• 2809 Citations
1991 …2019
If you made any changes in Pure, your changes will be visible here soon.

Personal profile

Research Interests

Nucleolus, nucleus, chromatin, nuclear structure and function, cancer, growth-regulations, signal-transductions,

Training Experience

1997Postdoctoral Fellowship, Cold Spring Harbor Laboratory

Education/Academic qualification

PhD, Rutgers University

… → 1990

MD, Fudan University

… → 1982


  • Cancer Biology
  • Cell Biology
  • Molecular Biology
  • Molecular Genetics
  • Nuclear Structure and Developmental Biology

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 7 Similar Profiles
Polypyrimidine Tract-Binding Protein Medicine & Life Sciences
RNA Precursors Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
RNA Medicine & Life Sciences
RNA Polymerase III Medicine & Life Sciences
Chromatin Medicine & Life Sciences
RNA-Binding Proteins Medicine & Life Sciences
amonafide Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2001 2017

Research Output 1991 2019

Chromosome conformation capture reveals two elements that interact with the PTBP3 (ROD1) transcription start site

Kubiak, M., Jurek, A., Kamińska, K., Kowalewski, J., Huang, S. & Lewandowska, M. A., Jan 1 2019, In : International journal of molecular sciences. 20, 2, 242.

Research output: Contribution to journalArticle

Polypyrimidine Tract-Binding Protein
Transcription Initiation Site
5 Citations (Scopus)

Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis

Frankowski, K. J., Wang, C., Patnaik, S., Schoenen, F. J., Southall, N., Li, D., Teper, Y., Sun, W., Kandela, I., Hu, D., Dextras, C., Knotts, Z., Bian, Y., Norton, J., Titus, S., Lewandowska, M. A., Wen, Y., Farley, K. I., Griner, L. M., Sultan, J. & 28 othersMeng, Z., Zhou, M., Vilimas, T., Powers, A. S., Kozlov, S., Nagashima, K., Quadri, H. S., Fang, M., Long, C., Khanolkar, O., Chen, W., Kang, J., Huang, H., Chow, E., Goldberg, E., Feldman, C., Xi, R., Kim, H. R., Sahagian, G., Baserga, S. J., Mazar, A., Ferrer, M., Zheng, W., Shilatifard, A., Aubé, J., Rudloff, U., Marugan, J. J. & Huang, S., May 16 2018, In : Science translational medicine. 10, 441, eaap8307.

Research output: Contribution to journalArticle

Neoplasm Metastasis
RNA Polymerase I
Peptide Elongation Factors
Pancreatic Neoplasms

Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-Kras G12D/+ ;Tp53 R172H/+ (KPC) mice, a genetically engineered model of pancreatic cancer

Vilimas, T., Wang, A. Q., Patnaik, S., Hughes, E. A., Singleton, M. D., Knotts, Z., Li, D., Frankowski, K., Schlomer, J. J., Guerin, T. M., Springer, S., Drennan, C., Dextras, C., Wang, C., Gilbert, D., Southall, N., Ferrer, M., Huang, S., Kozlov, S., Marugan, J. & 2 othersXu, X. & Rudloff, U., Dec 1 2018, In : Cancer Chemotherapy and Pharmacology. 82, 6, p. 1067-1080 14 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Area Under Curve
1 Citation (Scopus)

6-Methoxyethylamino-numonafide inhibits hepatocellular carcinoma xenograft growth as a single agent and in combination with sorafenib

Liu, Y., Lou, G., Norton, J. T., Wang, C., Kandela, I., Tang, S., Shank, N. I., Gupta, P., Huang, M., Avram, M. J., Green, R., Mazar, A., Appella, D., Chen, Z. & Huang, S., Jan 1 2017, In : FASEB Journal. 31, 12, p. 5453-5465 13 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
16 Citations (Scopus)

A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease

Rocchi, A., Yamamoto, S., Ting, T., Fan, Y., Sadleir, K., Wang, Y., Zhang, W., Huang, S., Levine, B., Vassar, R. & He, C., Aug 1 2017, In : PLoS Genetics. 13, 8, e1006962.

Research output: Contribution to journalArticle

Alzheimer disease