Grants per year
Personal profile
Research Interests
The laboratory is interested in understanding the mechanisms underlying the pathogenesis and immunoregulation of T cell-mediated autoimmune diseases, allergic disease, and rejection of tissue and organ transplants. In particular, we are studying the therapeutic use of short-term administration of costimulatory molecule agonists/antagonists and specific immune tolerance induced by infusion of antigen-coupled apoptotic cells and PLG nanoparticles for the treatment of animal models of multiple sclerosis and type 1 diabetes, allergic airway disease, as well as using tolerance for specific prevention of rejection of allogeneic and xenogeneic tissue and organ transplants.
Training Experience
| 1978 | Postdoctoral Fellowship, University of Colorado |
Education/Academic qualification
PhD, Pennsylvania State University
… → 1975
Research interests
- Autoimmune Diseases
- Diabetes
- Endocrinology
- Immune Regulation
- Immunology
- Metabolism
- Multiple Sclerosis
- Neuroscience
- Transplantation
- Viral Pathogenesis
Fingerprint Dive into the research topics where Stephen D Miller is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Theilovirus
Medicine & Life Sciences
T-Lymphocytes
Medicine & Life Sciences
Autoimmune Experimental Encephalomyelitis
Medicine & Life Sciences
Demyelinating Diseases
Medicine & Life Sciences
Multiple Sclerosis
Medicine & Life Sciences
Epitopes
Medicine & Life Sciences
Antigens
Medicine & Life Sciences
Autoimmune Diseases
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 1997 2022
Investigation of the Tumor Microenvironment as a Protective Niche that Supports Treatment Resistance of Bladder Cancer
U.S. Army Medical Research and Materiel Command
8/15/19 → 8/14/21
Project: Research project
Cellular Microenvironment
Tumor Microenvironment
Veterans
Urinary Bladder Neoplasms
Research Design
Research Projects for Cour Pharmaceutical Development Company Inc.
Cour Pharmaceutical Development Company, Inc.
7/9/19 → 1/31/22
Project: Research project
Drug products
Industry
Experiments
Availability
Combining Immune Tolerance and Myelin Repair Therapy in T cell-driven MS Models
National Institute of Allergy and Infectious Diseases
2/11/19 → 1/31/21
Project: Research project
Immune Tolerance
Myelin Sheath
Multiple Sclerosis
Autoimmune Experimental Encephalomyelitis
T-Lymphocytes
A novel therapy for scleroderma using biodegradable nanoparticles
Miller, S. D., Varga, J. & Xu, D.
9/1/18 → 8/31/21
Project: Research project
Nanoparticles
Monocytes
Macrophages
Skin
Fibrosis
Translation of novel and repurposed drugs to address the acute and late effects of mustard exposure
Miller, S. D., West, D. P. & Lu, K.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
8/1/18 → 7/31/22
Project: Research project
Drug Repositioning
Mustard Plant
Skin
Spironolactone
Diphosphonates
Research Output 1974 2019
2
Citations
(Scopus)
Designing drug-free biodegradable nanoparticles to modulate inflammatory monocytes and neutrophils for ameliorating inflammation
Saito, E., Kuo, R., Pearson, R. M., Gohel, N., Cheung, B., King, N. J. C., Miller, S. D. & Shea, L. D., Apr 28 2019, In : Journal of Controlled Release. 300, p. 185-196 12 p.Research output: Contribution to journal › Article
Nanoparticles
Monocytes
Neutrophils
Autoimmune Experimental Encephalomyelitis
Inflammation
Design of biodegradable nanoparticles to modulate phenotypes of antigen-presenting cells for antigen-specific treatment of autoimmune disease
Saito, E., Kuo, R., Kramer, K. R., Gohel, N., Giles, D. A., Moore, B. B., Miller, S. D. & Shea, L. D., Nov 1 2019, In : Biomaterials. 222, 119432.Research output: Contribution to journal › Article
Antigen-Presenting Cells
Antigens
Nanoparticles
Autoimmune Diseases
Phenotype
Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes
Singh, A., Ramachandran, S., Graham, M. L., Daneshmandi, S., Heller, D., Suarez-Pinzon, W. L., Balamurugan, A. N., Ansite, J. D., Wilhelm, J. J., Yang, A., Zhang, Y., Palani, N. P., Abrahante, J. E., Burlak, C., Miller, S. D., Luo, X. & Hering, B. J., Dec 1 2019, In : Nature communications. 10, 1, 3495.Research output: Contribution to journal › Article
Open Access
primates
Transplantation Tolerance
leukocytes
Primates
Allografts
Nanoparticles containing an insulin-ChGA hybrid peptide protect from transfer of autoimmune diabetes by shifting the balance between effector T cells and regulatory T cells
Jamison, B. L., Neef, T., Goodspeed, A., Bradley, B., Baker, R. L., Miller, S. D. & Haskins, K., Jan 1 2019, In : Journal of Immunology. 203, 1, p. 48-57 10 p.Research output: Contribution to journal › Article
Regulatory T-Lymphocytes
Type 1 Diabetes Mellitus
Nanoparticles
Insulin
T-Lymphocytes
2
Citations
(Scopus)
Overcoming challenges in treating autoimmuntity: Development of tolerogenic immune-modifying nanoparticles
Pearson, R. M., Podojil, J. R., Shea, L. D., King, N. J. C., Miller, S. D. & Getts, D. R., Jun 1 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 18, p. 282-291 10 p.Research output: Contribution to journal › Review article
Nanoparticles
Celiac Disease
T-Lymphocytes
Autoimmune Diseases
Clinical Trials