Grants per year
Personal profile
Research Interests
In the case of bacterial infection and mucosal injury neutrophil transepithelial migration is essential for host defense and tissue homeostasis, however, it may also lead to detrimental inflammation, which is a hallmark of inflammatory disorders of mucosal surfaces, particularly diseases of the gastrointestinal tract, including ulcerative colitis and Cohn’s disease. Our laboratory focuses on interactions of innate immune cells, specifically neutrophils with luminally expressed epithelial adhesive receptors, and the contribution of these interactions to regulation of epithelial barrier and mucosal wound healing, under the conditions of intestinal inflammation. A better understanding of the mechanisms regulating PMN recruitment and retention at the mucosal surfaces, and identification of specific molecules that may link PMN-epithelial cell interactions with epithelial barrier function and wound repair are imperative for the development of new and improved therapeutic approaches aiding in the resolution of mucosal inflammation, and reestablishing epithelial homeostasis. Reaserch Interest: • Understanding mechanisms regulating leukocyte recruitment to mucosal tissues • Determining the underlying mechanisms for leukocyte-associated effects on endothelial/epithelial function • Host-pathogen interactions • Innate immune contribution to colorectal cancer
Training Experience
2012 | Postdoctoral Fellowship, Emory University |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Biomedical Engineering, University of Rochester
… → 2008
Research interests keywords
- Cell Adhesion Mechanisms
- Cell Imaging
- Inflammation
- Inflammatory Bowel Disease
- Leukocyte-endothelial Cell Interactions
- Wound Care
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Collaborations and top research areas from the last five years
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Hyperbaric Oxygen Therapy for Ulcerative Colitis Patients Hospitalized for Moderate to Severe Flares: A Phase 3 Multi-Center, Randomized, Double-Blind, Sham-Controlled Trial
Bonner, L. B., Dulai, P. S., Hanauer, S. B., Hirano, I., Scholtens, D. M., Sumagin, R. & Yang, G.
National Institute of Diabetes and Digestive and Kidney Diseases
3/15/23 → 2/28/28
Project: Research project
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Perivascular Macrophages Regulate Neutrophil Transendothelial Migration in IBD
Crohn's and Colitis Foundation of America
7/1/22 → 6/30/25
Project: Research project
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Vascular endothelial cells and macrophages coordinate neutrophil trafficking in inflammation
National Institute of Allergy and Infectious Diseases
6/4/21 → 5/31/26
Project: Research project
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Neutrophils instruct macrophage responses to promote mucosal healing
Sumagin, R., Sumagin, R., Thorp, E. B. & Thorp, E. B.
National Institute of Diabetes and Digestive and Kidney Diseases
5/5/20 → 4/30/24
Project: Research project
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A microRNA panel that regulates proinflammatory cytokines as diagnostic and prognosis biomarkers in colon cancer
Martínez-Gutierrez, A., Carbajal-Lopez, B., Bui, T. M., Mendoza-Rodriguez, M., Campos-Parra, A. D., Calderillo-Ruiz, G., Cantú-De Leon, D., Madrigal-Santillán, E. O., Sumagin, R., Pérez-Plasencia, C. & Pérez-Yépez, E. A., Jul 2022, In: Biochemistry and Biophysics Reports. 30, 101252.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Atovaquone attenuates experimental colitis by reducing neutrophil infiltration of colonic mucosa
Manzanares, L. D., David, J., Ren, X., Yalom, L. K., Piccolo, E. B., Dehghan, Y., David, A. J., Hanauer, S. B. & Sumagin, R., Oct 14 2022, In: Frontiers in Pharmacology. 13, 1011115.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Experimental Colitis Enhances Temporal Variations in CX3CR1 Cell Colonization of the Gut and Brain Following Irradiation
Batra, A., Bui, T. M., Rehring, J. F., Yalom, L. K., Muller, W. A., Sullivan, D. P. & Sumagin, R., Feb 2022, In: American Journal of Pathology. 192, 2, p. 295-307 13 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Functional implications of neutrophil metabolism during ischemic tissue repair
Piccolo, E. B., Thorp, E. B. & Sumagin, R., Apr 2022, In: Current Opinion in Pharmacology. 63, 102191.Research output: Contribution to journal › Review article › peer-review
4 Scopus citations -
Neutrophils and micronuclei: An emerging link between genomic instability and cancer-driven inflammation
Bui, T. M. & Sumagin, R., Jan 1 2022, In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 824, 111778.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
Datasets
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Unveiling early cortical and subcortical neuronal degeneration in ALS mice by ultra-high field diffusion MRI
Gatto, R. G. (Creator), Amin, M. (Creator), Finkielsztein, A. (Creator), Weissmann, C. (Creator), Barrett, T. (Creator), Lamoutte, C. (Creator), Uchitel, O. (Creator), Sumagin, R. (Creator), Mareci, T. H. (Creator) & Magin, R. L. (Creator), Taylor & Francis, 2019
DOI: 10.6084/m9.figshare.8222450.v2, https://tandf.figshare.com/articles/Unveiling_early_cortical_and_subcortical_neuronal_degeneration_in_ALS_mice_by_ultra-high_field_diffusion_MRI/8222450/2
Dataset