Grants per year
Personal profile
Research Interests
Dr. Troyanovsky's research focuses on cadherin, intercellular adhesion, and signaling. Classic cadherins are critical proteins mediating cell-cell adhesion and various signaling pathways responsible for cellular proliferation, differentiation, and morphogenesis. Abnormalities in this system are causal factors in many pathologies, including cancer. The molecular mechanisms of cadherin-based adhesion, however, are largely unknown. How do cadherins establish the adhesion contact? How do they interact with the cytoskeleton? What are the signaling pathways they control? Our laboratory's work is centered around these questions. We are currently working on the following specific projects.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Oncology, All-Union Cancer Research Center
… → 1981
Research interests keywords
- Cell Adhesion Mechanisms
- Cell Biology
- Cell Imaging
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Collaborations and top research areas from the last five years
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Intercellular junctions and cell polarity
Troyanovsky, S. M., Godsel, L. M. & Green, K. J.
National Institute of General Medical Sciences
12/15/22 → 11/30/26
Project: Research project
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Cadherin Clusters and actin filaments
Troyanovsky, S. M. & Mitchell, B. J.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
3/1/22 → 1/31/27
Project: Research project
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Structure and function of desmosomal cadherins
Columbia University, National Institute of General Medical Sciences
3/1/17 → 2/28/21
Project: Research project
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Inter-junctional signaling in epithelial junctional complex
Troyanovsky, S. M., Godsel, L. M. & Green, K. J.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/1/16 → 7/31/22
Project: Research project
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Cadherin clusters and actin filaments
Troyanovsky, S. M. & Mitchell, B. J.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
7/1/16 → 2/28/22
Project: Research project
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Adherens junction: the ensemble of specialized cadherin clusters
Troyanovsky, S. M., May 2023, In: Trends in Cell Biology. 33, 5, p. 374-387 14 p.Research output: Contribution to journal › Review article › peer-review
5 Scopus citations -
Plakophilin-3 Binds the Membrane and Filamentous Actin without Bundling F-Actin
Gupta, J., Rangarajan, E. S., Troyanovsky, R. B., Indra, I., Troyanovsky, S. M. & Izard, T., Jun 2023, In: International journal of molecular sciences. 24, 11, 9458.Research output: Contribution to journal › Article › peer-review
Open Access -
Basolateral protein Scribble binds phosphatase PP1 to establish a signaling network maintaining apicobasal polarity
Troyanovsky, R. B., Indra, I., Kato, R., Mitchell, B. J. & Troyanovsky, S. M., Nov 1 2021, In: Journal of Biological Chemistry. 297, 5, 101289.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Plakophilin 3 and Par3 facilitate desmosomes' association with the apical junctional complex
Indra, I., Troyanovsky, R. B., Green, K. J. & Troyanovsky, S. M., Sep 1 2021, In: Molecular biology of the cell. 32, 19, p. 1824-1837 14 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Sorting of cadherin–catenin-associated proteins into individual clusters
Troyanovsky, R. B., Sergeeva, A. P., Indra, I., Chen, C. S., Kato, R., Shapiro, L., Honig, B. & Troyanovsky, S. M., Jul 20 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 29, e2105550118.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations