• 627 Citations
20072023
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Personal profile

Research Interests

The question of primary interest in my lab is why only select individuals, despite being genetically similar and living in the same allergen environment, are prone to developing allergic disease, and which processes drive this predisposition? To address this, we employ a systems biology approach and bioinformatics to explore whether there is underlying unity in the pathogenesis of seemingly disparate allergic diseases. By synthesizing large volumes of biological data, we link departures from homeostatic conditions (including changes in metabolic, developmental, and endocrine systems) at the epithelial barriers of the skin, gut, and airways with innate immune system responses as a possible suite of mechanisms driving initiation of allergic disease. Specifically, we are asking the following questions: Are allergic diseases at different barrier sites caused by common systemic processes? Do hormones (estrogen, androgen, growth hormones) maintain homeostasis of the mucosal barriers? Why are developmental pathways for maintenance of tissue homeostasis linked to early susceptibility of asthma? What is the impact of environmentally relevant xenobiotics (xenoestrogens, aromatic hydrocarbons) on epithelial barriers and priming of allergic responses? Secondarily, I keep being fascinated by a cell type that is intimately tied into mucosal biology, and plays central roles in many aspects of allergic disease - the eosinophil. I am intrigued by the fact that aside from being destructive in allergy, eosinophils play prominent roles in homeostasis and assist in normal development of tissues and maturation of other cell types – however, these alternate aspects of eosinophil biology remain largely unexplored. In my lab, we are studying the nature of reciprocal interactions between eosinophils and the mucosa in health and disease by asking the following questions: When and why are eosinophils homeostatic in the mucosa? What is their role in priming of immune responses?

Training Experience

2012Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine

Education/Academic qualification

PhD, University of Cincinnati

… → 2005

Keywords

  • Allergies
  • Bioinformatics
  • Developmental Biology
  • Endocrine Genetics
  • Extracellular Matrix
  • Immune Regulation
  • Metabolism
  • Systems Biology

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Grants 2013 2023

Systemic Scleroderma
Fibrosis
Myofibroblasts
Fibroblasts
Inflammation
Alveolar Epithelial Cells
Systemic Scleroderma
Interstitial Lung Diseases
Alveolar Macrophages
beta Catenin
Hormones
Hypersensitivity
Food Hypersensitivity
Atopic Dermatitis
Asthma

Research Output 2007 2018

  • 627 Citations
  • 23 Article
  • 3 Review article
  • 2 Comment/debate
  • 1 Letter

Matrix protein tenascin-C expands and reversibly blocks maturation of murine eosinophil progenitors

Doan, T. C., Jeong, B. M., Coden, M. E., Loffredo, L. F., Bhattacharyya, S., Chiarella, S. E., Varga, J., Abdala-Valencia, H. & Berdnikovs, S., Aug 1 2018, In : Journal of Allergy and Clinical Immunology. 142, 2, p. 695-698.e4

Research output: Contribution to journalArticle

Tenascin
Protein C
Eosinophils
4 Citations (Scopus)

Shaping eosinophil identity in the tissue contexts of development, homeostasis, and disease

Abdala-Valencia, H., Coden, M. E., Chiarella, S. E., Jacobsen, E. A., Bochner, B. S., Lee, J. J. & Berdnikovs, S., Jul 1 2018, In : Journal of Leukocyte Biology. 104, 1, p. 95-108 14 p.

Research output: Contribution to journalReview article

Eosinophils
Homeostasis
Hematopoiesis
Thromboplastin
Phenotype
12 Citations (Scopus)
Epithelial-Mesenchymal Transition
Asthma
Transcriptome
Epithelial Cells
Insulin
18 Citations (Scopus)
Allergens
Architectural Accessibility
Circadian Clocks
Endocrine System
Systems Biology

Gender-specific differences in the molecular signatures of adult Eosinophilic Oesophagitis

Gonsalves, N. P., Berdnikovs, S., Schroeder, H., Zalewski, A. & Bryce, P. J., Jul 1 2017, In : Clinical and Experimental Allergy. 47, 7, p. 969-971 3 p.

Research output: Contribution to journalLetter