Grants per year
Personal profile
Research Interests
Sanjiv J. Shah, MD is the Neil Stone, MD Professor in the Division of Cardiology, Department of Medicine; Director of the T1 Center for Cardiovascular Therapeutics; and Director of the Heart Failure with Preserved Ejection Fraction Program at Northwestern University Feinberg School of Medicine. Dr. Shah’s clinical expertise and research focuses on heart failure with preserved ejection fraction (HFpEF), which is one of the most prevalent cardiovascular diseases and for which there are few proven treatments. In 2007, Dr. Shah started the first dedicated HFpEF program in the world at Northwestern University. The Northwestern University HFpEF program has served as a model for several other similar programs in the United States and throughout the world. Dr. Shah has been continuously funded by grants from the American Heart Association and the National Institutes of Health since 2008. He directs a laboratory that investigates the pathogenesis of heart failure; conducts multicenter clinical trials of novel therapeutics for heart failure, pulmonary hypertension, and cardiac amyloidosis; and develops novel techniques for machine learning and artificial intelligence for the classification, diagnosis, and tracking of cardiovascular diseases. His is currently the principal investigator of 3 ongoing R01 grants from the National Institutes of Health and an American Heart Association Strategically Focused Research Network grant. He is also the Northwestern University principal investigator for the National Heart, Lung, and Blood Institute (NHLBI) Heart Failure Network. Dr. Shah’s research, which has spans basic research in animal models, clinical physiologic studies, human clinical trials, and population-based epidemiology studies, has highlighted the heterogeneity and systemic nature of the HFpEF syndrome, and has improved the understanding of the risk factors, pathogenesis, and pathophysiology of HFpEF. He has also pioneered the use of machine learning for novel classification of cardiovascular diseases. Dr. Shah has served as the international principal investigator, executive committee member, or steering committee member for 18 multicenter randomized clinical trials and studies in heart failure. His work on clinical trials has contributed to the development of the first proven treatment for transthyretin cardiac amyloidosis, a highly fatal disease. Current research in his laboratory is focused on the molecular pathogenesis of abnormal cardiac mechanics; artificial intelligence for the automated interpretation of echocardiograms; adipocyte-endothelium-cardiomyocyte interactions; and the development of novel therapeutics for heart failure and microvascular dysfunction. Dr. Shah has published >235 peer-reviewed scientific research publications in leading medical journals, a textbook on cardiovascular genetics, and handbooks on internal medicine and cardiovascular disease. He is an associate editor of JAMA Cardiology, he is on the editorial board of Circulation: Heart Failure, and he has served as guest editor for the Journal of Cardiovascular Translational Research. His work has been cited over 6,700 times (Scopus, August 2018). Dr. Shah has mentored > 50 individuals throughout his career, including undergraduates, medical students, post-doctoral fellows, cardiology fellows, and early-stage faculty. He has received multiple teaching awards, including the George Joost MD, Teach of the Year Award at the Feinberg School of Medicine and the American College of Cardiology W. Proctor Harvey, MD Teaching Award. As an internationally recognized leading authority on HFpEF, Dr. Shah routinely lectures at international cardiology meetings, continuing medical education meetings, and academic institutions (including honorary lectures at Johns Hopkins University and Tufts University).
