Grants per year
Personal profile
Research Interests
My research focuses are pediatric brain tumor and pediatric embryonal tumors with emphasis on atypical teratoid rhabdoid tumors (AT/RT) which are known by their extraordinary aggressiveness and resistance to therapy. My lab focuses on the study of kinases as potential therapeutic targets for these tumors. We identified key kinases overexpressed in embryonal brain tumors and are currently investigating the mechanisms of action and resistance to these kinase-inhibitors. Our studies also include the creation of a novel and unique animal model of rhabdoid tumors using zebrafish.
Education/Academic qualification
PhD, University of San Paulo
… → 1999
MD, Santa Casa Medical School
… → 1990
Research interests
- Brain Cancer / Nervous System Cancer
- Cancer Biology
- Cell Division
- Gene Regulation
- Pathology
- Pediatrics
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Grants
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Mitigating radiation induced cognitive decay in children with brain tumors
7/1/19 → 6/30/20
Project: Research project
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Production and quality analysis of clinical drug for a novel CNS protein kinase inhibitor therapeutic candidate
Northwestern University, National Institutes of Health
5/15/19 → 4/30/20
Project: Research project
Research Output
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Evaluation of protein kinase inhibitors with plk4 cross-over potential in a pre-clinical model of cancer
Suri, A., Bailey, A. W., Tavares, M. T., Gunosewoyo, H., Dyer, C. P., Grupenmacher, A. T., Piper, D. R., Horton, R. A., Tomita, T., Kozikowski, A. P., Roy, S. M. & Sredni, S. T., May 1 2019, In: International journal of molecular sciences. 20, 9, 2112.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Characterization of brain tumor initiating cells isolated from an animal model of CNS primitive neuroectodermal tumors
Malchenko, S., Sredni, S. T., Boyineni, J., Bi, Y., Margaryan, N. V., Guda, M. R., Kostenko, Y., Tomita, T., Davuluri, R. V., Velpula, K., Hendrix, M. J. C. & Soares, M. B., 2018, In: Oncotarget. 9, 17, p. 13733-13747 15 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Polo-like kinase 4 (PLK4) is overexpressed in central nervous system neuroblastoma (CNS-NB)
Bailey, A. W., Suri, A., Chou, P. M., Pundy, T., Gadd, S., Raimondi, S. L., Tomita, T. & Sredni, S. T., Dec 2018, In: Bioengineering. 5, 4, 96.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain
Sredni, S. T., Suzuki, M., Yang, J. P., Topczewski, J., Bailey, A. W., Gokirmak, T., Gross, J. N., de Andrade, A., Kondo, A., Piper, D. R. & Tomita, T., Nov 2017, In: Pediatric Blood and Cancer. 64, 11, e26551.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Inhibition of polo-like kinase 4 (PLK4): A new therapeutic option for rhabdoid tumors and pediatric medulloblastoma
Sredni, S. T., Bailey, A. W., Suri, A., Hashizume, R., He, X., Louis, N., Gokirmak, T., Piper, D. R., Watterson, D. M. & Tomita, T., 2017, In: Oncotarget. 8, 67, p. 111190-111212 23 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations