• 16698 Citations
1993 …2024
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Research Output 1993 2019

2019

Catacomb: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism

Piunti, A., Smith, E., Morgan, M. A., Ugarenko, M., Khaltyan, N., Helmin, K. A., Ryan, C. A., Murray, D. C., Rickels, R. A., Yilmaz, B. D., Rendleman, E. J., Savas, J. N., Singer, B., Bulun, S. E. & Shilatifard, A., Jan 1 2019, In : Science Advances. 5, 7, eaax2887.

Research output: Contribution to journalArticle

Open Access
methionine
methylation
genes
deoxyribonucleic acid
COMPASS (programming language)
1 Citation (Scopus)

Endometriosis

Bulun, S. E., Jan 1 2019, Yen & Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management: Eighth Edition. Elsevier Inc, p. 609-642.e7

Research output: Chapter in Book/Report/Conference proceedingChapter

Endometriosis
Mesenchymal Stromal Cells
Estrogens
Choristoma
Pelvic Pain
1 Citation (Scopus)

Endometriosis

Bulun, S. E., Yilmaz, B. D., Sison, C., Miyazaki, K., Bernardi Wendeln, L. A., Liu, S., Kohlmeier, A., Yin, P., Milad, M. P. & Wei, J-J., May 10 2019, In : Endocrine reviews. 40, 4, p. 1048-1079 32 p.

Research output: Contribution to journalReview article

Endometriosis
Stromal Cells
Estrogens
Pelvic Pain
Mesenchymal Stromal Cells

Endometriosis and nuclear receptors

Yilmaz, B. D. & Bulun, S. E., Jan 1 2019, In : Human Reproduction Update. 25, 4, p. 473-485 13 p., dmz005.

Research output: Contribution to journalArticle

Endometriosis
Cytoplasmic and Nuclear Receptors
Stromal Cells
Progesterone Receptors
Estrogens
2 Citations (Scopus)

Epithelial mutations in endometriosis: Link to ovarian cancer

Bulun, S. E., Wan, Y. & Matei, D. E., Feb 14 2019, In : Endocrinology. 160, 3, p. 626-638 13 p.

Research output: Contribution to journalReview article

Endometriosis
Ovarian Neoplasms
Mutation
Epithelial Cells
Estrogens
1 Citation (Scopus)

Progesterone receptor integrates the effects of mutated MED12 and altered DNA methylation to stimulate RANKL expression and stem cell proliferation in uterine leiomyoma

Liu, S., Yin, P., Kujawa, S. A., Coon, J. S., Okeigwe, I. & Bulun, S. E., Apr 11 2019, In : Oncogene. 38, 15, p. 2722-2735 14 p.

Research output: Contribution to journalArticle

Leiomyoma
Progesterone Receptors
DNA Methylation
Stem Cells
Binding Sites
2 Citations (Scopus)

The Essential Role of GATA6 in the Activation of Estrogen Synthesis in Endometriosis

Bernardi Wendeln, L. A., Dyson, M. T., Tokunaga, H., Sison, C., Oral, M., Robins, J. C. & Bulun, S. E., Jan 1 2019, In : Reproductive Sciences. 26, 1, p. 60-69 10 p.

Research output: Contribution to journalArticle

Endometriosis
Carrier Proteins
Estrogens
Nuclear Receptor Subfamily 6, Group A, Member 1
Stromal Cells
2018
1 Citation (Scopus)
Adiposity
Breast Neoplasms
Inflammation
Needles
Estradiol

Application of ex-vivo spheroid model system for the analysis of senescence and senolytic phenotypes in uterine leiomyoma

Xie, J., Xu, X., Yin, P., Li, Y., Guo, H., Kujawa, S., Chakravarti, D., Bulun, S. E., Kim, J. J. & Wei, J-J., Dec 1 2018, In : Laboratory Investigation. 98, 12, p. 1575-1587 13 p.

Research output: Contribution to journalArticle

Leiomyoma
Systems Analysis
Phenotype
Genes
Myometrium
1 Citation (Scopus)

Generation of Progesterone-Responsive Endometrial Stromal Fibroblasts from Human Induced Pluripotent Stem Cells: Role of the WNT/CTNNB1 Pathway

Miyazaki, K., Dyson, M. T., Coon V, J. S., Furukawa, Y., Yilmaz, B. D., Maruyama, T. & Bulun, S. E., Nov 13 2018, In : Stem cell reports. 11, 5, p. 1136-1155 20 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Fibroblasts
Stem cells
Progesterone
Cell culture
6 Citations (Scopus)

Literature Review on the Role of Uterine Fibroids in Endometrial Function

Ikhena, D. E. & Bulun, S. E., May 1 2018, In : Reproductive Sciences. 25, 5, p. 635-643 9 p.

Research output: Contribution to journalReview article

Leiomyoma
Endometrium
Type II Bone Morphogenetic Protein Receptors
Smooth Muscle Tumor
Hemorrhage
1 Citation (Scopus)

MeDEStrand: An improved method to infer genome-wide absolute methylation levels from DNA enrichment data

Xu, J., Liu, S., Yin, P., Bulun, S. E. & Dai, Y., Dec 22 2018, In : BMC bioinformatics. 19, 1, 540.

Research output: Contribution to journalArticle

Methylation
DNA Methylation
Genome
DNA
Genes
6 Citations (Scopus)

Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19

Park, M. J., Shen, H., Spaeth, J. M., Tolvanen, J. H., Failor, C., Knudtson, J. F., McLaughlin, J., Halder, S. K., Yang, Q., Bulun, S. E., Al-Hendy, A., Schenken, R. S., Aaltonen, L. A. & Boyer, T. G., Jan 1 2018, In : Journal of Biological Chemistry. 293, 13, p. 4870-4882 13 p.

Research output: Contribution to journalArticle

Cyclin C
Leiomyoma
Exons
Phosphotransferases
Chemical activation
2 Citations (Scopus)

RANKL/RANK Pathway and Its Inhibitor RANK-Fc in Uterine Leiomyoma Growth

Ikhena, D. E., Liu, S., Kujawa, S., Esencan, E., Coon, J. S., Robins, J. C., Bulun, S. E. & Yin, P., May 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 5, p. 1842-1849 8 p.

Research output: Contribution to journalArticle

Leiomyoma
Cytoplasmic and Nuclear Receptors
Ligands
Growth
Tumors
2 Citations (Scopus)

Shift from androgen to estrogen action causes abdominal muscle fibrosis, atrophy, and inguinal hernia in a transgenic male mouse model

Zhao, H., Zhou, L., Li, L., John, C. V., Chatterton Jr, R. T., Brooks, D. C., Jiang, E., Liu, L., Xu, X., Dong, Z., DeMayo, F. J., Stulberg, J. J., Tourtellotte, W. G. & Bulun, S. E., Oct 30 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 44, p. E10427-E10436

Research output: Contribution to journalArticle

Abdominal Muscles
Muscular Atrophy
Inguinal Hernia
Transgenic Mice
Androgens
3 Citations (Scopus)

The AKT/BCL-2 Axis Mediates Survival of Uterine Leiomyoma in a Novel 3D Spheroid Model

Vidimar, V., Chakravarti, D., Bulun, S. E., Yin, P., Nowak, R., Wei, J-J. & Kim, J. J., Mar 1 2018, In : Endocrinology. 159, 3, p. 1453-1462 10 p.

Research output: Contribution to journalArticle

Leiomyoma
Survival
Paraquat
Tumor Microenvironment
Myometrium

Transcription factor 21 regulates expression of ERβ and SF-1 via upstream stimulatory factor-2 in endometriotic tissues

Wu, P. L., Zhou, Y., Zeng, C., Li, X., Dong, Z. T., Zhou, Y. F., Bulun, S. E. & Xue, Q., Aug 1 2018, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1861, 8, p. 706-717 12 p.

Research output: Contribution to journalArticle

Upstream Stimulatory Factors
Transcription Factors
Tissue
Stromal Cells
E-Box Elements
2017
5 Citations (Scopus)

Altered retinoid signaling compromises decidualization in human endometriotic stromal cells

Pavone, M., Malpani, S., Dyson, M. T. & Bulun, S. E., Jan 1 2017, In : Reproduction. 154, 3, p. 207-216 10 p.

