Sarki Abba Abdulkadir

  • 2449 Citations
1990 …2022
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Personal profile

Training Experience

1999Residency, Barnes Jewish Hospital
2000Postdoctoral Fellowship, Washington University
2000Fellowship, Barnes Jewish Hospital

Research Interests

I am a molecular geneticist and clinical pathologist working in translational cancer research. My research has focused on deciphering the molecular mechanisms that drive epithelial cancer initiation, progression and recurrence with an emphasis on prostate cancer. My lab has been active in establishing accurate models of MYC and PIM driven prostate cancer and we were the first to show evidence of cooperativity between MYC and PIM kinase in prostate cancer and to provide evidence that PIM kinase inhibition can impair MYC-driven prostate cancer and reverse therapy resistance. These concepts have recently been extended to breast cancer by several investigators, including a collaborator on this U54 project, Dr. Horiuchi. I have extensive experience in cancer modeling in vitro (e.g. organoids), and in vivo (xenografts, genetically engineered mice, tissue recombination models). I serve as Director of Research for the Department of Urology at Northwestern and play a key role in the Chicago Prostate SPORE as PI of Project 3 and Head of the Leadership Development Program. I have excellent working relationships and active collaborations with all investigators in the U54. For example, I am co-PI with Chakravarti on a multi-PI RO1, co-I with Meeks on a PCF grant, and co-I with Yu on an H Foundation grant. I collaborate on CTCs with Cristofanilli and with Hussain on a SPORE supported clinical trial. I was selected to serve as a co-PI with Dr. Cristofanilli on this application.

Education/Academic qualification

PhD, Johns Hopkins University

… → 1995

MD, Ahmadu Bellow University, Nigeria

… → 1990

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Castration Medicine & Life Sciences

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Grants 2014 2022

Metagenomics
Prostatic Neoplasms
docetaxel
Veterans
Neoplasms
Polysaccharides
Prostatic Neoplasms
Biomarkers
Neoplasms
Serum
Prostatic Neoplasms
Biomarkers
Serum
Polysaccharides
Validation Studies
Astemizole
Castration
Nuclear Factor 90 Proteins
Prostatic Neoplasms
Zinc Compounds

Research Output 1990 2019

  • 2449 Citations
  • 48 Article
  • 3 Review article
  • 1 Comment/debate
  • 1 Letter

Targeting FOXA1-mediated repression of TGF-β signaling suppresses castration-resistant prostate cancer progression

Song, B., Park, S. H., Zhao, C., Fong, K. W., Li, S., Lee, Y., Yang, Y. A., Sridhar, S., Lu, X., Abdulkadir, S. A., Vessella, R. L., Morrissey, C., Kuzel, T. M., Catalona, W. J., Yang, X. J. & Yu, J., Feb 1 2019, In : Journal of Clinical Investigation. 129, 2, p. 569-582 14 p.

Research output: Contribution to journalArticle

LY-2157299
Castration
Androgen Antagonists
Prostatic Neoplasms
Epithelial-Mesenchymal Transition
1 Citations (Scopus)

A bioluminescent and fluorescent orthotopic syngeneic murine model of androgen-dependent and castration-resistant prostate cancer

Anker, J. F., Mok, H., Naseem, A. F., Thumbikat, P. & Abdulkadir, S. A., Mar 6 2018, In : Journal of Visualized Experiments. 2018, 133, e57301.

Research output: Contribution to journalArticle

Castration
Androgens
Tumors
Prostatic Neoplasms
Neoplasms
1 Citations (Scopus)

Anaplastic lymphoma kinase mutation (ALK F1174C) in small cell carcinoma of the prostate and molecular response to alectinib

Carneiro, B. A., Pamarthy, S., Shah, A. N., Sagar, V., Unno, K., Han, H. Y., Yang, X. J., Costa, R. B., Nagy, R. J., Lanman, R. B., Kuzel, T. M., Ross, J. S., Gay, L., Elvin, J. A., Ali, S. M., Cristofanilli, M., Chae, Y. K., Giles, F. J. & Abdulkadir, S. A., Jun 15 2018, In : Clinical Cancer Research. 24, 12, p. 2732-2739 8 p.

Research output: Contribution to journalArticle

Small Cell Carcinoma
Prostate
Mutation
Organoids
Prostatic Neoplasms
1 Citations (Scopus)

Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy

Anker, J. F., Naseem, A. F., Mok, H., Schaeffer, A. J., Abdulkadir, S. A. & Thumbikat, P., Dec 1 2018, In : Nature Communications. 9, 1, 1591.

Research output: Contribution to journalArticle

Tropics
tropical regions
Immunotherapy
Tumors
T-cells
2 Citations (Scopus)

Modeling African American prostate adenocarcinoma by inducing defined genetic alterations in organoids

Unno, K., Roh, M., Yoo, Y. A., Al-Shraideh, Y., Wang, L., Nonn, L. & Abdulkadir, S. A., Feb 7 2017, In : Oncotarget. 8, 31, p. 51264-51276 13 p.

Research output: Contribution to journalArticle

Organoids
African Americans
Prostate
Adenocarcinoma
Prostatic Neoplasms