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Personal profile

Research Interests

In the case of bacterial infection and mucosal injury neutrophil transepithelial migration is essential for host defense and tissue homeostasis, however, it may also lead to detrimental inflammation, which is a hallmark of inflammatory disorders of mucosal surfaces, particularly diseases of the gastrointestinal tract, including ulcerative colitis and Cohn’s disease. Our laboratory focuses on interactions of innate immune cells, specifically neutrophils with luminally expressed epithelial adhesive receptors, and the contribution of these interactions to regulation of epithelial barrier and mucosal wound healing, under the conditions of intestinal inflammation. A better understanding of the mechanisms regulating PMN recruitment and retention at the mucosal surfaces, and identification of specific molecules that may link PMN-epithelial cell interactions with epithelial barrier function and wound repair are imperative for the development of new and improved therapeutic approaches aiding in the resolution of mucosal inflammation, and reestablishing epithelial homeostasis. Reaserch Interest: • Understanding mechanisms regulating leukocyte recruitment to mucosal tissues • Determining the underlying mechanisms for leukocyte-associated effects on endothelial/epithelial function • Host-pathogen interactions • Innate immune contribution to colorectal cancer

Training Experience

2012Postdoctoral Fellowship, Emory University

Education/Academic qualification

PhD, University of Rochester

… → 2008

Research interests

  • Cell Adhesion Mechanisms
  • Cell Imaging
  • Inflammation
  • Inflammatory Bowel Disease
  • Leukocyte-endothelial Cell Interactions
  • Wound Care

Fingerprint Dive into the research topics where Ronen Sumagin is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 6 Similar Profiles
Neutrophils Medicine & Life Sciences
Transendothelial and Transepithelial Migration Medicine & Life Sciences
Intercellular Adhesion Molecule-1 Medicine & Life Sciences
Leukocytes Medicine & Life Sciences
Inflammation Medicine & Life Sciences
Epithelial Cells Medicine & Life Sciences
Wounds and Injuries Medicine & Life Sciences
Arterioles Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2012 2022

Inflammatory Bowel Diseases
Carcinogenesis
Neutrophils
Inflammation
Colorectal Neoplasms
Salmonella
Salmonella Infections
Neutrophils
Locomotion
Inflammation
Colorectal Neoplasms
Neutrophils
Neoplasm Metastasis
Neoplasms
MicroRNAs
Genomic Instability
MicroRNAs
Carcinogenesis
Neutrophils
Inflammation

Research Output 2005 2019

  • 987 Citations
  • 37 Article
  • 4 Review article
  • 1 Conference contribution

Neutrophil-Derived Reactive Oxygen Orchestrates Epithelial Cell Signaling Events during Intestinal Repair

Matthews, J. D., Owens, J. A., Naudin, C. R., Saeedi, B. J., Alam, A., Reedy, A. R., Hinrichs, B. H., Sumagin, R., Neish, A. S. & Jones, R. M., Nov 2019, In : American Journal of Pathology. 189, 11, p. 2221-2232 12 p.

Research output: Contribution to journalArticle

Open Access
Neutrophils
Epithelial Cells
Oxygen
Focal Adhesions
Hydrogen Peroxide
8 Citations (Scopus)

Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing

Butin-Israeli, V., Bui, T. M., Wiesolek, H. L., Mascarenhas, L., Lee, J. J., Mehl, L. C., Knutson, K. R., Adam, S. A., Goldman, R., Beyder, A., Wiesmuller, L., Hanauer, S. B. & Sumagin, R., Feb 1 2019, In : Journal of Clinical Investigation. 129, 2, p. 712-726 15 p.

Research output: Contribution to journalArticle

Genomic Instability
Wound Healing
Neutrophils
Homologous Recombination
Inflammation

Progressing from Recurring Tissue Injury to Genomic Instability: A New Mechanism of Neutrophil Pathogenesis

Bui, T. M. & Sumagin, R., Aug 2019, In : DNA and Cell Biology. 38, 8, p. 747-753 7 p.

Research output: Contribution to journalArticle

Genomic Instability
Neutrophils
Down-Regulation
Recombinational DNA Repair
Neutrophil Infiltration

Unveiling early cortical and subcortical neuronal degeneration in ALS mice by ultra-high field diffusion MRI

Gatto, R. G., Amin, M., Finkielsztein, A., Weissmann, C., Barrett, T., Lamoutte, C., Uchitel, O., Sumagin, R., Mareci, T. H. & Magin, R. L., Oct 2 2019, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 20, 7-8, p. 549-561 13 p.

Research output: Contribution to journalArticle

Diffusion Magnetic Resonance Imaging
Amyotrophic Lateral Sclerosis
Neurites
Diffusion Tensor Imaging
Brain
8 Citations (Scopus)

Extracellular vesicles regulate immune responses and cellular function in intestinal inflammation and repair

Bui, T. M., Mascarenhas, L. A. & Sumagin, R., Apr 3 2018, In : Tissue Barriers. 6, 2, e1431038.

Research output: Contribution to journalReview article

Cellular Immunity
Repair
Inflammation
Tissue
Tissue homeostasis