Grants per year
Personal profile
Research Interests
I am a surgeon; my main professional goal is to provide surgical treatment for women with breast cancer, those at high risk for it, and those with benign breast problems. To deliver the best surgical care, I strive to help women with breast cancer and those with benign breast conditions understand their disease so that they will make informed treatment decisions that give them the best chance of cure with the best quality of life. In addition to treatment of breast diseases, I have a major clinical and research interest in understanding breast cancer risk and finding safe ways of preventing breast cancer so that I can accurately identify high risk women and help them make the decisions that will leave them with the lowest risk of breast cancer with the best quality of life.
Certifications and Licenses
| Surgery |
Training Experience
| 1982 | Residency, Saint Agnes Hospital |
| 1984 | Residency, Saint Joseph's Hospital |
| 1986 | Fellowship, Roswell Park Cancer Institute |
| 1989 | Fellowship, Roswell Park Cancer Institute |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine, MD, Dow Medical College, Pakistan
… → 1978
Research interests keywords
- Breast Cancer
- Breast Disease
- Epidemiology
- Genetic Testing/Counseling
- Preventive Medicine
- Quality of Life
- Surgery
- Women's Health
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Lipid-initiated epigenetic reprogramming of the breast to a neural phenotype
Clare, S. E. (PD/PI) & Khan, S. A. (Co-Investigator)
3/10/25 → 2/28/27
Project: Research project
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Develop a novel therapy with immuno- and onco-targeting dual efficacies to treat the triple negative breast cancer
Fang, D. (PD/PI), Khan, S. A. (Co-Investigator) & Watterson, D. M. (Co-Investigator)
1/1/25 → 12/31/29
Project: Research project
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Preclinical and clinical studies of breast cancer prevention and with transdermal antiprogesterone agents
Khan, S. A. (PD/PI) & Lee, O. (Co-Investigator)
Breast Cancer Research Foundation
10/1/24 → 9/30/25
Project: Research project
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Early Phase Clinical Cancer Prevention Consortium - Start-up costs
Khan, S. A. (PD/PI)
University of Michigan, National Cancer Institute
7/1/24 → 6/30/25
Project: Research project
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Suppression of progesterone receptor signaling by heavy metals promotes tamoxifen resistance and metastasis or ER+ breast cancer
Bonini, M. (PD/PI), Khan, S. A. (Co-Investigator) & Kocherginsky, M. (Co-Investigator)
National Institute of Environmental Health Sciences
6/24/24 → 3/31/29
Project: Research project
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A metabolic shift to the serine pathway induced by lipids fosters epigenetic reprogramming in nontransformed breast cells
Eduardo, M. B., Cottone, G., McCloskey, C. W., Liu, S., Palma, F. R., Zappia, M. P., Islam, A. B. M. M. K., Gao, P., Setya, J., Dennis, S., Gao, H., Zhang, Q., Xuei, X., Luo, Y., Locasale, J., Bonini, M., Khokha, R., Frolov, M. V., Benevolenskaya, E. V. & Chandel, N. S. & 2 others, , Mar 21 2025, In: Science Advances. 11, 12, eads9182.Research output: Contribution to journal › Article › peer-review
Open Access -
Can We Omit Surgery for Low-Risk Ductal Carcinoma In Situ of the Breast?
