Sanjiv J Shah

  • 10855 Citations
19992023
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Personal profile

Research Interests

Sanjiv J. Shah, MD is the Neil Stone, MD Professor in the Division of Cardiology, Department of Medicine; Director of the T1 Center for Cardiovascular Therapeutics; and Director of the Heart Failure with Preserved Ejection Fraction Program at Northwestern University Feinberg School of Medicine. Dr. Shah’s clinical expertise and research focuses on heart failure with preserved ejection fraction (HFpEF), which is one of the most prevalent cardiovascular diseases and for which there are few proven treatments. In 2007, Dr. Shah started the first dedicated HFpEF program in the world at Northwestern University. The Northwestern University HFpEF program has served as a model for several other similar programs in the United States and throughout the world. Dr. Shah has been continuously funded by grants from the American Heart Association and the National Institutes of Health since 2008. He directs a laboratory that investigates the pathogenesis of heart failure; conducts multicenter clinical trials of novel therapeutics for heart failure, pulmonary hypertension, and cardiac amyloidosis; and develops novel techniques for machine learning and artificial intelligence for the classification, diagnosis, and tracking of cardiovascular diseases. His is currently the principal investigator of 3 ongoing R01 grants from the National Institutes of Health and an American Heart Association Strategically Focused Research Network grant. He is also the Northwestern University principal investigator for the National Heart, Lung, and Blood Institute (NHLBI) Heart Failure Network. Dr. Shah’s research, which has spans basic research in animal models, clinical physiologic studies, human clinical trials, and population-based epidemiology studies, has highlighted the heterogeneity and systemic nature of the HFpEF syndrome, and has improved the understanding of the risk factors, pathogenesis, and pathophysiology of HFpEF. He has also pioneered the use of machine learning for novel classification of cardiovascular diseases. Dr. Shah has served as the international principal investigator, executive committee member, or steering committee member for 18 multicenter randomized clinical trials and studies in heart failure. His work on clinical trials has contributed to the development of the first proven treatment for transthyretin cardiac amyloidosis, a highly fatal disease. Current research in his laboratory is focused on the molecular pathogenesis of abnormal cardiac mechanics; artificial intelligence for the automated interpretation of echocardiograms; adipocyte-endothelium-cardiomyocyte interactions; and the development of novel therapeutics for heart failure and microvascular dysfunction. Dr. Shah has published >235 peer-reviewed scientific research publications in leading medical journals, a textbook on cardiovascular genetics, and handbooks on internal medicine and cardiovascular disease. He is an associate editor of JAMA Cardiology, he is on the editorial board of Circulation: Heart Failure, and he has served as guest editor for the Journal of Cardiovascular Translational Research. His work has been cited over 6,700 times (Scopus, August 2018). Dr. Shah has mentored > 50 individuals throughout his career, including undergraduates, medical students, post-doctoral fellows, cardiology fellows, and early-stage faculty. He has received multiple teaching awards, including the George Joost MD, Teach of the Year Award at the Feinberg School of Medicine and the American College of Cardiology W. Proctor Harvey, MD Teaching Award. As an internationally recognized leading authority on HFpEF, Dr. Shah routinely lectures at international cardiology meetings, continuing medical education meetings, and academic institutions (including honorary lectures at Johns Hopkins University and Tufts University).

Certifications and Licenses

Advanced Heart Failure & Transplant Cardiology
Cardiovascular Disease
Internal Medicine

Training Experience

2003Residency, Univ. of CA-San Francisco Med. Ctr.
2006Fellowship, University of California Medical Center, San Francisco/Parnassus
2007Fellowship, University of Chicago Hospitals

Education/Academic qualification

MD, Northwestern University Feinberg School of Medicine

… → 2000

Research interests

  • Cardiac Assessment
  • Diastolic Heart Failure
  • Echocardiography
  • Pulmonary Hypertension

