Sadie Wignall

It is estimated that 10-25% of human embryos are chromosomally abnormal, resulting in a high incidence of miscarriages and birth defects. Most of these abnormalities are the result of chromosome segregation defects in the female reproductive cells (oocytes), yet surprisingly little is known about the biological mechanisms that underlie the vulnerability of oocytes to segregation errors.  The Wignall lab is focused on investigating this important problem, by combining high-resolution microscopy with genetic, genomic, and biochemical approaches in the nematode C. elegans.  Current work in the lab is focused on two major areas:  1) investigating the molecular mechanisms of spindle assembly in oocytes, and 2) exploring mechanisms of chromosome congression and segregation.