Khan, S. A. & Whelan, T., Mar 18 2025, In: JAMA. 333, 11, p. 948-949 2 p.Research output: Contribution to journal › Editorial › peer-review
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Current and emerging strategies for the prevention of hepatocellular carcinoma
Yeo, Y. H., Abdelmalek, M., Khan, S., Moylan, C. A., Rodriquez, L., Villanueva, A. & Yang, J. D., Mar 2025, In: Nature Reviews Gastroenterology and Hepatology. 22, 3, p. 173-190 18 p., e0279442.Research output: Contribution to journal › Review article › peer-review
4 Scopus citations -
Neoadjuvant Chemotherapy Response and Genetic Susceptibility in Recently Parous Women with Breast Cancer: A Retrospective Analysis
Dennis, S., Tsukioki, T., Kocherginsky, M., Qi, A. K., DeHorn, S., Gurley, M., Wrubel, E., Luo, Y. & Khan, S., 2025, (Accepted/In press) In: Annals of surgical oncology. 100985.Research output: Contribution to journal › Article › peer-review
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A randomized Phase I pre-operative window trial of transdermal endoxifen in women planning mastectomy: Evaluation of dermal safety, intra-mammary drug distribution, and biologic effects
Lee, O., Bazzi, L. A., Xu, Y., Pearson, E., Wang, M., Hosseini, O., Akasha, A. M., Choi, J. N., Karlan, S., Pilewskie, M., Kocherginsky, M., Benante, K., Helland, T., Mellgren, G., Dimond, E., Perloff, M., Heckman-Stoddard, B. M. & Khan, S. A., Feb 2024, In: Biomedicine and Pharmacotherapy. 171, 116105.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations
Datasets
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MOESM8 of BRCA1 mutation influences progesterone response in human benign mammary organoids
Davaadelger, B. (Contributor), Choi, M.-R. (Creator), Singhal, H. (Creator), Clare, S. E. (Creator), Khan, S. A. (Creator) & Kim, J. J. (Contributor), figshare, 2019
DOI: 10.6084/m9.figshare.11273327, https://springernature.figshare.com/articles/MOESM8_of_BRCA1_mutation_influences_progesterone_response_in_human_benign_mammary_organoids/11273327
Dataset
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Using natural language processing and machine learning to identify breast cancer local recurrence
Zeng, Z. (Contributor), Espino, S. (Contributor), Roy, A. (Contributor), Li, X. (Contributor), Khan, S. A. (Creator), Clare, S. E. (Creator), Jiang, X. (Creator), Neapolitan, R. (Creator) & Luo, Y. (Creator), figshare, 2018
DOI: 10.6084/m9.figshare.c.4349627, https://springernature.figshare.com/collections/Using_natural_language_processing_and_machine_learning_to_identify_breast_cancer_local_recurrence/4349627
Dataset
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Progesterone receptor blockade in human breast cancer cells decreases cell cycle progression through G2/M by repressing G2/M genes
Clare, S. E. (Creator), Gupta, A. (Creator), Choi, M. (Creator), Ranjan, M. (Creator), Lee, O. (Contributor), Wang, J. (Creator), Ivancic, D. Z. (Creator), Kim, J. J. (Contributor) & Khan, S. A. (Creator), figshare, 2016
DOI: 10.6084/m9.figshare.c.3596489, https://springernature.figshare.com/collections/Progesterone_receptor_blockade_in_human_breast_cancer_cells_decreases_cell_cycle_progression_through_G2_M_by_repressing_G2_M_genes/3596489
Dataset
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Additional file 1: of Using natural language processing and machine learning to identify breast cancer local recurrence
Zeng, Z. (Contributor), Espino, S. (Contributor), Roy, A. (Contributor), Li, X. (Contributor), Khan, S. A. (Creator), Clare, S. E. (Creator), Jiang, X. (Creator), Neapolitan, R. (Creator) & Luo, Y. (Creator), figshare, 2018
DOI: 10.6084/m9.figshare.7528163, https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Using_natural_language_processing_and_machine_learning_to_identify_breast_cancer_local_recurrence/7528163
Dataset
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Additional file 4: Table S5. of Progesterone receptor blockade in human breast cancer cells decreases cell cycle progression through G2/M by repressing G2/M genes
Clare, S. E. (Creator), Gupta, A. (Creator), Choi, M. (Creator), Ranjan, M. (Creator), Lee, O. (Contributor), Wang, J. (Creator), Ivancic, D. Z. (Creator), Kim, J. J. (Contributor) & Khan, S. A. (Creator), figshare, 2016
DOI: 10.6084/m9.figshare.c.3596489_d1, https://springernature.figshare.com/articles/dataset/Additional_file_4_Table_S5_of_Progesterone_receptor_blockade_in_human_breast_cancer_cells_decreases_cell_cycle_progression_through_G2_M_by_repressing_G2_M_genes/4318784
Dataset