• 5022 Citations
1991 …2020

Research output per year

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Personal profile

Research Interests

The primary goals of research projects in Cheng laboratory is to improve our understanding of the molecular mechanisms and signaling pathways of human cancer initiation, tumorigenesis, invasion, metastases and angiogenesis, and to develop novel approaches for anti-cancer therapies by targeting molecular pathways by which human tumors develop and progress. Our approaches include molecular, cellular biology, histology, tumor xenografts in cell culture and animals model systems of human brain tumors (in particular, glioblastomas) and breast cancers.

Training Experience

1993Postdoctoral Fellowship, University of California, San Diego

Education/Academic qualification

PhD, Ohio State University

… → 1992

Research interests

  • Angiogenesis
  • Brain Cancer / Nervous System Cancer
  • Breast Cancer
  • Cancer Biology
  • Metabolism
  • Molecular Biology
  • Signal Transduction
  • Stem Cells

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  • Research Output

    Bone morphogenetic protein 4 targeting glioma stem-like cells for malignant glioma treatment: Latest advances and implications for clinical application

    Nayak, S., Mahenthiran, A., Yang, Y., McClendon, M., Mania-Farnell, B., James, C. D., Kessler, J. A., Tomita, T., Cheng, S. Y., Stupp, S. I. & Xi, G., Feb 2020, In : Cancers. 12, 2, 516.

    Research output: Contribution to journalReview article

    Open Access
  • CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity

    Sang, Y., Li, Y., Zhang, Y., Alvarez, A. A., Yu, B., Zhang, W., Hu, B., Cheng, S. Y. & Feng, H., Dec 1 2019, In : Nature communications. 10, 1, 4013.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations
    Open Access
  • Open Access
  • Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response

    Wang, Y., Hou, Y., Zhang, W., Alvarez, A. A., Bai, Y., Hu, B., Cheng, S. Y., Yang, K., Li, Y. & Feng, H., Apr 5 2019, In : Journal of Experimental and Clinical Cancer Research. 38, 1, 147.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations