• 17536 Citations
1993 …2020

Research output per year

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Personal profile

Research Interests

The laboratory research of Serdar E. Bulun, MD, focuses on studying estrogen biosynthesis and metabolism, in particular aromatase expression, in hormone-dependent human diseases such as breast cancer, endometriosis and uterine fibroids. A team of investigators works on understanding the epitheial-stromal interactions and aromotase overexpression in breast cancer tissue. Since aromatase inhibitors treat breast tumors primarily via suppressing intratumoral estrogen biosynthesis, these efforts are important for discovering new targets of treatment. Another team studies endometriosis. Basic data from this laboratory led to the introduction of aromatase inhibitors into endometriosis treatment. Human tissues and a primate model are used to elucidate cellular and molecular mechanisms responsible for the development of endometriosis. Regulation of aromatase expression is also studied in uterine fibroids, benign tumors that are dependent on estrogen for growth, by a third team. A fourth team is investigating the link between progesterone action and estrogen inactivation in normal endometrium and endometriosis. Lastly, a fifth team has identified novel mutations that cause familial excessive estrogen formation syndrome. This syndrome is characterized by short stature, gynecomastia, and hypogandism in males and early breast development and irregular menses in females. In this syndrome, heterozygous inversions in chromosome 15q21, which cause the coding region of the aromatase gene to lie adjacent to constitutively active cryptic promoters that normally transcribe other genes, result in estrogen excess owing to the overexpression of aromatase in many tissues.

Certifications and Licenses

Obstetrics & Gynecology
Reproductive Endocrinology & Infertility

Training Experience

1987Residency, University of Arizona College of Medicine
1988Internship, Columbia University College of Physicians and Surgeons
1991Residency, SUNY/State University of New York, Buffalo
1993Fellowship, Parkland Memorial Hospital

Education/Academic qualification

MD, Istanbul University

… → 1983

Research interests

  • Breast Disease
  • Cancer Biology
  • Endocrinology
  • Infertility (female)
  • Sexual dysfunction
  • Women's Health / Women's Reproductive Health

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Grants

Research Output

GATA2 and Progesterone Receptor Interaction in Endometrial Stromal Cells Undergoing Decidualization

Kohlmeier, A., Sison, C. A. M., Yilmaz, B. D., Coon V, J. S., Dyson, M. T. & Bulun, S. E., Jun 1 2020, In : Endocrinology. 161, 6

Research output: Contribution to journalArticle

  • Whole-Genome Sequencing and Target Validation Analysis of Müllerian Adenosarcoma: A Tumor With Complex but Specific Genetic Alterations

    Ban, Y., Fischer, J. V., Maniar, K. P., Guo, H., Zeng, C., Li, Y., Zhang, Q., Wang, X., Zhang, W., Bulun, S. E. & Wei, J. J., Apr 15 2020, In : Frontiers in Oncology. 10, 538.

    Research output: Contribution to journalArticle

    Open Access
  • Catacomb: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism

    Piunti, A., Smith, E. R., Morgan, M. A. J., Ugarenko, M., Khaltyan, N., Helmin, K. A., Ryan, C. A., Murray, D. C., Rickels, R. A., Yilmaz, B. D., Rendleman, E. J., Savas, J. N., Singer, B. D., Bulun, S. E. & Shilatifard, A., Jan 1 2019, In : Science Advances. 5, 7, eaax2887.

    Research output: Contribution to journalArticle

    Open Access
  • 5 Scopus citations

    Endometriosis

    Bulun, S. E., Jan 1 2019, Yen & Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management: Eighth Edition. Elsevier Inc, p. 609-642.e7

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • 1 Scopus citations

    Endometriosis

    Bulun, S. E., Yilmaz, B. D., Sison, C., Miyazaki, K., Bernardi, L., Liu, S., Kohlmeier, A., Yin, P., Milad, M. & Wei, J. J., May 10 2019, In : Endocrine reviews. 40, 4, p. 1048-1079 32 p.

    Research output: Contribution to journalReview article

  • 15 Scopus citations