Grants per year
Personal profile
Research Interests
My research focuses on understanding how information encoded in DNA is utilized to direct the process of embryonic development, using as a model system the fruit fly Drosophila melanogaster. Genomic DNA is stored in the nucleus not as a naked polymer, but rather as a complex nucleoprotein complex referred to as chromatin. Chromatin structure subdivides functional domains within the genome, relegating DNA sequences to either 'active' or 'inactive' compartments. My research combines classical embryology, genetics, genomics, and quantitative imaging to focus on three main questions. 1) How does chromatin structure evolve over the course of embryonic development as cells acquire unique fates and distinct patterns of active and inactive compartments? 2) What are the mechanisms and regulatory strategies used by the embryo to drive these changes in chromatin structure? 3) Can we develop optical tools to both observe and manipulate chromatin states in real time?
Education/Academic qualification
PhD, University of Pennsylvania
… → 2009
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Collaborations and top research areas from the last five years
Grants
- 3 Active
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Genetic variation and function of body axis determinants in midges and other flies
The University of Chicago, National Institute of General Medical Sciences
1/19/22 → 12/31/26
Project: Research project
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Defining epigenetic mechanisms for embryonic patterning
National Institute of Child Health and Human Development
4/1/21 → 3/31/26
Project: Research project
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A pipeline for precise and efficient genome editing by sgRNA-Cas9 RNPs in Drosophila
Nyberg, K. G., Nguyen, J. Q., Kwon, Y. J., Blythe, S., Beitel, G. J. & Carthew, R., Mar 1 2020, In: Fly. 14, 1-4, p. 34-48 15 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Chromatin accessibility and histone acetylation in the regulation of competence in early development
Esmaeili, M., Blythe, S. A., Tobias, J. W., Zhang, K., Yang, J. & Klein, P. S., Jun 1 2020, In: Developmental Biology. 462, 1, p. 20-35 16 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
Quantitative dissection of transcription in development yields evidence for transcription factor-driven chromatin accessibility
Eck, E., Liu, J., Kazemzadeh-Atoufi, M., Ghoreishi, S., Blythe, S. & Garcia, H. G., Oct 2020, In: eLife. 9, p. 1-99 99 p., e56429.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Rapid Dynamics of Signal-Dependent Transcriptional Repression by Capicua
Keenan, S. E., Blythe, S. A., Marmion, R. A., Djabrayan, N. J. V., Wieschaus, E. F. & Shvartsman, S. Y., Mar 23 2020, In: Developmental Cell. 52, 6, p. 794-801.e4Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
Zygotic pioneer factor activity of odd-paired/zic is necessary for late function of the drosophila segmentation network
Soluri, I. V., Zumerling, L. M., Parra, O. A. P., Clark, E. G. & Blythe, S. A., Apr 2020, In: eLife. 9, e53916.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations
Datasets
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A pipeline for precise and efficient genome editing by sgRNA-Cas9 RNPs in Drosophila
Nyberg, K. G. (Creator), Nguyen, J. Q. (Creator), Kwon, Y. (Contributor), Blythe, S. (Creator), Beitel, G. J. (Creator) & Carthew, R. W. (Creator), Taylor & Francis, 2020
DOI: 10.6084/m9.figshare.13049813.v3, https://tandf.figshare.com/articles/dataset/A_Pipeline_for_Precise_and_Efficient_Genome_Editing_by_sgRNA-Cas9_RNPs_in_i_Drosophila_i_/13049813/3
Dataset