• 5071 Citations
1991 …2020

Research output per year

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Research Output

2020

Bone morphogenetic protein 4 targeting glioma stem-like cells for malignant glioma treatment: Latest advances and implications for clinical application

Nayak, S., Mahenthiran, A., Yang, Y., McClendon, M., Mania-Farnell, B., James, C. D., Kessler, J. A., Tomita, T., Cheng, S. Y., Stupp, S. I. & Xi, G., Feb 2020, In : Cancers. 12, 2, 516.

Research output: Contribution to journalReview article

Open Access
2019

CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity

Sang, Y., Li, Y., Zhang, Y., Alvarez, A. A., Yu, B., Zhang, W., Hu, B., Cheng, S. Y. & Feng, H., Dec 1 2019, In : Nature communications. 10, 1, 4013.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
Open Access
Open Access

Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response

Wang, Y., Hou, Y., Zhang, W., Alvarez, A. A., Bai, Y., Hu, B., Cheng, S. Y., Yang, K., Li, Y. & Feng, H., Apr 5 2019, In : Journal of Experimental and Clinical Cancer Research. 38, 1, 147.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

MIR93 (microRNA -93) regulates tumorigenicity and therapy response of glioblastoma by targeting autophagy

Huang, T., Wan, X., Alvarez, A. A., James, C. D., Song, X., Yang, Y., Sastry, N., Nakano, I., Sulman, E. P., Hu, B. & Cheng, S. Y., Jun 3 2019, In : Autophagy. 15, 6, p. 1100-1111 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation

Minata, M., Audia, A., Shi, J., Lu, S., Bernstock, J., Pavlyukov, M. S., Das, A., Kim, S. H., Shin, Y. J., Lee, Y., Koo, H., Snigdha, K., Waghmare, I., Guo, X., Mohyeldin, A., Gallego-Perez, D., Wang, J., Chen, D., Cheng, P., Mukheef, F. & 13 others, Contreras, M., Reyes, J. F., Vaillant, B., Sulman, E. P., Cheng, S-Y., Markert, J. M., Tannous, B. A., Lu, X., Kango-Singh, M., Lee, L. J., Nam, D. H., Nakano, I. & Bhat, K. P., Feb 12 2019, In : Cell reports. 26, 7, p. 1893-1905.e7

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

SRSF3-regulated RNA alternative splicing promotes glioblastoma tumorigenicity by affecting multiple cellular processes

Song, X., Wan, X., Huang, T., Zeng, C., Sastry, N., Wu, B., David James, C., Horbinski, C., Nakano, I., Zhang, W., Hu, B. & Cheng, S. Y., Oct 15 2019, In : Cancer Research. 79, 20, p. 5288-5301 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Targeting PDGFRα-activated glioblastoma through specific inhibition of SHP-2-mediated signaling

Sang, Y., Hou, Y., Cheng, R., Zheng, L., Alvarez, A. A., Hu, B., Cheng, S. Y., Zhang, W., Li, Y. & Feng, H., Nov 4 2019, In : Neuro-oncology. 21, 11, p. 1423-1435 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

TGF-β-activated lncRNA LINC00115 is a critical regulator of glioma stem-like cell tumorigenicity

Tang, J., Yu, B., Li, Y., Zhang, W., Alvarez, A. A., Hu, B., Cheng, S. Y. & Feng, H., Dec 5 2019, In : EMBO Reports. 20, 12, e48170.

Research output: Contribution to journalArticle

3 Scopus citations
2018

Autophagy and hallmarks of cancer

Huang, T., Song, X., Yang, Y., Wan, X., Alvarez, A. A., Sastry, N., Feng, H., Hu, B. & Cheng, S. Y., Jan 1 2018, In : Critical Reviews in Oncogenesis. 23, 5-6, p. 247-267 21 p.

Research output: Contribution to journalArticle

1 Scopus citations

Differential response of glioma stem cells to arsenic trioxide therapy is regulated by MNK1 and mRNA translation

Bell, J. B., Eckerdt, F., Dhruv, H. D., Finlay, D., Peng, S., Kim, S., Kroczynska, B., Beauchamp, E. M., Alley, K., Clymer, J., Goldman, S., Cheng, S. Y., James, C. D., Nakano, I., Horbinski, C., Mazar, A. P., Vuori, K., Kumthekar, P., Raizer, J., Berens, M. E. & 1 others, Platanias, L. C., Jan 2018, In : Molecular Cancer Research. 16, 1, p. 32-46 15 p.

