Grants per year
Personal profile
Research Interests
The laboratory is interested in understanding the mechanisms underlying the pathogenesis and immunoregulation of T cell-mediated autoimmune diseases, allergic disease, and rejection of tissue and organ transplants. In particular, we are studying the therapeutic use of short-term administration of costimulatory molecule agonists/antagonists and specific immune tolerance induced by infusion of antigen-coupled apoptotic cells and PLG nanoparticles for the treatment of animal models of multiple sclerosis and type 1 diabetes, allergic airway disease, as well as using tolerance for specific prevention of rejection of allogeneic and xenogeneic tissue and organ transplants.
Training Experience
| 1978 | Postdoctoral Fellowship, University of Colorado |
Education/Academic qualification
PhD, Pennsylvania State University
… → 1975
Keywords
- Autoimmune Diseases
- Immune Regulation
- Immunology
- Multiple Sclerosis
- Neuroscience
- Transplantation
- Viral Pathogenesis
- Diabetes
- Endocrinology
- Metabolism
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 1997 2022
Combining Immune Tolerance and Myelin Repair Therapy in T cell-driven MS Models
National Institute of Allergy and Infectious Diseases
2/11/19 → 1/31/21
Project: Research project
Immune Tolerance
Myelin Sheath
Multiple Sclerosis
Autoimmune Experimental Encephalomyelitis
T-Lymphocytes
A novel therapy for scleroderma using biodegradable nanoparticles
Miller, S. D., Varga, J. & Xu, D.
9/1/18 → 8/31/21
Project: Research project
Nanoparticles
Monocytes
Macrophages
Skin
Fibrosis
Translation of novel and repurposed drugs to address the acute and late effects of mustard exposure
Miller, S. D., West, D. P. & Lu, K.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
8/1/18 → 7/31/22
Project: Research project
Drug Repositioning
Mustard Plant
Skin
Spironolactone
Diphosphonates
Regulation of the Profibrotic Mechanisms of MACRO+ Myeloid Cells in Scleroderma
Bhattacharyya, S., Miller, S. D., Varga, J. & Xu, D.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
6/1/18 → 5/31/20
Project: Research project
Myeloid Cells
Monocytes
Macrophages
Nanoparticles
Fibrosis
Postdoctoral Fellowship for Tobias Neef: Biodegradable PLG Nanoparticles for Tolerance Induction in Type 1 Diabetes
2/1/18 → 1/31/21
Project: Research project
Type 1 Diabetes Mellitus
Nanoparticles
Immune Tolerance
Insulin-Secreting Cells
T-Lymphocytes
Research Output 1974 2019
Designing drug-free biodegradable nanoparticles to modulate inflammatory monocytes and neutrophils for ameliorating inflammation
Saito, E., Kuo, R., Pearson, R. M., Gohel, N., Cheung, B., King, N. J. C., Miller, S. D. & Shea, L. D., Apr 28 2019, In : Journal of Controlled Release. 300, p. 185-196 12 p.Research output: Contribution to journal › Article
Nanoparticles
Monocytes
Neutrophils
Autoimmune Experimental Encephalomyelitis
Inflammation
1
Citation
(Scopus)
Sephin1, which prolongs the integrated stress response, is a promising therapeutic for multiple sclerosis
Chen, Y., Podojil, J. R., Kunjamma, R. B., Jones, J., Weiner, M., Lin, W., Miller, S. D. & Popko, B., Feb 1 2019, In : Brain. 142, 2, p. 344-361 18 p.Research output: Contribution to journal › Article
Multiple Sclerosis
Oligodendroglia
Therapeutics
Autoimmune Experimental Encephalomyelitis
CNS Demyelinating Autoimmune Diseases
9
Citations
(Scopus)
APOBEC-mediated mutagenesis in urothelial carcinoma is associated with improved survival, mutations in DNA damage response genes, and immune response
Glaser, A. P., Fantini, D., Wang, Y., Yu, Y., Rimar, K. J., Podojil, J. R., Miller, S. D. & Meeks, J. J., Jan 1 2018, In : Oncotarget. 9, 4, p. 4537-4548 12 p.Research output: Contribution to journal › Article
Mutagenesis
DNA Damage
Carcinoma
Mutation
Survival
2
Citations
(Scopus)
B7-H4 modulates regulatory CD4+T cell induction and function via ligation of a semaphorin 3a/Plexin A4/Neuropilin-1 Complex
Podojil, J. R., Chiang, M. Y., Ifergan, I., Copeland, R., Liu, L. N., Maloveste, S., Langermann, S., Liebenson, D., Balabanov, R. D., Chi, H., Chen, L., Vignali, D. A. A. & Miller, S. D., Aug 1 2018, In : Journal of Immunology. 201, 3, p. 897-907 11 p.Research output: Contribution to journal › Article
Semaphorin-3A
Neuropilin-1
Regulatory T-Lymphocytes
Ligation
Semaphorins
5
Citations
(Scopus)
Conjugation of Transforming Growth Factor Beta to Antigen-Loaded Poly(lactide- co -glycolide) Nanoparticles Enhances Efficiency of Antigen-Specific Tolerance
Casey, L. M., Pearson, R. M., Hughes, K. R., Liu, J. M. H., Rose, J. A., North, M. G., Wang, L. Z., Lei, M., Miller, S. D. & Shea, L. D., Mar 21 2018, In : Bioconjugate Chemistry. 29, 3, p. 813-823 11 p.Research output: Contribution to journal › Article
Polyglactin 910
Antigens
Transforming Growth Factor beta
Nanoparticles
Autoimmunity