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  • 4 Similar Profiles
Heart Failure Medicine & Life Sciences
Pulmonary Hypertension Medicine & Life Sciences
Systemic Scleroderma Medicine & Life Sciences
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Stroke Volume Medicine & Life Sciences
Confidence Intervals Medicine & Life Sciences
Exercise Medicine & Life Sciences
Hemodynamics Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 1999 2023

Chronic Obstructive Pulmonary Disease
Reading
Safety
Right Ventricular Function
Manuscripts
Epithelium
Heart Failure
Inflammation
Bacterial Toxins
Systems Biology
Rare Diseases
Cardiomyopathies
Workflow
Heart Diseases
Disease Progression

Research Output 1999 2020

Associations of awake and asleep blood pressure and blood pressure dipping with abnormalities of cardiac structure: The Coronary Artery Risk Development in Young Adults study

Bello, N. A., Jaeger, B. C., Booth, J. N., Abdalla, M., Anstey, D. E., Pugliese, D. N., Lewis, C. E., Gidding, S. S., Lloyd-Jones, D., Shah, S. J., Schwartz, J. E., Shikany, J. M., Muntner, P. & Shimbo, D., Jan 1 2020, In : Journal of hypertension. 38, 1, p. 102-110 9 p.

Research output: Contribution to journalArticle

Left Ventricular Hypertrophy
Young Adult
Coronary Vessels
Blood Pressure
Confidence Intervals
5 Citations (Scopus)

10-Year Risk Equations for Incident Heart Failure in the General Population

Khan, S. S., Ning, H., Shah, S. J., Yancy, C. W., Carnethon, M. R., Berry, J. D., Mentz, R. J., O'Brien, E., Correa, A., Suthahar, N., de Boer, R. A., Wilkins, J. T. & Lloyd-Jones, D. M., May 21 2019, In : Journal of the American College of Cardiology. 73, 19, p. 2388-2397 10 p.

Research output: Contribution to journalArticle

Heart Failure
Population
Primary Prevention
Calibration
Fasting
Echocardiography
Heart Failure
Biopsy
Precision Medicine
Cardio-Renal Syndrome
1 Citation (Scopus)

Adverse Renal Response to Decongestion in the Obese Phenotype of Heart Failure With Preserved Ejection Fraction

Reddy, Y. N. V., Obokata, M., Testani, J. M., Felker, G. M., Tang, W. H. W., Abou-Ezzeddine, O. F., Sun, J. L., Chakrabothy, H., McNulty, S., Shah, S. J., Lewis, G. D., Stevenson, L. W., Redfield, M. M. & Borlaug, B. A., Jan 1 2019, (Accepted/In press) In : Journal of Cardiac Failure.

Research output: Contribution to journalArticle

Heart Failure
Phenotype
Kidney
Ventricular Remodeling
Plasma Volume
41 Citations (Scopus)

Angiotensin–neprilysin inhibition in heart failure with preserved ejection fraction

Solomon, S. D., McMurray, J. J. V., Anand, I. S., Ge, J., Lam, C. S. P., Maggioni, A. P., Martinez, F., Packer, M., Pfeffer, M. A., Pieske, B., Redfield, M. M., Rouleau, J. L., Van Veldhuisen, D. J., Zannad, F., Zile, M. R., Desai, A. S., Claggett, B., Jhund, P. S., Boytsov, S. A., Comin-Colet, J. & 14 others, Cleland, J., Düngen, H. D., Goncalvesova, E., Katova, T., Kerr Saraiva, J. F., Lelonek, M., Merkely, B., Senni, M., Shah, S. J., Zhou, J., Rizkala, A. R., Gong, J., Shi, V. C. & Lefkowitz, M. P., Oct 24 2019, In : New England Journal of Medicine. 381, 17, p. 1609-1620 12 p.

Research output: Contribution to journalArticle

Valsartan
Heart Failure
Confidence Intervals
Cause of Death
Hospitalization