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Simone Trieger Sredni

  • 771 Citations
19972021

Research output per year

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Personal profile

Research Interests

My research focuses are pediatric brain tumor and pediatric embryonal tumors with emphasis on atypical teratoid rhabdoid tumors (AT/RT) which are known by their extraordinary aggressiveness and resistance to therapy. My lab focuses on the study of kinases as potential therapeutic targets for these tumors. We identified key kinases overexpressed in embryonal brain tumors and are currently investigating the mechanisms of action and resistance to these kinase-inhibitors. Our studies also include the creation of a novel and unique animal model of rhabdoid tumors using zebrafish.

Education/Academic qualification

PhD, University of San Paulo

… → 1999

MD, Santa Casa Medical School

… → 1990

Research interests

  • Brain Cancer / Nervous System Cancer
  • Cancer Biology
  • Cell Division
  • Gene Regulation
  • Pathology
  • Pediatrics

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Grants

A new orally bioavailable neuroprotective co-therapy for children with brain tumors

Sredni, S. T.

Collaborative Pediatric Cancer Research Awards Program

7/1/19 → 6/30/21

Project: Research project

Polo-like kinase 4 (PLK4) small molecule inhibitors: A new therapeutic opportunity for pediatric brain tumors

Sredni, S. T.

Rally Foundation for Childhood Cancer Research

7/1/19 → 6/30/21

Project: Research project

Mitigating radiation induced cognitive decay in children with brain tumors

Sredni, S. T.

St. Baldrick's Foundation

7/1/19 → 6/30/20

Project: Research project

Qualification of the PLK4 inhibitor CFI-400945 for future clinical trials on pediatric brain tumors: moving from the bench to the bedside

Sredni, S. T.

The Musella Foundation For Brain Tumor Research & Information, Inc

5/1/17 → 12/31/18

Project: Research project

Qualification of the PLK4 inhibitor CFI-400945 for future clinical trials on pediatric brain tumors: moving from the bench to the bedside

Sredni, S. T.

The Musella Foundation For Brain Tumor Research & Information, Inc

5/1/17 → 12/31/18

Project: Research project

Research Output

  • 771 Citations
  • 47 Article
  • 7 Letter
  • 2 Comment/debate

Evaluation of protein kinase inhibitors with plk4 cross-over potential in a pre-clinical model of cancer

Suri, A., Bailey, A. W., Tavares, M. T., Gunosewoyo, H., Dyer, C. P., Grupenmacher, A. T., Piper, D. R., Horton, R. A., Tomita, T., Kozikowski, A. P., Roy, S. M. & Sredni, S. T., May 1 2019, In : International journal of molecular sciences. 20, 9, 2112.

Research output: Contribution to journal › Article

Open Access
    • 3 Scopus citations

    Characterization of brain tumor initiating cells isolated from an animal model of CNS primitive neuroectodermal tumors

    Malchenko, S., Sredni, S. T., Boyineni, J., Bi, Y., Margaryan, N. V., Guda, M. R., Kostenko, Y., Tomita, T., Davuluri, R. V., Velpula, K., Hendrix, M. J. C. & Soares, M. B., Jan 1 2018, In : Oncotarget. 9, 17, p. 13733-13747 15 p.

    Research output: Contribution to journal › Article

    • 3 Scopus citations

    Polo-like kinase 4 (PLK4) is overexpressed in central nervous system neuroblastoma (CNS-NB)

    Bailey, A. W., Suri, A., Chou, P. M., Pundy, T., Gadd, S., Raimondi, S. L., Tomita, T. & Sredni, S. T., Dec 2018, In : Bioengineering. 5, 4, 96.

    Research output: Contribution to journal › Article

    • 4 Scopus citations

    A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain

    Sredni, S. T., Suzuki, M., Yang, J. P., Topczewski, J., Bailey, A. W., Gokirmak, T., Gross, J. N., de Andrade, A., Kondo, A., Piper, D. R. & Tomita, T., Nov 2017, In : Pediatric Blood and Cancer. 64, 11, e26551.

    Research output: Contribution to journal › Article

    • 7 Scopus citations

    Inhibition of polo-like kinase 4 (PLK4): A new therapeutic option for rhabdoid tumors and pediatric medulloblastoma

    Sredni, S. T., Bailey, A. W., Suri, A., Hashizume, R., He, X., Louis, N., Gokirmak, T., Piper, D. R., Watterson, D. M. & Tomita, T., Jan 1 2017, In : Oncotarget. 8, 67, p. 111190-111212 23 p.

    Research output: Contribution to journal › Article

    • 8 Scopus citations