Grants per year
Personal profile
Research Interests
My research focuses are pediatric brain tumor and pediatric embryonal tumors with emphasis on atypical teratoid rhabdoid tumors (AT/RT) which are known by their extraordinary aggressiveness and resistance to therapy. My lab focuses on the study of kinases as potential therapeutic targets for these tumors. We identified key kinases overexpressed in embryonal brain tumors and are currently investigating the mechanisms of action and resistance to these kinase-inhibitors. Our studies also include the creation of a novel and unique animal model of rhabdoid tumors using zebrafish.
Education/Academic qualification
PhD, University of San Paulo
… → 1999
MD, Santa Casa Medical School
… → 1990
Research interests
- Brain Cancer / Nervous System Cancer
- Cancer Biology
- Cell Division
- Gene Regulation
- Pathology
- Pediatrics
Fingerprint Dive into the research topics where Simone Trieger Sredni is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 7 Similar Profiles
Neoplasms
Medicine & Life Sciences
Rhabdoid Tumor
Medicine & Life Sciences
MicroRNAs
Medicine & Life Sciences
Wilms Tumor
Medicine & Life Sciences
Brain Neoplasms
Medicine & Life Sciences
Primitive Neuroectodermal Tumors
Medicine & Life Sciences
Pediatrics
Medicine & Life Sciences
Phosphotransferases
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2012 2018
- 4 Finished
Hailey Fish, A Zebrafish Model of Malignant Rhabdoid Tumor
Sredni, S. T., Tomita, T. & Topczewski, J.
Collaborative Pediatric Cancer Research Awards Program
4/1/15 → 6/30/18
Project: Research project
Investigating New Therapeutic Targets for Malignant Rhabdoid Tumors
Sredni, S. T., Tomita, T. & Topczewski, J.
Collaborative Pediatric Cancer Research Awards Program
4/1/14 → 7/31/15
Project: Research project
AVOIDING UNNECESSARY TOXICITY AND IMPROVING SURVIVAL OF CHILDREN WITH LOW GRADE GLIOMAS
11/1/12 → 12/31/17
Project: Research project
Research Output 1997 2019
2
Citations
(Scopus)
Evaluation of protein kinase inhibitors with plk4 cross-over potential in a pre-clinical model of cancer
Suri, A., Bailey, A. W., Tavares, M. T., Gunosewoyo, H., Dyer, C. P., Grupenmacher, A. T., Piper, D. R., Horton, R. A., Tomita, T., Kozikowski, A. P., Roy, S. M. & Sredni, S. T., May 1 2019, In : International journal of molecular sciences. 20, 9, 2112.Research output: Contribution to journal › Article
Open Access
Protein Kinase Inhibitors
inhibitors
brain
Brain
Phosphotransferases
2
Citations
(Scopus)
Characterization of brain tumor initiating cells isolated from an animal model of CNS primitive neuroectodermal tumors
Malchenko, S., Sredni, S. T., Boyineni, J., Bi, Y., Margaryan, N. V., Guda, M. R., Kostenko, Y., Tomita, T., Davuluri, R. V., Velpula, K., Hendrix, M. J. C. & Soares, M. B., Jan 1 2018, In : Oncotarget. 9, 17, p. 13733-13747 15 p.Research output: Contribution to journal › Article
Primitive Neuroectodermal Tumors
Neoplastic Stem Cells
Brain Neoplasms
Animal Models
Carcinogenesis
2
Citations
(Scopus)
Polo-like kinase 4 (PLK4) is overexpressed in central nervous system neuroblastoma (CNS-NB)
Bailey, A. W., Suri, A., Chou, P. M., Pundy, T., Gadd, S. L., Raimondi, S. L., Tomita, T. & Sredni, S. T., Dec 1 2018, In : Bioengineering. 5, 4, 96.Research output: Contribution to journal › Article
Neurology
Tumors
Phosphotransferases
Brain
Pediatrics
7
Citations
(Scopus)
A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain
Sredni, S. T., Suzuki, M., Yang, J. P., Topczewski, J., Bailey, A. W., Gokirmak, T., Gross, J. N., de Andrade, A., Kondo, A., Piper, D. R. & Tomita, T., Nov 1 2017, In : Pediatric Blood and Cancer. 64, 11, e26551.Research output: Contribution to journal › Article
Rhabdoid Tumor
Brain Neoplasms
Phosphotransferases
Clustered Regularly Interspaced Short Palindromic Repeats
Tumor Cell Line
7
Citations
(Scopus)
Inhibition of polo-like kinase 4 (PLK4): A new therapeutic option for rhabdoid tumors and pediatric medulloblastoma
Sredni, S. T., Bailey, A. W., Suri, A., Hashizume, R., He, X., Louis, N., Gokirmak, T., Piper, D. R., Watterson, D. M. & Tomita, T., Jan 1 2017, In : Oncotarget. 8, 67, p. 111190-111212 23 p.Research output: Contribution to journal › Article
Rhabdoid Tumor
Medulloblastoma
Phosphotransferases
Pediatrics
Neoplasms