Grants per year
Personal profile
Research Interests
The laboratory is interested in understanding the mechanisms underlying the pathogenesis and immunoregulation of T cell-mediated autoimmune diseases, allergic disease, and rejection of tissue and organ transplants. In particular, we are studying the therapeutic use of short-term administration of costimulatory molecule agonists/antagonists and specific immune tolerance induced by infusion of antigen-coupled apoptotic cells and PLG nanoparticles for the treatment of animal models of multiple sclerosis and type 1 diabetes, allergic airway disease, as well as using tolerance for specific prevention of rejection of allogeneic and xenogeneic tissue and organ transplants.
Training Experience
| 1978 | Postdoctoral Fellowship, University of Colorado |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Pennsylvania State University
… → 1975
Research interests
- Autoimmune Diseases
- Diabetes
- Endocrinology
- Immune Regulation
- Immunology
- Metabolism
- Multiple Sclerosis
- Neuroscience
- Transplantation
- Viral Pathogenesis
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Core C for Dr. Stephen Miller
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/17/21 → 7/31/25
Project: Research project
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Barrier Damage and The Immune Cascade: Northwestern University CounterACT Center of Excellence (NUCCX) *Admin Core A*
Lu, K., Lavker, R. M., Guitart, J., Kennedy, M., Kim, K. A., Paller, A., Peng, H., Perez White, B. E., Dravid, V. P., Gianneschi, N., Goldberg, B. B., Le Poole, I. C., Miller, S. D., Nguyen, S., Rangel, S. M., Thaxton, C. S. & Xu, D.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/17/21 → 7/31/25
Project: Research project
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Mechanisms of ILDR2-mFc (CGEN15001) Therapy of Type-1 Diabetes
Miller, S. D. & Podojil, J. R.
6/1/21 → 5/31/23
Project: Research project
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Allergen loaded nanoparticles for food allergy tolerance
University of Michigan, National Institute of Allergy and Infectious Diseases
9/16/20 → 8/31/25
Project: Research project
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Biodegradable nanoparticles induce cGAS/STING-dependent reprogramming of myeloid cells to promote tumor immunotherapy
Podojil, J. R., Cogswell, A. C., Chiang, M. Y., Eaton, V., Ifergan, I., Neef, T., Xu, D., Meghani, K. A., Yu, Y., Orbach, S. M., Murthy, T., Boyne, M. T., Elhofy, A., Shea, L. D., Meeks, J. J. & Miller, S. D., Aug 18 2022, In: Frontiers in immunology. 13, 887649.Research output: Contribution to journal › Article › peer-review
Open Access -
Mechanistic contributions of Kupffer cells and liver sinusoidal endothelial cells in nanoparticle-induced antigen-specific immune tolerance
Casey, L. M., Hughes, K. R., Saunders, M. N., Miller, S. D., Pearson, R. M. & Shea, L. D., Apr 2022, In: Biomaterials. 283, 121457.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
PLG nanoparticles target fibroblasts and MARCO+ monocytes to reverse multiorgan fibrosis
Xu, D., Bhattacharyya, S., Wang, W., Ifergan, I., Wong, M. Y. A. C., Procissi, D., Yeldandi, A., Bale, S., Marangoni, R. G., Horbinski, C., Miller, S. D. & Varga, J., Mar 8 2022, In: JCI Insight. 7, 5, e151037.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Repurposing the cardiac glycoside digoxin to stimulate myelin regeneration in chemically-induced and immune-mediated mouse models of multiple sclerosis
Titus, H. E., Xu, H., Robinson, A. P., Patel, P. A., Chen, Y., Fantini, D., Eaton, V., Karl, M., Garrison, E. D., Rose, I. V. L., Chiang, M. Y., Podojil, J. R., Balabanov, R., Liddelow, S. A., Miller, R. H., Popko, B. & Miller, S. D., Oct 2022, In: Glia. 70, 10, p. 1950-1970 21 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Tolerogenic Delivery of a Hybrid Insulin Peptide Markedly Prolongs Islet Graft Survival in the NOD Mouse
Jamison, B. L., Dilisio, J. E., Scott Beard, K., Neef, T., Bradley, B., Goodman, J., Gill, R. G., Miller, S. D., Baker, R. L. & Haskins, K., Mar 2022, In: Diabetes. 71, 3, p. 483-496 14 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations