Steven J Schwulst

  • 413 Citations
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Personal profile

Research Interests

The Centers for Disease Control and Prevention (CDC) have estimated that nearly 2 million people sustain a traumatic brain injury (TBI) annually in the United States. Of these cases, over 300,000 patients require in-patient hospitalization and over 50,000 people die. In fact, TBI is a contributing factor to over 30% of all injury related deaths in the United States. The leading cause of death after TBI is infection and its resultant multisystem organ failure. Several studies have demonstrated that TBI results in a rapid and profound immune suppression. The proposed mechanism by which TBI leaves patients susceptible to secondary infection involves a brain-mediated switch towards an overall anti-inflammatory state. Previous studies have shown that preventing this switch towards an anti-inflammatory state may be a novel approach to treating a myriad of infection related problems after injury. The guiding hypothesis of my laboratory is that preventing the TBI-induced anti-inflammatory response will improve survival from secondary infection after TBI. Thus, therapies targeted toward preventing an anti-inflammatory response to brain injury may emerge as a novel tool to combat this highly lethal disorder.

Certifications and Licenses

Surgical Critical Care
General Surgery

Training Experience

2007Postdoctoral Fellowship, Washington University School of Medicine
2010Residency, Barnes Hospital, Washington University School of Medicine, St. Louis
2011Fellowship, Washington University School of Medicine

Education/Academic qualification

MD, University of Illinois - Chicago

… → 2003

Research interests

  • Brain Trauma
  • Immune Regulation
  • Infectious Diseases: Bacteria
  • Injury Prevention
  • Trauma

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  • 1 Similar Profiles
Sepsis Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Lymphocytes Medicine & Life Sciences
Monocytes Medicine & Life Sciences
Wounds and Injuries Medicine & Life Sciences
Appendicitis Medicine & Life Sciences
Microglia Medicine & Life Sciences
Patient Care Bundles Medicine & Life Sciences

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Grants 2012 2024

Corpus Striatum
Protein Tyrosine Phosphatases
Traumatic Brain Injury
Innate Immunity
Centers for Disease Control and Prevention (U.S.)
Health Expenditures
Cause of Death
Delivery of Health Care
Innate Immunity
Anti-Inflammatory Agents
Innate Immunity
Wounds and Injuries
Anti-Inflammatory Agents
Innate Immunity
Brain Injuries

Research Output 2002 2019

  • 413 Citations
  • 21 Article
  • 2 Chapter
  • 2 Review article
  • 1 Short survey
Diagnostic Imaging
2 Citations (Scopus)

Monocyte depletion attenuates the development of posttraumatic hydrocephalus and preserves white matter integrity after traumatic brain injury

Makinde, H. M., Just, T. B., Cuda, C. M., Bertolino, N., Procissi, D. & Schwulst, S. J., Nov 1 2018, In : PloS one. 13, 11, e0202722.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Nonclassical monocytes mediate secondary injury, neurocognitive outcome, and neutrophil infiltration after traumatic brain injury

Makinde, H. M., Cuda, C. M., Just, T. B., Perlman, H. R. & Schwulst, S. J., Nov 15 2017, In : Journal of Immunology. 199, 10, p. 3583-3591 9 p.

Research output: Contribution to journalArticle

Neutrophil Infiltration
Wounds and Injuries
Traumatic Brain Injury
8 Citations (Scopus)

The Role of Microglia in the Etiology and Evolution of Chronic Traumatic Encephalopathy

Makinde, H. M., Just, T. B., Cuda, C. M., Perlman, H. & Schwulst, S. J., Sep 1 2017, In : Shock. 48, 3, p. 276-283 8 p.

Research output: Contribution to journalReview article

tau Proteins
Neurofibrillary Tangles
Amyloid Plaques
Wounds and Injuries
13 Citations (Scopus)

Differential activation of infiltrating monocyte-derived cells after mild and severe traumatic brain injury

Trahanas, D. M., Cuda, C. M., Perlman, H. R. & Schwulst, S. J., Mar 1 2015, In : Shock. 43, 3, p. 255-260 6 p.

Research output: Contribution to journalArticle

Brain Concussion
Wounds and Injuries