• 4457 Citations
1991 …2023
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Personal profile

Research Interests

The primary goals of research projects in Cheng laboratory is to improve our understanding of the molecular mechanisms and signaling pathways of human cancer initiation, tumorigenesis, invasion, metastases and angiogenesis, and to develop novel approaches for anti-cancer therapies by targeting molecular pathways by which human tumors develop and progress. Our approaches include molecular, cellular biology, histology, tumor xenografts in cell culture and animals model systems of human brain tumors (in particular, glioblastomas) and breast cancers.

Training Experience

1993Postdoctoral Fellowship, University of California, San Diego

Education/Academic qualification

PhD, Ohio State University

… → 1992

Keywords

  • Angiogenesis
  • Brain Cancer / Nervous System Cancer
  • Breast Cancer
  • Cancer Biology
  • Metabolism
  • Molecular Biology
  • Signal Transduction
  • Stem Cells

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2012 2023

Autophagy
Glioblastoma
Brain Neoplasms
Therapeutics
Neoplasms
Glioblastoma
Epigenomics
Biomarkers
Brain Neoplasms
Therapeutics
Long Noncoding RNA
Glioblastoma
Biomarkers
Atlases
Untranslated RNA

Research Output 1991 2019

Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response

Wang, Y., Hou, Y., Zhang, W., Alvarez, A. A., Bai, Y., Hu, B., Cheng, S-Y., Yang, K., Li, Y. & Feng, H., Apr 5 2019, In : Journal of Experimental and Clinical Cancer Research. 38, 1, 147.

Research output: Contribution to journalArticle

Open Access
Switch Genes
Glioma
Stem Cells
Radiation
Glioblastoma

MIR93 (microRNA -93) regulates tumorigenicity and therapy response of glioblastoma by targeting autophagy

Huang, T., Wan, X., Alvarez, A. A., James, C. D., Song, X., Yang, Y., Sastry, N., Nakano, I., Sulman, E. P., Hu, B. & Cheng, S-Y., Jun 3 2019, In : Autophagy. 15, 6, p. 1100-1111 12 p.

Research output: Contribution to journalArticle

Autophagy
Glioblastoma
MicroRNAs
temozolomide
Sirolimus
1 Citation (Scopus)

Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation

Minata, M., Audia, A., Shi, J., Lu, S., Bernstock, J., Pavlyukov, M. S., Das, A., Kim, S. H., Shin, Y. J., Lee, Y., Koo, H., Snigdha, K., Waghmare, I., Guo, X., Mohyeldin, A., Gallego-Perez, D., Wang, J., Chen, D., Cheng, P., Mukheef, F. & 13 othersContreras, M., Reyes, J. F., Vaillant, B., Sulman, E. P., Cheng, S-Y., Markert, J. M., Tannous, B. A., Lu, X., Kango-Singh, M., Lee, L. J., Nam, D. H., Nakano, I. & Bhat, K. P., Feb 12 2019, In : Cell reports. 26, 7, p. 1893-1905.e7

Research output: Contribution to journalArticle

Open Access
Ionizing radiation
Ionizing Radiation
Glioma
Plasticity
Tumors

Autophagy and hallmarks of cancer

Huang, T., Song, X., Yang, Y., Wan, X., Alvarez, A. A., Sastry, N., Feng, H., Hu, B. & Cheng, S-Y., Jan 1 2018, In : Critical Reviews in Oncogenesis. 23, 5-6, p. 247-267 21 p.

Research output: Contribution to journalArticle

Autophagy
Neoplasms
Lysosomes
Organelles
Antineoplastic Agents
4 Citations (Scopus)

Differential response of glioma stem cells to arsenic trioxide therapy is regulated by MNK1 and mRNA translation

Bell, J. B., Eckerdt, F., Dhruv, H. D., Finlay, D., Peng, S., Kim, S., Kroczynska, B., Beauchamp, E. M., Alley, K., Clymer, J., Goldman, S., Cheng, S. Y., James, C. D., Nakano, I., Horbinski, C., Mazar, A. P., Vuori, K., Kumthekar, P., Raizer, J., Berens, M. E. & 1 othersPlatanias, L. C., Jan 1 2018, In : Molecular Cancer Research. 16, 1, p. 32-46 15 p.

Research output: Contribution to journalArticle

MAP Kinase Kinase 1
Protein Biosynthesis
Glioma
Stem Cells
Glioblastoma