• 23768 Citations
1974 …2020

Research output per year

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Personal profile

Research Interests

The laboratory is interested in understanding the mechanisms underlying the pathogenesis and immunoregulation of T cell-mediated autoimmune diseases, allergic disease, and rejection of tissue and organ transplants. In particular, we are studying the therapeutic use of short-term administration of costimulatory molecule agonists/antagonists and specific immune tolerance induced by infusion of antigen-coupled apoptotic cells and PLG nanoparticles for the treatment of animal models of multiple sclerosis and type 1 diabetes, allergic airway disease, as well as using tolerance for specific prevention of rejection of allogeneic and xenogeneic tissue and organ transplants.

Training Experience

1978Postdoctoral Fellowship, University of Colorado

Education/Academic qualification

PhD, Pennsylvania State University

… → 1975

Research interests

  • Autoimmune Diseases
  • Diabetes
  • Endocrinology
  • Immune Regulation
  • Immunology
  • Metabolism
  • Multiple Sclerosis
  • Neuroscience
  • Transplantation
  • Viral Pathogenesis

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Grants

  • Research Output

    Antibody targeting of B7-H4 enhances the immune response in urothelial carcinoma

    Podojil, J. R., Glaser, A. P., Baker, D., Courtois, E. T., Fantini, D., Yu, Y., Eaton, V., Sivajothi, S., Chiang, M., Das, A., McLaughlin, K. A., Robson, P., Miller, S. D. & Meeks, J. J., Jan 1 2020, In : OncoImmunology. 9, 1, 1744897.

    Research output: Contribution to journalArticle

    Open Access
  • Gliadin Nanoparticles Induce Immune Tolerance to Gliadin in Mouse Models of Celiac Disease

    Freitag, T. L., Podojil, J. R., Pearson, R. M., Fokta, F. J., Sahl, C., Messing, M., Andersson, L. C., Leskinen, K., Saavalainen, P., Hoover, L. I., Huang, K., Phippard, D., Maleki, S., King, N. J. C., Shea, L. D., Miller, S. D., Meri, S. K. & Getts, D. R., May 2020, In : Gastroenterology. 158, 6, p. 1667-1681.e12

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Herpesvirus entry mediator binding partners mediate immunopathogenesis of ocular herpes simplex virus 1 infection

    Park, S. J., Riccio, R. E., Kopp, S. J., Ifergan, I., Miller, S. D. & Longnecker, R., Jan 1 2020, In : mBio. 11, 3, e00790-20.

    Research output: Contribution to journalArticle

    Open Access
  • Immunosuppressive IDO in Cancer: Mechanisms of Action, Animal Models, and Targeting Strategies

    Zhai, L., Bell, A., Ladomersky, E., Lauing, K. L., Bollu, L., Sosman, J. A., Zhang, B., Wu, J. D., Miller, S. D., Meeks, J. J., Lukas, R. V., Wyatt, E. J., Doglio, L., Schiltz, G. E., McCusker, R. H. & Wainwright, D. A., Jun 16 2020, In : Frontiers in immunology. 11, 1185.

    Research output: Contribution to journalReview article

    Open Access
  • Intravenous Immunomodulatory Nanoparticle Treatment for Traumatic Brain Injury

    Sharma, S., Ifergan, I., Kurz, J. E., Linsenmeier, R. A., Xu, D., Cooper, J. G., Miller, S. D. & Kessler, J. A., Mar 1 2020, In : Annals of neurology. 87, 3, p. 442-455 14 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations