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Personal profile

Research Interests

Alzheimer's disease, Memory disorders, Neuropsychology, Early Onset Dementia, Primary Progressive Aphasia, Frontotemporal Dementia, Superaging. The ability to use language can be progressively disrupted by neurodegenerative diseases of the brain that target circumscribed regions that normally mediate language in healthy individuals. My clinical and research interests focus on Individuals with Primary Progressive Aphasia, Frontotemporal Dementia and Alzheimer's Disease. Research projects address the neuropsychological, neuroimaging and neuropathological variables associated with these syndromes, in order to contribute to our understanding of risk and the genetic factors that determine regional brain vulnerability to these diseases and to identify biomarkers that can be used in diagnosis during the patient's lifetime. To date, there are no biomarkers that definitively predict the type of the neuropathology in these clinical syndromes in the individual patient. Additional interests in the area of brain aging and its effects on cognition lie in determining factors associated with "Superaging", the maintenance of a high level of cognitive ability into the 9th decade of life and beyond.

Education/Academic qualification

PhD, Boston University

… → 1978

Keywords

  • Aging
  • Alzheimer's Disease
  • Dementia
  • Neuropsychology

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Grants 1997 2023

Multimodal Imaging
Frontotemporal Dementia
Alzheimer Disease
Differential Diagnosis
Biomarkers

Research Output 1975 2019

Clinical and cortical decline in the aphasic variant of Alzheimer's disease

Rogalski, E., Sridhar, J., Martersteck, A., Rader, B., Cobia, D., Arora, A. K., Fought, A. J., Bigio, E. H., Weintraub, S., Mesulam, M-M. & Rademaker, A. W., Apr 1 2019, In : Alzheimer's and Dementia. 15, 4, p. 543-552 10 p.

Research output: Contribution to journalArticle

Primary Progressive Aphasia
Alzheimer Disease
Language
Amyloid
Atrophy
3 Citations (Scopus)

Cognitive trajectories and spectrum of neuropathology in SuperAgers: The first 10 cases

Rogalski, E., Gefen, T. D., Mao, Q., Connelly, M., Weintraub, S., Geula, C., Bigio, E. H. & Mesulam, M-M., May 1 2019, In : Hippocampus. 29, 5, p. 458-467 10 p.

Research output: Contribution to journalArticle

Episodic Memory
Personality
Autopsy
Entorhinal Cortex
Neocortex

Cortical cholinergic denervation in primary progressive aphasia with Alzheimer pathology

Mesulam, M-M., Lalehzari, N., Rahmani, F., Ohm, D., Shahidehpour, R., Kim, G., Gefen, T. D., Weintraub, S., Bigio, E. H. & Geula, C., Apr 2 2019, In : Neurology. 92, 14, p. e1580-e1588

Research output: Contribution to journalArticle

Primary Progressive Aphasia
Denervation
Cholinergic Agents
Pathology
Cholinergic Neurons

Genetic screen in a large series of patients with primary progressive aphasia

Ramos, E. M., Dokuru, D. R., Van Berlo, V., Wojta, K., Wang, Q., Huang, A. Y., Miller, Z. A., Karydas, A. M., Bigio, E. H., Rogalski, E., Weintraub, S., Rader, B., Miller, B. L., Gorno-Tempini, M. L., Mesulam, M-M. & Coppola, G., Apr 1 2019, In : Alzheimer's and Dementia. 15, 4, p. 553-560 8 p.

Research output: Contribution to journalArticle

Primary Progressive Aphasia
Frontotemporal Dementia
Alzheimer Disease
Dementia
Genes
3 Citations (Scopus)

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD

Pottier, C., Ren, Y., Perkerson, R. B., Baker, M., Jenkins, G. D., van Blitterswijk, M., DeJesus-Hernandez, M., van Rooij, J. G. J., Murray, M. E., Christopher, E., McDonnell, S. K., Fogarty, Z., Batzler, A., Tian, S., Vicente, C. T., Matchett, B., Karydas, A. M., Hsiung, G. Y. R., Seelaar, H., Mol, M. O. & 85 othersFinger, E. C., Graff, C., Öijerstedt, L., Neumann, M., Heutink, P., Synofzik, M., Wilke, C., Prudlo, J., Rizzu, P., Simon-Sanchez, J., Edbauer, D., Roeber, S., Diehl-Schmid, J., Evers, B. M., King, A., Mesulam, M-M., Weintraub, S., Geula, C., Bieniek, K. F., Petrucelli, L., Ahern, G. L., Reiman, E. M., Woodruff, B. K., Caselli, R. J., Huey, E. D., Farlow, M. R., Grafman, J. H., Mead, S., Grinberg, L. T., Spina, S., Grossman, M., Irwin, D. J., Lee, E. B., Suh, E. R., Snowden, J., Mann, D., Ertekin-Taner, N., Uitti, R. J., Wszolek, Z. K., Josephs, K. A., Parisi, J. E., Knopman, D. S., Petersen, R. C., Hodges, J. R., Piguet, O., Geier, E. G., Yokoyama, J. S., Rissman, R. A., Rogaeva, E., Keith, J., Zinman, L., Tartaglia, M. C., Cairns, N. J., Cruchaga, C., Ghetti, B., Kofler, J., Lopez, O. L., Beach, T. G., Arzberger, T., Herms, J., Honig, L. S., Vonsattel, J. P., Halliday, G. M., Kwok, J. B., White, C. L., Gearing, M., Glass, J., Rollinson, S., Pickering-Brown, S., Rohrer, J. D., Trojanowski, J. Q., Van Deerlin, V., Bigio, E. H., Troakes, C., Al-Sarraj, S., Asmann, Y., Miller, B. L., Graff-Radford, N. R., Boeve, B. F., Seeley, W. W., Mackenzie, I. R. A., van Swieten, J. C., Dickson, D. W., Biernacka, J. M. & Rademakers, R., Jan 1 2019, In : Acta Neuropathologica.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Frontotemporal Dementia
Genome
Genes
Mutation