• 16698 Citations
1993 …2024
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Research Output 1993 2019

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2019

Catacomb: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism

Piunti, A., Smith, E., Morgan, M. A., Ugarenko, M., Khaltyan, N., Helmin, K. A., Ryan, C. A., Murray, D. C., Rickels, R. A., Yilmaz, B. D., Rendleman, E. J., Savas, J. N., Singer, B., Bulun, S. E. & Shilatifard, A., Jan 1 2019, In : Science Advances. 5, 7, eaax2887.

Research output: Contribution to journalArticle

Open Access
methionine
methylation
genes
deoxyribonucleic acid
COMPASS (programming language)

Endometriosis and nuclear receptors

Yilmaz, B. D. & Bulun, S. E., Jan 1 2019, In : Human Reproduction Update. 25, 4, p. 473-485 13 p., dmz005.

Research output: Contribution to journalArticle

Endometriosis
Cytoplasmic and Nuclear Receptors
Stromal Cells
Progesterone Receptors
Estrogens
1 Citation (Scopus)

Progesterone receptor integrates the effects of mutated MED12 and altered DNA methylation to stimulate RANKL expression and stem cell proliferation in uterine leiomyoma

Liu, S., Yin, P., Kujawa, S. A., Coon, J. S., Okeigwe, I. & Bulun, S. E., Apr 11 2019, In : Oncogene. 38, 15, p. 2722-2735 14 p.

Research output: Contribution to journalArticle

Leiomyoma
Progesterone Receptors
DNA Methylation
Stem Cells
Binding Sites
2 Citations (Scopus)

The Essential Role of GATA6 in the Activation of Estrogen Synthesis in Endometriosis

Bernardi Wendeln, L. A., Dyson, M. T., Tokunaga, H., Sison, C., Oral, M., Robins, J. C. & Bulun, S. E., Jan 1 2019, In : Reproductive Sciences. 26, 1, p. 60-69 10 p.

Research output: Contribution to journalArticle

Endometriosis
Carrier Proteins
Estrogens
Nuclear Receptor Subfamily 6, Group A, Member 1
Stromal Cells
2018
1 Citation (Scopus)
Adiposity
Breast Neoplasms
Inflammation
Needles
Estradiol

Application of ex-vivo spheroid model system for the analysis of senescence and senolytic phenotypes in uterine leiomyoma

Xie, J., Xu, X., Yin, P., Li, Y., Guo, H., Kujawa, S., Chakravarti, D., Bulun, S. E., Kim, J. J. & Wei, J-J., Dec 1 2018, In : Laboratory Investigation. 98, 12, p. 1575-1587 13 p.

Research output: Contribution to journalArticle

Leiomyoma
Systems Analysis
Phenotype
Genes
Myometrium
1 Citation (Scopus)

Generation of Progesterone-Responsive Endometrial Stromal Fibroblasts from Human Induced Pluripotent Stem Cells: Role of the WNT/CTNNB1 Pathway

Miyazaki, K., Dyson, M. T., Coon V, J. S., Furukawa, Y., Yilmaz, B. D., Maruyama, T. & Bulun, S. E., Nov 13 2018, In : Stem cell reports. 11, 5, p. 1136-1155 20 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Fibroblasts
Stem cells
Progesterone
Cell culture
1 Citation (Scopus)

MeDEStrand: An improved method to infer genome-wide absolute methylation levels from DNA enrichment data

Xu, J., Liu, S., Yin, P., Bulun, S. E. & Dai, Y., Dec 22 2018, In : BMC bioinformatics. 19, 1, 540.

Research output: Contribution to journalArticle

Methylation
DNA Methylation
Genome
DNA
Genes
6 Citations (Scopus)

Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19

Park, M. J., Shen, H., Spaeth, J. M., Tolvanen, J. H., Failor, C., Knudtson, J. F., McLaughlin, J., Halder, S. K., Yang, Q., Bulun, S. E., Al-Hendy, A., Schenken, R. S., Aaltonen, L. A. & Boyer, T. G., Jan 1 2018, In : Journal of Biological Chemistry. 293, 13, p. 4870-4882 13 p.

