Grants per year
Personal profile
Research Interests
In the case of bacterial infection and mucosal injury neutrophil transepithelial migration is essential for host defense and tissue homeostasis, however, it may also lead to detrimental inflammation, which is a hallmark of inflammatory disorders of mucosal surfaces, particularly diseases of the gastrointestinal tract, including ulcerative colitis and Cohn’s disease. Our laboratory focuses on interactions of innate immune cells, specifically neutrophils with luminally expressed epithelial adhesive receptors, and the contribution of these interactions to regulation of epithelial barrier and mucosal wound healing, under the conditions of intestinal inflammation. A better understanding of the mechanisms regulating PMN recruitment and retention at the mucosal surfaces, and identification of specific molecules that may link PMN-epithelial cell interactions with epithelial barrier function and wound repair are imperative for the development of new and improved therapeutic approaches aiding in the resolution of mucosal inflammation, and reestablishing epithelial homeostasis. Reaserch Interest: • Understanding mechanisms regulating leukocyte recruitment to mucosal tissues • Determining the underlying mechanisms for leukocyte-associated effects on endothelial/epithelial function • Host-pathogen interactions • Innate immune contribution to colorectal cancer
Training Experience
2012 | Postdoctoral Fellowship, Emory University |
Education/Academic qualification
PhD, University of Rochester
… → 2008
Research interests
- Cell Adhesion Mechanisms
- Cell Imaging
- Inflammation
- Inflammatory Bowel Disease
- Leukocyte-endothelial Cell Interactions
- Wound Care
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Network
Grants
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Neutrophils modulate DNA Damage Repair to promote survival/progression of colorectal cancer
U.S. Army Medical Research and Materiel Command
9/1/20 → 8/31/22
Project: Research project
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Neutrophils instruct macrophage responses to promote mucosal healing
National Institute of Diabetes and Digestive and Kidney Diseases
5/5/20 → 4/30/24
Project: Research project
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Neutrophil-driven inflammation leads to carcinogenesis in IBD
Crohn's and Colitis Foundation of America
7/1/19 → 6/30/22
Project: Research project
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Mechanisms of Salmonella Clearance by Neutrophils in the Intestinal Lumen
National Institute of Diabetes and Digestive and Kidney Diseases
5/1/18 → 4/30/21
Project: Research project
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Roles for Neutrophils in Development and Metastasis of Colorectal Cancer
Butin-Israeli, V. & Sumagin, R.
1/1/18 → 12/31/21
Project: Research project
Research Output
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Diaphanous-related formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment
Mei, Y., Han, X., Liu, Y., Yang, J., Sumagin, R. & Ji, P., Dec 1 2020, In: Nature communications. 11, 1, 3172.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Emerging neutrophil plasticity: Terminally differentiated cells no more
Sumagin, R., 2020, (Accepted/In press) In: Journal of Leukocyte Biology.Research output: Contribution to journal › Editorial › peer-review
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ICAM-1: A master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis
Bui, T. M., Wiesolek, H. L. & Sumagin, R., Sep 1 2020, In: Journal of Leukocyte Biology. 108, 3, p. 787-799 13 p.Research output: Contribution to journal › Review article › peer-review
5 Scopus citations -
Intercellular Adhesion Molecule 1 Functions as an Efferocytosis Receptor in Inflammatory Macrophages
Wiesolek, H. L., Bui, T. M., Lee, J. J., Dalal, P., Finkielsztein, A., Batra, A., Thorp, E. B. & Sumagin, R., Apr 2020, In: American Journal of Pathology. 190, 4, p. 874-885 12 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Neutrophil-Derived Reactive Oxygen Orchestrates Epithelial Cell Signaling Events during Intestinal Repair
Matthews, J. D., Owens, J. A., Naudin, C. R., Saeedi, B. J., Alam, A., Reedy, A. R., Hinrichs, B. H., Sumagin, R., Neish, A. S. & Jones, R. M., Nov 2019, In: American Journal of Pathology. 189, 11, p. 2221-2232 12 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations