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Personal profile

Research Interests

My research interests center on better understanding the cellular and molecular building blocks that make up the basal ganglia macrocircuit as well as their implications on neural activity level, pattern and plasticity in the basal ganglia in health and disease. My long-term research goal is to elucidate cellular components involved in the pathophysiology and motor symptoms of Parkinson's disease and other related disorders. We hope to translate our insight into developing novel treatments for neurological disorders of the basal ganglia such as Parkinson's disease.

Education/Academic qualification

PhD, Chinese University of Hong Kong

… → 2001

Research interests

  • Biophysics
  • Cellular Electrophysiology
  • Electrophysiology
  • Gene Therapy
  • Ion Channels
  • Nervous System Diseases
  • Neuroscience
  • Physiology

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Grants

  • Research Output

    • 3145 Citations
    • 36 Article
    • 4 Review article
    • 3 Chapter
    • 2 Comment/debate

    Npas1+-Nkx2.1+ Neurons Are an Integral Part of the Cortico-pallido-cortical Loop

    Abecassis, Z. A., Berceau, B. L., Win, P. H., García, D., Xenias, H. S., Cui, Q., Pamukcu, A., Cherian, S., Hernández, V. M., Chon, U., Lim, B. K., Kim, Y., Justice, N. J., Awatramani, R., Hooks, B. M., Gerfen, C. R., Boca, S. M. & Chan, C. S., Jan 22 2020, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 40, 4, p. 743-768 26 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    PRISM: A Progenitor-Restricted Intersectional Fate Mapping Approach Redefines Forebrain Lineages

    Poulin, J. F., Luppi, M. P., Hofer, C., Caronia, G., Hsu, P. K., Chan, C. S. & Awatramani, R., Jun 22 2020, In : Developmental Cell. 53, 6, p. 740-753.e3

    Research output: Contribution to journalArticle

    Open Access
  • Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons

    Carrillo-Reid, L., Day, M., Xie, Z., Melendez, A. E., Kondapalli, J., Plotkin, J. L., Wokosin, D. L., Chen, Y., Kress, G. J., Kaplitt, M., Ilijic, E., Guzman, J. N., Chan, C. S. & Surmeier, D. J., Apr 2019, In : eLife. 8, e40818.

    Research output: Contribution to journalArticle

    Open Access
  • 5 Scopus citations

    Mapping projections of molecularly defined dopamine neuron subtypes using intersectional genetic approaches

    Poulin, J. F., Caronia, G., Hofer, C., Cui, Q., Helm, B., Ramakrishnan, C., Chan, C. S., Dombeck, D. A., Deisseroth, K. & Awatramani, R., Sep 1 2018, In : Nature Neuroscience. 21, 9, p. 1260-1271 12 p.

    Research output: Contribution to journalArticle

  • 48 Scopus citations

    Paraventricular hypothalamic and amygdalar CRF neurons synapse in the external globus pallidus

    Hunt, A. J., Dasgupta, R., Rajamanickam, S., Jiang, Z., Beierlein, M., Chan, C. S. & Justice, N. J., Jul 1 2018, In : Brain Structure and Function. 223, 6, p. 2685-2698 14 p.

    Research output: Contribution to journalArticle

  • 7 Scopus citations