Grants per year
Personal profile
Research Interests
It is estimated that 10-25% of human embryos are chromosomally abnormal, resulting in a high incidence of miscarriages and birth defects. Most of these abnormalities are the result of chromosome segregation defects in the female reproductive cells (oocytes), yet surprisingly little is known about the biological mechanisms that underlie the vulnerability of oocytes to segregation errors. The Wignall lab is focused on investigating this important problem, by combining high-resolution microscopy with genetic, genomic, and biochemical approaches in the nematode C. elegans. Current work in the lab is focused on two major areas: 1) investigating the molecular mechanisms of spindle assembly in oocytes, and 2) exploring mechanisms of chromosome congression and segregation.
Education/Academic qualification
Molecular and Cell Biology, PhD, University of California at Berkeley
… → 2003
Biological Sciences, MPhil, University of Cambridge
… → 1997
Biology, BS, University of North Carolina at Chapel Hill
… → 1996
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Regulation of chromosome segregation during oocyte meiosis
Wignall, S. (PD/PI)
National Institute of General Medical Sciences
9/18/23 → 7/31/27
Project: Research project
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Mechanisms of acentrosomal spindle assembly and stability during oocyte meiosis
Wignall, S. (PD/PI) & Wignall, S. (PD/PI)
National Institute of General Medical Sciences
9/22/22 → 8/31/26
Project: Research project
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The Robert H. Lurie Comprehensive Cancer Center
Platanias, L. C. (PD/PI), Arispe, L. (Co-Investigator), Arvanitis, C. (Co-Investigator), Bonini, M. (Co-Investigator), Butt, Z. (Co-Investigator), Kocherginsky, M. (Co-Investigator), Kumthekar, P. U. (Co-Investigator), Rini, C. (Co-Investigator), Shilatifard, A. (Co-Investigator), Wignall, S. (Co-Investigator), Zhang, Z. (Co-Investigator), Agulnik, M. (Other), Awatramani, R. (Other), Backman, V. (Other), Benson III, A. B. (Other), Carthew, R. W. (Other), Cella, D. (Other), Chakravarti, D. (Other), Chandel, N. (Other), Crispino, J. D. (Other), Cristofanilli, M. (Other), Eklund, E. A. (Other), Frankfurt, O. (Other), Gordon, L. I. (Other), Green, K. J. (Other), Hahn, E. A. (Other), Hitsman, B. L. (Other), Horbinski, C. M. (Other), Horvath, C. M. (Other), Hussain, M. (Other), James, C. D. (Other), Kelleher, N. L. (Other), Khan, S. A. (Other), LaBonne, C. (Other), Larson, A. C. (Other), Matei, D. E. (Other), Meade, T. J. (Other), Mondragon, A. (Other), Mrksich, M. (Other), Munshi, H. G. (Other), Murphy, A. B. (Other), Obeng, R. (Other), Penedo, F. J. (Other), Perlman, H. R. (Other), Peter, M. E. (Other), Rademaker, A. W. (Other), Rappoport, J. Z. (Other), Rosenzweig, A. C. (Other), Scheidt, K. A. (Other), Simon, M. A. (Other), Sosman, J. A. (Other), Spring, B. (Other), Wei, J.-J. (Other), Weiss, E. L. (Other) & Woloschak, G. E. (Other)
8/10/18 → 7/31/23
Project: Research project
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Regulation of chromosome segregation during oocyte meiosis
Wignall, S. (PD/PI)
National Institute of General Medical Sciences
2/1/18 → 9/17/23
Project: Research project
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Characterization of Kinesin-12/KLP-18 activity essential for acentrosomal meiotic spindle assembly in C. elegans
Wignall, S. (PD/PI)
American Heart Association Midwest Affiliate
1/1/17 → 12/31/18
Project: Research project
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Acentrosomal spindle assembly and maintenance in Caenorhabditis elegans oocytes requires a kinesin-12 nonmotor microtubule interaction domain
Wolff, I. D., Hollis, J. A. & Wignall, S. M., Jul 1 2022, In: Molecular biology of the cell. 33, 8, ar71.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Dynamic zinc fluxes regulate meiotic progression in Caenorhabditis elegans
Mendoza, A. D., Sue, A., Antipova, O., Vogt, S., Woodruff, T. K., Wignall, S. M. & O'Halloran, T. V., Aug 1 2022, In: Biology of reproduction. 107, 2, p. 406-418 13 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Methods for Investigating Cell Division Mechanisms in C. elegans
Wolff, I. D., Divekar, N. S. & Wignall, S. M., 2022, Methods in Molecular Biology. Humana Press Inc., p. 19-35 17 p. (Methods in Molecular Biology; vol. 2415).Research output: Chapter in Book/Report/Conference proceeding › Chapter
6 Scopus citations -
Multiple motors cooperate to establish and maintain acentrosomal spindle bipolarity in C. elegans oocyte meiosis
Cavin-Meza, G., Kwan, M. M. & Wignall, S. M., Feb 11 2022, In: eLife. 11Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Newfound features of meiotic chromosome organization that promote efficient congression and segregation in Caenorhabditis elegans oocytes
Horton, H. H., Divekar, N. S. & Wignall, S. M., Dec 1 2022, In: Molecular biology of the cell. 33, 14, br25.Research output: Contribution to journal › Article › peer-review
Open Access