Simone Trieger Sredni

  • 758 Citations
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Personal profile

Research Interests

My research focuses are pediatric brain tumor and pediatric embryonal tumors with emphasis on atypical teratoid rhabdoid tumors (AT/RT) which are known by their extraordinary aggressiveness and resistance to therapy. My lab focuses on the study of kinases as potential therapeutic targets for these tumors. We identified key kinases overexpressed in embryonal brain tumors and are currently investigating the mechanisms of action and resistance to these kinase-inhibitors. Our studies also include the creation of a novel and unique animal model of rhabdoid tumors using zebrafish.

Education/Academic qualification

PhD, University of San Paulo

… → 1999

MD, Santa Casa Medical School

… → 1990

Research interests

  • Brain Cancer / Nervous System Cancer
  • Cancer Biology
  • Cell Division
  • Gene Regulation
  • Pathology
  • Pediatrics

Fingerprint Dive into the research topics where Simone Trieger Sredni is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Neoplasms Medicine & Life Sciences
Rhabdoid Tumor Medicine & Life Sciences
MicroRNAs Medicine & Life Sciences
Wilms Tumor Medicine & Life Sciences
Brain Neoplasms Medicine & Life Sciences
Primitive Neuroectodermal Tumors Medicine & Life Sciences
Pediatrics Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences

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Grants 2012 2018

Research Output 1997 2019

  • 758 Citations
  • 47 Article
  • 7 Letter
  • 2 Comment/debate
3 Citations (Scopus)

Evaluation of protein kinase inhibitors with plk4 cross-over potential in a pre-clinical model of cancer

Suri, A., Bailey, A. W., Tavares, M. T., Gunosewoyo, H., Dyer, C. P., Grupenmacher, A. T., Piper, D. R., Horton, R. A., Tomita, T., Kozikowski, A. P., Roy, S. M. & Sredni, S. T., May 1 2019, In : International journal of molecular sciences. 20, 9, 2112.

Research output: Contribution to journalArticle

Open Access
Protein Kinase Inhibitors
2 Citations (Scopus)

Characterization of brain tumor initiating cells isolated from an animal model of CNS primitive neuroectodermal tumors

Malchenko, S., Sredni, S. T., Boyineni, J., Bi, Y., Margaryan, N. V., Guda, M. R., Kostenko, Y., Tomita, T., Davuluri, R. V., Velpula, K., Hendrix, M. J. C. & Soares, M. B., Jan 1 2018, In : Oncotarget. 9, 17, p. 13733-13747 15 p.

Research output: Contribution to journalArticle

Primitive Neuroectodermal Tumors
Neoplastic Stem Cells
Brain Neoplasms
Animal Models
4 Citations (Scopus)

Polo-like kinase 4 (PLK4) is overexpressed in central nervous system neuroblastoma (CNS-NB)

Bailey, A. W., Suri, A., Chou, P. M., Pundy, T., Gadd, S., Raimondi, S. L., Tomita, T. & Sredni, S. T., Dec 2018, In : Bioengineering. 5, 4, 96.

Research output: Contribution to journalArticle

7 Citations (Scopus)

A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain

Sredni, S. T., Suzuki, M., Yang, J. P., Topczewski, J., Bailey, A. W., Gokirmak, T., Gross, J. N., de Andrade, A., Kondo, A., Piper, D. R. & Tomita, T., Nov 1 2017, In : Pediatric Blood and Cancer. 64, 11, e26551.

Research output: Contribution to journalArticle

Rhabdoid Tumor
Brain Neoplasms
Clustered Regularly Interspaced Short Palindromic Repeats
Tumor Cell Line
7 Citations (Scopus)

Inhibition of polo-like kinase 4 (PLK4): A new therapeutic option for rhabdoid tumors and pediatric medulloblastoma

Sredni, S. T., Bailey, A. W., Suri, A., Hashizume, R., He, X., Louis, N., Gokirmak, T., Piper, D. R., Watterson, D. M. & Tomita, T., Jan 1 2017, In : Oncotarget. 8, 67, p. 111190-111212 23 p.

Research output: Contribution to journalArticle

Rhabdoid Tumor