Research output: Contribution to journalArticle

11 Scopus citations

Erratum: The Anti-Warburg Effect Elicited by the cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes (Cell Reports (2017) 468(2) (468–481)(S2211124716317429)(10.1016/j.celrep.2016.12.037))

Xing, F., Luan, Y., Cai, J., Wu, S., Mai, J., Gu, J., Zhang, H., Li, K., Lin, Y., Xiao, X., Liang, J., Li, Y., Chen, W., Tan, Y., Sheng, L., Lu, B., Lu, W., Gao, M., Qiu, P., Su, X. & 13 others, Yin, W., Hu, J., Chen, Z., Sai, K., Wang, J., Chen, F., Chen, Y., Zhu, S., Liu, D., Cheng, S., Xie, Z., Zhu, W. & Yan, G., May 29 2018, In : Cell reports. 23, 9, p. 2832-2833 2 p.

Research output: Contribution to journalComment/debate

Open Access

Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma

Pangeni, R. P., Zhang, Z., Alvarez, A. A., Wan, X., Sastry, N., Lu, S., Shi, T., Huang, T., Lei, C. X., James, C. D., Kessler, J. A., Brennan, C. W., Nakano, I., Lu, X., Hu, B., Zhang, W. & Cheng, S. Y., Apr 3 2018, In : Epigenetics. 13, 4, p. 432-448 17 p.

Research output: Contribution to journalArticle

11 Scopus citations

TRIM59 promotes gliomagenesis by inhibiting tc45 dephosphorylation of STAT3

Sang, Y., Li, Y., Song, L., Alvarez, A. A., Zhang, W., Lv, D., Tang, J., Liu, F., Chang, Z., Hatakeyama, S., Hu, B., Cheng, S. Y. & Feng, H., Apr 1 2018, In : Cancer Research. 78, 7, p. 1792-1804 13 p.

Research output: Contribution to journalArticle

17 Scopus citations
2017

Histone acetyltransferase KAT6A upregulates PI3K/AKT signaling through TRIM24 binding

Lv, D., Jia, F., Hou, Y., Sang, Y., Alvarez, A. A., Zhang, W., Gao, W. Q., Hu, B., Cheng, S. Y., Ge, J., Li, Y. & Feng, H., Nov 15 2017, In : Cancer Research. 77, 22, p. 6190-6201 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Internalized CD44s splice isoform attenuates EGFR degradation by targeting Rab7A

Wang, W., Zhang, H., Liu, S., Kim, C. K., Xu, Y., Hurley, L. A., Nishikawa, R., Nagane, M., Hu, B., Stegh, A. H., Cheng, S. Y. & Cheng, C., Aug 1 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 31, p. 8366-8371 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma

Huang, T., Kim, C. K., Alvarez, A. A., Pangeni, R. P., Wan, X., Song, X., Shi, T., Yang, Y., Sastry, N., Horbinski, C. M., Lu, S., Stupp, R., Kessler, J. A., Nishikawa, R., Nakano, I., Sulman, E. P., Lu, X., James, C. D., Yin, X. M., Hu, B. & 1 others, Cheng, S. Y., Dec 11 2017, In : Cancer Cell. 32, 6, p. 840-855.e8

Research output: Contribution to journalArticle

61 Scopus citations

The Anti-Warburg Effect Elicited by the cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes

Xing, F., Luan, Y., Cai, J., Wu, S., Mai, J., Gu, J., Zhang, H., Li, K., Lin, Y., Xiao, X., Liang, J., Li, Y., Chen, W., Tan, Y., Sheng, L., Lu, B., Lu, W., Gao, M., Qiu, P., Su, X. & 13 others, Yin, W., Hu, J., Chen, Z., Sai, K., Wang, J., Chen, F., Chen, Y., Zhu, S., Liu, D., Cheng, S., Xie, Z., Zhu, W. & Yan, G., Jan 10 2017, In : Cell reports. 18, 2, p. 468-481 14 p.

Research output: Contribution to journalArticle

27 Scopus citations

TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma

Lv, D., Li, Y., Zhang, W., Alvarez, A. A., Song, L., Tang, J., Gao, W. Q., Hu, B., Cheng, S. Y. & Feng, H., Dec 1 2017, In : Nature communications. 8, 1, 1454.

