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Sadie Wignall

  • 354 Citations
20012022

Research output per year

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Personal profile

Research Interests

It is estimated that 10-25% of human embryos are chromosomally abnormal, resulting in a high incidence of miscarriages and birth defects. Most of these abnormalities are the result of chromosome segregation defects in the female reproductive cells (oocytes), yet surprisingly little is known about the biological mechanisms that underlie the vulnerability of oocytes to segregation errors.  The Wignall lab is focused on investigating this important problem, by combining high-resolution microscopy with genetic, genomic, and biochemical approaches in the nematode C. elegans.  Current work in the lab is focused on two major areas:  1) investigating the molecular mechanisms of spindle assembly in oocytes, and 2) exploring mechanisms of chromosome congression and segregation.

Education/Academic qualification

Molecular and Cell Biology, PhD, University of California, Berkeley

… → 2003

Biological Sciences, MPhil, University of Cambridge

… → 1997

Biology, BS, University of North Carolina at Chapel Hill

… → 1996

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Grants

Regulation of chromosome segregation during oocyte meiosis

Wignall, S.

National Institute of General Medical Sciences

2/1/18 → 12/31/22

Project: Research project

    • Characterization of Kinesin-12/KLP-18 activity essential for acentrosomal meiotic spindle assembly in C. elegans

    Wignall, S.

    American Heart Association Midwest Affiliate

    1/1/17 → 12/31/18

    Project: Research project

    • Mechanisms of chromosome congression and segregation in mammalian oocytes

    Wignall, S.

    March of Dimes Foundation

    6/1/16 → 1/31/19

    Project: Research project

    • Mechanisms of chromosome congression and segregation during oocyte meiosis

    Wignall, S.

    March of Dimes Foundation

    2/1/13 → 7/31/15

    Project: Research project

    Targeting centrosome-clustering mechanisms to selectively kill cancer cells

    Wignall, S.

    Damon Runyon Cancer Research Foundation

    1/1/13 → 6/30/16

    Project: Research project

    Research Output

    • 354 Citations
    • 14 Article
    • 2 Review article

    Chromokinesin Kif4 promotes proper anaphase in mouse oocyte meiosis

    Heath, C. M. & Wignall, S. M., Jul 1 2019, In : Molecular biology of the cell. 30, 14, p. 1691-1704 14 p.

    Research output: Contribution to journal › Article

    Open Access

    • Spindle assembly and chromosome dynamics during oocyte meiosis

    Mullen, T. J., Davis-Roca, A. C. & Wignall, S. M., Oct 2019, In : Current Opinion in Cell Biology. 60, p. 53-59 7 p.

    Research output: Contribution to journal › Review article

    • 1 Scopus citations

    Dynamic SUMO remodeling drives a series of critical events during the meiotic divisions in Caenorhabditis elegans

    Davis-Roca, A. C., Divekar, N. S., Ng, R. K. & Wignall, S. M., Sep 2018, In : PLoS genetics. 14, 9, e1007626.

    Research output: Contribution to journal › Article

    • 3 Scopus citations

    Caenorhabditis elegans oocytes detect meiotic errors in the absence of canonical end-on kinetochore attachments

    Davis-Roca, A. C., Muscat, C. C. & Wignall, S. M., May 1 2017, In : Journal of Cell Biology. 216, 5, p. 1243-1253 11 p.

    Research output: Contribution to journal › Article

    • 6 Scopus citations

    Interplay between microtubule bundling and sorting factors ensures acentriolar spindle stability during C. elegans oocyte meiosis

    Mullen, T. J. & Wignall, S. M., Sep 2017, In : PLoS genetics. 13, 9, e1006986.

    Research output: Contribution to journal › Article

    • 8 Scopus citations