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Personal profile

Research Interests

My research interests center on better understanding the cellular and molecular building blocks that make up the basal ganglia macrocircuit as well as their implications on neural activity level, pattern and plasticity in the basal ganglia in health and disease. My long-term research goal is to elucidate cellular components involved in the pathophysiology and motor symptoms of Parkinson's disease and other related disorders. We hope to translate our insight into developing novel treatments for neurological disorders of the basal ganglia such as Parkinson's disease.

Education/Academic qualification

PhD, Chinese University of Hong Kong

… → 2001

Research interests

  • Biophysics
  • Cellular Electrophysiology
  • Electrophysiology
  • Gene Therapy
  • Ion Channels
  • Nervous System Diseases
  • Neuroscience
  • Physiology

Fingerprint Dive into the research topics where Savio Chan is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 30 Similar Profiles
Neurons Medicine & Life Sciences
Globus Pallidus Medicine & Life Sciences
Corpus Striatum Medicine & Life Sciences
Parkinson Disease Medicine & Life Sciences
Dopaminergic Neurons Medicine & Life Sciences
Basal Ganglia Medicine & Life Sciences
Synapses Medicine & Life Sciences
Dopamine Medicine & Life Sciences

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Grants 2008 2022

Dystonia
Synaptic Transmission
Dopamine
Tyrosine 3-Monooxygenase
Dystonic Disorders
Globus Pallidus
Parkinson Disease
Parvalbumins
Neurons
Corpus Striatum
Parkinson Disease
Corpus Striatum
Mutation
Viral Genes
Neurodegenerative Diseases

Research Output 1998 2018

  • 2856 Citations
  • 34 Article
  • 4 Review article
  • 2 Chapter
  • 2 Comment/debate
20 Citations (Scopus)

Mapping projections of molecularly defined dopamine neuron subtypes using intersectional genetic approaches

Poulin, J. F., Caronia-Brown, G., Hofer, C., Cui, Q., Helm, B., Ramakrishnan, C., Chan, S., Dombeck, D. A., Deisseroth, K. & Awatramani, R., Sep 1 2018, In : Nature Neuroscience. 21, 9, p. 1260-1271 12 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Ventral Tegmental Area
Caudate Nucleus
Putamen
Nucleus Accumbens
4 Citations (Scopus)

Paraventricular hypothalamic and amygdalar CRF neurons synapse in the external globus pallidus

Hunt, A. J., Dasgupta, R., Rajamanickam, S., Jiang, Z., Beierlein, M., Chan, S. & Justice, N. J., Jul 1 2018, In : Brain Structure and Function. 223, 6, p. 2685-2698 14 p.

Research output: Contribution to journalArticle

Globus Pallidus
Corticotropin-Releasing Hormone
Synapses
Neurons
Limbic System
5 Citations (Scopus)

Suppression of hyperpolarization-activated cyclic nucleotide-gated channel function in thalamocortical neurons prevents genetically determined and pharmacologically induced absence seizures

David, F., Çarçak, N., Furdan, S., Onat, F., Gould, T., Mészáros, Á., Di Giovanni, G., Hernández, V. M., Chan, S., Lőrincz, M. L. & Crunelli, V., Jul 25 2018, In : Journal of Neuroscience. 38, 30, p. 6615-6627 13 p.

Research output: Contribution to journalArticle

Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Absence Epilepsy
Neurons
Thalamus
Cyclic Nucleotides

Corrigendum to “TRPC3 channels critically regulate hippocampal excitability and contextual fear memory” (Behavioural Brain Research (2015) 281 (69–77) (S0166432814008122) (10.1016/j.bbr.2014.12.018))

Neuner, S. M., Wilmott, L. A., Hope, K. A., Hoffmann, B., Chong, J. A., Abramowitz, J., Birnbaumer, L., O'Connell, K., Tryba, A. K., Greene, A. S., Chan, C. S. & Kaczorowski, C. C., Aug 14 2017, In : Behavioural Brain Research. 332, 1 p.

Research output: Contribution to journalComment/debate

Behavioral Research
Fear
Brain
Small Interfering RNA
Freezing
7 Citations (Scopus)

Ethanol-Sensitive Pacemaker Neurons in the Mouse External Globus Pallidus

Abrahao, K. P., Chancey, J. H., Chan, S. & Lovinger, D. M., Apr 1 2017, In : Neuropsychopharmacology. 42, 5, p. 1070-1081 12 p.

Research output: Contribution to journalArticle

Globus Pallidus
Ethanol
Neurons
Large-Conductance Calcium-Activated Potassium Channels
Basal Ganglia