Grants per year
Personal profile
Education/Academic qualification
Organic Chemistry, PhD, Jadavpur University
… → 2007
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Dive into the research topics where Saktimayee Mitra Roy is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Grants
- 1 Finished
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Preclinical development of a selective attenuator of neuroinflammation for MCI/AD
University of Kentucky, National Institute on Aging
9/1/15 → 4/30/19
Project: Research project
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Therapeutic treatment with the antiinflammatory drug candidate MW151 may partially reduce memory impairment and normalizes hippocampal metabolic markers in a mouse model of comorbid amyloid and vascular pathology
Braun, D. J., Powell, D. K., McLouth, C. J., Roy, S. M., Watterson, D. M. & Van Eldik, L. J., Jan 2022, In: PloS one. 17, 1 January, e0262474.Research output: Contribution to journal › Article › peer-review
Open Access -
First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers
Van Eldik, L. J., Sawaki, L., Bowen, K., Laskowitz, D. T., Noveck, R. J., Hauser, B., Jordan, L., Spears, T. G., Wu, H., Watt, K., Raja, S., Roy, S. M., Watterson, D. M. & Guptill, J. T., Feb 2021, In: Clinical Pharmacology in Drug Development. 10, 2, p. 131-143 13 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Erratum: A selective and brain penetrant p38αMAPK inhibitor candidate for neurologic and neuropsychiatric disorders that attenuates neuroinflammation and cognitive dysfunction (J. Med. Chem. (2019) 62:11 (5298-5311) DOI: 10.1021/acs.jmedchem.9b00058)
Roy, S. M., Minasov, G., Arancio, O., Chico, L. W., van Eldik, L. J., Anderson, W. F., Pelletier, J. C. & Martin Watterson, D., Aug 13 2020, In: Journal of Medicinal Chemistry. 63, 15, p. 8649 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction
Roy, S. M., Minasov, G., Arancio, O., Chico, L. W., Van Eldik, L. J., Anderson, W. F., Pelletier, J. C. & Watterson, D. M., Jun 13 2019, In: Journal of Medicinal Chemistry. 62, 11, p. 5298-5311 14 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Evaluation of protein kinase inhibitors with plk4 cross-over potential in a pre-clinical model of cancer
Suri, A., Bailey, A. W., Tavares, M. T., Gunosewoyo, H., Dyer, C. P., Grupenmacher, A. T., Piper, D. R., Horton, R. A., Tomita, T., Kozikowski, A. P., Roy, S. M. & Sredni, S. T., May 1 2019, In: International journal of molecular sciences. 20, 9, 2112.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations
Datasets
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4R3C : Crystal structure of p38 alpha MAP kinase in complex with a novel isoform selective drug candidate
Roy, S. M. (Contributor), Tokars, V. L. (Contributor), Minasov, G. (Contributor), Anderson, W. F. (Contributor) & Watterson, D. M. (Contributor), RCSB-PDB, 2015
DOI: 10.2210/pdb4r3c/pdb, https://www.rcsb.org/structure/4R3C
Dataset
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CCDC 1851508: Experimental Crystal Structure Determination
Roy, S. M. (Contributor) & Watterson, D. M. (Contributor), Cambridge Crystallographic Data Centre, 2018
DOI: 10.5517/ccdc.csd.cc204n2x, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc204n2x&sid=DataCite
Dataset
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Additional file 2: Table S2. of Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes
Zhou, Z. (Contributor), Bachstetter, A. D. (Creator), Späni, C. B. (Creator), Roy, S. M. (Contributor), Watterson, D. M. (Contributor) & Van Eldik, L. J. (Contributor), figshare, 2017
DOI: 10.6084/m9.figshare.c.3735430_d2.v1, https://springernature.figshare.com/articles/dataset/Additional_file_2_Table_S2_of_Retention_of_normal_glia_function_by_an_isoform-selective_protein_kinase_inhibitor_drug_candidate_that_modulates_cytokine_production_and_cognitive_outcomes/4822510/1
Dataset
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4YO4 : Crystal Structure of DAPK1 catalytic domain in complex with the hinge binding fragment phthalazine
Watterson, D. M. (Contributor), Tokars, V. L. (Contributor), Roy, S. M. (Contributor), Minasov, G. (Contributor) & Anderson, W. F. (Contributor), RCSB-PDB, 2015
DOI: 10.2210/pdb4yo4/pdb, https://www.rcsb.org/structure/4YO4
Dataset
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Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes
Zhou, Z. (Contributor), Bachstetter, A. D. (Creator), Späni, C. B. (Creator), Roy, S. M. (Contributor), Watterson, D. M. (Contributor) & Van Eldik, L. J. (Contributor), figshare, 2017
DOI: 10.6084/m9.figshare.c.3735430.v1, https://figshare.com/collections/Retention_of_normal_glia_function_by_an_isoform-selective_protein_kinase_inhibitor_drug_candidate_that_modulates_cytokine_production_and_cognitive_outcomes/3735430/1
Dataset