Grants per year
Personal profile
Research Interests
The question of primary interest in my lab is why only select individuals, despite being genetically similar and living in the same allergen environment, are prone to developing allergic disease, and which processes drive this predisposition? To address this, we employ a systems biology approach and bioinformatics to explore whether there is underlying unity in the pathogenesis of seemingly disparate allergic diseases. By synthesizing large volumes of biological data, we link departures from homeostatic conditions (including changes in metabolic, developmental, and endocrine systems) at the epithelial barriers of the skin, gut, and airways with innate immune system responses as a possible suite of mechanisms driving initiation of allergic disease. Specifically, we are asking the following questions: Are allergic diseases at different barrier sites caused by common systemic processes? Do hormones (estrogen, androgen, growth hormones) maintain homeostasis of the mucosal barriers? Why are developmental pathways for maintenance of tissue homeostasis linked to early susceptibility of asthma? What is the impact of environmentally relevant xenobiotics (xenoestrogens, aromatic hydrocarbons) on epithelial barriers and priming of allergic responses? Secondarily, I keep being fascinated by a cell type that is intimately tied into mucosal biology, and plays central roles in many aspects of allergic disease - the eosinophil. I am intrigued by the fact that aside from being destructive in allergy, eosinophils play prominent roles in homeostasis and assist in normal development of tissues and maturation of other cell types – however, these alternate aspects of eosinophil biology remain largely unexplored. In my lab, we are studying the nature of reciprocal interactions between eosinophils and the mucosa in health and disease by asking the following questions: When and why are eosinophils homeostatic in the mucosa? What is their role in priming of immune responses?
Training Experience
2012 | Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Biological science, University of Cincinnati
… → 2005
Research interests keywords
- Allergies
- Bioinformatics
- Developmental Biology
- Endocrine Genetics
- Extracellular Matrix
- Immune Regulation
- Metabolism
- Systems Biology
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Airway metabolic dysfunction and severe respiratory viral infections
Berdnikovs, S. (PD/PI)
7/1/24 → 6/30/26
Project: Research project
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The Neu-Lung Consortium: Neutrophilic Mechanisms of Inflammation, Injury, and Repair in Lung and Airways Diseases
Berdnikovs, S. (Co-Investigator), Sumagin, R. (Co-Investigator) & Muller, W. A. (Other)
National Institute of Allergy and Infectious Diseases
4/1/24 → 3/31/29
Project: Research project
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Viral and Host Determinants of Infant and Childhood Allergy and Asthma
Berdnikovs, S. (PD/PI), Berdnikovs, S. (PD/PI) & Berdnikovs, S. (PD/PI)
Vanderbilt University Medical Center, National Institute of Allergy and Infectious Diseases
8/2/21 → 5/31/25
Project: Research project
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Northwestern University Allergy and Immunology Research (NUAIR) Program
Berdnikovs, S. (PD/PI), Eisenbarth, S. C. (PD/PI), Schleimer, R. P. (PD/PI), Berdnikovs, S. (Co-Investigator), Bochner, B. S. (Co-Investigator) & Saltoun, C. A. (Other)
National Institute of Allergy and Infectious Diseases
8/1/20 → 7/31/25
Project: Research project
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Northwestern University Allergy and Immunology Research (NUAIR) Program
Bochner, B. S. (PD/PI), Schleimer, R. P. (PD/PI), Berdnikovs, S. (Other) & Saltoun, C. A. (Other)
National Institute of Allergy and Infectious Diseases
8/1/20 → 7/31/25
Project: Research project
