Stephen D Miller

  • 22082 Citations
1974 …2022
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Personal profile

Research Interests

The laboratory is interested in understanding the mechanisms underlying the pathogenesis and immunoregulation of T cell-mediated autoimmune diseases, allergic disease, and rejection of tissue and organ transplants. In particular, we are studying the therapeutic use of short-term administration of costimulatory molecule agonists/antagonists and specific immune tolerance induced by infusion of antigen-coupled apoptotic cells and PLG nanoparticles for the treatment of animal models of multiple sclerosis and type 1 diabetes, allergic airway disease, as well as using tolerance for specific prevention of rejection of allogeneic and xenogeneic tissue and organ transplants.

Training Experience

1978Postdoctoral Fellowship, University of Colorado

Education/Academic qualification

PhD, Pennsylvania State University

… → 1975


  • Autoimmune Diseases
  • Immune Regulation
  • Immunology
  • Multiple Sclerosis
  • Neuroscience
  • Transplantation
  • Viral Pathogenesis
  • Diabetes
  • Endocrinology
  • Metabolism

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Grants 1997 2022

Immune Tolerance
Myelin Sheath
Multiple Sclerosis
Autoimmune Experimental Encephalomyelitis
Type 1 Diabetes Mellitus
Immune Tolerance
Insulin-Secreting Cells

Research Output 1974 2019

Designing drug-free biodegradable nanoparticles to modulate inflammatory monocytes and neutrophils for ameliorating inflammation

Saito, E., Kuo, R., Pearson, R. M., Gohel, N., Cheung, B., King, N. J. C., Miller, S. D. & Shea, L. D., Apr 28 2019, In : Journal of Controlled Release. 300, p. 185-196 12 p.

Research output: Contribution to journalArticle

Autoimmune Experimental Encephalomyelitis
1 Citation (Scopus)

Sephin1, which prolongs the integrated stress response, is a promising therapeutic for multiple sclerosis

Chen, Y., Podojil, J. R., Kunjamma, R. B., Jones, J., Weiner, M., Lin, W., Miller, S. D. & Popko, B., Feb 1 2019, In : Brain. 142, 2, p. 344-361 18 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Autoimmune Experimental Encephalomyelitis
CNS Demyelinating Autoimmune Diseases
9 Citations (Scopus)

APOBEC-mediated mutagenesis in urothelial carcinoma is associated with improved survival, mutations in DNA damage response genes, and immune response

Glaser, A. P., Fantini, D., Wang, Y., Yu, Y., Rimar, K. J., Podojil, J. R., Miller, S. D. & Meeks, J. J., Jan 1 2018, In : Oncotarget. 9, 4, p. 4537-4548 12 p.

Research output: Contribution to journalArticle

DNA Damage
2 Citations (Scopus)

B7-H4 modulates regulatory CD4+T cell induction and function via ligation of a semaphorin 3a/Plexin A4/Neuropilin-1 Complex

Podojil, J. R., Chiang, M. Y., Ifergan, I., Copeland, R., Liu, L. N., Maloveste, S., Langermann, S., Liebenson, D., Balabanov, R. D., Chi, H., Chen, L., Vignali, D. A. A. & Miller, S. D., Aug 1 2018, In : Journal of Immunology. 201, 3, p. 897-907 11 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
5 Citations (Scopus)

Conjugation of Transforming Growth Factor Beta to Antigen-Loaded Poly(lactide- co -glycolide) Nanoparticles Enhances Efficiency of Antigen-Specific Tolerance

Casey, L. M., Pearson, R. M., Hughes, K. R., Liu, J. M. H., Rose, J. A., North, M. G., Wang, L. Z., Lei, M., Miller, S. D. & Shea, L. D., Mar 21 2018, In : Bioconjugate Chemistry. 29, 3, p. 813-823 11 p.

Research output: Contribution to journalArticle

Polyglactin 910
Transforming Growth Factor beta