Research output: Contribution to journalArticle

Cyclin C
Leiomyoma
Exons
Phosphotransferases
Chemical activation
2 Citations (Scopus)

RANKL/RANK Pathway and Its Inhibitor RANK-Fc in Uterine Leiomyoma Growth

Ikhena, D. E., Liu, S., Kujawa, S., Esencan, E., Coon, J. S., Robins, J. C., Bulun, S. E. & Yin, P., May 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 5, p. 1842-1849 8 p.

Research output: Contribution to journalArticle

Leiomyoma
Cytoplasmic and Nuclear Receptors
Ligands
Growth
Tumors
2 Citations (Scopus)

Shift from androgen to estrogen action causes abdominal muscle fibrosis, atrophy, and inguinal hernia in a transgenic male mouse model

Zhao, H., Zhou, L., Li, L., John, C. V., Chatterton Jr, R. T., Brooks, D. C., Jiang, E., Liu, L., Xu, X., Dong, Z., DeMayo, F. J., Stulberg, J. J., Tourtellotte, W. G. & Bulun, S. E., Oct 30 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 44, p. E10427-E10436

Research output: Contribution to journalArticle

Abdominal Muscles
Muscular Atrophy
Inguinal Hernia
Transgenic Mice
Androgens
3 Citations (Scopus)

The AKT/BCL-2 Axis Mediates Survival of Uterine Leiomyoma in a Novel 3D Spheroid Model

Vidimar, V., Chakravarti, D., Bulun, S. E., Yin, P., Nowak, R., Wei, J-J. & Kim, J. J., Mar 1 2018, In : Endocrinology. 159, 3, p. 1453-1462 10 p.

Research output: Contribution to journalArticle

Leiomyoma
Survival
Paraquat
Tumor Microenvironment
Myometrium

Transcription factor 21 regulates expression of ERβ and SF-1 via upstream stimulatory factor-2 in endometriotic tissues

Wu, P. L., Zhou, Y., Zeng, C., Li, X., Dong, Z. T., Zhou, Y. F., Bulun, S. E. & Xue, Q., Aug 1 2018, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1861, 8, p. 706-717 12 p.

Research output: Contribution to journalArticle

Upstream Stimulatory Factors
Transcription Factors
Tissue
Stromal Cells
E-Box Elements
2017
5 Citations (Scopus)

Altered retinoid signaling compromises decidualization in human endometriotic stromal cells

Pavone, M., Malpani, S., Dyson, M. T. & Bulun, S. E., Jan 1 2017, In : Reproduction. 154, 3, p. 207-216 10 p.

Research output: Contribution to journalArticle

Retinoids
Stromal Cells
Endometrium
Vitamin A
Estradiol
1 Citation (Scopus)

Paracrine pathways in uterine leiomyoma stem cells involve insulinlike growth factor 2 and insulin receptor a

Moravek, M. B., Yin, P., Coon, J. S., Ono, M., Druschitz, S. A., Malpani, S. S., Dyson, M. T., Rademaker, A. W., Robins, J. C., Wei, J-J., Kim, J. J. & Bulun, S. E., May 1 2017, In : Journal of Clinical Endocrinology and Metabolism. 102, 5, p. 1588-1595 8 p.

Research output: Contribution to journalArticle

Growth Factor Receptors
Insulin Receptor
Cell proliferation
Leiomyoma
Stem cells
2016

Cassing Hammond, MD

Bulun, S. E., Jan 1 2016, (Accepted/In press) In : Seminars in Reproductive Medicine.