Research output: Contribution to journalArticle

33 Scopus citations
2016

A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways

Huang, T., Alvarez, A. A., Pangeni, R. P., Horbinski, C. M., Lu, S., Kim, S. H., James, C. D., Raizer, J. J., Kessler, J. A., Brenann, C. W., Sulman, E. P., Finocchiaro, G., Tan, M., Nishikawa, R., Lu, X., Nakano, I., Hu, B. & Cheng, S. Y., Oct 4 2016, In : Nature communications. 7, 12885.

Research output: Contribution to journalArticle

33 Scopus citations

A simple, low-cost staining method for rapid-throughput analysis of tumor spheroids

Eckerdt, F., Alvarez, A., Bell, J., Arvanitis, C., Iqbal, A., Arslan, A. D., Hu, B., Cheng, S. Y., Goldman, S. & Platanias, L. C., Jan 2016, In : BioTechniques. 60, 1, p. 43-46 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth

Hashizume, R., Zhang, A., Mueller, S., Prados, M. D., Lulla, R. R., Goldman, S., Saratsis, A. M., Mazar, A. P., Stegh, A. H., Cheng, S. Y., Horbinski, C., Haas-Kogan, D. A., Sarkaria, J. N., Waldman, T. & James, C. D., Nov 1 2016, In : Neuro-oncology. 18, 11, p. 1519-1528 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

MNK inhibition disrupts mesenchymal glioma stem cells and prolongs survival in a mouse model of glioblastoma

Bell, J. B., Eckerdt, F. D., Alley, K., Magnusson, L. P., Hussain, H., Bi, Y., Arslan, A. D., Clymer, J., Alvarez, A. A., Goldman, S., Cheng, S. Y., Nakano, I., Horbinski, C., Davuluri, R. V., David James, C. & Platanias, L. C., Oct 1 2016, In : Molecular Cancer Research. 14, 10, p. 984-993 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Naturally Existing Oncolytic Virus M1 Is Nonpathogenic for the Nonhuman Primates after Multiple Rounds of Repeated Intravenous Injections

Zhang, H., Lin, Y., Li, K., Liang, J., Xiao, X., Cai, J., Tan, Y., Xing, F., Mai, J., Li, Y., Chen, W., Sheng, L., Gu, J., Zhu, W., Yin, W., Qiu, P., Su, X., Lu, B., Tian, X., Liu, J. & 13 others, Lu, W., Dou, Y., Huang, Y., Hu, B., Kang, Z., Gao, G., Mao, Z., Cheng, S. Y., Lu, L., Bai, X. T., Gong, S., Yan, G. & Hu, J., Sep 1 2016, In : Human Gene Therapy. 27, 9, p. 700-711 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner

Kim, S. H., Ezhilarasan, R., Phillips, E., Gallego-Perez, D., Sparks, A., Taylor, D., Ladner, K., Furuta, T., Sabit, H., Chhipa, R., Cho, J. H., Mohyeldin, A., Beck, S., Kurozumi, K., Kuroiwa, T., Iwata, R., Asai, A., Kim, J., Sulman, E. P., Cheng, S. Y. & 7 others, Lee, L. J., Nakada, M., Guttridge, D., DasGupta, B., Goidts, V., Bhat, K. P. & Nakano, I., Feb 8 2016, In : Cancer Cell. 29, 2, p. 201-213 13 p.

Research output: Contribution to journalArticle

75 Scopus citations

SHP-2-upregulated ZEB1 is important for PDGFRα-driven glioma epithelial-mesenchymal transition and invasion in mice and humans

Zhang, L., Zhang, W., Li, Y., Alvarez, A., Li, Z., Wang, Y., Song, L., Lv, D., Nakano, I., Hu, B., Cheng, S. Y. & Feng, H., Oct 27 2016, In : Oncogene. 35, 43, p. 5641-5652 12 p.

