• 523 Citations

Research output per year

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Personal profile

Research Interests

My research focuses on understanding how information encoded in DNA is utilized to direct the process of embryonic development, using as a model system the fruit fly Drosophila melanogaster. Genomic DNA is stored in the nucleus not as a naked polymer, but rather as a complex nucleoprotein complex referred to as chromatin. Chromatin structure subdivides functional domains within the genome, relegating DNA sequences to either 'active' or 'inactive' compartments. My research combines classical embryology, genetics, genomics, and quantitative imaging to focus on three main questions. 1) How does chromatin structure evolve over the course of embryonic development as cells acquire unique fates and distinct patterns of active and inactive compartments? 2) What are the mechanisms and regulatory strategies used by the embryo to drive these changes in chromatin structure? 3) Can we develop optical tools to both observe and manipulate chromatin states in real time?

Education/Academic qualification

PhD, University of Pennsylvania

… → 2009

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Research Output

  • 523 Citations
  • 13 Article
  • 1 Conference contribution
  • 1 Short survey

Chromatin accessibility and histone acetylation in the regulation of competence in early development

Esmaeili, M., Blythe, S. A., Tobias, J. W., Zhang, K., Yang, J. & Klein, P. S., Jun 1 2020, In : Developmental Biology. 462, 1, p. 20-35 16 p.

Research output: Contribution to journalArticle

  • 1 Scopus citations

    Rapid Dynamics of Signal-Dependent Transcriptional Repression by Capicua

    Keenan, S. E., Blythe, S. A., Marmion, R. A., Djabrayan, N. J. V., Wieschaus, E. F. & Shvartsman, S. Y., Mar 23 2020, In : Developmental Cell. 52, 6, p. 794-801.e4

    Research output: Contribution to journalArticle

  • Zygotic pioneer factor activity of odd-paired/zic is necessary for late function of the drosophila segmentation network

    Soluri, I. V., Zumerling, L. M., Parra, O. A. P., Clark, E. G. & Blythe, S. A., Apr 2020, In : eLife. 9, e53916.

    Research output: Contribution to journalArticle

    Open Access
  • Concentration dependent chromatin states induced by the bicoid morphogen gradient

    Hannon, C. E., Blythe, S. A. & Wieschaus, E. F., Sep 11 2017, In : eLife. 6, e28275.

    Research output: Contribution to journalArticle

  • 17 Scopus citations

    Establishment and maintenance of heritable chromatin structure during early drosophila embryogenesis

    Blythe, S. A. & Wieschaus, E. F., Nov 23 2016, In : eLife. 5, NOVEMBER2016, e20148.

    Research output: Contribution to journalArticle

  • 52 Scopus citations