Steven J Schwulst

  • 466 Citations
20022020

Research output per year

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Personal profile

Research Interests

The Centers for Disease Control and Prevention (CDC) have estimated that nearly 2 million people sustain a traumatic brain injury (TBI) annually in the United States. Of these cases, over 300,000 patients require in-patient hospitalization and over 50,000 people die. In fact, TBI is a contributing factor to over 30% of all injury related deaths in the United States. The leading cause of death after TBI is infection and its resultant multisystem organ failure. Several studies have demonstrated that TBI results in a rapid and profound immune suppression. The proposed mechanism by which TBI leaves patients susceptible to secondary infection involves a brain-mediated switch towards an overall anti-inflammatory state. Previous studies have shown that preventing this switch towards an anti-inflammatory state may be a novel approach to treating a myriad of infection related problems after injury. The guiding hypothesis of my laboratory is that preventing the TBI-induced anti-inflammatory response will improve survival from secondary infection after TBI. Thus, therapies targeted toward preventing an anti-inflammatory response to brain injury may emerge as a novel tool to combat this highly lethal disorder.

Certifications and Licenses

Surgical Critical Care
General Surgery

Training Experience

2007Postdoctoral Fellowship, Washington University School of Medicine
2010Residency, Barnes Hospital, Washington University School of Medicine, St. Louis
2011Fellowship, Washington University School of Medicine

Education/Academic qualification

MD, University of Illinois at Chicago

… → 2003

Research interests

  • Brain Trauma
  • Immune Regulation
  • Infectious Diseases: Bacteria
  • Injury Prevention
  • Trauma

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Grants

  • Research Output

    Microglia Adopt Longitudinal Transcriptional Changes After Traumatic Brain Injury

    Makinde, H. M., Just, T. B., Gadhvi, G. T., Winter, D. R. & Schwulst, S. J., Feb 1 2020, In : Journal of Surgical Research. 246, p. 113-122 10 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations
    3 Scopus citations

    Murine model of controlled cortical impact for the induction of traumatic brain injury

    Schwulst, S. J. & Islam, M. B. A. R., Aug 2019, In : Journal of Visualized Experiments. 2019, 150, e60027.

    Research output: Contribution to journalArticle

  • What's new in shock, October 2019?

    Schwulst, S. J. & Turnbull, I. R., Oct 1 2019, In : Shock. 52, 4, p. 397-399 3 p.

    Research output: Contribution to journalComment/debate

    Monocyte depletion attenuates the development of posttraumatic hydrocephalus and preserves white matter integrity after traumatic brain injury

    Makinde, H. M., Just, T. B., Cuda, C. M., Bertolino, N., Procissi, D. & Schwulst, S. J., Nov 2018, In : PloS one. 13, 11, e0202722.

    Research output: Contribution to journalArticle

  • 7 Scopus citations