Grants per year
Personal profile
Education/Academic qualification
Organic Chemistry, PhD, Jadavpur University
… → 2007
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Dive into the research topics where Saktimayee Mitra Roy is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Grants
- 1 Finished
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Preclinical development of a selective attenuator of neuroinflammation for MCI/AD
Watterson, D. M. (PD/PI) & Roy, S. M. (Other)
University of Kentucky, National Institute on Aging
9/1/15 → 4/30/19
Project: Research project
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A small molecule p38α MAPK inhibitor, MW150, attenuates behavioral deficits and neuronal dysfunction in a mouse model of mixed amyloid and vascular pathologies
Frazier, H. N., Braun, D. J., Bailey, C. S., Coleman, M. J., Davis, V. A., Dundon, S. R., McLouth, C. J., Muzyk, H. C., Powell, D. K., Rogers, C. B., Roy, S. M. & Van Eldik, L. J., Oct 2024, In: Brain, Behavior, and Immunity - Health. 40, 100826.Research output: Contribution to journal › Article › peer-review
Open Access -
The 5HT2b Receptor in Alzheimer's Disease: Increased Levels in Patient Brains and Antagonist Attenuation of Amyloid and Tau Induced Dysfunction
Acquarone, E., Argyrousi, E. K., Arancio, O., Watterson, D. M. & Roy, S. M., Apr 16 2024, In: Journal of Alzheimer's Disease. 98, 4, p. 1349-1360 12 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Therapeutic treatment with the antiinflammatory drug candidate MW151 may partially reduce memory impairment and normalizes hippocampal metabolic markers in a mouse model of comorbid amyloid and vascular pathology
Braun, D. J., Powell, D. K., McLouth, C. J., Roy, S. M., Watterson, D. M. & Van Eldik, L. J., Jan 2022, In: PloS one. 17, 1 January, e0262474.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers
Van Eldik, L. J., Sawaki, L., Bowen, K., Laskowitz, D. T., Noveck, R. J., Hauser, B., Jordan, L., Spears, T. G., Wu, H., Watt, K., Raja, S., Roy, S. M., Watterson, D. M. & Guptill, J. T., Feb 2021, In: Clinical Pharmacology in Drug Development. 10, 2, p. 131-143 13 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Erratum: A selective and brain penetrant p38αMAPK inhibitor candidate for neurologic and neuropsychiatric disorders that attenuates neuroinflammation and cognitive dysfunction (J. Med. Chem. (2019) 62:11 (5298-5311) DOI: 10.1021/acs.jmedchem.9b00058)
Roy, S. M., Minasov, G., Arancio, O., Chico, L. W., van Eldik, L. J., Anderson, W. F., Pelletier, J. C. & Martin Watterson, D., Aug 13 2020, In: Journal of Medicinal Chemistry. 63, 15, p. 8649 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access
Datasets
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4R3C : Crystal structure of p38 alpha MAP kinase in complex with a novel isoform selective drug candidate
Roy, S. M. (Contributor), Grum-Tokars, V. L. (Contributor), Minasov, G. (Contributor), Anderson, W. F. (Contributor) & Watterson, D. M. (Contributor), RCSB-PDB, 2015
DOI: 10.2210/pdb4r3c/pdb, https://www.rcsb.org/structure/4R3C
Dataset
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Additional file 2: Table S2. of Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes
Zhou, Z. (Contributor), Bachstetter, A. D. (Creator), Späni, C. B. (Creator), Roy, S. M. (Contributor), Watterson, D. M. (Contributor) & Van Eldik, L. J. (Contributor), figshare, 2017
DOI: 10.6084/m9.figshare.c.3735430_d2.v1, https://springernature.figshare.com/articles/dataset/Additional_file_2_Table_S2_of_Retention_of_normal_glia_function_by_an_isoform-selective_protein_kinase_inhibitor_drug_candidate_that_modulates_cytokine_production_and_cognitive_outcomes/4822510/1
Dataset
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Additional file 3: Table S3. of Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes
Zhou, Z. (Contributor), Bachstetter, A. D. (Creator), Späni, C. B. (Creator), Roy, S. M. (Contributor), Watterson, D. M. (Contributor) & Van Eldik, L. J. (Contributor), figshare, 2017
DOI: 10.6084/m9.figshare.c.3735430_d3.v1, https://springernature.figshare.com/articles/dataset/Additional_file_3_Table_S3_of_Retention_of_normal_glia_function_by_an_isoform-selective_protein_kinase_inhibitor_drug_candidate_that_modulates_cytokine_production_and_cognitive_outcomes/4822528/1
Dataset
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Human P38alpha MAPK in Complex with a Novel and Selective Small Molecule Inhibitor
Watterson, D. M. (Contributor), Grum-Tokars, V. L. (Contributor), Roy, S. M. (Contributor), Schavocky, J. P. (Contributor), de Bradaric, B. (Contributor), Bachstetter, A. D. (Contributor), Xing, B. (Contributor), Dimayuga, E. (Contributor), Saeed, F. (Contributor), Zhang, H. (Contributor), Staniszewski, A. (Contributor), Pelletier, J. C. (Contributor), Minasov, G. (Contributor), Anderson, W. F. (Contributor), Arancio, O. (Contributor) & van Eldik, L. J. (Contributor), Protein Data Bank (PDB), Jun 5 2013
DOI: 10.2210/pdb4F9W/pdb, https://www.wwpdb.org/pdb?id=pdb_00004f9w
Dataset
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Human P38 alpha MAPK In Complex With a Novel and Selective Small Molecule Inhibitor
Watterson, D. M. (Contributor), Grum-Tokars, V. L. (Contributor), Roy, S. M. (Contributor), Schavocky, J. P. (Contributor), de Bradaric, B. (Contributor), Bachstetter, A. D. (Contributor), Xing, B. (Contributor), Dimayuga, E. (Contributor), Saeed, F. (Contributor), Zhang, H. (Contributor), Staniszewski, A. (Contributor), Pelletier, J. C. (Contributor), Minasov, G. (Contributor), Anderson, W. F. (Contributor), Arancio, O. (Contributor) & van Eldik, L. J. (Contributor), Protein Data Bank (PDB), Jun 5 2013
DOI: 10.2210/pdb4F9Y/pdb, https://www.wwpdb.org/pdb?id=pdb_00004f9y
Dataset