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Ronen Sumagin

  • 1131 Citations
20052020

Research output per year

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Personal profile

Research Interests

In the case of bacterial infection and mucosal injury neutrophil transepithelial migration is essential for host defense and tissue homeostasis, however, it may also lead to detrimental inflammation, which is a hallmark of inflammatory disorders of mucosal surfaces, particularly diseases of the gastrointestinal tract, including ulcerative colitis and Cohn’s disease. Our laboratory focuses on interactions of innate immune cells, specifically neutrophils with luminally expressed epithelial adhesive receptors, and the contribution of these interactions to regulation of epithelial barrier and mucosal wound healing, under the conditions of intestinal inflammation. A better understanding of the mechanisms regulating PMN recruitment and retention at the mucosal surfaces, and identification of specific molecules that may link PMN-epithelial cell interactions with epithelial barrier function and wound repair are imperative for the development of new and improved therapeutic approaches aiding in the resolution of mucosal inflammation, and reestablishing epithelial homeostasis. Reaserch Interest: • Understanding mechanisms regulating leukocyte recruitment to mucosal tissues • Determining the underlying mechanisms for leukocyte-associated effects on endothelial/epithelial function • Host-pathogen interactions • Innate immune contribution to colorectal cancer

Training Experience

2012Postdoctoral Fellowship, Emory University

Education/Academic qualification

PhD, University of Rochester

… → 2008

Research interests

  • Cell Adhesion Mechanisms
  • Cell Imaging
  • Inflammation
  • Inflammatory Bowel Disease
  • Leukocyte-endothelial Cell Interactions
  • Wound Care

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Grants

Neutrophils instruct macrophage responses to promote mucosal healing

Sumagin, R. & Thorp, E. B.

National Institute of Diabetes, Digestive and Kidney Diseases

5/5/20 → 4/30/24

Project: Research project

    • Neutrophil-driven inflammation leads to carcinogenesis in IBD

    Sumagin, R.

    Crohn's and Colitis Foundation of America

    7/1/19 → 6/30/22

    Project: Research project

    • How immune cells promote tissue injury to increase risk of colon cancer

    Sumagin, R.

    Northwestern Memorial Hospital

    7/1/19 → 6/30/20

    Project: Research project

    Roles for Neutrophils in Development and Metastasis of Colorectal Cancer

    Butin-Israeli, V. & Sumagin, R.

    American Cancer Society

    1/1/18 → 12/31/21

    Project: Research project

    • Mechanisms of Salmonella Clearance by Neutrophils in the Intestinal Lumen

    Sumagin, R.

    National Institute of Diabetes, Digestive and Kidney Diseases

    5/1/18 → 4/30/20

    Project: Research project

    • Research Output

    • 1131 Citations
    • 38 Article
    • 5 Review article
    • 1 Conference contribution

    ICAM-1: A master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis

    Bui, T. M., Wiesolek, H. L. & Sumagin, R., Jan 1 2020, (Accepted/In press) In : Journal of Leukocyte Biology.

    Research output: Contribution to journal › Review article

    • Intercellular Adhesion Molecule 1 Functions as an Efferocytosis Receptor in Inflammatory Macrophages

    Wiesolek, H. L., Bui, T. M., Lee, J. J., Dalal, P., Finkielsztein, A., Batra, A., Thorp, E. B. & Sumagin, R., Apr 2020, In : American Journal of Pathology. 190, 4, p. 874-885 12 p.

    Research output: Contribution to journal › Article

    • Neutrophil-Derived Reactive Oxygen Orchestrates Epithelial Cell Signaling Events during Intestinal Repair

    Matthews, J. D., Owens, J. A., Naudin, C. R., Saeedi, B. J., Alam, A., Reedy, A. R., Hinrichs, B. H., Sumagin, R., Neish, A. S. & Jones, R. M., Nov 2019, In : American Journal of Pathology. 189, 11, p. 2221-2232 12 p.

    Research output: Contribution to journal › Article

    Open Access
    • 1 Scopus citations

    Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing

    Butin-Israeli, V., Bui, T. M., Wiesolek, H. L., Mascarenhas, L., Lee, J. J., Mehl, L. C., Knutson, K. R., Adam, S. A., Goldman, R. D., Beyder, A., Wiesmuller, L., Hanauer, S. B. & Sumagin, R., Feb 1 2019, In : Journal of Clinical Investigation. 129, 2, p. 712-726 15 p.

    Research output: Contribution to journal › Article

    • 15 Scopus citations

    Progressing from Recurring Tissue Injury to Genomic Instability: A New Mechanism of Neutrophil Pathogenesis

    Bui, T. M. & Sumagin, R., Aug 2019, In : DNA and Cell Biology. 38, 8, p. 747-753 7 p.

    Research output: Contribution to journal › Article

    • 2 Scopus citations