Research output: Contribution to journalArticle

Cassing Hammond, MD

Bulun, S. E., May 1 2016, In : Seminars in reproductive medicine. 34, 3, p. 129-130 2 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Gynecology
Obstetrics
12 Citations (Scopus)

Decreased expression of microRNA-29 family in leiomyoma contributes to increased major fibrillar collagen production

Marsh, E. E., Steinberg, M. L., Parker, J. B., Wu, J., Chakravarti, D. & Bulun, S. E., Sep 1 2016, In : Fertility and Sterility. 106, 3, p. 766-772 7 p.

Research output: Contribution to journalArticle

Fibrillar Collagens
Leiomyoma
MicroRNAs
Myometrium
Down-Regulation
7 Citations (Scopus)
Leiomyoma
Superoxide Dismutase
Oxidation-Reduction
Myometrium
Cell Survival
1 Citation (Scopus)

Epidermal growth factor-containing fibulin-like extracellular matrix protein 1 expression and regulation in uterine leiomyoma

Marsh, E. E., Chibber, S., Wu, J., Siegersma, K., Kim, J. J. & Bulun, S. E., Apr 1 2016, In : Fertility and Sterility. 105, 4, p. 1070-1075 6 p.

Research output: Contribution to journalArticle

Extracellular Matrix Proteins
Leiomyoma
Epidermal Growth Factor
decitabine
fibulin
19 Citations (Scopus)

Estrogen receptor β regulates endometriotic cell survival through serum and glucocorticoid-regulated kinase activation

Monsivais, D., Dyson, M. T., Yin, P., Navarro, A., Coon, J. S., Pavone, M. & Bulun, S. E., May 1 2016, In : Fertility and Sterility. 105, 5, p. 1266-1273 8 p.

Research output: Contribution to journalArticle

Endometriosis
Estrogen Receptors
Cell Survival
Poly(ADP-ribose) Polymerases
Chromatin Immunoprecipitation
4 Citations (Scopus)

Fenretinide: A Potential Treatment for Endometriosis

Pavone, M., Malpani, S. S., Dyson, M. T., Kim, J. J. & Bulun, S. E., Sep 1 2016, In : Reproductive Sciences. 23, 9, p. 1139-1147 9 p.

Research output: Contribution to journalArticle

Fenretinide
Endometriosis
Retinoids
Tretinoin
Apoptosis

Implantation and Placental Development

Bulun, S. E., Jan 5 2016, In : Seminars in Reproductive Medicine. 34, 1

Research output: Contribution to journalArticle

21st Century History
Placentation
Endocrinology
Reproduction
Pregnancy

James Segars, MD

Bulun, S. E., Sep 1 2016, In : Seminars in Reproductive Medicine. 34, 5, p. 257-258 2 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Reproductive Medicine
Biomedical Research

Jeanne Sheffield, MD

Bulun, S. E., Sep 1 2016, In : Seminars in Reproductive Medicine. 34, 5, p. 255-256 2 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Reproductive Medicine
Biomedical Research
2015
14 Citations (Scopus)

Aberrant expression and localization of deoxyribonucleic acid methyltransferase 3B in endometriotic stromal cells

Dyson, M. T., Kakinuma, T., Pavone, M., Monsivais, D., Navarro, A., Malpani, S. S., Ono, M. & Bulun, S. E., Oct 1 2015, In : Fertility and Sterility. 104, 4, p. 953-963.e2

Research output: Contribution to journalArticle

Methyltransferases
Stromal Cells
Endometrium
DNA
Endometriosis
8 Citations (Scopus)

CD34 and CD49f double-positive and lineage marker-negative cells isolated from human myometrium exhibit stem cell-like properties involved in pregnancy-induced uterine remodeling

Ono, M., Kajitani, T., Uchida, H., Arase, T., Oda, H., Uchida, S., Ota, K., Nagashima, T., Masuda, H., Miyazaki, K., Asada, H., Hida, N., Mabuchi, Y., Morikawa, S., Ito, M., Bulun, S. E., Okano, H., Matsuzaki, Y., Yoshimura, Y. & Maruyama, T., Aug 1 2015, In : Biology of reproduction. 93, 2, 37.

