Grants per year
Personal profile
Research Interests
My research interests center on better understanding the cellular and molecular building blocks that make up the basal ganglia macrocircuit as well as their implications on neural activity level, pattern and plasticity in the basal ganglia in health and disease. My long-term research goal is to elucidate cellular components involved in the pathophysiology and motor symptoms of Parkinson's disease and other related disorders. We hope to translate our insight into developing novel treatments for neurological disorders of the basal ganglia such as Parkinson's disease.
Education/Academic qualification
PhD, Chinese University of Hong Kong
… → 2001
Research interests
- Biophysics
- Cellular Electrophysiology
- Electrophysiology
- Gene Therapy
- Ion Channels
- Nervous System Diseases
- Neuroscience
- Physiology
Fingerprint Dive into the research topics where Savio Chan is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 31 Similar Profiles
Neurons
Medicine & Life Sciences
Globus Pallidus
Medicine & Life Sciences
Corpus Striatum
Medicine & Life Sciences
Parkinson Disease
Medicine & Life Sciences
Dopaminergic Neurons
Medicine & Life Sciences
Basal Ganglia
Medicine & Life Sciences
Synapses
Medicine & Life Sciences
Dopamine
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2008 2022
Transformation of the stress response into motor behavior by the external globus pallidus
University of Texas Health Science Center at Houston, National Institute of Mental Health
6/5/17 → 3/31/22
Project: Research project
Globus Pallidus
Neurons
Light
R 121919
Fluorescent Antibody Technique
2017 HHMI-PF Medical Research Fellows Award
Howard Hughes Medical Institute
5/1/17 → 5/31/20
Project: Research project
GABAergic Signaling in the External Globus Pallidus
National Institute of Neurological Disorders and Stroke
2/1/17 → 1/31/22
Project: Research project
Globus Pallidus
Parkinson Disease
Parvalbumins
Neurons
Corpus Striatum
LRRK2-mediated molecular and synaptic events in the striatum
National Institute of Neurological Disorders and Stroke
8/15/16 → 7/31/21
Project: Research project
Parkinson Disease
Corpus Striatum
Mutation
Viral Genes
Neurodegenerative Diseases
Age-Related Histone Modification Effect on Antipsychotic Action
Chan, S., Csernansky, J. G., Dong, H., Fang, D. & Meltzer, H. Y.
National Institute of Mental Health
5/26/16 → 2/28/21
Project: Research project
Histone Code
Antipsychotic Agents
Histone Deacetylase Inhibitors
Drug-Related Side Effects and Adverse Reactions
Epigenomics
Research Output 1998 2018
34
Citations
(Scopus)
Mapping projections of molecularly defined dopamine neuron subtypes using intersectional genetic approaches
Poulin, J. F., Caronia-Brown, G., Hofer, C., Cui, Q., Helm, B., Ramakrishnan, C., Chan, S., Dombeck, D. A., Deisseroth, K. & Awatramani, R., Sep 1 2018, In : Nature Neuroscience. 21, 9, p. 1260-1271 12 p.Research output: Contribution to journal › Article
Dopaminergic Neurons
Ventral Tegmental Area
Caudate Nucleus
Putamen
Nucleus Accumbens
6
Citations
(Scopus)
Paraventricular hypothalamic and amygdalar CRF neurons synapse in the external globus pallidus
Hunt, A. J., Dasgupta, R., Rajamanickam, S., Jiang, Z., Beierlein, M., Chan, S. & Justice, N. J., Jul 1 2018, In : Brain Structure and Function. 223, 6, p. 2685-2698 14 p.Research output: Contribution to journal › Article
Globus Pallidus
Corticotropin-Releasing Hormone
Synapses
Neurons
Limbic System
6
Citations
(Scopus)
Suppression of hyperpolarization-activated cyclic nucleotide-gated channel function in thalamocortical neurons prevents genetically determined and pharmacologically induced absence seizures
David, F., Çarçak, N., Furdan, S., Onat, F., Gould, T., Mészáros, Á., Di Giovanni, G., Hernández, V. M., Chan, C. S., Lőrincz, M. L. & Crunelli, V., Jul 25 2018, In : Journal of Neuroscience. 38, 30, p. 6615-6627 13 p.Research output: Contribution to journal › Article
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Absence Epilepsy
Neurons
Thalamus
Cyclic Nucleotides
Corrigendum to “TRPC3 channels critically regulate hippocampal excitability and contextual fear memory” (Behavioural Brain Research (2015) 281 (69–77) (S0166432814008122) (10.1016/j.bbr.2014.12.018))
Neuner, S. M., Wilmott, L. A., Hope, K. A., Hoffmann, B., Chong, J. A., Abramowitz, J., Birnbaumer, L., O'Connell, K., Tryba, A. K., Greene, A. S., Chan, C. S. & Kaczorowski, C. C., Aug 14 2017, In : Behavioural Brain Research. 332, 1 p.Research output: Contribution to journal › Comment/debate
Behavioral Research
Fear
Brain
Small Interfering RNA
Freezing
8
Citations
(Scopus)
Ethanol-Sensitive Pacemaker Neurons in the Mouse External Globus Pallidus
Abrahao, K. P., Chancey, J. H., Chan, S. & Lovinger, D. M., Apr 1 2017, In : Neuropsychopharmacology. 42, 5, p. 1070-1081 12 p.Research output: Contribution to journal › Article
Globus Pallidus
Ethanol
Neurons
Large-Conductance Calcium-Activated Potassium Channels
Basal Ganglia