Sanjiv J Shah

  • 9258 Citations
19992023
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Personal profile

Research Interests

Sanjiv J. Shah, MD is the Neil Stone, MD Professor in the Division of Cardiology, Department of Medicine; Director of the T1 Center for Cardiovascular Therapeutics; and Director of the Heart Failure with Preserved Ejection Fraction Program at Northwestern University Feinberg School of Medicine. Dr. Shah’s clinical expertise and research focuses on heart failure with preserved ejection fraction (HFpEF), which is one of the most prevalent cardiovascular diseases and for which there are few proven treatments. In 2007, Dr. Shah started the first dedicated HFpEF program in the world at Northwestern University. The Northwestern University HFpEF program has served as a model for several other similar programs in the United States and throughout the world. Dr. Shah has been continuously funded by grants from the American Heart Association and the National Institutes of Health since 2008. He directs a laboratory that investigates the pathogenesis of heart failure; conducts multicenter clinical trials of novel therapeutics for heart failure, pulmonary hypertension, and cardiac amyloidosis; and develops novel techniques for machine learning and artificial intelligence for the classification, diagnosis, and tracking of cardiovascular diseases. His is currently the principal investigator of 3 ongoing R01 grants from the National Institutes of Health and an American Heart Association Strategically Focused Research Network grant. He is also the Northwestern University principal investigator for the National Heart, Lung, and Blood Institute (NHLBI) Heart Failure Network. Dr. Shah’s research, which has spans basic research in animal models, clinical physiologic studies, human clinical trials, and population-based epidemiology studies, has highlighted the heterogeneity and systemic nature of the HFpEF syndrome, and has improved the understanding of the risk factors, pathogenesis, and pathophysiology of HFpEF. He has also pioneered the use of machine learning for novel classification of cardiovascular diseases. Dr. Shah has served as the international principal investigator, executive committee member, or steering committee member for 18 multicenter randomized clinical trials and studies in heart failure. His work on clinical trials has contributed to the development of the first proven treatment for transthyretin cardiac amyloidosis, a highly fatal disease. Current research in his laboratory is focused on the molecular pathogenesis of abnormal cardiac mechanics; artificial intelligence for the automated interpretation of echocardiograms; adipocyte-endothelium-cardiomyocyte interactions; and the development of novel therapeutics for heart failure and microvascular dysfunction. Dr. Shah has published >235 peer-reviewed scientific research publications in leading medical journals, a textbook on cardiovascular genetics, and handbooks on internal medicine and cardiovascular disease. He is an associate editor of JAMA Cardiology, he is on the editorial board of Circulation: Heart Failure, and he has served as guest editor for the Journal of Cardiovascular Translational Research. His work has been cited over 6,700 times (Scopus, August 2018). Dr. Shah has mentored > 50 individuals throughout his career, including undergraduates, medical students, post-doctoral fellows, cardiology fellows, and early-stage faculty. He has received multiple teaching awards, including the George Joost MD, Teach of the Year Award at the Feinberg School of Medicine and the American College of Cardiology W. Proctor Harvey, MD Teaching Award. As an internationally recognized leading authority on HFpEF, Dr. Shah routinely lectures at international cardiology meetings, continuing medical education meetings, and academic institutions (including honorary lectures at Johns Hopkins University and Tufts University).

Certifications and Licenses

Advanced Heart Failure & Transplant Cardiology
Cardiovascular Disease
Internal Medicine

Training Experience

2003Residency, Univ. of CA-San Francisco Med. Ctr.
2006Fellowship, University of California Medical Center, San Francisco/Parnassus
2007Fellowship, University of Chicago Hospitals

Education/Academic qualification

MD, Northwestern University Feinberg School of Medicine

… → 2000

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Grants 1999 2023

Plasminogen Activator Inhibitor 1
Fibrosis
Mutation
Cardiomyopathies
Cardiac Myocytes
Heart-Assist Devices
Mortality
Tissue Donors
Heart Transplantation
Heart Failure
Plasminogen Activator Inhibitor 1
Blood Vessels
Cardiovascular System
Population
Personal Financing

Research Output 1999 2019

1 Citation (Scopus)

10-Year Risk Equations for Incident Heart Failure in the General Population

Khan, S. S., Ning, H., Shah, S. J., Yancy, C. W., Carnethon, M. R., Berry, J. D., Mentz, R. J., O'Brien, E., Correa, A., Suthahar, N., de Boer, R. A., Wilkins, J. T. & Lloyd-Jones, D. M., May 21 2019, In : Journal of the American College of Cardiology. 73, 19, p. 2388-2397 10 p.

Research output: Contribution to journalArticle

Heart Failure
Population
Primary Prevention
Calibration
Fasting
4 Citations (Scopus)

Central and Peripheral Determinants of Exercise Capacity in Heart Failure Patients With Preserved Ejection Fraction

Wolsk, E., Kaye, D., Komtebedde, J., Shah, S. J., Borlaug, B. A., Burkhoff, D., Kitzman, D. W., Lam, C. S. P., van Veldhuisen, D. J., Ponikowski, P., Petrie, M. C., Hassager, C., Møller, J. E. & Gustafsson, F., Apr 1 2019, In : JACC: Heart Failure. 7, 4, p. 321-332 12 p.

Research output: Contribution to journalArticle

Heart Failure
Exercise
Workload
Stroke Volume
Pulmonary Wedge Pressure

Characterization of the Obese Phenotype of Heart Failure With Preserved Ejection Fraction: A RELAX Trial Ancillary Study

Reddy, Y. N. V., Lewis, G. D., Shah, S. J., Obokata, M., Abou-Ezzedine, O. F., Fudim, M., Sun, J. L., Chakraborty, H., McNulty, S., LeWinter, M. M., Mann, D. L., Stevenson, L. W., Redfield, M. M. & Borlaug, B. A., Jul 1 2019, In : Mayo Clinic Proceedings. 94, 7, p. 1199-1209 11 p.

Research output: Contribution to journalArticle

Open Access
Heart Failure
Phenotype
Exercise
Body Mass Index
Quality of Life

Clinical correlates and heritability of cardiac mechanics: The HyperGEN study

Khan, S. S., Kim, K-Y. A., Peng, J., Aguilar, F. G., Selvaraj, S., Martinez, E. E., Baldridge, A. S., Sha, J., Irvin, M. R., Broeckel, U., Arnett, D. K., Rasmussen-Torvik, L. J. & Shah, S. J., Jan 1 2019, In : International Journal of Cardiology. 274, p. 208-213 6 p.

Research output: Contribution to journalArticle

Molecular Epidemiology
Mechanics
Hypertension
African Americans
Social Adjustment
2 Citations (Scopus)
Heart Failure
Clinical Trials
Pharmaceutical Preparations
Drug therapy
Therapeutics