• 360 Citations

Research output per year

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Personal profile

Research Interests

It is estimated that 10-25% of human embryos are chromosomally abnormal, resulting in a high incidence of miscarriages and birth defects. Most of these abnormalities are the result of chromosome segregation defects in the female reproductive cells (oocytes), yet surprisingly little is known about the biological mechanisms that underlie the vulnerability of oocytes to segregation errors.  The Wignall lab is focused on investigating this important problem, by combining high-resolution microscopy with genetic, genomic, and biochemical approaches in the nematode C. elegans.  Current work in the lab is focused on two major areas:  1) investigating the molecular mechanisms of spindle assembly in oocytes, and 2) exploring mechanisms of chromosome congression and segregation.

Education/Academic qualification

Molecular and Cell Biology, PhD, University of California, Berkeley

… → 2003

Biological Sciences, MPhil, University of Cambridge

… → 1997

Biology, BS, University of North Carolina at Chapel Hill

… → 1996

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  • Research Output

    • 360 Citations
    • 14 Article
    • 2 Review article

    Chromokinesin Kif4 promotes proper anaphase in mouse oocyte meiosis

    Heath, C. M. & Wignall, S. M., Jul 1 2019, In : Molecular biology of the cell. 30, 14, p. 1691-1704 14 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Spindle assembly and chromosome dynamics during oocyte meiosis

    Mullen, T. J., Davis-Roca, A. C. & Wignall, S. M., Oct 2019, In : Current Opinion in Cell Biology. 60, p. 53-59 7 p.

    Research output: Contribution to journalReview article

  • 1 Scopus citations

    Dynamic SUMO remodeling drives a series of critical events during the meiotic divisions in Caenorhabditis elegans

    Davis-Roca, A. C., Divekar, N. S., Ng, R. K. & Wignall, S. M., Sep 2018, In : PLoS genetics. 14, 9, e1007626.

    Research output: Contribution to journalArticle

  • 4 Scopus citations

    Caenorhabditis elegans oocytes detect meiotic errors in the absence of canonical end-on kinetochore attachments

    Davis-Roca, A. C., Muscat, C. C. & Wignall, S. M., May 1 2017, In : Journal of Cell Biology. 216, 5, p. 1243-1253 11 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations
  • 9 Scopus citations