• 22898 Citations
1974 …2022
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Personal profile

Research Interests

The laboratory is interested in understanding the mechanisms underlying the pathogenesis and immunoregulation of T cell-mediated autoimmune diseases, allergic disease, and rejection of tissue and organ transplants. In particular, we are studying the therapeutic use of short-term administration of costimulatory molecule agonists/antagonists and specific immune tolerance induced by infusion of antigen-coupled apoptotic cells and PLG nanoparticles for the treatment of animal models of multiple sclerosis and type 1 diabetes, allergic airway disease, as well as using tolerance for specific prevention of rejection of allogeneic and xenogeneic tissue and organ transplants.

Training Experience

1978Postdoctoral Fellowship, University of Colorado

Education/Academic qualification

PhD, Pennsylvania State University

… → 1975

Research interests

  • Autoimmune Diseases
  • Diabetes
  • Endocrinology
  • Immune Regulation
  • Immunology
  • Metabolism
  • Multiple Sclerosis
  • Neuroscience
  • Transplantation
  • Viral Pathogenesis

Fingerprint Dive into the research topics where Stephen D Miller is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 13 Similar Profiles
Theilovirus Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Autoimmune Experimental Encephalomyelitis Medicine & Life Sciences
Demyelinating Diseases Medicine & Life Sciences
Multiple Sclerosis Medicine & Life Sciences
Epitopes Medicine & Life Sciences
Antigens Medicine & Life Sciences
Autoimmune Diseases Medicine & Life Sciences

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Grants 1997 2022

Cellular Microenvironment
Tumor Microenvironment
Urinary Bladder Neoplasms
Research Design
Drug products
Immune Tolerance
Myelin Sheath
Multiple Sclerosis
Autoimmune Experimental Encephalomyelitis

Research Output 1974 2019

5 Citations (Scopus)

Designing drug-free biodegradable nanoparticles to modulate inflammatory monocytes and neutrophils for ameliorating inflammation

Saito, E., Kuo, R., Pearson, R. M., Gohel, N., Cheung, B., King, N. J. C., Miller, S. D. & Shea, L. D., Apr 28 2019, In : Journal of Controlled Release. 300, p. 185-196 12 p.

Research output: Contribution to journalArticle

Autoimmune Experimental Encephalomyelitis

Design of biodegradable nanoparticles to modulate phenotypes of antigen-presenting cells for antigen-specific treatment of autoimmune disease

Saito, E., Kuo, R., Kramer, K. R., Gohel, N., Giles, D. A., Moore, B. B., Miller, S. D. & Shea, L. D., Nov 2019, In : Biomaterials. 222, 119432.

Research output: Contribution to journalArticle

Antigen-Presenting Cells
Autoimmune Diseases

Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes

Singh, A., Ramachandran, S., Graham, M. L., Daneshmandi, S., Heller, D., Suarez-Pinzon, W. L., Balamurugan, A. N., Ansite, J. D., Wilhelm, J. J., Yang, A., Zhang, Y., Palani, N. P., Abrahante, J. E., Burlak, C., Miller, S. D., Luo, X. & Hering, B. J., Dec 1 2019, In : Nature communications. 10, 1, 3495.

Research output: Contribution to journalArticle

Open Access
Transplantation Tolerance

Nanoparticles containing an insulin-ChGA hybrid peptide protect from transfer of autoimmune diabetes by shifting the balance between effector T cells and regulatory T cells

Jamison, B. L., Neef, T., Goodspeed, A., Bradley, B., Baker, R. L., Miller, S. D. & Haskins, K., Jan 1 2019, In : Journal of Immunology. 203, 1, p. 48-57 10 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Type 1 Diabetes Mellitus
3 Citations (Scopus)

Overcoming challenges in treating autoimmuntity: Development of tolerogenic immune-modifying nanoparticles

Pearson, R. M., Podojil, J. R., Shea, L. D., King, N. J. C., Miller, S. D. & Getts, D. R., Jun 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 18, p. 282-291 10 p.

Research output: Contribution to journalReview article

Celiac Disease
Autoimmune Diseases
Clinical Trials