylation
Glioblastoma
Genes
Alkylating Agents
temozolomide
9 Citations (Scopus)

Rôle de la MGMT et implications cliniques dans les tumeurs cérébrales

Translated title of the contribution: Role of MGMT and clinical applications in brain tumoursPaus, C., Murat, A., Stupp, R., Regli, L. & Hegi, M., Sep 1 2007, In : Bulletin du cancer. 94, 9, p. 769-773 5 p.

Research output: Contribution to journalReview article

Alkylating Agents
temozolomide
Methyltransferases
Brain Neoplasms
Methylation
12 Citations (Scopus)

Un guide pratique au traitement des gliomes

Translated title of the contribution: A practical guide for the management of gliomasStupp, R., Pica, A., Mirimanoff, R. O. & Michielin, O., Sep 1 2007, In : Bulletin du cancer. 94, 9, p. 817-822 6 p.

Research output: Contribution to journalReview article

Glioma
temozolomide
Radiotherapy
Oligodendroglioma
Drug Therapy
2006
307 Citations (Scopus)

Changing paradigms - An update on the multidisciplinary management of malignant glioma

Stupp, R., Hegi, M. E., Van Den Bent, M. J., Mason, W. P., Weller, M., Mirimanoff, R. O. & Cairncross, J. G., Feb 1 2006, In : Oncologist. 11, 2, p. 165-180 16 p.

Research output: Contribution to journalReview article

Glioma
temozolomide
Drug Therapy
Radiotherapy
irinotecan
5 Citations (Scopus)

Correlative studies in neuro-oncology trials: Should they influence treatment?

Hegi, M. E. & Stupp, R., Jan 1 2006, In : Current Oncology Reports. 8, 1, p. 54-57 4 p.

Research output: Contribution to journalReview article

Complementary Therapies
Glioma
Patient Selection
Therapeutics
Clinical Trials