Research output: Contribution to journalArticle

Myometrium
Stem Cells
Pregnancy
Glycophorin
Heterologous Transplantation
6 Citations (Scopus)

Estrogen-dependent sushi domain containing 3 regulates cytoskeleton organization and migration in breast cancer cells

Moy, I., Todorović, V., Dubash, A. D., Coon, J. S., Parker, J. B., Buranapramest, M., Huang, C. C., Zhao, H., Green, K. J. & Bulun, S. E., Jan 15 2015, In : Oncogene. 34, 3, p. 362-372 11 p.

Research output: Contribution to journalArticle

Cytoskeleton
Estrogens
Breast Neoplasms
Aromatase Inhibitors
Estradiol
4 Citations (Scopus)

Estrogen receptor alpha (Esr1) regulates aromatase (Cyp19a1) expression in the mouse brain

Yilmaz, M. B., Zhao, H., Brooks, D. C., Fenkci, I. V., Imir-Yenicesu, G., Attar, E., Akbal, E., Kaynak, B. A. & Bulun, S. E., Jan 1 2015, In : Neuroendocrinology Letters. 36, 2, p. 178-182 5 p.

Research output: Contribution to journalArticle

Aromatase
Estrogen Receptor alpha
Brain
Messenger RNA
Hypothalamus
27 Citations (Scopus)

Human uterine leiomyoma stem/progenitor cells expressing CD34 and CD49b initiate tumors in vivo

Yin, P., Ono, M., Moravek, M. B., Coon, J. S. V., Navarro, A., Monsivais, D., Dyson, M. T., Druschitz, S. A., Malpani, S. S., Serna, V. A., Qiang, W., Chakravarti, D., Kim, J. J. & Bulun, S. E., Apr 1 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 4, p. E601-E606

Research output: Contribution to journalArticle

Leiomyoma
Stem cells
Tumors
Stem Cells
Side-Population Cells
41 Citations (Scopus)

Molecular biology of endometriosis: From aromatase to genomic abnormalities

Bulun, S. E., Monsivais, D., Kakinuma, T., Furukawa, Y., Bernardi Wendeln, L. A., Pavone, M. & Dyson, M. T., May 4 2015, In : Seminars in reproductive medicine. 33, 3, p. 220-224 5 p.

Research output: Contribution to journalArticle

Aromatase
Endometriosis
Molecular Biology
Choristoma
Progesterone Receptors

Ovarian Aging, from Bench to Bedside

Bulun, S. E., Nov 1 2015, In : Seminars in Reproductive Medicine. 33, 6, p. 373-374 2 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Female Infertility
Reproductive Medicine
Assisted Reproductive Techniques
60 Citations (Scopus)

Ovarian steroids, stem cells and uterine leiomyoma: Therapeutic implications

Moravek, M. B., Yin, P., Ono, M., Coon, V. J. S., Dyson, M. T., Navarro, A., Marsh, E. E., Chakravarti, D., Kim, J. J., Wei, J-J. & Bulun, S. E., Jan 1 2015, In : Human Reproduction Update. 21, 1, p. 1-12 12 p., dmu048.

Research output: Contribution to journalArticle

Leiomyoma
Stem Cells
Steroids
Therapeutics
Hormones

Tissue Stem Cells and Uterine Physiology and Pathology

Bulun, S. E., Sep 1 2015, In : Seminars in Reproductive Medicine. 33, 5, p. 313-314 2 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Cell Physiological Phenomena
Adult Stem Cells
Gynecology
22 Citations (Scopus)

Uterine Leiomyoma Stem Cells: Linking Progesterone to Growth

Bulun, S. E., Moravek, M. B., Yin, P., Ono, M., Coon V, J. S., Dyson, M. T., Navarro, A., Marsh, E. E., Zhao, H., Maruyama, T., Chakravarti, D., Kim, J. J. & Wei, J-J., Aug 6 2015, In : Seminars in Reproductive Medicine. 33, 5, p. 357-365 9 p.