Certifications and Licenses
Advanced Heart Failure & Transplant Cardiology | |
Cardiovascular Disease | |
Internal Medicine |
Training Experience
2003 | Residency, Univ. of CA-San Francisco Med. Ctr. |
2006 | Fellowship, University of California Medical Center, San Francisco/Parnassus |
2007 | Fellowship, University of Chicago Hospitals |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine, MD, Northwestern University
… → 2000
Research interests keywords
- Cardiac Assessment
- Diastolic Heart Failure
- Echocardiography
- Pulmonary Hypertension
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Collaborations and top research areas from the last five years
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Unveiling Splanchnic Circulation Dynamics in Heart Failure: A Novel Exercise Magnetic Resonance Imaging Approach
Shah, S. J. (PD/PI) & Kim, D. (Other)
1/1/25 → 12/31/26
Project: Research project
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AIDA-AI: Amyloidosis Diagnosis Acceleration with Artificial Intelligence
Ahmad, F. S. (PD/PI) & Shah, S. J. (Co-PD/PI)
AstraZeneca Pharmaceuticals LP
12/5/24 → 12/4/27
Project: Research project
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Prot #STU00220314: Evaluation of the Boston Scientific WCM Patch as a Non-Invasive Tool for the Diagnosis and Management of Heart Failure: A Pilot Study
Shah, S. J. (PD/PI)
10/28/24 → 10/28/26
Project: Research project
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Prot #ITL-2001-CL-311: MAGNITUDE-2: A Phase 3, Multinational, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of NTLA-2001 in Participants with Hereditary Transthyretin Amyloidosis with Polyneuropathy (ATTRv-PN)
Shah, S. J. (PD/PI)
10/24/24 → 10/24/27
Project: Research project
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An Automated Machine Learning–Based Quantitative Multiparametric Approach for Mitral Regurgitation Severity Grading
Sadeghpour, A., Jiang, Z., Hummel, Y. M., Frost, M., Lam, C. S. P., Shah, S. J., Lund, L. H., Stone, G. W., Swaminathan, M., Weissman, N. J. & Asch, F. M., Jan 2025, In: JACC: Cardiovascular Imaging. 18, 1, p. 1-12 12 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Differences in Pulmonary Artery Flow Hemodynamics Between PAH and PH-HFpEF: Insights From 4D-Flow CMR
Kim, B. J., Lee, J., Berhane, H., Freed, B. H., Shah, S. J. & Thomas, J. D., Jan 2025, In: Pulmonary Circulation. 15, 1, e70022.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Effect of Finerenone on the KCCQ in Patients With HFmrEF/HFpEF: A Prespecified Analysis of FINEARTS-HF
Yang, M., Henderson, A. D., Talebi, A., Atherton, J. J., Chiang, C. E., Chopra, V., Comin-Colet, J., Kosiborod, M. N., Kerr Saraiva, J. F., Claggett, B. L., Desai, A. S., Kolkhof, P., Viswanathan, P., Lage, A., Lam, C. S. P., Senni, M., Shah, S. J., Rohwedder, K., Voors, A. A. & Zannad, F. & 5 others, , Jan 21 2025, In: Journal of the American College of Cardiology. 85, 2, p. 120-136 17 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Effects of the Nonsteroidal MRA Finerenone With and Without Concomitant SGLT2 Inhibitor Use in Heart Failure
Vaduganathan, M., Claggett, B. L., Kulac, I. J., Miao, Z. M., Desai, A. S., Jhund, P. S., Henderson, A. D., Brinker, M., Lay-Flurrie, J., Viswanathan, P., Scheerer, M. F., Lage, A., Lam, C. S. P., Senni, M., Shah, S. J., Voors, A. A., Zannad, F., Pitt, B., McMurray, J. J. V. & Solomon, S. D., Jan 14 2025, In: Circulation. 151, 2, p. 149-158 10 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Efficacy and Safety of Finerenone Across the Ejection Fraction Spectrum in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Prespecified Analysis of the FINEARTS-HF Trial
Docherty, K. F., Henderson, A. D., Jhund, P. S., Claggett, B. L., Desai, A. S., Mueller, K., Viswanathan, P., Scalise, A., Lam, C. S. P., Senni, M., Shah, S. J., Voors, A. A., Zannad, F., Pitt, B., Vaduganathan, M., Solomon, S. D. & McMurray, J. J. V., Jan 7 2025, In: Circulation. 151, 1, p. 45-58 14 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations
Datasets
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Supplementary Material for: Real-Life Multimarker Monitoring in Patients with Heart Failure: Continuous Remote Monitoring of Mobility and Patient-Reported Outcomes as Digital End Points in Future Heart-Failure Trials
Kramer, F. (Creator), Butler, J. (Creator), Shah, S. J. (Creator), Jung, C. (Creator), Nodari, S. (Creator), Rosenkranz, S. (Creator), Senni, M. (Creator), Bamber, L. (Creator), Cichos, S. (Creator), Dori, C. (Creator), Karakoyun, T. (Creator), Köhler, G. J. (Creator), Patel, K. (Creator), Piraino, P. (Creator), Viethen, T. (Creator), Chennuru, P. (Creator), Paydar, A. (Creator), Sims, J. (Creator), Clark, R. (Creator), Müller, A. (Creator), Gwaltney, C. (Creator), Smajlovic, S. (Creator), Düngen, H.-D. (Creator), Dinh, W. (Creator), Jung, C. (Creator), Patel, K. (Creator), Piraino, P. (Creator) & Clark, R. (Creator), Karger Publishers, 2020
DOI: 10.6084/m9.figshare.12587702.v1, https://karger.figshare.com/articles/Supplementary_Material_for_Real-Life_Multimarker_Monitoring_in_Patients_with_Heart_Failure_Continuous_Remote_Monitoring_of_Mobility_and_Patient-Reported_Outcomes_as_Digital_End_Points_in_Future_Heart-Failure_Trials/12587702/1
Dataset
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MOESM1 of Combining patient proteomics and in vitro cardiomyocyte phenotype testing to identify potential mediators of heart failure with preserved ejection fraction
Raphael, R. (Creator), Purushotham, D. (Creator), Gastonguay, C. (Creator), Chesnik, M. A. (Creator), Kwok, W.-M. (Contributor), Wu, H.-E. (Contributor), Shah, S. J. (Creator), Mirza, S. P. (Contributor) & Strande, J. L. (Creator), figshare, 2016
DOI: 10.6084/m9.figshare.c.3637169_d2, https://springernature.figshare.com/articles/figure/MOESM1_of_Combining_patient_proteomics_and_in_vitro_cardiomyocyte_phenotype_testing_to_identify_potential_mediators_of_heart_failure_with_preserved_ejection_fraction/4443872
Dataset
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Glucose dysregulation and subclinical cardiac dysfunction in older adults: The Cardiovascular Health Study
Garg, P. K. (Creator), Biggs, M. L. (Creator), Kizer, J. R. (Creator), Shah, S. J. (Creator), Psaty, B. (Creator), Carnethon, M. (Creator), Gottdiener, J. S. (Creator), Siscovick, D. (Creator) & Mukamal, K. J. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.c.6056549, https://springernature.figshare.com/collections/Glucose_dysregulation_and_subclinical_cardiac_dysfunction_in_older_adults_The_Cardiovascular_Health_Study/6056549
Dataset
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Effects of sacubitril/valsartan on glycemia in patients with diabetes and heart failure: the PARAGON-HF and PARADIGM-HF trials
Wijkman, M. O. (Creator), Claggett, B. (Creator), Vaduganathan, M. (Creator), Cunningham, J. W. (Creator), Rørth, R. (Creator), Jackson, A. (Creator), Packer, M. (Creator), Zile, M. (Creator), Rouleau, J. (Creator), Swedberg, K. (Creator), Lefkowitz, M. (Creator), Shah, S. J. (Creator), Pfeffer, M. A. (Creator), McMurray, J. J. V. (Creator) & Solomon, S. D. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.c.6053308, https://springernature.figshare.com/collections/Effects_of_sacubitril_valsartan_on_glycemia_in_patients_with_diabetes_and_heart_failure_the_PARAGON-HF_and_PARADIGM-HF_trials/6053308
Dataset
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Combining patient proteomics and in vitro cardiomyocyte phenotype testing to identify potential mediators of heart failure with preserved ejection fraction
Raphael, R. (Creator), Purushotham, D. (Creator), Gastonguay, C. (Creator), Chesnik, M. A. (Creator), Kwok, W.-M. (Contributor), Wu, H.-E. (Contributor), Shah, S. J. (Creator), Mirza, S. P. (Contributor) & Strande, J. L. (Creator), figshare, 2016
DOI: 10.6084/m9.figshare.c.3637169, https://figshare.com/collections/Combining_patient_proteomics_and_in_vitro_cardiomyocyte_phenotype_testing_to_identify_potential_mediators_of_heart_failure_with_preserved_ejection_fraction/3637169
Dataset