• 4619 Citations
1991 …2023
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Personal profile

Research Interests

The primary goals of research projects in Cheng laboratory is to improve our understanding of the molecular mechanisms and signaling pathways of human cancer initiation, tumorigenesis, invasion, metastases and angiogenesis, and to develop novel approaches for anti-cancer therapies by targeting molecular pathways by which human tumors develop and progress. Our approaches include molecular, cellular biology, histology, tumor xenografts in cell culture and animals model systems of human brain tumors (in particular, glioblastomas) and breast cancers.

Training Experience

1993Postdoctoral Fellowship, University of California, San Diego

Education/Academic qualification

PhD, Ohio State University

… → 1992

Research interests

  • Angiogenesis
  • Brain Cancer / Nervous System Cancer
  • Breast Cancer
  • Cancer Biology
  • Metabolism
  • Molecular Biology
  • Signal Transduction
  • Stem Cells

Fingerprint Dive into the research topics where Shi-Yuan Cheng is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 13 Similar Profiles
Glioma Medicine & Life Sciences
Glioblastoma Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Vascular Endothelial Growth Factor A Medicine & Life Sciences
Stem Cells Medicine & Life Sciences
Growth Medicine & Life Sciences
Angiopoietin-2 Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2012 2023

Autophagy
Glioblastoma
Brain Neoplasms
Therapeutics
Neoplasms
Autophagy
Glioblastoma
Carcinogenesis
Phosphorylation
temozolomide
Glioblastoma
Epigenomics
Biomarkers
Brain Neoplasms
Therapeutics

Research Output 1991 2019

CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity

Sang, Y., Li, Y., Zhang, Y., Alvarez, A. A., Yu, B., Zhang, W., Hu, B., Cheng, S-Y. & Feng, H., Dec 1 2019, In : Nature communications. 10, 1, 4013.

Research output: Contribution to journalArticle

Open Access
phosphorylation
Phosphorylation
Ubiquitination
Glioblastoma
Tumors
Open Access
Glioma
Publications
Stem Cells
Radiation
Gene Expression

Correction to: Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response (Journal of Orthopaedic Surgery and Research (2019) 38 (147) DOI: 10.1186/s13046-019-1151-x)

Wang, Y., Hou, Y., Zhang, W., Alvarez, A. A., Bai, Y., Hu, B., Cheng, S-Y., Yang, K., Li, Y. & Feng, H., Jul 16 2019, In : Journal of Orthopaedic Surgery and Research. 14, 1, 215.

Research output: Contribution to journalComment/debate

Open Access
Glioma
Orthopedics
Publications
Stem Cells
Radiation
1 Citation (Scopus)

Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response

Wang, Y., Hou, Y., Zhang, W., Alvarez, A. A., Bai, Y., Hu, B., Cheng, S-Y., Yang, K., Li, Y. & Feng, H., Apr 5 2019, In : Journal of Experimental and Clinical Cancer Research. 38, 1, 147.

Research output: Contribution to journalArticle

Open Access
Switch Genes
Glioma
Stem Cells
Radiation
Glioblastoma
2 Citations (Scopus)

MIR93 (microRNA -93) regulates tumorigenicity and therapy response of glioblastoma by targeting autophagy

Huang, T., Wan, X., Alvarez, A. A., James, C. D., Song, X., Yang, Y., Sastry, N., Nakano, I., Sulman, E. P., Hu, B. & Cheng, S-Y., Jun 3 2019, In : Autophagy. 15, 6, p. 1100-1111 12 p.

Research output: Contribution to journalArticle

Autophagy
Glioblastoma
MicroRNAs
temozolomide
Sirolimus