Grants per year
Personal profile
Research Interests
The primary goals of research projects in Cheng laboratory is to improve our understanding of the molecular mechanisms and signaling pathways of human cancer initiation, tumorigenesis, invasion, metastases and angiogenesis, and to develop novel approaches for anti-cancer therapies by targeting molecular pathways by which human tumors develop and progress. Our approaches include molecular, cellular biology, histology, tumor xenografts in cell culture and animals model systems of human brain tumors (in particular, glioblastomas) and breast cancers.
Training Experience
| 1993 | Postdoctoral Fellowship, University of California, San Diego |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Biochemistry, Ohio State University
… → 1992
Research interests keywords
- Angiogenesis
- Brain Cancer / Nervous System Cancer
- Breast Cancer
- Cancer Biology
- Metabolism
- Molecular Biology
- Signal Transduction
- Stem Cells
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Therapeutic Targeting in EGFR-amplified Glioblastoma
Cheng, S.-Y. (PD/PI), Hu, B. (Co-Investigator) & Zhang, W. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
4/16/24 → 3/31/29
Project: Research project
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Targeting RNA Splicing in Glioma
Cheng, S.-Y. (PD/PI), Cheng, S.-Y. (PD/PI), Hu, B. (Co-Investigator), Hu, B. (Co-Investigator), Zhang, W. (Co-Investigator) & Zhang, W. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
7/1/22 → 4/30/27
Project: Research project
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Cysteine Depletion-induced Ferroptosis as a Therapeutic Vulnerability in Glioblastoma Temozolomide Resistance
Cheng, S.-Y. (PD/PI), Cheng, S.-Y. (PD/PI), Cheng, S.-Y. (PD/PI), Cheng, S.-Y. (PD/PI), Hu, B. (Co-Investigator), Hu, B. (Co-Investigator), Hu, B. (Co-Investigator), Hu, B. (Co-Investigator), James, C. D. (Co-Investigator), James, C. D. (Co-Investigator), James, C. D. (Co-Investigator) & James, C. D. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
6/15/22 → 4/30/26
Project: Research project
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Role of Protein Methylation in Cell Mitosis and Glioblastoma
Cheng, S.-Y. (PD/PI), Cheng, S.-Y. (PD/PI), Cheng, S.-Y. (PD/PI), Hu, B. (Co-Investigator), Hu, B. (Co-Investigator), Hu, B. (Co-Investigator), James, C. D. (Co-Investigator), James, C. D. (Co-Investigator) & James, C. D. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
4/15/20 → 12/31/25
Project: Research project
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Correction to: EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180 (Oncogene, (2014), 33, 19, (2504-2512), 10.1038/onc.2013.198)
Feng, H., Hu, B., Vuori, K., Sarkaria, J. N., Furnari, F. B., Cavenee, W. K. & Cheng, S. Y., Mar 24 2025, In: Oncogene. 44, 10, p. 710-711 2 p.Research output: Contribution to journal › Comment/debate › peer-review
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Kupffer Cell-derived IL6 Promotes Hepatocellular Carcinoma Metastasis Via the JAK1-ACAP4 Pathway
Li, T., Song, X., Chen, J., Li, Y., Lin, J., Li, P., Yu, S., Durojaye, O. A., Yang, F., Liu, X., Li, J., Cheng, S., Yao, X. & Ding, X., 2025, In: International Journal of Biological Sciences. 21, 1, p. 285-305 21 p.Research output: Contribution to journal › Article › peer-review
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Oxidative stress induced protein aggregation via GGCT produced pyroglutamic acid in drug resistant glioblastoma
Tiek, D., Song, X., Yu, X., Wu, R., Iglesia, R., Catezone, A., McCortney, K., Walshon, J., Horbinski, C., Jamshidi, P., Castellani, R., Vassar, R., Miska, J., Hu, B. & Cheng, S. Y., Feb 21 2025, In: iScience. 28, 2, 111769.Research output: Contribution to journal › Article › peer-review
