• 2809 Citations
1991 …2019
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Personal profile

Research Interests

Nucleolus, nucleus, chromatin, nuclear structure and function, cancer, growth-regulations, signal-transductions,

Training Experience

1997Postdoctoral Fellowship, Cold Spring Harbor Laboratory

Education/Academic qualification

PhD, Rutgers University

… → 1990

MD, Fudan University

… → 1982

Keywords

  • Cancer Biology
  • Cell Biology
  • Molecular Biology
  • Molecular Genetics
  • Nuclear Structure and Developmental Biology

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RNA-Binding Proteins Medicine & Life Sciences
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Grants 2001 2017

Research Output 1991 2019

Chromosome conformation capture reveals two elements that interact with the PTBP3 (ROD1) transcription start site

Kubiak, M., Jurek, A., Kamińska, K., Kowalewski, J., Huang, S. & Lewandowska, M. A., Jan 1 2019, In : International journal of molecular sciences. 20, 2, 242.

Research output: Contribution to journalArticle

Polypyrimidine Tract-Binding Protein
Transcription Initiation Site
chromosomes
chromatin
Transcription
5 Citations (Scopus)

Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis

Frankowski, K. J., Wang, C., Patnaik, S., Schoenen, F. J., Southall, N., Li, D., Teper, Y., Sun, W., Kandela, I., Hu, D., Dextras, C., Knotts, Z., Bian, Y., Norton, J., Titus, S., Lewandowska, M. A., Wen, Y., Farley, K. I., Griner, L. M., Sultan, J. & 28 othersMeng, Z., Zhou, M., Vilimas, T., Powers, A. S., Kozlov, S., Nagashima, K., Quadri, H. S., Fang, M., Long, C., Khanolkar, O., Chen, W., Kang, J., Huang, H., Chow, E., Goldberg, E., Feldman, C., Xi, R., Kim, H. R., Sahagian, G., Baserga, S. J., Mazar, A., Ferrer, M., Zheng, W., Shilatifard, A., Aubé, J., Rudloff, U., Marugan, J. J. & Huang, S., May 16 2018, In : Science translational medicine. 10, 441, eaap8307.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Neoplasms
RNA Polymerase I
Peptide Elongation Factors
Pancreatic Neoplasms

Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-Kras G12D/+ ;Tp53 R172H/+ (KPC) mice, a genetically engineered model of pancreatic cancer

Vilimas, T., Wang, A. Q., Patnaik, S., Hughes, E. A., Singleton, M. D., Knotts, Z., Li, D., Frankowski, K., Schlomer, J. J., Guerin, T. M., Springer, S., Drennan, C., Dextras, C., Wang, C., Gilbert, D., Southall, N., Ferrer, M., Huang, S., Kozlov, S., Marugan, J. & 2 othersXu, X. & Rudloff, U., Dec 1 2018, In : Cancer Chemotherapy and Pharmacology. 82, 6, p. 1067-1080 14 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Pancreatic Neoplasms
Tumors
Area Under Curve
Pharmacodynamics
1 Citation (Scopus)

6-Methoxyethylamino-numonafide inhibits hepatocellular carcinoma xenograft growth as a single agent and in combination with sorafenib

Liu, Y., Lou, G., Norton, J. T., Wang, C., Kandela, I., Tang, S., Shank, N. I., Gupta, P., Huang, M., Avram, M. J., Green, R., Mazar, A., Appella, D., Chen, Z. & Huang, S., Jan 1 2017, In : FASEB Journal. 31, 12, p. 5453-5465 13 p.

Research output: Contribution to journalArticle

Heterografts
Tumors
Hepatocellular Carcinoma
amonafide
Growth
16 Citations (Scopus)

A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease

Rocchi, A., Yamamoto, S., Ting, T., Fan, Y., Sadleir, K., Wang, Y., Zhang, W., Huang, S., Levine, B., Vassar, R. & He, C., Aug 1 2017, In : PLoS Genetics. 13, 8, e1006962.

Research output: Contribution to journalArticle

autophagy
cognition
Autophagy
amyloid
Alzheimer disease