Research output: Contribution to journalArticle

Retinoids
Stromal Cells
Endometrium
Vitamin A
Estradiol
7 Citations (Scopus)

AMP-activated protein kinase and energy balance in breast cancer

Zhao, H., Orhan, Y. C., Zha, X., Esencan, E., Chatterton Jr, R. T. & Bulun, S. E., Jan 1 2017, In : American Journal of Translational Research. 9, 2, p. 197-213 17 p., AJTR0038853.

Research output: Contribution to journalReview article

AMP-Activated Protein Kinases
Energy balance
Breast Neoplasms
Growth
Neoplasms

Margareta DPisarska, MD

Bulun, S. E., May 1 2017, In : Seminars in Reproductive Medicine. 35, 3, 1 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)

Paracrine pathways in uterine leiomyoma stem cells involve insulinlike growth factor 2 and insulin receptor a

Moravek, M. B., Yin, P., Coon, J. S., Ono, M., Druschitz, S. A., Malpani, S. S., Dyson, M. T., Rademaker, A. W., Robins, J. C., Wei, J-J., Kim, J. J. & Bulun, S. E., May 1 2017, In : Journal of Clinical Endocrinology and Metabolism. 102, 5, p. 1588-1595 8 p.

Research output: Contribution to journalArticle

Growth Factor Receptors
Insulin Receptor
Cell proliferation
Leiomyoma
Stem cells
3 Citations (Scopus)

Steroids, cytokines, and implantation

Bulun, S. E., Jun 1 2017, In : Endocrinology. 158, 6, p. 1575-1576 2 p.

Research output: Contribution to journalShort survey

Steroids
Cytokines

Tommaso Falcone, MD, FRCS(C), FACOG

Bulun, S. E., Jan 1 2017, In : Seminars in Reproductive Medicine. 35, 1, p. 1-2 2 p., 001055.

Research output: Contribution to journalEditorial

Uterine fibroids and the endometrium

Ikhena, D. E. & Bulun, S. E., Jan 1 2017, The Endometrial Factor: A Reproductive Precision Medicine Approach. CRC Press, p. 120-129 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Leiomyoma
Endometrium
Dysmenorrhea
Smooth Muscle Tumor
Working Women
2016
3 Citations (Scopus)

Aromatase, microRNA, and inflammation: a complex relationship

Bulun, S. E. & Nezhat, C., Sep 1 2016, In : Fertility and Sterility. 106, 3, p. 552-553 2 p.

Research output: Contribution to journalEditorial

Aromatase
MicroRNAs
Inflammation
25 Citations (Scopus)

Aromatase expression and regulation in breast and endometrial cancer

Zhao, H., Zhou, L., Shangguan, A. J. & Bulun, S. E., Jul 1 2016, In : Journal of Molecular Endocrinology. 57, 1, p. R19-R33

Research output: Contribution to journalReview article

Aromatase
Endometrial Neoplasms
Estrogens
Breast Neoplasms
Breast

Cassing Hammond, MD

Bulun, S. E., Jan 1 2016, (Accepted/In press) In : Seminars in Reproductive Medicine.

Research output: Contribution to journalArticle

Cassing Hammond, MD

Bulun, S. E., May 1 2016, In : Seminars in reproductive medicine. 34, 3, p. 129-130 2 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Gynecology
Obstetrics
12 Citations (Scopus)

Decreased expression of microRNA-29 family in leiomyoma contributes to increased major fibrillar collagen production

Marsh, E. E., Steinberg, M. L., Parker, J. B., Wu, J., Chakravarti, D. & Bulun, S. E., Sep 1 2016, In : Fertility and Sterility. 106, 3, p. 766-772 7 p.

Research output: Contribution to journalArticle

Fibrillar Collagens
Leiomyoma
MicroRNAs
Myometrium
Down-Regulation
7 Citations (Scopus)
Leiomyoma
Superoxide Dismutase
Oxidation-Reduction
Myometrium
Cell Survival
1 Citation (Scopus)

Epidermal growth factor-containing fibulin-like extracellular matrix protein 1 expression and regulation in uterine leiomyoma

Marsh, E. E., Chibber, S., Wu, J., Siegersma, K., Kim, J. J. & Bulun, S. E., Apr 1 2016, In : Fertility and Sterility. 105, 4, p. 1070-1075 6 p.

Research output: Contribution to journalArticle

Extracellular Matrix Proteins
Leiomyoma
Epidermal Growth Factor
decitabine
fibulin
19 Citations (Scopus)

Estrogen receptor β regulates endometriotic cell survival through serum and glucocorticoid-regulated kinase activation

Monsivais, D., Dyson, M. T., Yin, P., Navarro, A., Coon, J. S., Pavone, M. & Bulun, S. E., May 1 2016, In : Fertility and Sterility. 105, 5, p. 1266-1273 8 p.

Research output: Contribution to journalArticle

Endometriosis
Estrogen Receptors
Cell Survival
Poly(ADP-ribose) Polymerases
Chromatin Immunoprecipitation
4 Citations (Scopus)

Fenretinide: A Potential Treatment for Endometriosis

Pavone, M., Malpani, S. S., Dyson, M. T., Kim, J. J. & Bulun, S. E., Sep 1 2016, In : Reproductive Sciences. 23, 9, p. 1139-1147 9 p.

Research output: Contribution to journalArticle

Fenretinide
Endometriosis
Retinoids
Tretinoin
Apoptosis

Implantation and Placental Development

Bulun, S. E., Jan 5 2016, In : Seminars in Reproductive Medicine. 34, 1

Research output: Contribution to journalArticle

21st Century History
Placentation
Endocrinology
Reproduction
Pregnancy

James Segars, MD

Bulun, S. E., Sep 1 2016, In : Seminars in Reproductive Medicine. 34, 5, p. 257-258 2 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Reproductive Medicine
Biomedical Research

Jeanne Sheffield, MD

Bulun, S. E., Sep 1 2016, In : Seminars in Reproductive Medicine. 34, 5, p. 255-256 2 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Reproductive Medicine
Biomedical Research
2015
14 Citations (Scopus)

Aberrant expression and localization of deoxyribonucleic acid methyltransferase 3B in endometriotic stromal cells

Dyson, M. T., Kakinuma, T., Pavone, M., Monsivais, D., Navarro, A., Malpani, S. S., Ono, M. & Bulun, S. E., Oct 1 2015, In : Fertility and Sterility. 104, 4, p. 953-963.e2

Research output: Contribution to journalArticle

Methyltransferases
Stromal Cells
Endometrium
DNA
Endometriosis
8 Citations (Scopus)

CD34 and CD49f double-positive and lineage marker-negative cells isolated from human myometrium exhibit stem cell-like properties involved in pregnancy-induced uterine remodeling

Ono, M., Kajitani, T., Uchida, H., Arase, T., Oda, H., Uchida, S., Ota, K., Nagashima, T., Masuda, H., Miyazaki, K., Asada, H., Hida, N., Mabuchi, Y., Morikawa, S., Ito, M., Bulun, S. E., Okano, H., Matsuzaki, Y., Yoshimura, Y. & Maruyama, T., Aug 1 2015, In : Biology of reproduction. 93, 2, 37.

Research output: Contribution to journalArticle

Myometrium
Stem Cells
Pregnancy
Glycophorin
Heterologous Transplantation
20 Citations (Scopus)

Endocrinology of uterine fibroids: Steroid hormones, stem cells, and genetic contribution

Moravek, M. B. & Bulun, S. E., Aug 1 2015, In : Current Opinion in Obstetrics and Gynecology. 27, 4, p. 276-283 8 p.

Research output: Contribution to journalReview article

Endocrinology
Leiomyoma
Stem Cells
Steroids
Hormones
6 Citations (Scopus)

Estrogen-dependent sushi domain containing 3 regulates cytoskeleton organization and migration in breast cancer cells

Moy, I., Todorović, V., Dubash, A. D., Coon, J. S., Parker, J. B., Buranapramest, M., Huang, C. C., Zhao, H., Green, K. J. & Bulun, S. E., Jan 15 2015, In : Oncogene. 34, 3, p. 362-372 11 p.

Research output: Contribution to journalArticle

Cytoskeleton
Estrogens
Breast Neoplasms
Aromatase Inhibitors
Estradiol
4 Citations (Scopus)

Estrogen receptor alpha (Esr1) regulates aromatase (Cyp19a1) expression in the mouse brain

Yilmaz, M. B., Zhao, H., Brooks, D. C., Fenkci, I. V., Imir-Yenicesu, G., Attar, E., Akbal, E., Kaynak, B. A. & Bulun, S. E., Jan 1 2015, In : Neuroendocrinology Letters. 36, 2, p. 178-182 5 p.

