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Personal profile

Research Interests

The question of primary interest in my lab is why only select individuals, despite being genetically similar and living in the same allergen environment, are prone to developing allergic disease, and which processes drive this predisposition? To address this, we employ a systems biology approach and bioinformatics to explore whether there is underlying unity in the pathogenesis of seemingly disparate allergic diseases. By synthesizing large volumes of biological data, we link departures from homeostatic conditions (including changes in metabolic, developmental, and endocrine systems) at the epithelial barriers of the skin, gut, and airways with innate immune system responses as a possible suite of mechanisms driving initiation of allergic disease. Specifically, we are asking the following questions: Are allergic diseases at different barrier sites caused by common systemic processes? Do hormones (estrogen, androgen, growth hormones) maintain homeostasis of the mucosal barriers? Why are developmental pathways for maintenance of tissue homeostasis linked to early susceptibility of asthma? What is the impact of environmentally relevant xenobiotics (xenoestrogens, aromatic hydrocarbons) on epithelial barriers and priming of allergic responses? Secondarily, I keep being fascinated by a cell type that is intimately tied into mucosal biology, and plays central roles in many aspects of allergic disease - the eosinophil. I am intrigued by the fact that aside from being destructive in allergy, eosinophils play prominent roles in homeostasis and assist in normal development of tissues and maturation of other cell types – however, these alternate aspects of eosinophil biology remain largely unexplored. In my lab, we are studying the nature of reciprocal interactions between eosinophils and the mucosa in health and disease by asking the following questions: When and why are eosinophils homeostatic in the mucosa? What is their role in priming of immune responses?

Training Experience

2012Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine

Education/Academic qualification

PhD, University of Cincinnati

… → 2005

Research interests

  • Allergies
  • Bioinformatics
  • Developmental Biology
  • Endocrine Genetics
  • Extracellular Matrix
  • Immune Regulation
  • Metabolism
  • Systems Biology

Fingerprint Dive into the research topics where Sergejs Berdnikovs is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Eosinophils Medicine & Life Sciences
Inflammation Medicine & Life Sciences
Leukocytes Medicine & Life Sciences
Tocopherols Medicine & Life Sciences
Asthma Medicine & Life Sciences
Vitamin E Medicine & Life Sciences
Transendothelial and Transepithelial Migration Medicine & Life Sciences
Protein Isoforms Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2013 2024

Natural History
Longitudinal Studies
Epithelial Cells
Reactive Oxygen Species
Systemic Scleroderma
Alveolar Epithelial Cells
Systemic Scleroderma
Interstitial Lung Diseases
Alveolar Macrophages
beta Catenin

Research Output 2007 2019

  • 835 Citations
  • 25 Article
  • 3 Review article
  • 2 Comment/debate
  • 1 Letter

Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans

Shigemura, M., Lecuona, E., Angulo, M., Dada, L. A., Edwards, M. B., Welch, L. C., Casalino-Matsuda, S. M., Sporn, P. H. S., Vadász, I., Helenius, I. T., Nader, G. A., Gruenbaum, Y., Sharabi, K., Cummins, E., Taylor, C., Bharat, A., Gottardi, C. J., Beitel, G. J., Kaminski, N., Budinger, G. R. S. & 2 others, Berdnikovs, S. & Sznajder, J. I., Dec 1 2019, In : Scientific reports. 9, 1, 18251.

Research output: Contribution to journalArticle

Open Access
Wnt Signaling Pathway
Caenorhabditis elegans
Drosophila melanogaster

Gene expression of TMEM178, which encodes a negative regulator of NFATc1, decreases with the progression of asthma severity

Patel, N. B., Ostilla, L. A., Cuervo-Pardo, L., Berdnikovs, S. & Chiarella, S. E., Aug 8 2019, In : Clinical and Translational Allergy. 9, 1, 38.

Research output: Contribution to journalArticle

Open Access
Gene Expression
Epithelial Cells
1 Citation (Scopus)

Matrix protein tenascin-C expands and reversibly blocks maturation of murine eosinophil progenitors

Doan, T. C., Jeong, B. M., Coden, M. E., Loffredo, L. F., Bhattacharyya, S., Chiarella, S. E., Varga, J., Abdala-Valencia, H. & Berdnikovs, S., Aug 2018, In : Journal of Allergy and Clinical Immunology. 142, 2, p. 695-698.e4

Research output: Contribution to journalArticle

Protein C
20 Citations (Scopus)

Shaping eosinophil identity in the tissue contexts of development, homeostasis, and disease

Abdala-Valencia, H., Coden, M. E., Chiarella, S. E., Jacobsen, E. A., Bochner, B. S., Lee, J. J. & Berdnikovs, S., Jul 2018, In : Journal of Leukocyte Biology. 104, 1, p. 95-108 14 p.

Research output: Contribution to journalReview article

18 Citations (Scopus)
Epithelial-Mesenchymal Transition
Epithelial Cells