Grants per year
Personal profile
Research Interests
The Centers for Disease Control and Prevention (CDC) have estimated that nearly 2 million people sustain a traumatic brain injury (TBI) annually in the United States. Of these cases, over 300,000 patients require in-patient hospitalization and over 50,000 people die. In fact, TBI is a contributing factor to over 30% of all injury related deaths in the United States. The leading cause of death after TBI is infection and its resultant multisystem organ failure. Several studies have demonstrated that TBI results in a rapid and profound immune suppression. The proposed mechanism by which TBI leaves patients susceptible to secondary infection involves a brain-mediated switch towards an overall anti-inflammatory state. Previous studies have shown that preventing this switch towards an anti-inflammatory state may be a novel approach to treating a myriad of infection related problems after injury. The guiding hypothesis of my laboratory is that preventing the TBI-induced anti-inflammatory response will improve survival from secondary infection after TBI. Thus, therapies targeted toward preventing an anti-inflammatory response to brain injury may emerge as a novel tool to combat this highly lethal disorder.
Certifications and Licenses
| Surgical Critical Care | |
| General Surgery |
Training Experience
| 2007 | Postdoctoral Fellowship, Washington University School of Medicine |
| 2010 | Residency, Barnes Hospital, Washington University School of Medicine, St. Louis |
| 2011 | Fellowship, Washington University School of Medicine |
Education/Academic qualification
MD, University of Illinois at Chicago
… → 2003
Research interests
- Brain Trauma
- Immune Regulation
- Infectious Diseases: Bacteria
- Injury Prevention
- Trauma
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Grants
The role of innate immunity in the traumatic brain injury-induced immune suppression syndrome
National Institute of General Medical Sciences
9/20/15 → 8/31/19
Project: Research project
The role of innate immunity in traumatic brain injury-induced immune suppression.
7/1/15 → 6/30/18
Project: Research project
The role of innate immunity in the traumatic brain injury-induced immune suppression syndrome
Central Surgical Association Foundation
5/1/15 → 10/31/16
Project: Research project
Research Output
Microglia Adopt Longitudinal Transcriptional Changes After Traumatic Brain Injury
Makinde, H. M., Just, T. B., Gadhvi, G. T., Winter, D. R. & Schwulst, S. J., Feb 1 2020, In : Journal of Surgical Research. 246, p. 113-122 10 p.Research output: Contribution to journal › Article
1
Scopus
citations
Diagnostic Imaging in Pregnant Patients with Suspected Appendicitis
Schwulst, S. J. & Son, M., Jan 1 2019, In : JAMA - Journal of the American Medical Association.Research output: Contribution to journal › Short survey
3
Scopus
citations
Murine model of controlled cortical impact for the induction of traumatic brain injury
Schwulst, S. J. & Islam, M. B. A. R., Aug 2019, In : Journal of Visualized Experiments. 2019, 150, e60027.Research output: Contribution to journal › Article
What's new in shock, October 2019?
Schwulst, S. J. & Turnbull, I. R., Oct 1 2019, In : Shock. 52, 4, p. 397-399 3 p.Research output: Contribution to journal › Comment/debate
Monocyte depletion attenuates the development of posttraumatic hydrocephalus and preserves white matter integrity after traumatic brain injury
Makinde, H. M., Just, T. B., Cuda, C. M., Bertolino, N., Procissi, D. & Schwulst, S. J., Nov 2018, In : PloS one. 13, 11, e0202722.Research output: Contribution to journal › Article
7
Scopus
citations