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Whole Blood Transcriptomics Identifies Differences in Innate Immune Pathway Expression in Infants at Risk for Peanut Allergy
Lang, A., Gadd, S., Gunderman, L., Lippner, E., Devonshire, A., Schipma, M. J., Berdnikovs, S. & Kumar, R., Jan 2025, In: Clinical and Experimental Allergy. 55, 1, p. 100-103 4 p.Research output: Contribution to journal › Letter › peer-review
Open Access -
Eosinophil biology from the standpoint of metabolism: implications for metabolic disorders and asthma
Haruna, N. F., Berdnikovs, S. & Nie, Z., Aug 2024, In: Journal of Leukocyte Biology. 116, 2, p. 288-296 9 p.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
How early life respiratory viral infections impact airway epithelial development and may lead to asthma
Berdnikovs, S., Newcomb, D. C. & Hartert, T. V., 2024, In: Frontiers in Pediatrics. 12, 1441293.Research output: Contribution to journal › Review article › peer-review
Open Access3 Scopus citations -
Little to no mRNA for the α- or β-chains of FcεRI in human eosinophils
Chhiba, K. D., Kuang, F. L., Berdnikovs, S., Kato, A. & Bochner, B. S., Feb 2024, In: Journal of Allergy and Clinical Immunology. 153, 2, p. 533-534 2 p.Research output: Contribution to journal › Letter › peer-review
Open Access1 Scopus citations -
scRNA-seq profiling of human granulocytes reveals expansion of developmentally flexible neutrophil precursors with mixed neutrophil and eosinophil properties in asthma
Haruna, N. F., Politanska, Y., Connelly, A. R., O'Connor, K., Bhattacharya, S., Miklaszewski, G. E., Pérez-Leonor, X. G., Rerko, G., Hentenaar, I. T., Nguyen, D. C., Lamothe Molina, P. A., Bochner, B. S., Abdala-Valencia, H., Gill, M. A., Lee, F. E. H. & Berdnikovs, S., Nov 4 2024, In: Journal of Leukocyte Biology. 116, 5, p. 1184-1197 14 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Datasets
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Human_Transcripts from Hypercapnia selectively modulates LPS-induced changes in innate immune and DNA replication-related gene transcription in the macrophage
Casalino-Matsuda, S. M. (Creator), Berdnikovs, S. (Creator), Wang, N. (Contributor), Nair, A. (Creator), Gates, K. L. (Contributor), Beitel, G. J. (Creator) & Sporn, P. H. S. (Creator), The Royal Society, 2021
DOI: 10.6084/m9.figshare.13698029, https://rs.figshare.com/articles/dataset/Human_Transcripts_from_Hypercapnia_selectively_modulates_LPS-induced_changes_in_innate_immune_and_DNA_replication-related_gene_transcription_in_the_macrophage/13698029
Dataset
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Supplementary material from "Hypercapnia selectively modulates LPS-induced changes in innate immune and DNA replication-related gene transcription in the macrophage"
Casalino-Matsuda, S. M. (Creator), Berdnikovs, S. (Creator), Wang, N. (Contributor), Nair, A. (Creator), Gates, K. L. (Contributor), Beitel, G. J. (Creator), Sporn, P. H. S. (Creator) & Casalino-Matsuda, S. M. (Creator), The Royal Society, 2021
DOI: 10.6084/m9.figshare.c.5290088, https://rs.figshare.com/collections/Supplementary_material_from_Hypercapnia_selectively_modulates_LPS-induced_changes_in_innate_immune_and_DNA_replication-related_gene_transcription_in_the_macrophage_/5290088
Dataset
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Mouse_transcrpts from Hypercapnia selectively modulates LPS-induced changes in innate immune and DNA replication-related gene transcription in the macrophage
Casalino-Matsuda, S. M. (Creator), Berdnikovs, S. (Creator), Wang, N. (Contributor), Nair, A. (Creator), Gates, K. L. (Contributor), Beitel, G. J. (Creator) & Sporn, P. H. S. (Creator), The Royal Society, 2021
DOI: 10.6084/m9.figshare.13698020, https://rs.figshare.com/articles/dataset/Mouse_transcrpts_from_Hypercapnia_selectively_modulates_LPS-induced_changes_in_innate_immune_and_DNA_replication-related_gene_transcription_in_the_macrophage/13698020
Dataset