Research output: Contribution to journalArticle

59 Scopus citations

Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110a inhibition

Iqbal, A., Eckerdt, F., Bell, J., Nakano, I., Giles, F. J., Cheng, S. Y., Lulla, R. R., Goldman, S. & Platanias, L. C., May 31 2016, In : Oncotarget. 7, 22, p. 33192-33201 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Gene expression profiling distinguishes proneural glioma stem cells from mesenchymal glioma stem cells

Chandran, U. R., Luthra, S., Santana-Santos, L., Mao, P., Kim, S. H., Minata, M., Li, J., Benos, P. V., DeWang, M., Hu, B., Cheng, S. Y., Nakano, I. & Sobol, R. W., Sep 1 2015, In : Genomics Data. 5, p. 333-336 4 p.

Research output: Contribution to journalArticle

17 Scopus citations

Identifying driver genomic alterations in cancers by searching minimum-weight, mutually exclusive sets

Lu, S., Lu, K., Cheng, S. Y., Hu, B., Ma, X., Nystrom, N. & Lu, X., Dec 16 2015, Proceedings - 2015 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2015. Schapranow, L. M., Zhou, J., Hu, X. T., Ma, B., Rajasekaran, S., Miyano, S., Yoo, I., Pierce, B., Shehu, A., Gombar, V. K., Chen, B., Pai, V. & Huan, J. (eds.). Institute of Electrical and Electronics Engineers Inc., p. 1728-1730 3 p. 7359942. (Proceedings - 2015 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2015).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Identifying Driver Genomic Alterations in Cancers by Searching Minimum-Weight, Mutually Exclusive Sets

Lu, S., Lu, K. N., Cheng, S. Y., Hu, B., Ma, X., Nystrom, N. & Lu, X., Aug 1 2015, In : PLoS computational biology. 11, 8, e1004257.

Research output: Contribution to journalArticle

10 Scopus citations

Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation

Li, Y., Zhou, Q. L., Sun, W., Chandrasekharan, P., Cheng, H. S., Ying, Z., Lakshmanan, M., Raju, A., Tenen, D. G., Cheng, S. Y., Chuang, K. H., Li, J., Prabhakar, S., Li, M. & Tergaonkar, V., Oct 3 2015, In : Nature Cell Biology. 17, 10, p. 1327-1338 12 p.

Research output: Contribution to journalArticle

89 Scopus citations

Protein kinase A-dependent phosphorylation of Dock180 at serine residue 1250 is important for glioma growth and invasion stimulated by platelet derived-growth factor receptor α

Feng, H., Li, Y., Yin, Y., Zhang, W., Hou, Y., Zhang, L., Li, Z., Xie, B., Gao, W. Q., Sarkaria, J. N., Raizer, J. J., James, C. D., Parsa, A. T., Hu, B. & Cheng, S. Y., Jan 1 2015, In : Neuro-oncology. 17, 6, p. 832-842 11 p.

Research output: Contribution to journalArticle

9 Scopus citations
2014

EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis

Feng, H., Lopez, G. Y., Kim, C. K., Alvarez, A., Duncan, C. G., Nishikawa, R., Nagane, M., Su, A. J. A., Auron, P. E., Hedberg, M. L., Wang, L., Raizer, J. J., Kessler, J. A., Parsa, A. T., Gao, W. Q., Kim, S. H., Minata, M., Nakano, I., Grandis, J. R., McLendon, R. E. & 7 others, Bigner, D. D., Lin, H. K., Furnari, F. B., Cavenee, W. K., Hu, B., Yan, H. & Cheng, S. Y., Sep 2 2014, In : Journal of Clinical Investigation. 124, 9, p. 3741-3756 16 p.

Research output: Contribution to journalArticle

41 Scopus citations

EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180

Feng, H., Hu, B., Vuori, K., Sarkaria, J. N., Furnari, F. B., Cavenee, W. K. & Cheng, S. Y., May 8 2014, In : Oncogene. 33, 19, p. 2504-2512 9 p.

Research output: Contribution to journalArticle

43 Scopus citations
2 Scopus citations

Intratumoral decorin gene delivery by AAV vector inhibits brain glioblastomas and prolongs survival of animals by inducing cell differentiation

Ma, H. I., Hueng, D. Y., Shui, H. A., Han, J. M., Wang, C. H., Lai, Y. H., Cheng, S. Y., Xiao, X., Chen, M. T. & Yang, Y. P., Mar 12 2014, In : International journal of molecular sciences. 15, 3, p. 4393-4414 22 p.

