Grants per year
Personal profile
Research Interests
The laboratory is interested in understanding the mechanisms underlying the pathogenesis and immunoregulation of T cell-mediated autoimmune diseases, allergic disease, and rejection of tissue and organ transplants. In particular, we are studying the therapeutic use of short-term administration of costimulatory molecule agonists/antagonists and specific immune tolerance induced by infusion of antigen-coupled apoptotic cells and PLG nanoparticles for the treatment of animal models of multiple sclerosis and type 1 diabetes, allergic airway disease, as well as using tolerance for specific prevention of rejection of allogeneic and xenogeneic tissue and organ transplants.
Training Experience
1978 | Postdoctoral Fellowship, University of Colorado |
Education/Academic qualification
PhD, Pennsylvania State University
… → 1975
Research interests
- Autoimmune Diseases
- Diabetes
- Endocrinology
- Immune Regulation
- Immunology
- Metabolism
- Multiple Sclerosis
- Neuroscience
- Transplantation
- Viral Pathogenesis
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Grants
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Allergen loaded nanoparticles for food allergy tolerance
University of Michigan, National Institute of Allergy and Infectious Diseases
9/16/20 → 8/31/25
Project: Research project
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Research Projects for Cour Pharmaceutical Development Company Inc.
Cour Pharmaceutical Development Company, Inc.
7/9/19 → 1/31/22
Project: Research project
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A novel therapy for scleroderma using biodegradable nanoparticles
Varga, J., Xu, D. & Miller, S. D.
9/1/18 → 8/31/21
Project: Research project
Research Output
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Antibody targeting of B7-H4 enhances the immune response in urothelial carcinoma
Podojil, J. R., Glaser, A. P., Baker, D., Courtois, E. T., Fantini, D., Yu, Y., Eaton, V., Sivajothi, S., Chiang, M., Das, A., McLaughlin, K. A., Robson, P., Miller, S. D. & Meeks, J. J., Jan 1 2020, In: OncoImmunology. 9, 1, 1744897.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis
Morris, A. H., Hughes, K. R., Oakes, R. S., Cai, M. M., Miller, S. D., Irani, D. N. & Shea, L. D., Dec 1 2020, In: Nature communications. 11, 1, 3871.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Gliadin Nanoparticles Induce Immune Tolerance to Gliadin in Mouse Models of Celiac Disease
Freitag, T. L., Podojil, J. R., Pearson, R. M., Fokta, F. J., Sahl, C., Messing, M., Andersson, L. C., Leskinen, K., Saavalainen, P., Hoover, L. I., Huang, K., Phippard, D., Maleki, S., King, N. J. C., Shea, L. D., Miller, S. D., Meri, S. K. & Getts, D. R., May 2020, In: Gastroenterology. 158, 6, p. 1667-1681.e12Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Herpesvirus entry mediator binding partners mediate immunopathogenesis of ocular herpes simplex virus 1 infection
Park, S. J., Riccio, R. E., Kopp, S. J., Ifergan, I., Miller, S. D. & Longnecker, R., 2020, In: mBio. 11, 3, e00790-20.Research output: Contribution to journal › Article › peer-review
Open Access -
Immunosuppressive IDO in Cancer: Mechanisms of Action, Animal Models, and Targeting Strategies
Zhai, L., Bell, A., Ladomersky, E., Lauing, K. L., Bollu, L., Sosman, J. A., Zhang, B., Wu, J. D., Miller, S. D., Meeks, J. J., Lukas, R. V., Wyatt, E., Doglio, L., Schiltz, G. E., McCusker, R. H. & Wainwright, D. A., Jun 16 2020, In: Frontiers in immunology. 11, 1185.Research output: Contribution to journal › Review article › peer-review
Open Access8 Scopus citations