Research output: Contribution to journalArticle

Leiomyoma
Progesterone
Stem Cells
Growth
Estrogens
2014
19 Citations (Scopus)

5-hydroxymethylcytosine promotes proliferation of human uterine leiomyoma: A biological link to a new epigenetic modification in benign tumors

Navarro, A., Yin, P., Ono, M., Monsivais, D., Moravek, M. B., Coon, J. S. V., Dyson, M. T., Wei, J-J. & Bulun, S. E., Nov 1 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 11, p. E2437-E2445

Research output: Contribution to journalArticle

Leiomyoma
Epigenomics
Tumors
Tissue
Cell proliferation
26 Citations (Scopus)

ERβ- and prostaglandin E2-regulated pathways integrate cell proliferation via Ras-like and estrogen-regulated growth inhibitor in endometriosis

Monsivais, D., Dyson, M. T., Yin, P., Coon, J. S., Navarro, A., Feng, G., Malpani, S. S., Ono, M., Ercan, C. M., Wei, J-J., Pavone, M., Su, E. & Bulun, S. E., Jan 1 2014, In : Molecular Endocrinology. 28, 8, p. 1304-1315 12 p.

Research output: Contribution to journalArticle

Growth Inhibitors
Endometriosis
Dinoprostone
Estrogen Receptors
Estrogens
10 Citations (Scopus)

Fenretinide: A novel treatment for endometrial cancer

Mittal, N., Malpani, S., Dyson, M. T., Ono, M., Coon, J. S., Kim, J. J., Schink, J. C., Bulun, S. E. & Pavone, M., Oct 23 2014, In : PloS one. 9, 10, e110410.

Research output: Contribution to journalArticle

Fenretinide
Endometrial Neoplasms
neoplasms
Tumors
apoptosis
78 Citations (Scopus)

Genome-Wide DNA Methylation Analysis Predicts an Epigenetic Switch for GATA Factor Expression in Endometriosis

Dyson, M. T., Roqueiro, D., Monsivais, D., Ercan, C. M., Pavone, M., Brooks, D. C., Kakinuma, T., Ono, M., Jafari, N., Dai, Y. & Bulun, S. E., Jan 1 2014, In : PLoS Genetics. 10, 3, e1004158.

Research output: Contribution to journalArticle

GATA Transcription Factors
methylation
DNA methylation
DNA Methylation
Endometriosis
36 Citations (Scopus)

Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth

Ono, M., Yin, P., Navarro, A., Moravek, M. B., Coon V, J. S., Druschitz, S. A., Gottardi, C. & Bulun, S. E., Jan 1 2014, In : Fertility and Sterility. 101, 5

Research output: Contribution to journalArticle

Catenins
Leiomyoma
Niclosamide
Growth
Uterine Myomectomy
22 Citations (Scopus)

Methylation of a novel CpG island of intron 1 is associated with steroidogenic factor 1 expression in endometriotic stromal cells

Xue, Q., Xu, Y., Yang, H., Zhang, L., Shang, J., Zeng, C., Yin, P. & Bulun, S. E., Mar 1 2014, In : Reproductive Sciences. 21, 3, p. 395-400 6 p.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
CpG Islands
Stromal Cells
Introns
Methylation

Steven L. Young, MD, PhD, FACOG

Bulun, S. E., Sep 1 2014, In : Seminars in Reproductive Medicine. 32, 5, p. 333-334 2 p.

Research output: Contribution to journalArticle

21st Century History
Endometrium
Gynecology
2013
11 Citations (Scopus)

Aromatase inhibitor treatment limits progression of peritoneal endometriosis in baboons

Langoi, D., Pavone, M., Gurates, B., Chai, D., Fazleabas, A. & Bulun, S. E., Mar 1 2013, In : Fertility and Sterility. 99, 3

Research output: Contribution to journalArticle

Aromatase Inhibitors
Papio
Endometriosis
Aromatase
Papio anubis
8 Citations (Scopus)

Expression of estrogen-related gene markers in breast cancer tissue predicts aromatase inhibitor responsiveness

Moy, I., Lin, Z., Rademaker, A. W., Reierstad, S., Khan, S. A. & Bulun, S. E., Nov 6 2013, In : PloS one. 8, 11, e77543.

