• 13175 Citations
1991 …2020

Research output per year

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Research Output

2019

Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium

Ricard, N., Scott, R. P., Booth, C. J., Velazquez, H., Cilfone, N. A., Baylon, J. L., Gulcher, J. R., Quaggin, S. E., Chittenden, T. W. & Simons, M., Aug 1 2019, In : Journal of Experimental Medicine. 216, 8, p. 1874-1890 17 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Forward genetic screen in human podocytes identifies diphthamide biosynthesis genes as regulators of adhesion

Cinà, D. P., Ketela, T., Brown, K. R., Chandrashekhar, M., Mero, P., Li, C., Onay, T., Fu, Y., Han, Z., Saleem, M., Moffat, J. & Quaggin, S. E., 2019, In : American Journal of Physiology - Renal Physiology. 317, 6, p. F1593-F1604

Research output: Contribution to journalArticle

Genetic Deletion of Emp2 Does Not Cause Proteinuric Kidney Disease in Mice

Donnan, M. D., Scott, R. P., Onay, T., Tarjus, A., Onay, U. V. & Quaggin, S. E., Aug 27 2019, In : Frontiers in Medicine. 6, 189.

Research output: Contribution to journalArticle

Open Access

Global Health Training Opportunities in North American Nephrology Fellowships

International Society of Nephrology North American and Caribbean Regional Board, Jul 2019, In : Kidney International Reports. 4, 7, p. 904-907 4 p.

Research output: Contribution to journalEditorial

Open Access

Passive sweat collection and colorimetric analysis of biomarkers relevant to kidney disorders using a soft microfluidic system

Zhang, Y., Guo, H., Kim, S. B., Wu, Y., Ostojich, D., Park, S. H., Wang, X., Weng, Z., Li, R., Bandodkar, A. J., Sekine, Y., Choi, J., Xu, S., Quaggin, S., Ghaffari, R. & Rogers, J. A., May 7 2019, In : Lab on a Chip. 19, 9, p. 1545-1555 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function

Hurcombe, J. A., Hartley, P., Lay, A. C., Ni, L., Bedford, J. J., Leader, J. P., Singh, S., Murphy, A., Scudamore, C. L., Marquez, E., Barrington, A. F., Pinto, V., Marchetti, M., Wong, L. F., Uney, J., Saleem, M. A., Mathieson, P. W., Patel, S., Walker, R. J., Woodgett, J. R. & 3 others, Quaggin, S. E., Welsh, G. I. & Coward, R. J. M., Dec 1 2019, In : Nature communications. 10, 1, 403.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Targeting VE-PTP phosphatase protects the kidney from diabetic injury

Carota, I. A., Kenig-Kozlovsky, Y., Onay, T., Scott, R., Thomson, B. R., Souma, T., Bartlett, C. S., Li, Y., Procissi, D., Ramirez, V., Yamaguchi, S., Tarjus, A., Tanna, C. E., Li, C., Eremina, V., Vestweber, D., Oladipupo, S. S., Breyer, M. D. & Quaggin, S. E., Apr 1 2019, In : Journal of Experimental Medicine. 216, 4, p. 936-949 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Working title: Targeting the vascular-specific phosphatase ptprb protects against retinal ganglion cell loss in a pre-clinical model of glaucoma

Thomson, B. R., Carota, I. A., Souma, T., Soman, S., Vestweber, D. & Quaggin, S. E., Oct 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
2018

Angiopoietin-1 deficiency increases renal capillary rarefaction and tubulointerstitial fibrosis in mice

Loganathan, K., Said, E. S., Winterrowd, E., Orebrand, M., He, L., Vanlandewijck, M., Betsholtz, C., Quaggin, S. E. & Jeansson, M., Jan 2018, In : PloS one. 13, 1, e0189433.

Research output: Contribution to journalArticle

7 Scopus citations

Angiopoietins bind thrombomodulin and inhibit its function as a thrombin cofactor

Daly, C., Qian, X., Castanaro, C., Pasnikowski, E., Jiang, X., Thomson, B. R., Quaggin, S. E., Papadopoulos, N., Wei, Y., Rudge, J. S., Thurston, G., Yancopoulos, G. D. & Davis, S., Dec 1 2018, In : Scientific reports. 8, 1, 505.

Research output: Contribution to journalArticle

9 Scopus citations

Ascending vasa recta are angiopoietin/Tie2-dependent lymphatic-like vessels

Kenig-Kozlovsky, Y., Scott, R. P., Onay, T., Carota, I. A., Thomson, B. R., Gil, H. J., Ramirez, V., Yamaguchi, S., Tanna, C. E., Heinen, S., Wu, C., Stan, R. V., Klein, J. D., Sands, J. M., Oliver, G. & Quaggin, S. E., Apr 2018, In : Journal of the American Society of Nephrology. 29, 4, p. 1097-1107 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Endothelial mineralocorticoid receptor ablation does not alter blood pressure, kidney function or renal vessel contractility

Laursen, S. B., Finsen, S., Marcussen, N., Quaggin, S. E., Hansen, P. B. L. & Dimke, H., Feb 2018, In : PloS one. 13, 2, e0193032.

