Stephen D Miller

  • 22082 Citations
1974 …2022
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Personal profile

Research Interests

The laboratory is interested in understanding the mechanisms underlying the pathogenesis and immunoregulation of T cell-mediated autoimmune diseases, allergic disease, and rejection of tissue and organ transplants. In particular, we are studying the therapeutic use of short-term administration of costimulatory molecule agonists/antagonists and specific immune tolerance induced by infusion of antigen-coupled apoptotic cells and PLG nanoparticles for the treatment of animal models of multiple sclerosis and type 1 diabetes, allergic airway disease, as well as using tolerance for specific prevention of rejection of allogeneic and xenogeneic tissue and organ transplants.

Training Experience

1978Postdoctoral Fellowship, University of Colorado

Education/Academic qualification

PhD, Pennsylvania State University

… → 1975

Keywords

  • Autoimmune Diseases
  • Immune Regulation
  • Immunology
  • Multiple Sclerosis
  • Neuroscience
  • Transplantation
  • Viral Pathogenesis
  • Diabetes
  • Endocrinology
  • Metabolism

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Grants 1997 2022

Immune Tolerance
Myelin Sheath
Multiple Sclerosis
Autoimmune Experimental Encephalomyelitis
T-Lymphocytes
Nanoparticles
Monocytes
Macrophages
Skin
Fibrosis
Type 1 Diabetes Mellitus
Nanoparticles
Immune Tolerance
Insulin-Secreting Cells
T-Lymphocytes

Research Output 1974 2019

Designing drug-free biodegradable nanoparticles to modulate inflammatory monocytes and neutrophils for ameliorating inflammation

Saito, E., Kuo, R., Pearson, R. M., Gohel, N., Cheung, B., King, N. J. C., Miller, S. D. & Shea, L. D., Apr 28 2019, In : Journal of Controlled Release. 300, p. 185-196 12 p.

Research output: Contribution to journalArticle

Nanoparticles
Monocytes
Neutrophils
Autoimmune Experimental Encephalomyelitis
Inflammation
1 Citation (Scopus)

Sephin1, which prolongs the integrated stress response, is a promising therapeutic for multiple sclerosis

Chen, Y., Podojil, J. R., Kunjamma, R. B., Jones, J., Weiner, M., Lin, W., Miller, S. D. & Popko, B., Feb 1 2019, In : Brain. 142, 2, p. 344-361 18 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Oligodendroglia
Therapeutics
Autoimmune Experimental Encephalomyelitis
CNS Demyelinating Autoimmune Diseases
9 Citations (Scopus)

APOBEC-mediated mutagenesis in urothelial carcinoma is associated with improved survival, mutations in DNA damage response genes, and immune response

Glaser, A. P., Fantini, D., Wang, Y., Yu, Y., Rimar, K. J., Podojil, J. R., Miller, S. D. & Meeks, J. J., Jan 1 2018, In : Oncotarget. 9, 4, p. 4537-4548 12 p.

Research output: Contribution to journalArticle

Mutagenesis
DNA Damage
Carcinoma
Mutation
Survival
2 Citations (Scopus)

B7-H4 modulates regulatory CD4+T cell induction and function via ligation of a semaphorin 3a/Plexin A4/Neuropilin-1 Complex

Podojil, J. R., Chiang, M. Y., Ifergan, I., Copeland, R., Liu, L. N., Maloveste, S., Langermann, S., Liebenson, D., Balabanov, R. D., Chi, H., Chen, L., Vignali, D. A. A. & Miller, S. D., Aug 1 2018, In : Journal of Immunology. 201, 3, p. 897-907 11 p.

Research output: Contribution to journalArticle

Semaphorin-3A
Neuropilin-1
Regulatory T-Lymphocytes
Ligation
Semaphorins
5 Citations (Scopus)

Conjugation of Transforming Growth Factor Beta to Antigen-Loaded Poly(lactide- co -glycolide) Nanoparticles Enhances Efficiency of Antigen-Specific Tolerance

Casey, L. M., Pearson, R. M., Hughes, K. R., Liu, J. M. H., Rose, J. A., North, M. G., Wang, L. Z., Lei, M., Miller, S. D. & Shea, L. D., Mar 21 2018, In : Bioconjugate Chemistry. 29, 3, p. 813-823 11 p.

Research output: Contribution to journalArticle

Polyglactin 910
Antigens
Transforming Growth Factor beta
Nanoparticles
Autoimmunity