Grants per year
Personal profile
Research Interests
The primary goals of research projects in Cheng laboratory is to improve our understanding of the molecular mechanisms and signaling pathways of human cancer initiation, tumorigenesis, invasion, metastases and angiogenesis, and to develop novel approaches for anti-cancer therapies by targeting molecular pathways by which human tumors develop and progress. Our approaches include molecular, cellular biology, histology, tumor xenografts in cell culture and animals model systems of human brain tumors (in particular, glioblastomas) and breast cancers.
Training Experience
| 1993 | Postdoctoral Fellowship, University of California, San Diego |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Biochemistry, Ohio State University
… → 1992
Research interests keywords
- Angiogenesis
- Brain Cancer / Nervous System Cancer
- Breast Cancer
- Cancer Biology
- Metabolism
- Molecular Biology
- Signal Transduction
- Stem Cells
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Targeting RNA Splicing in Glioma
Cheng, S., Cheng, S., Hu, B., Hu, B., Zhang, W. & Zhang, W.
National Institute of Neurological Disorders and Stroke
7/1/22 → 4/30/27
Project: Research project
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Role of Protein Methylation in Cell Mitosis and Glioblastoma
Cheng, S., Cheng, S., Hu, B., Hu, B., James, C. D. & James, C. D.
National Institute of Neurological Disorders and Stroke
4/15/20 → 12/31/24
Project: Research project
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Novel relationships of splicing factors in temozolomide-resistant glioblastoma
2/1/20 → 9/18/23
Project: Research project
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Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis
Zeng, C., Song, X., Zhang, Z., Cai, Q., Cai, J., Horbinski, C., Hu, B., Cheng, S. Y. & Zhang, W., Dec 2023, In: Acta Neuropathologica Communications. 11, 1, 133.Research output: Contribution to journal › Article › peer-review
Open Access -
Oncogenic long noncoding RNA LINC02283 enhances PDGF receptor A-mediated signaling and drives glioblastoma tumorigenesis
Goenka, A., Song, X., Tiek, D., Iglesia, R. P., Lu, M., Zeng, C., Horbinski, C., Zhang, W., Hu, B. & Cheng, S. Y., Sep 2023, In: Neuro-oncology. 25, 9, p. 1592-1604 13 p.Research output: Contribution to journal › Article › peer-review
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PETCH-DB: a Portal for Exploring Tissue-specific and Complex disease-associated 5-Hydroxymethylcytosines
Cai, Q., Zhang, Z., Cui, X., Zeng, C., Cai, J., Cai, J., Wu, K., Zhang, X., Shi, Y., Arvanitakis, Z., Bissonnette, M. A., Chiu, B. C. H., Cheng, S. Y., He, C. & Zhang, W., 2023, In: Database. 2023, baad042.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Repurposing Clemastine to Target Glioblastoma Cell Stemness
Sun, M. A., Yang, R., Liu, H., Wang, W., Song, X., Hu, B., Reynolds, N., Roso, K., Chen, L. H., Greer, P. K., Keir, S. T., McLendon, R. E., Cheng, S. Y., Bigner, D. D., Ashley, D. M., Pirozzi, C. J. & He, Y., Sep 2023, In: Cancers. 15, 18, 4619.Research output: Contribution to journal › Article › peer-review
Open Access -
The mammalian Sterile 20-like kinase 4 (MST4) signaling in tumor progression: Implications for therapy
Getu, A. A., Zhou, M., Cheng, S. Y. & Tan, M., Jun 1 2023, In: Cancer Letters. 563, 216183.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations
Datasets
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Analysis of mRNA profiles distinguishes proneural (PN) glioma stem cells (GSC) from mesenchymal (Mes) GSCs
Kim, S. (Contributor), Nakano, I. (Contributor), Hu, B. (Contributor) & Cheng, S. (Contributor), Gene Expression Omnibus, Mar 19 2015
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE67089
Dataset
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Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response
Wang, Y. (Contributor), Hou, Y. (Contributor), Zhang, W. (Contributor), Alvarez, A. A. (Creator), Bai, Y. (Contributor), Hu, B. (Creator), Cheng, S. (Creator), Yang, K. (Creator), Li, Y. (Contributor) & Feng, H. (Contributor), figshare, 2019
DOI: 10.6084/m9.figshare.c.4462211, https://springernature.figshare.com/collections/Lipolytic_inhibitor_G0S2_modulates_glioma_stem-like_cell_radiation_response/4462211
Dataset
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Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in GBM and GSCs
Huang, T. (Contributor), Alvarez, A. A. (Contributor), Pangeni, R. P. (Contributor), Shi, T. (Contributor), Sastry, N. (Contributor), Lu, S. (Contributor), Kessler, J. (Contributor), Nakano, I. (Contributor), Lu, X. (Contributor), James, C. D. (Contributor), Hu, B. (Contributor) & Cheng, S. (Contributor), Gene Expression Omnibus, Nov 25 2016
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE90498
Dataset
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Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma
Pangeni, R. P. (Creator), Zhang, Z. (Creator), Alvarez, A. A. (Creator), Wan, X. (Contributor), Sastry, N. (Contributor), Lu, S. (Contributor), Shi, T. (Contributor), Huang, T. (Contributor), Lei, C. X. (Creator), James, C. D. (Contributor), Kessler, J. (Creator), Brennan, C. W. (Creator), Nakano, I. (Creator), Lu, X. (Contributor), Hu, B. (Creator), Zhang, W. (Creator) & Cheng, S. (Creator), Taylor & Francis, 2018
DOI: 10.6084/m9.figshare.6638873.v1, https://tandf.figshare.com/articles/Genome-wide_methylomic_and_transcriptomic_analyses_identify_subtype-specific_epigenetic_signatures_commonly_dysregulated_in_glioma_stem_cells_and_glioblastoma/6638873/1
Dataset
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Additional file 1: of Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response
Wang, Y. (Contributor), Hou, Y. (Contributor), Zhang, W. (Contributor), Alvarez, A. A. (Creator), Bai, Y. (Contributor), Hu, B. (Creator), Cheng, S. (Creator), Yang, K. (Creator), Li, Y. (Contributor) & Feng, H. (Contributor), figshare, 2019
DOI: 10.6084/m9.figshare.7961468, https://springernature.figshare.com/articles/Additional_file_1_of_Lipolytic_inhibitor_G0S2_modulates_glioma_stem-like_cell_radiation_response/7961468
Dataset