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Sergey M Troyanovsky

  • 3740 Citations
1985 …2021

Research output per year

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Personal profile

Research Interests

Dr. Troyanovsky's research focuses on cadherin, intercellular adhesion, and signaling. Classic cadherins are critical proteins mediating cell-cell adhesion and various signaling pathways responsible for cellular proliferation, differentiation, and morphogenesis. Abnormalities in this system are causal factors in many pathologies, including cancer. The molecular mechanisms of cadherin-based adhesion, however, are largely unknown. How do cadherins establish the adhesion contact? How do they interact with the cytoskeleton? What are the signaling pathways they control? Our laboratory's work is centered around these questions. We are currently working on the following specific projects.

Education/Academic qualification

PhD, All-Union Cancer Research Center

… → 1981

Research interests

  • Cell Adhesion Mechanisms
  • Cell Biology
  • Cell Imaging

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Grants

Structure and function of desmosomal cadherins

Troyanovsky, S. M.

Columbia University, National Institute of General Medical Sciences

3/1/17 → 2/28/21

Project: Research project

    • Inter-junctional signaling in epithelial junctional complex

    Godsel, L. M., Green, K. J. & Troyanovsky, S. M.

    National Institute of Arthritis and Musculoskeletal and Skin Diseases

    9/1/16 → 7/31/21

    Project: Research project

    • Cadherin clusters and actin filaments

    Mitchell, B. J. & Troyanovsky, S. M.

    National Institute of Arthritis and Musculoskeletal and Skin Diseases

    7/1/16 → 5/31/21

    Project: Research project

    • Inter-junctional signaling in epithelial junctional complex

    Godsel, L. M., Green, K. J. & Troyanovsky, S. M.

    National Institute of Arthritis and Musculoskeletal and Skin Diseases

    9/1/15 → 8/31/16

    Project: Research project

    • Intercadherin Interactions in Epithelial Cells

    Mitchell, B. J., Mitchell, B. J. & Troyanovsky, S. M.

    National Institute of Arthritis and Musculoskeletal and Skin Diseases

    9/30/10 → 8/31/15

    Project: Research project

    • Research Output

    • 3740 Citations
    • 64 Article
    • 6 Review article
    • 1 Chapter
    • 1 Comment/debate

    Scribble, Erbin, and Lano redundantly regulate epithelial polarity and apical adhesion complex

    Choi, J., Troyanovsky, R. B., Indra, I., Mitchell, B. J. & Troyanovsky, S. M., Jan 1 2019, In : Journal of Cell Biology. 218, 7, p. 2277-2293 17 p.

    Research output: Contribution to journal › Article

    Open Access
    • 2 Scopus citations

    Trans-endocytosis elicited by nectins transfers cytoplasmic cargo, including infectious material, between cells

    Generous, A. R., Harrison, O. J., Troyanovsky, R. B., Mateo, M., Navaratnarajah, C. K., Donohue, R. C., Pfaller, C. K., Alekhina, O., Sergeeva, A. P., Indra, I., Thornburg, T., Kochetkova, I., Billadeau, D. D., Taylor, M. P., Troyanovsky, S. M., Honig, B., Shapiro, L. & Cattaneo, R., Aug 23 2019, In : Journal of cell science. 132, 16

    Research output: Contribution to journal › Article

    Open Access
    • 8 Scopus citations

    Homophilic and Heterophilic Interactions of Type II Cadherins Identify Specificity Groups Underlying Cell-Adhesive Behavior

    Brasch, J., Katsamba, P. S., Harrison, O. J., Ahlsén, G., Troyanovsky, R. B., Indra, I., Kaczynska, A., Kaeser, B., Troyanovsky, S. M., Honig, B. & Shapiro, L., May 8 2018, In : Cell reports. 23, 6, p. 1840-1852 13 p.

    Research output: Contribution to journal › Article

    • 11 Scopus citations

    Spatial and temporal organization of cadherin in punctate adherens junctions

    Indra, I., Choi, J., Chen, C. S., Troyanovsky, R. B., Shapiro, L., Honig, B. & Troyanovsky, S. M., May 8 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 19, p. E4406-E4415

    Research output: Contribution to journal › Article

    • 6 Scopus citations

    Cadherin controls nectin recruitment into adherens junctions by remodeling the actin cytoskeleton

    Troyanovsky, R. B., Indra, I., Chen, C. S., Hong, S. & Troyanovsky, S. M., Jan 1 2015, In : Journal of cell science. 128, 1, p. 140-149 10 p.

    Research output: Contribution to journal › Article

    • 11 Scopus citations