Ryan M Drenan

  • 1529 Citations
20012023
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Personal profile

Research Interests

We study the physiological processes regulated by native nicotinic acetylcholine receptors (nAChRs), a large family of ligand gated ion channel proteins. These receptors mediate key aspects of cholinergic signaling in the brain, and are involved in several important cognitive processes, including motivated behavior, affective behavior, attention, and learning/memory. Aberrant nAChR activity is linked to several neurological diseases/disorders, such as nicotine addiction, schizophrenia, major depressive disorder, Alzheimer's disease, and Parkinson's disease. We utilize a broad range of techniques, including patch clamp electrophysiology, confocal and two-photon imaging, immunohistochemistry, and behavioral approaches.

Training Experience

2010Postdoctoral Fellowship, California Institute of Technology

Education/Academic qualification

PhD, Washington University

… → 2006

Research interests

  • Addiction
  • Alcohol and Drug Dependency
  • Cell Imaging
  • Cellular Electrophysiology
  • Drug Abuse
  • Electrophysiology
  • Ion Channels
  • Neuroscience

Fingerprint Dive into the research topics where Ryan M Drenan is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 20 Similar Profiles
Nicotinic Receptors Medicine & Life Sciences
Nicotine Medicine & Life Sciences
Neurons Chemical Compounds
Cholinergic Receptors Medicine & Life Sciences
Dopamine Medicine & Life Sciences
Cholinergic Agents Medicine & Life Sciences
Ventral Tegmental Area Medicine & Life Sciences
Dopaminergic Neurons Medicine & Life Sciences

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Grants 2016 2023

Nicotine
Tobacco Use Disorder
Ligands
Presynaptic Terminals
Aptitude
Nicotinic Receptors
Guide RNA
Electrophysiology
Clustered Regularly Interspaced Short Palindromic Repeats
Ligand-Gated Ion Channels
Nicotine
Habenula
Tobacco Use Disorder
Nicotinic Receptors
Recurrence
Nicotinic Receptors
Nicotine
Dopamine
Reward
Dopaminergic Neurons

Research Output 2001 2019

  • 1529 Citations
  • 36 Article
  • 2 Conference contribution

Probing nicotinic acetylcholine receptor function in mouse brain slices via laser flash photolysis of photoactivatable nicotine

Arvin, M. C., Wokosin, D. L., Banala, S., Lavis, L. D. & Drenan, R. M., Jan 1 2019, In : Journal of Visualized Experiments. 2019, 143, e58873.

Research output: Contribution to journalArticle

Nicotine
Photolysis
Nicotinic Receptors
Brain
Lasers
4 Citations (Scopus)

Nicotinic Cholinergic Receptors in VTA Glutamate Neurons Modulate Excitatory Transmission

Yan, Y., Peng, C., Arvin, M. C., Jin, X. T., Kim, V. J., Ramsey, M. D., Wang, Y., Banala, S., Wokosin, D. L., McIntosh, J. M., Lavis, L. D. & Drenan, R. M., May 22 2018, In : Cell reports. 23, 8, p. 2236-2244 9 p.

Research output: Contribution to journalArticle

Ventral Tegmental Area
Nicotinic Receptors
Cholinergic Receptors
Neurons
Glutamic Acid
6 Citations (Scopus)

Photoactivatable drugs for nicotinic optopharmacology

Banala, S., Arvin, M. C., Bannon, N. M., Jin, X. T., Macklin, J. J., Wang, Y., Peng, C., Zhao, G., Marshall, J. J., Gee, K. R., Wokosin, D. L., Kim, V. J., McIntosh, J. M., Contractor, A., Lester, H. A., Kozorovitskiy, Y., Drenan, R. M. & Lavis, L. D., Apr 27 2018, In : Nature Methods. 15, 5, p. 347-350 4 p.

Research output: Contribution to journalArticle

Photons
Nicotinic Receptors
Neurosciences
Nicotine
Ammonium Compounds
2 Citations (Scopus)

Altered nicotine reward-associated behavior following α4 nAChR subunit deletion in ventral midbrain

Peng, C., Engle, S. E., Yan, Y., Weera, M. M., Berry, J. N., Arvin, M. C., Zhao, G., McIntosh, J. M., Chester, J. A. & Drenan, R. M., Jul 1 2017, In : PloS one. 12, 7, e0182142.

Research output: Contribution to journalArticle

nicotine
Mesencephalon
Nicotine
Reward
brain
2 Citations (Scopus)

Deletion of lynx1 reduces the function of α6∗ nicotinic receptors

Parker, R. L., O’Neill, H. C., Henley, B. M., Wageman, C. R., Drenan, R. M., Marks, M. J., Miwa, J. M., Grady, S. R. & Lester, H. A., Dec 1 2017, In : PloS one. 12, 12, e0188715.

Research output: Contribution to journalArticle

cholinergic receptors
nicotine
Nicotinic Receptors
Nicotine
receptors