Grants per year
Personal profile
Research Interests
In the case of bacterial infection and mucosal injury neutrophil transepithelial migration is essential for host defense and tissue homeostasis, however, it may also lead to detrimental inflammation, which is a hallmark of inflammatory disorders of mucosal surfaces, particularly diseases of the gastrointestinal tract, including ulcerative colitis and Cohn’s disease. Our laboratory focuses on interactions of innate immune cells, specifically neutrophils with luminally expressed epithelial adhesive receptors, and the contribution of these interactions to regulation of epithelial barrier and mucosal wound healing, under the conditions of intestinal inflammation. A better understanding of the mechanisms regulating PMN recruitment and retention at the mucosal surfaces, and identification of specific molecules that may link PMN-epithelial cell interactions with epithelial barrier function and wound repair are imperative for the development of new and improved therapeutic approaches aiding in the resolution of mucosal inflammation, and reestablishing epithelial homeostasis. Reaserch Interest: • Understanding mechanisms regulating leukocyte recruitment to mucosal tissues • Determining the underlying mechanisms for leukocyte-associated effects on endothelial/epithelial function • Host-pathogen interactions • Innate immune contribution to colorectal cancer
Training Experience
2012 | Postdoctoral Fellowship, Emory University |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Biomedical Engineering, University of Rochester
… → 2008
Research interests keywords
- Cell Adhesion Mechanisms
- Cell Imaging
- Inflammation
- Inflammatory Bowel Disease
- Leukocyte-endothelial Cell Interactions
- Wound Care
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Collaborations and top research areas from the last five years
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Exploring Neutrophil contribution to anti-TNFa therapy resistance in IBD
Sumagin, R. (PD/PI)
Crohn's and Colitis Foundation of America
1/1/25 → 12/31/27
Project: Research project
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Aging Exacerbates Neutrophil Persistence and Negatively Impacts Stroke Outcomes
Batra, A. (PD/PI), Sullivan, D. P. (PD/PI), Muller, W. A. (Co-Investigator) & Sumagin, R. (Co-Investigator)
5/15/24 → 4/30/26
Project: Research project
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The Neu-Lung Consortium: Neutrophilic Mechanisms of Inflammation, Injury, and Repair in Lung and Airways Diseases
Berdnikovs, S. (Co-Investigator), Berdnikovs, S. (Co-Investigator), Sumagin, R. (Co-Investigator) & Muller, W. A. (Other)
National Institute of Allergy and Infectious Diseases
4/1/24 → 3/31/29
Project: Research project
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Identifying Neutrophil Specific Mechanisms for Resistance to Biologics in Ulcerative Colitis
Sumagin, R. (PD/PI)
National Institute of Diabetes and Digestive and Kidney Diseases
8/1/23 → 5/31/27
Project: Research project
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Hyperbaric Oxygen Therapy for Ulcerative Colitis Patients Hospitalized for Moderate to Severe Flares: A Phase 3 Multi-Center, Randomized, Double-Blind, Sham-Controlled Trial
Bonner, L. B. (PD/PI), Bonner, L. B. (PD/PI), Dulai, P. S. (PD/PI), Dulai, P. S. (PD/PI), Hanauer, S. B. (Co-Investigator), Hanauer, S. B. (Co-Investigator), Hanauer, S. B. (Co-Investigator), Hirano, I. (Co-Investigator), Hirano, I. (Co-Investigator), Scholtens, D. M. (Co-Investigator), Scholtens, D. M. (Co-Investigator), Sumagin, R. (Co-Investigator), Sumagin, R. (Co-Investigator), Sumagin, R. (Co-Investigator), Yang, G.-Y. (Co-Investigator), Yang, G.-Y. (Co-Investigator) & Yang, G.-Y. (Co-Investigator)
National Institute of Diabetes and Digestive and Kidney Diseases
3/15/23 → 2/29/28
Project: Research project
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Paradoxical Response to Neoadjuvant Therapy in Undifferentiated Pleomorphic Sarcoma: Increased Tumor Size on MRI Associated with Favorable Pathology
Goreish, M. H., Gennaro, N., Perronne, L., Durak, G., Borhani, A. A., Savas, H., Kelahan, L., Avery, R., Subedi, K., Agirlar Trabzonlu, T., Bagci, U., Turkbey, B., Bakas, S., Sachdev, S., Sumagin, R., Alexiev, B. A., Hermida de Viveiros, P., Pollack, S. M. & Velichko, Y. S., Mar 2025, In: Cancers. 17, 5, 830.Research output: Contribution to journal › Article › peer-review
Open Access -
Spatially separated epithelium-associated and lamina propria neutrophils present distinct functional identities in the inflamed colon mucosa
Yalom, L. K., Herrnreiter, C. J., Bui, T. M., Lockhart, J., Piccolo, E. B., Ren, X., Wei, C., Serdiukova, A., Thorp, E. B., Dulai, P. S. & Sumagin, R., 2025, (Accepted/In press) In: Mucosal Immunology.Research output: Contribution to journal › Article › peer-review
Open Access -
Hypoxia-inducible factor-2α enhances neutrophil survival to promote cardiac injury following myocardial infarction
Piccolo, E. B., Ge, Z. D., Filipp, M. E., Sullivan, D. P., Thorp, E. B. & Sumagin, R., Nov 2024, In: American Journal of Physiology - Heart and Circulatory Physiology. 327, 5, p. H1230-H1243Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Mediator complex subunit 1 architects a tumorigenic Treg cell program independent of inflammation
Chaudhuri, S. M., Weinberg, S. E., Wang, D., Yalom, L. K., Montauti, E., Iyer, R., Tang, A. Y., Torres Acosta, M. A., Shen, J., Mani, N. L., Wang, S., Liu, K., Lu, W., Bui, T. M., Manzanares, L. D., Dehghani, Z., Wai, C. M., Gao, B., Wei, J. & Yue, F. & 5 others, , Mar 19 2024, In: Cell Reports Medicine. 5, 3, 101441.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
miR-3065-5p and miR-26a-5p as Clinical Biomarkers in Colorectal Cancer: A Translational Study
Carbajal-López, B., Martínez-Gutierrez, A. D., Madrigal-Santillán, E. O., Calderillo-Ruiz, G., Morales-González, J. A., Coronel-Hernández, J., Lockhart, J., Millan-Catalan, O., Mendoza-Rodriguez, M. G., Lino-Silva, L. S., Calderillo-Trejo, G., Sumagin, R., Pérez-Plasencia, C. & Pérez-Yépez, E. A., Nov 2024, In: Cancers. 16, 21, 3649.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Unveiling early cortical and subcortical neuronal degeneration in ALS mice by ultra-high field diffusion MRI
Gatto, R. G. (Creator), Amin, M. (Creator), Finkielsztein, A. (Creator), Weissmann, C. (Creator), Barrett, T. (Creator), Lamoutte, C. (Creator), Uchitel, O. (Creator), Sumagin, R. (Creator), Mareci, T. H. (Creator) & Magin, R. L. (Creator), Taylor & Francis, 2019
DOI: 10.6084/m9.figshare.8222450, https://tandf.figshare.com/articles/Unveiling_early_cortical_and_subcortical_neuronal_degeneration_in_ALS_mice_by_ultra-high_field_diffusion_MRI/8222450
Dataset