Research output: Contribution to journalArticle

Aromatase
Estrogen Receptor alpha
Brain
Messenger RNA
Hypothalamus
27 Citations (Scopus)

Human uterine leiomyoma stem/progenitor cells expressing CD34 and CD49b initiate tumors in vivo

Yin, P., Ono, M., Moravek, M. B., Coon, J. S. V., Navarro, A., Monsivais, D., Dyson, M. T., Druschitz, S. A., Malpani, S. S., Serna, V. A., Qiang, W., Chakravarti, D., Kim, J. J. & Bulun, S. E., Apr 1 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 4, p. E601-E606

Research output: Contribution to journalArticle

Leiomyoma
Stem cells
Tumors
Stem Cells
Side-Population Cells

Innovations in reproductive endocrinology: A tribute to Bruce Carr, MD

Bulun, S. E. & Legro, R. S., May 4 2015, In : Seminars in reproductive medicine. 33, 3, 1 p.

Research output: Contribution to journalEditorial

21st Century History
20th Century History
Reproductive Medicine
Endocrinology
Obstetrics
41 Citations (Scopus)

Molecular biology of endometriosis: From aromatase to genomic abnormalities

Bulun, S. E., Monsivais, D., Kakinuma, T., Furukawa, Y., Bernardi Wendeln, L. A., Pavone, M. & Dyson, M. T., May 4 2015, In : Seminars in reproductive medicine. 33, 3, p. 220-224 5 p.

Research output: Contribution to journalArticle

Aromatase
Endometriosis
Molecular Biology
Choristoma
Progesterone Receptors

Ovarian Aging, from Bench to Bedside

Bulun, S. E., Nov 1 2015, In : Seminars in Reproductive Medicine. 33, 6, p. 373-374 2 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Female Infertility
Reproductive Medicine
Assisted Reproductive Techniques
60 Citations (Scopus)

Ovarian steroids, stem cells and uterine leiomyoma: Therapeutic implications

Moravek, M. B., Yin, P., Ono, M., Coon, V. J. S., Dyson, M. T., Navarro, A., Marsh, E. E., Chakravarti, D., Kim, J. J., Wei, J-J. & Bulun, S. E., Jan 1 2015, In : Human Reproduction Update. 21, 1, p. 1-12 12 p., dmu048.

Research output: Contribution to journalArticle

Leiomyoma
Stem Cells
Steroids
Therapeutics
Hormones

Tissue Stem Cells and Uterine Physiology and Pathology

Bulun, S. E., Sep 1 2015, In : Seminars in Reproductive Medicine. 33, 5, p. 313-314 2 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Cell Physiological Phenomena
Adult Stem Cells
Gynecology

Uterine Fibroids

Moravek, M. B. & Bulun, S. E., Jan 1 2015, Endocrinology: Adult and Pediatric. Elsevier Inc, Vol. 2-2. p. 2255-2259.e3

Research output: Chapter in Book/Report/Conference proceedingChapter

22 Citations (Scopus)

Uterine Leiomyoma Stem Cells: Linking Progesterone to Growth

Bulun, S. E., Moravek, M. B., Yin, P., Ono, M., Coon V, J. S., Dyson, M. T., Navarro, A., Marsh, E. E., Zhao, H., Maruyama, T., Chakravarti, D., Kim, J. J. & Wei, J-J., Aug 6 2015, In : Seminars in Reproductive Medicine. 33, 5, p. 357-365 9 p.

Research output: Contribution to journalArticle

Leiomyoma
Progesterone
Stem Cells
Growth
Estrogens
2014
19 Citations (Scopus)

5-hydroxymethylcytosine promotes proliferation of human uterine leiomyoma: A biological link to a new epigenetic modification in benign tumors

Navarro, A., Yin, P., Ono, M., Monsivais, D., Moravek, M. B., Coon, J. S. V., Dyson, M. T., Wei, J-J. & Bulun, S. E., Nov 1 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 11, p. E2437-E2445

Research output: Contribution to journalArticle

Leiomyoma
Epigenomics
Tumors
Tissue
Cell proliferation