• 22670 Citations
1974 …2022
If you made any changes in Pure, your changes will be visible here soon.

Personal profile

Research Interests

The laboratory is interested in understanding the mechanisms underlying the pathogenesis and immunoregulation of T cell-mediated autoimmune diseases, allergic disease, and rejection of tissue and organ transplants. In particular, we are studying the therapeutic use of short-term administration of costimulatory molecule agonists/antagonists and specific immune tolerance induced by infusion of antigen-coupled apoptotic cells and PLG nanoparticles for the treatment of animal models of multiple sclerosis and type 1 diabetes, allergic airway disease, as well as using tolerance for specific prevention of rejection of allogeneic and xenogeneic tissue and organ transplants.

Training Experience

1978Postdoctoral Fellowship, University of Colorado

Education/Academic qualification

PhD, Pennsylvania State University

… → 1975

Research interests

  • Autoimmune Diseases
  • Diabetes
  • Endocrinology
  • Immune Regulation
  • Immunology
  • Metabolism
  • Multiple Sclerosis
  • Neuroscience
  • Transplantation
  • Viral Pathogenesis

Fingerprint Dive into the research topics where Stephen D Miller is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 13 Similar Profiles
Theilovirus Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Autoimmune Experimental Encephalomyelitis Medicine & Life Sciences
Demyelinating Diseases Medicine & Life Sciences
Multiple Sclerosis Medicine & Life Sciences
Epitopes Medicine & Life Sciences
Antigens Medicine & Life Sciences
Autoimmune Diseases Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 1997 2022

Cellular Microenvironment
Tumor Microenvironment
Veterans
Urinary Bladder Neoplasms
Research Design
Drug products
Industry
Experiments
Availability
Immune Tolerance
Myelin Sheath
Multiple Sclerosis
Autoimmune Experimental Encephalomyelitis
T-Lymphocytes
Nanoparticles
Monocytes
Macrophages
Skin
Fibrosis

Research Output 1974 2019

2 Citations (Scopus)

Designing drug-free biodegradable nanoparticles to modulate inflammatory monocytes and neutrophils for ameliorating inflammation

Saito, E., Kuo, R., Pearson, R. M., Gohel, N., Cheung, B., King, N. J. C., Miller, S. D. & Shea, L. D., Apr 28 2019, In : Journal of Controlled Release. 300, p. 185-196 12 p.

Research output: Contribution to journalArticle

Nanoparticles
Monocytes
Neutrophils
Autoimmune Experimental Encephalomyelitis
Inflammation

Design of biodegradable nanoparticles to modulate phenotypes of antigen-presenting cells for antigen-specific treatment of autoimmune disease

Saito, E., Kuo, R., Kramer, K. R., Gohel, N., Giles, D. A., Moore, B. B., Miller, S. D. & Shea, L. D., Nov 1 2019, In : Biomaterials. 222, 119432.

Research output: Contribution to journalArticle

Antigen-Presenting Cells
Antigens
Nanoparticles
Autoimmune Diseases
Phenotype

Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes

Singh, A., Ramachandran, S., Graham, M. L., Daneshmandi, S., Heller, D., Suarez-Pinzon, W. L., Balamurugan, A. N., Ansite, J. D., Wilhelm, J. J., Yang, A., Zhang, Y., Palani, N. P., Abrahante, J. E., Burlak, C., Miller, S. D., Luo, X. & Hering, B. J., Dec 1 2019, In : Nature communications. 10, 1, 3495.

Research output: Contribution to journalArticle

Open Access
primates
Transplantation Tolerance
leukocytes
Primates
Allografts

Nanoparticles containing an insulin-ChGA hybrid peptide protect from transfer of autoimmune diabetes by shifting the balance between effector T cells and regulatory T cells

Jamison, B. L., Neef, T., Goodspeed, A., Bradley, B., Baker, R. L., Miller, S. D. & Haskins, K., Jan 1 2019, In : Journal of Immunology. 203, 1, p. 48-57 10 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Type 1 Diabetes Mellitus
Nanoparticles
Insulin
T-Lymphocytes
2 Citations (Scopus)

Overcoming challenges in treating autoimmuntity: Development of tolerogenic immune-modifying nanoparticles

Pearson, R. M., Podojil, J. R., Shea, L. D., King, N. J. C., Miller, S. D. & Getts, D. R., Jun 1 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 18, p. 282-291 10 p.

Research output: Contribution to journalReview article

Nanoparticles
Celiac Disease
T-Lymphocytes
Autoimmune Diseases
Clinical Trials