• 908 Citations
20072024

Research output per year

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Personal profile

Research Interests

The question of primary interest in my lab is why only select individuals, despite being genetically similar and living in the same allergen environment, are prone to developing allergic disease, and which processes drive this predisposition? To address this, we employ a systems biology approach and bioinformatics to explore whether there is underlying unity in the pathogenesis of seemingly disparate allergic diseases. By synthesizing large volumes of biological data, we link departures from homeostatic conditions (including changes in metabolic, developmental, and endocrine systems) at the epithelial barriers of the skin, gut, and airways with innate immune system responses as a possible suite of mechanisms driving initiation of allergic disease. Specifically, we are asking the following questions: Are allergic diseases at different barrier sites caused by common systemic processes? Do hormones (estrogen, androgen, growth hormones) maintain homeostasis of the mucosal barriers? Why are developmental pathways for maintenance of tissue homeostasis linked to early susceptibility of asthma? What is the impact of environmentally relevant xenobiotics (xenoestrogens, aromatic hydrocarbons) on epithelial barriers and priming of allergic responses? Secondarily, I keep being fascinated by a cell type that is intimately tied into mucosal biology, and plays central roles in many aspects of allergic disease - the eosinophil. I am intrigued by the fact that aside from being destructive in allergy, eosinophils play prominent roles in homeostasis and assist in normal development of tissues and maturation of other cell types – however, these alternate aspects of eosinophil biology remain largely unexplored. In my lab, we are studying the nature of reciprocal interactions between eosinophils and the mucosa in health and disease by asking the following questions: When and why are eosinophils homeostatic in the mucosa? What is their role in priming of immune responses?

Training Experience

2012Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine

Education/Academic qualification

PhD, University of Cincinnati

… → 2005

Research interests

  • Allergies
  • Bioinformatics
  • Developmental Biology
  • Endocrine Genetics
  • Extracellular Matrix
  • Immune Regulation
  • Metabolism
  • Systems Biology

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Grants

  • Research Output

    • 908 Citations
    • 28 Article
    • 4 Review article
    • 2 Comment/debate
    • 1 Letter

    Allergic inflammation is initiated by IL-33–dependent crosstalk between mast cells and basophils

    Hsu, C. L., Chhiba, K. D., Krier-Burris, R., Hosakoppal, S., Berdnikovs, S., Miller, M. L. & Bryce, P. J., Jan 2020, In : PloS one. 15, 1, e0226701.

    Research output: Contribution to journalArticle

    Open Access
  • Eosinophil accumulation in postnatal lung is specific to the primary septation phase of development

    Loffredo, L. F., Coden, M. E., Jeong, B. M., Walker, M. T., Anekalla, K. R., Doan, T. C., Rodriguez, R., Browning, M., Nam, K., Lee, J. J., Abdala-Valencia, H. & Berdnikovs, S., Dec 1 2020, In : Scientific reports. 10, 1, 4425.

    Research output: Contribution to journalArticle

    Open Access
  • Eosinophils in wound healing and epithelial remodeling: Is coagulation a missing link?

    Coden, M. E. & Berdnikovs, S., Jan 1 2020, (Accepted/In press) In : Journal of Leukocyte Biology.

    Research output: Contribution to journalReview article

  • Fibrinogen is a specific trigger for cytolytic eosinophil degranulation

    Coden, M. E., Loffredo, L. F., Walker, M. T., Jeong, B. M., Nam, K., Bochner, B. S., Abdala-Valencia, H. & Berdnikovs, S., Jan 1 2020, In : Journal of Immunology. 204, 2, p. 438-448 11 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans

    Shigemura, M., Lecuona, E., Angulo, M., Dada, L. A., Edwards, M. B., Welch, L. C., Casalino-Matsuda, S. M., Sporn, P. H. S., Vadász, I., Helenius, I. T., Nader, G. A., Gruenbaum, Y., Sharabi, K., Cummins, E., Taylor, C., Bharat, A., Gottardi, C. J., Beitel, G. J., Kaminski, N., Budinger, G. R. S. & 2 others, Berdnikovs, S. & Sznajder, J. I., Dec 1 2019, In : Scientific reports. 9, 1, 18251.

    Research output: Contribution to journalArticle

    Open Access