Grants per year
Personal profile
Research Interests
The laboratory is interested in understanding the mechanisms underlying the pathogenesis and immunoregulation of T cell-mediated autoimmune diseases, allergic disease, and rejection of tissue and organ transplants. In particular, we are studying the therapeutic use of short-term administration of costimulatory molecule agonists/antagonists and specific immune tolerance induced by infusion of antigen-coupled apoptotic cells and PLG nanoparticles for the treatment of animal models of multiple sclerosis and type 1 diabetes, allergic airway disease, as well as using tolerance for specific prevention of rejection of allogeneic and xenogeneic tissue and organ transplants.
Training Experience
| 1978 | Postdoctoral Fellowship, University of Colorado |
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Pennsylvania State University
… → 1975
Research interests
- Autoimmune Diseases
- Diabetes
- Endocrinology
- Immune Regulation
- Immunology
- Metabolism
- Multiple Sclerosis
- Neuroscience
- Transplantation
- Viral Pathogenesis
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Dissecting mechanisms by which PD1 deletions drive aggressive cutaneous T cell lymphoma
7/13/21 → 7/12/22
Project: Research project
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Mechanisms of ILDR2-mFc (CGEN15001) Therapy of Type-1 Diabetes
Miller, S. D. & Podojil, J. R.
6/1/21 → 5/31/23
Project: Research project
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Allergen loaded nanoparticles for food allergy tolerance
University of Michigan, National Institute of Allergy and Infectious Diseases
9/16/20 → 8/31/25
Project: Research project
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Diversity Supplement for Sarah Sanchez, Interferon-modulated vaccines against HIV
Penaloza-MacMaster, P. & Miller, S. D.
National Institute on Drug Abuse
7/1/20 → 6/30/24
Project: Research project
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TAK-101 Nanoparticles Induce Gluten-Specific Tolerance in Celiac Disease: A Randomized, Double-Blind, Placebo-Controlled Study
TAK-101 Study Group, Jul 2021, In: Gastroenterology. 161, 1, p. 66-80.e8Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Targeting CD38-dependent NAD+ metabolism to mitigate multiple organ fibrosis
Shi, B., Wang, W., Korman, B. D., Kai, L., Wang, Q., Wei, J., Bale, S., Goncalves Marangoni, R., Bhattacharyya, S., Miller, S., Xu, D., Akbarpour, M., Cheresh, P., Proccissi, D., Gursel, D., Espindola-Netto, J. M., Chini, C. C. S., de Oliveira, G. C., Gudjonsson, J. E., Chini, E. N. & 1 others, , Jan 22 2021, In: iScience. 24, 1, 101902.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Antibody targeting of B7-H4 enhances the immune response in urothelial carcinoma
Podojil, J. R., Glaser, A. P., Baker, D., Courtois, E. T., Fantini, D., Yu, Y., Eaton, V., Sivajothi, S., Chiang, M., Das, A., McLaughlin, K. A., Robson, P., Miller, S. D. & Meeks, J. J., Jan 1 2020, In: OncoImmunology. 9, 1, 1744897.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis
Morris, A. H., Hughes, K. R., Oakes, R. S., Cai, M. M., Miller, S. D., Irani, D. N. & Shea, L. D., Dec 1 2020, In: Nature communications. 11, 1, 3871.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Gliadin Nanoparticles Induce Immune Tolerance to Gliadin in Mouse Models of Celiac Disease
Freitag, T. L., Podojil, J. R., Pearson, R. M., Fokta, F. J., Sahl, C., Messing, M., Andersson, L. C., Leskinen, K., Saavalainen, P., Hoover, L. I., Huang, K., Phippard, D., Maleki, S., King, N. J. C., Shea, L. D., Miller, S. D., Meri, S. K. & Getts, D. R., May 2020, In: Gastroenterology. 158, 6, p. 1667-1681.e12Research output: Contribution to journal › Article › peer-review
21 Scopus citations