Open Access -
Retraction Note: Dynamin 2 mediates PDGFRα-SHP-2-promoted glioblastoma growth and invasion (Oncogene, (2012), 31, 21, (2691-2702), 10.1038/onc.2011.436)
Feng, H., Liu, K. W., Guo, P., Zhang, P., Cheng, T., McNiven, M. A., Johnson, G. R., Hu, B. & Cheng, S. Y., Apr 7 2025, In: Oncogene. 44, 12, p. 850 1 p.Research output: Contribution to journal › Comment/debate › peer-review
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USP14 modulates stem-like properties, tumorigenicity, and radiotherapy resistance in glioblastoma stem cells through stabilization of MST4-phosphorylated ALKBH5
Zhou, X., Xia, Q., Wang, B., Li, J., Liu, B., Wang, S., Huang, M., Zhong, R., Cheng, S. Y., Wang, X., Jiang, X. & Huang, T., 2025, In: Theranostics. 15, 6, p. 2293-2314 22 p.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in GBM and GSCs
Huang, T. (Contributor), Alvarez, A. A. (Contributor), Pangeni, R. P. (Contributor), Shi, T. (Contributor), Sastry, N. (Contributor), Lu, S. (Contributor), Kessler, J. A. (Contributor), Nakano, I. (Contributor), Lu, X. (Contributor), James, C. D. (Contributor), Hu, B. (Contributor) & Cheng, S.-Y. (Contributor), Gene Expression Omnibus, Nov 25 2016
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE90498
Dataset
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Additional file 1: of Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response
Wang, Y. (Creator), Hou, Y. (Creator), Zhang, W. (Creator), Alvarez, A. A. (Creator), Bai, Y. (Creator), Hu, B. (Creator), Cheng, S.-Y. (Creator), Yang, K. (Creator), Li, Y. (Creator) & Feng, H. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.7961468, https://springernature.figshare.com/articles/figure/Additional_file_1_of_Lipolytic_inhibitor_G0S2_modulates_glioma_stem-like_cell_radiation_response/7961468
Dataset
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Additional file 2: of Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response
Wang, Y. (Creator), Hou, Y. (Creator), Zhang, W. (Creator), Alvarez, A. A. (Creator), Bai, Y. (Creator), Hu, B. (Creator), Cheng, S.-Y. (Creator), Yang, K. (Creator), Li, Y. (Creator) & Feng, H. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.7961480, https://springernature.figshare.com/articles/figure/Additional_file_2_of_Lipolytic_inhibitor_G0S2_modulates_glioma_stem-like_cell_radiation_response/7961480
Dataset
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Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma
Pangeni, R. P. (Creator), Zhang, Z. (Creator), Alvarez, A. A. (Creator), Wan, X. (Creator), Sastry, N. (Creator), Lu, S. (Creator), Shi, T. (Creator), Huang, T. (Creator), Lei, C. X. (Creator), James, C. D. (Contributor), Kessler, J. A. (Creator), Brennan, C. W. (Contributor), Nakano, I. (Creator), Lu, X. (Creator), Hu, B. (Creator), Zhang, W. (Creator) & Cheng, S.-Y. (Creator), Taylor & Francis, 2018
DOI: 10.6084/m9.figshare.6638873.v1, https://tandf.figshare.com/articles/dataset/Genome-wide_methylomic_and_transcriptomic_analyses_identify_subtype-specific_epigenetic_signatures_commonly_dysregulated_in_glioma_stem_cells_and_glioblastoma/6638873/1
Dataset
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Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response
Wang, Y. (Creator), Hou, Y. (Creator), Zhang, W. (Creator), Alvarez, A. A. (Creator), Bai, Y. (Creator), Hu, B. (Creator), Cheng, S.-Y. (Creator), Yang, K. (Creator), Li, Y. (Creator) & Feng, H. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.c.4462211, https://springernature.figshare.com/collections/Lipolytic_inhibitor_G0S2_modulates_glioma_stem-like_cell_radiation_response/4462211
Dataset