Steven M Belknap

  • 2621 Citations
1987 …2019
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Personal profile

Research Interests

I am interested in computational medicine and specifically pharmacoalgorithmics, informally defined as "the study of what the drug prescription does to the patient." Drug therapy is more than just drugs, it includes the instructions for safely and effectively using the drugs and the resources to support those instructions (e.g., nurses, pharmacists, physicians, infusion pumps, and drug concentration measurements). A prescription is a health-care program implemented by a physician or other qualified practitioner in the form of instructions that govern the plan of care for an individual patient. Working with a team of investigators, I showed that application of computer programming design and debugging methods results in a marked increase in the safety of opioid prescriptions in hospitalized adults. The methods we have developed in pharmacoalgorithmics have application to reducing the risk of adverse drug events, optimizing the efficacy of drug therapy, and reducing the cost of medical care.

Training Experience

1985Residency, Roger Williams General Hospital

Education/Academic qualification

MD, Northwestern University Feinberg School of Medicine

… → 1982

Research interests

  • Clinical Pharmacology
  • Internal Medicine / General Medicine

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Pharmaceutical Preparations Medicine & Life Sciences
Safety Medicine & Life Sciences
Drug Labeling Medicine & Life Sciences
Pharmacovigilance Medicine & Life Sciences
Clinical Trials Medicine & Life Sciences

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Grants 2003 2019

Computer science
Computer programming languages
Software design
Software reliability
Computer programming languages
Computer science
Software design
Software reliability

Research Output 1987 2018

POP-PL: A patient-oriented prescription programming language

Florence, S. P., Fetscher, B., Flatt, M., Temps, W. H., St Amour, V., Kiguradze, T., West, D. P., Niznik, C., Yarnold, P. R., Findler, R. & Belknap, S. M., Aug 2018, In : ACM Transactions on Programming Languages and Systems. 40, 3, A10.

Research output: Contribution to journalArticle

Computer programming languages
Drug therapy
Electronic medical equipment
Health care


Belknap, S. M., Feb 21 2017, In : Annals of internal medicine. 166, 4, p. JC23

Research output: Contribution to journalComment/debate

25 Citations (Scopus)

Persistent erectile dysfunction in men exposed to the 5α-reductase inhibitors, finasteride, or dutasteride

Kiguradze, T., Temps, W. H., Yarnold, P. R., Cashy, J., Brannigan, R. E., Nardone, B., Micali, G., West, D. P. & Belknap, S. M., Jan 1 2017, In : PeerJ. 2017, 3, e3020.

Research output: Contribution to journalArticle

Erectile Dysfunction
nonsteroidal anti-inflammatory agents
adverse effects
6 Citations (Scopus)

Score of Toxic Epidermal Necrosis Predicts the Outcomes of Pediatric Epidermal Necrolysis

Sorrell, J., Anthony, L., Rademaker, A. W., Belknap, S. M., Callahan, S., West, D. P. & Paller, A., Jul 1 2017, In : Pediatric Dermatology. 34, 4, p. 433-437 5 p.

Research output: Contribution to journalArticle

Length of Stay
Stevens-Johnson Syndrome