Research output: Contribution to journalArticle

17 Scopus citations

NT113, A pan-ERBB inhibitor with high brain penetrance, inhibits the growth of glioblastoma xenografts with EGFR amplification

Yoshida, Y., Ozawa, T., Yao, T. W., Shen, W., Brown, D., Parsa, A. T., Raizer, J. J., Cheng, S. Y., Stegh, A. H., Mazar, A. P., Giles, F. J., Sarkaria, J. N., Butowski, N., Nicolaides, T. & James, C. D., Dec 1 2014, In : Molecular cancer therapeutics. 13, 12, p. 2919-2929 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Rho GTPases and their activators, guanine nucleotide exchange factors (GEFs): Their roles in glioma cell invasion

Hu, B., Symons, M., Salhia, B., Fortin, S. P., Tran, N. L., Rutka, J. & Cheng, S. Y., Jan 1 2014, Signaling Pathways and Molecular Mediators in Metastasis. Springer Netherlands, p. 143-169 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2013

Bmi-1 Promotes Glioma Angiogenesis by Activating NF-κB Signaling

Jiang, L., Song, L., Wu, J., Yang, Y., Zhu, X., Hu, B., Cheng, S. Y. & Li, M., Jan 31 2013, In : PloS one. 8, 1, e55527.

Research output: Contribution to journalArticle

34 Scopus citations

Downregulation of miR-452 promotes stem-like traits and tumorigenicity of gliomas

Liu, L., Chen, K., Wu, J., Shi, L., Hu, B., Cheng, S., Li, M. & Song, L., Jul 1 2013, In : Clinical Cancer Research. 19, 13, p. 3429-3438 10 p.

Research output: Contribution to journalArticle

33 Scopus citations
2 Scopus citations

Loss of miR-204 expression enhances glioma migration and stem cell-like phenotype

Ying, Z., Li, Y., Wu, J., Zhu, X., Yang, Y., Tian, H., Li, W., Hu, B., Cheng, S. Y. & Li, M., Jan 15 2013, In : Cancer Research. 73, 2, p. 990-999 10 p.

Research output: Contribution to journalArticle

116 Scopus citations

Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3

Mao, P., Joshi, K., Li, J., Kim, S. H., Li, P., Santana-Santos, L., Luthra, S., Chandran, U. R., Benos, P. V., Smith, L., Wang, M., Hu, B., Cheng, S. Y., Sobol, R. W. & Nakano, I., May 21 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 21, p. 8644-8649 6 p.

Research output: Contribution to journalArticle

309 Scopus citations

MiR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops

Song, L., Lin, C., Gong, H., Wang, C., Liu, L., Wu, J., Tao, S., Hu, B., Cheng, S. Y., Li, M. & Li, J., Feb 1 2013, In : Cell Research. 23, 2, p. 274-289 16 p.

Research output: Contribution to journalArticle

67 Scopus citations

Noncoding RNAs in cancer and cancer stem cells

Huang, T., Alvarez, A., Hu, B. & Cheng, S. Y., 2013, In : Chinese Journal of Cancer. 32, 11, p. 582-593 12 p.

Research output: Contribution to journalReview article

75 Scopus citations

The p53-PUMA axis suppresses iPSC generation

Li, Y., Feng, H., Gu, H., Lewis, D. W., Yuan, Y., Zhang, L., Yu, H., Zhang, P., Cheng, H., Miao, W., Yuan, W., Cheng, S. Y., Gollin, S. M. & Cheng, T., Aug 2 2013, In : Nature communications. 4, 2174.

Research output: Contribution to journalArticle

38 Scopus citations

YM-155 potentiates the effect of ABT-737 in malignant humanglioma cells via survivin and Mcl-1 downregulation in an EGFR-dependent context

Jane, E. P., Premkumar, D. R., DiDomenico, J. D., Hu, B., Cheng, S. Y. & Pollack, I. F., Mar 1 2013, In : Molecular cancer therapeutics. 12, 3, p. 326-338 13 p.

Research output: Contribution to journalArticle

28 Scopus citations
2012

An Opposite Effect of the CDK Inhibitor, p18INK4c on Embryonic Stem Cells Compared with Tumor and Adult Stem Cells

Li, Y., Pal, R., Sung, L. Y., Feng, H., Miao, W., Cheng, S. Y., Tian, C. & Cheng, T., Sep 26 2012, In : PloS one. 7, 9, e45212.

Research output: Contribution to journalArticle

7 Scopus citations