• 16643 Citations
1993 …2024
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Personal profile

Research Interests

The laboratory research of Serdar E. Bulun, MD, focuses on studying estrogen biosynthesis and metabolism, in particular aromatase expression, in hormone-dependent human diseases such as breast cancer, endometriosis and uterine fibroids. A team of investigators works on understanding the epitheial-stromal interactions and aromotase overexpression in breast cancer tissue. Since aromatase inhibitors treat breast tumors primarily via suppressing intratumoral estrogen biosynthesis, these efforts are important for discovering new targets of treatment. Another team studies endometriosis. Basic data from this laboratory led to the introduction of aromatase inhibitors into endometriosis treatment. Human tissues and a primate model are used to elucidate cellular and molecular mechanisms responsible for the development of endometriosis. Regulation of aromatase expression is also studied in uterine fibroids, benign tumors that are dependent on estrogen for growth, by a third team. A fourth team is investigating the link between progesterone action and estrogen inactivation in normal endometrium and endometriosis. Lastly, a fifth team has identified novel mutations that cause familial excessive estrogen formation syndrome. This syndrome is characterized by short stature, gynecomastia, and hypogandism in males and early breast development and irregular menses in females. In this syndrome, heterozygous inversions in chromosome 15q21, which cause the coding region of the aromatase gene to lie adjacent to constitutively active cryptic promoters that normally transcribe other genes, result in estrogen excess owing to the overexpression of aromatase in many tissues.

Certifications and Licenses

Obstetrics & Gynecology
Reproductive Endocrinology & Infertility

Training Experience

1987Residency, University of Arizona College of Medicine
1988Internship, Columbia University College of Physicians and Surgeons
1991Residency, SUNY/State University of New York, Buffalo
1993Fellowship, Parkland Memorial Hospital

Education/Academic qualification

MD, Istanbul University

… → 1983

Research interests

  • Breast Disease
  • Cancer Biology
  • Endocrinology
  • Infertility (female)
  • Sexual dysfunction
  • Women's Health / Women's Reproductive Health

Fingerprint Dive into the research topics where Serdar E Bulun is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 14 Similar Profiles
Aromatase Medicine & Life Sciences
Endometriosis Medicine & Life Sciences
Estrogens Medicine & Life Sciences
Leiomyoma Medicine & Life Sciences
Stromal Cells Medicine & Life Sciences
Aromatase Inhibitors Medicine & Life Sciences
Breast Neoplasms Medicine & Life Sciences
Tissue Chemical Compounds

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Grants 2000 2024

Abdominal Muscles
Estrogens
Fibrosis
Muscles
Aromatase
Leiomyoma
Endometriosis
Molecular Biology
Therapeutics
Pelvic Pain
Leiomyoma
Genomics
Computational Biology
Epigenomics
Smooth Muscle Tumor
Leiomyoma
Research
Growth
Progestins
Cytoplasmic and Nuclear Receptors

Research Output 1993 2019

Catacomb: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism

Piunti, A., Smith, E., Morgan, M. A., Ugarenko, M., Khaltyan, N., Helmin, K. A., Ryan, C. A., Murray, D. C., Rickels, R. A., Yilmaz, B. D., Rendleman, E. J., Savas, J. N., Singer, B., Bulun, S. E. & Shilatifard, A., Jan 1 2019, In : Science Advances. 5, 7, eaax2887.

Research output: Contribution to journalArticle

Open Access
methionine
methylation
genes
deoxyribonucleic acid
COMPASS (programming language)
1 Citation (Scopus)

Endometriosis

Bulun, S. E., Yilmaz, B. D., Sison, C., Miyazaki, K., Bernardi Wendeln, L. A., Liu, S., Kohlmeier, A., Yin, P., Milad, M. P. & Wei, J-J., May 10 2019, In : Endocrine reviews. 40, 4, p. 1048-1079 32 p.

Research output: Contribution to journalReview article

Endometriosis
Stromal Cells
Estrogens
Pelvic Pain
Mesenchymal Stromal Cells

Endometriosis and nuclear receptors

Yilmaz, B. D. & Bulun, S. E., Jan 1 2019, In : Human Reproduction Update. 25, 4, p. 473-485 13 p., dmz005.

Research output: Contribution to journalArticle

Endometriosis
Cytoplasmic and Nuclear Receptors
Stromal Cells
Progesterone Receptors
Estrogens

Epithelial mutations in endometriosis: Link to ovarian cancer

Bulun, S. E., Wan, Y. & Matei, D. E., Feb 14 2019, In : Endocrinology. 160, 3, p. 626-638 13 p.

Research output: Contribution to journalReview article

Endometriosis
Ovarian Neoplasms
Mutation
Epithelial Cells
Estrogens
1 Citation (Scopus)

Progesterone receptor integrates the effects of mutated MED12 and altered DNA methylation to stimulate RANKL expression and stem cell proliferation in uterine leiomyoma

Liu, S., Yin, P., Kujawa, S. A., Coon, J. S., Okeigwe, I. & Bulun, S. E., Apr 11 2019, In : Oncogene. 38, 15, p. 2722-2735 14 p.

Research output: Contribution to journalArticle

Leiomyoma
Progesterone Receptors
DNA Methylation
Stem Cells
Binding Sites