Grants per year
Personal profile
Research Interests
Dr. Troyanovsky's research focuses on cadherin, intercellular adhesion, and signaling. Classic cadherins are critical proteins mediating cell-cell adhesion and various signaling pathways responsible for cellular proliferation, differentiation, and morphogenesis. Abnormalities in this system are causal factors in many pathologies, including cancer. The molecular mechanisms of cadherin-based adhesion, however, are largely unknown. How do cadherins establish the adhesion contact? How do they interact with the cytoskeleton? What are the signaling pathways they control? Our laboratory's work is centered around these questions. We are currently working on the following specific projects.
Education/Academic qualification
PhD, All-Union Cancer Research Center
… → 1981
Research interests
- Cell Adhesion Mechanisms
- Cell Biology
- Cell Imaging
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Grants
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Structure and function of desmosomal cadherins
Columbia University, National Institute of General Medical Sciences
3/1/17 → 2/28/21
Project: Research project
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Inter-junctional signaling in epithelial junctional complex
Godsel, L. M., Green, K. J. & Troyanovsky, S. M.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/1/16 → 7/31/21
Project: Research project
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Cadherin clusters and actin filaments
Mitchell, B. J. & Troyanovsky, S. M.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
7/1/16 → 5/31/21
Project: Research project
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Inter-junctional signaling in epithelial junctional complex
Godsel, L. M., Green, K. J. & Troyanovsky, S. M.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/1/15 → 8/31/16
Project: Research project
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Intercadherin Interactions in Epithelial Cells
Mitchell, B. J., Mitchell, B. J. & Troyanovsky, S. M.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/30/10 → 8/31/15
Project: Research project
Research Output
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Sensing Actin Dynamics through Adherens Junctions
Indra, I., Troyanovsky, R. B., Shapiro, L., Honig, B. & Troyanovsky, S. M., Feb 25 2020, In: Cell reports. 30, 8, p. 2820-2833.e3Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Scribble, Erbin, and Lano redundantly regulate epithelial polarity and apical adhesion complex
Choi, J., Troyanovsky, R. B., Indra, I., Mitchell, B. J. & Troyanovsky, S. M., Jan 1 2019, In: Journal of Cell Biology. 218, 7, p. 2277-2293 17 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Trans-endocytosis elicited by nectins transfers cytoplasmic cargo, including infectious material, between cells
Generous, A. R., Harrison, O. J., Troyanovsky, R. B., Mateo, M., Navaratnarajah, C. K., Donohue, R. C., Pfaller, C. K., Alekhina, O., Sergeeva, A. P., Indra, I., Thornburg, T., Kochetkova, I., Billadeau, D. D., Taylor, M. P., Troyanovsky, S. M., Honig, B., Shapiro, L. & Cattaneo, R., Aug 23 2019, In: Journal of cell science. 132, 16Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Homophilic and Heterophilic Interactions of Type II Cadherins Identify Specificity Groups Underlying Cell-Adhesive Behavior
Brasch, J., Katsamba, P. S., Harrison, O. J., Ahlsén, G., Troyanovsky, R. B., Indra, I., Kaczynska, A., Kaeser, B., Troyanovsky, S., Honig, B. & Shapiro, L., May 8 2018, In: Cell reports. 23, 6, p. 1840-1852 13 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
Spatial and temporal organization of cadherin in punctate adherens junctions
Indra, I., Choi, J., Chen, C. S., Troyanovsky, R. B., Shapiro, L., Honig, B. & Troyanovsky, S. M., May 8 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 19, p. E4406-E4415Research output: Contribution to journal › Article › peer-review
12 Scopus citations