Research output: Contribution to journalArticle

Aromatase Inhibitors
breast neoplasms
estrogens
Estrogens
messenger RNA
14 Citations (Scopus)

Expression profiling of nuclear receptors identifies key roles of NR4A subfamily in uterine fibroids

Yin, H., Lo, J. H., Kim, J. Y., Marsh, E. E., Kim, J. J., Ghosh, A. K., Bulun, S. E. & Chakravarti, D., May 1 2013, In : Molecular Endocrinology. 27, 5, p. 726-740 15 p.

Research output: Contribution to journalArticle

Leiomyoma
Cytoplasmic and Nuclear Receptors
Leuprolide
Smooth Muscle Tumor
Myometrium
10 Citations (Scopus)

Genomic basis of aromatase excess syndrome: Recombination- and replication-Mediated rearrangements leading to CYP19A1 overexpression

Fukami, M., Tsuchiya, T., Vollbach, H., Brown, K. A., Abe, S., Ohtsu, S., Wabitsch, M., Burger, H., Simpson, E. R., Umezawa, A., Shihara, D., Nakabayashi, K., Bulun, S. E., Shozu, M. & Ogata, T., Dec 1 2013, In : Journal of Clinical Endocrinology and Metabolism. 98, 12

Research output: Contribution to journalArticle

Aromatase
Genetic Recombination
Genes
Exons
Gene Rearrangement
6 Citations (Scopus)

Ligand-Activated Peroxisome Proliferator-Activated Receptor β/δ Modulates Human Endometrial Cancer Cell Survival

Ma, J. J., Monsivais, D., Dyson, M. T., Coon, J. S., Malpani, S., Ono, M., Zhao, H., Xin, H., Pavone, M., Kim, J. J., Chakravarti, D. & Bulun, S. E., Dec 1 2013, In : Hormones and Cancer. 4, 6, p. 358-370 13 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Endometrial Neoplasms
Cell Survival
Ligands
Glycogen Synthase Kinase 3
70 Citations (Scopus)

Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth

Ono, M., Yin, P., Navarro, A., Moravek, M. B., Coon V, J. S., Druschitz, S. A., Serna, V. A., Qiang, W., Brooks, D. C., Malpani, S. S., Ma, J., Ercan, C. M., Mittal, N., Monsivais, D., Dyson, M. T., Yemelyanov, A., Maruyama, T., Chakravarti, D., Kim, J. J., Kurita, T. & 2 others, Gottardi, C. & Bulun, S. E., Oct 15 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 42, p. 17053-17058 6 p.

Research output: Contribution to journalArticle

Catenins
Neoplastic Stem Cells
Leiomyoma
Side-Population Cells
Growth
24 Citations (Scopus)

The use of aromatase inhibitors for ovulation induction and superovulation

Pavone, M. & Bulun, S. E., May 1 2013, In : Journal of Clinical Endocrinology and Metabolism. 98, 5, p. 1838-1844 7 p.

Research output: Contribution to journalArticle

Superovulation
Aromatase Inhibitors
Ovulation Induction
Clomiphene
Infertility
2012
19 Citations (Scopus)

Activated glucocorticoid and eicosanoid pathways in endometriosis

Monsivais, D., Bray, J. D., Su, E., Pavone, M., Dyson, M. T., Navarro, A., Kakinuma, T. & Bulun, S. E., Jul 1 2012, In : Fertility and Sterility. 98, 1, p. 117-125 9 p.

Research output: Contribution to journalArticle

Eicosanoids
Endometriosis
Glucocorticoids
Hydrocortisone
Messenger RNA