Grants per year
Personal profile
Research Interests
It is estimated that 10-25% of human embryos are chromosomally abnormal, resulting in a high incidence of miscarriages and birth defects. Most of these abnormalities are the result of chromosome segregation defects in the female reproductive cells (oocytes), yet surprisingly little is known about the biological mechanisms that underlie the vulnerability of oocytes to segregation errors. The Wignall lab is focused on investigating this important problem, by combining high-resolution microscopy with genetic, genomic, and biochemical approaches in the nematode C. elegans. Current work in the lab is focused on two major areas: 1) investigating the molecular mechanisms of spindle assembly in oocytes, and 2) exploring mechanisms of chromosome congression and segregation.
Education/Academic qualification
Molecular and Cell Biology, PhD, University of California, Berkeley
… → 2003
Biological Sciences, MPhil, University of Cambridge
… → 1997
Biology, BS, University of North Carolina at Chapel Hill
… → 1996
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Grants
Regulation of chromosome segregation during oocyte meiosis
National Institute of General Medical Sciences
2/1/18 → 12/31/22
Project: Research project
Characterization of Kinesin-12/KLP-18 activity essential for acentrosomal meiotic spindle assembly in C. elegans
American Heart Association Midwest Affiliate
1/1/17 → 12/31/18
Project: Research project
Mechanisms of chromosome congression and segregation in mammalian oocytes
6/1/16 → 1/31/19
Project: Research project
Mechanisms of chromosome congression and segregation during oocyte meiosis
2/1/13 → 7/31/15
Project: Research project
Targeting centrosome-clustering mechanisms to selectively kill cancer cells
Damon Runyon Cancer Research Foundation
1/1/13 → 6/30/16
Project: Research project
Research Output
Chromokinesin Kif4 promotes proper anaphase in mouse oocyte meiosis
Heath, C. M. & Wignall, S. M., Jul 1 2019, In : Molecular biology of the cell. 30, 14, p. 1691-1704 14 p.Research output: Contribution to journal › Article
Open Access
1
Scopus
citations
Spindle assembly and chromosome dynamics during oocyte meiosis
Mullen, T. J., Davis-Roca, A. C. & Wignall, S. M., Oct 2019, In : Current Opinion in Cell Biology. 60, p. 53-59 7 p.Research output: Contribution to journal › Review article
1
Scopus
citations
Dynamic SUMO remodeling drives a series of critical events during the meiotic divisions in Caenorhabditis elegans
Davis-Roca, A. C., Divekar, N. S., Ng, R. K. & Wignall, S. M., Sep 2018, In : PLoS genetics. 14, 9, e1007626.Research output: Contribution to journal › Article
4
Scopus
citations
Caenorhabditis elegans oocytes detect meiotic errors in the absence of canonical end-on kinetochore attachments
Davis-Roca, A. C., Muscat, C. C. & Wignall, S. M., May 1 2017, In : Journal of Cell Biology. 216, 5, p. 1243-1253 11 p.Research output: Contribution to journal › Article
6
Scopus
citations
Interplay between microtubule bundling and sorting factors ensures acentriolar spindle stability during C. elegans oocyte meiosis
Mullen, T. J. & Wignall, S. M., Sep 2017, In : PLoS genetics. 13, 9, e1006986.Research output: Contribution to journal › Article
9
Scopus
citations