Research output: Contribution to journalArticle

9 Scopus citations

Glomerular endothelial cell maturation depends on ADAM10, a key regulator of Notch signaling

Farber, G., Hurtado, R., Loh, S., Monette, S., Mtui, J., Kopan, R., Quaggin, S. E., Meyer-Schwesinger, C., Herzlinger, D., Scott, R. P. & Blobel, C. P., May 1 2018, In : Angiogenesis. 21, 2, p. 335-347 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Inverse correlation between vascular endothelial growth factor back-filtration and capillary filtration pressures

Kuppe, C., Rohlfs, W., Grepl, M., Schulte, K., Veron, D., Elger, M., Sanden, S. K., Saritas, T., Andrae, J., Betsholtz, C., Trautwein, C., Hausmann, R., Quaggin, S., Bachmann, S., Kriz, W., Tufro, A., Floege, J. & Moeller, M. J., Sep 1 2018, In : Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 33, 9, p. 1514-1525 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Morphological analysis of schlemm’s canal in mice

Thomson, B. R. & Quaggin, S. E., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 153-160 8 p. (Methods in Molecular Biology; vol. 1846).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
9 Scopus citations

Plasma Vascular Endothelial Growth Factor Concentrations after Intravitreous Anti–Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema

Diabetic Retinopathy Clinical Research Network, Jul 1 2018, In : Ophthalmology. 125, 7, p. 1054-1063 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
5 Scopus citations

ShcA adaptor protein promotes nephrin endocytosis and is upregulated in proteinuric nephropathies

Martin, C. E., Petersen, K. A., Aoudjit, L., Tilak, M., Eremina, V., Rod Hardy, W., Quaggin, S. E., Takano, T. & Jones, N., Jan 2018, In : Journal of the American Society of Nephrology. 29, 1, p. 92-103 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Transcription factor 21 is required for branching morphogenesis and regulates the Gdnf-Axis in kidney development

Ide, S., Finer, G., Maezawa, Y., Onay, T., Souma, T., Scott, R. P., Ide, K., Akimoto, Y., Li, C., Ye, M., Zhao, X., Baba, Y., Minamizuka, T., Jin, J., Takemoto, M., Yokote, K. & Quaggin, S. E., Dec 2018, In : Journal of the American Society of Nephrology. 29, 12, p. 2795-2808 14 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Angiopoietin-1 deficiency increases tumor metastasis in mice

Michael, I. P., Orebrand, M., Lima, M., Pereira, B., Volpert, O., Quaggin, S. E. & Jeansson, M., Jan 1 2017, In : BMC cancer. 17, 1, 539.

Research output: Contribution to journalArticle

8 Scopus citations

Angiopoietin-1 is required for Schlemm’s canal development in mice and humans

Thomson, B. R., Souma, T., Tompson, S. W., Onay, T., Kizhatil, K., Siggs, O. M., Feng, L., Whisenhunt, K. N., Yanovitch, T. L., Kalaydjieva, L., Azmanov, D. N., Finzi, S., Tanna, C. E., Hewitt, A. W., Mackey, D. A., Bradfield, Y. S., Souzeau, E., Javadiyan, S., Wiggs, J. L., Pasutto, F. & 6 others, Liu, X., John, S. W. M., Craig, J. E., Jin, J., Young, T. L. & Quaggin, S. E., Dec 1 2017, In : Journal of Clinical Investigation. 127, 12, p. 4421-4436 16 p.

Research output: Contribution to journalArticle

16 Scopus citations

A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis

Rai, R., Verma, S. K., Kim, D., Ramirez, V., Lux, E., Li, C., Sahoo, S., Wilsbacher, L. D., Vaughan, D. E., Quaggin, S. E. & Ghosh, A. K., Nov 2 2017, In : Epigenetics. 12, 11, p. 1004-1013 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

A novel assay to assess the effect of pharmaceutical compounds on the differentiation of podocytes

Kindt, F., Hammer, E., Kemnitz, S., Blumenthal, A., Klemm, P., Schlüter, R., Quaggin, S. E., van den Brandt, J., Fuellen, G., Völker, U., Endlich, K. & Endlich, N., Jan 1 2017, In : British journal of pharmacology. 174, 2, p. 163-176 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Beneficial effects of myo-inositol oxygenase deficiency in cisplatin-induced AKI

Dutta, R. K., Kondeti, V. K., Sharma, I., Chandel, N. S., Quaggin, S. E. & Kanwar, Y. S., May 2017, In : Journal of the American Society of Nephrology. 28, 5, p. 1421-1436 16 p.

Research output: Contribution to journalArticle

16 Scopus citations

Glomerular disease: A suPAR kidney connection found in the bone marrow

Gallon, L. & Quaggin, S. E., May 1 2017, In : Nature Reviews Nephrology. 13, 5, p. 263-264 2 p.

Research output: Contribution to journalShort survey

3 Scopus citations

Glomerular mesangial cell recruitment and function require the co-receptor neuropilin-1

Bartlett, C. S., Scott, R. P., Carota, I. A., Wnuk, M. L., Kanwar, Y. S., Miner, J. H. & Quaggin, S. E., Dec 2017, In : American Journal of Physiology - Renal Physiology. 313, 6, p. F1232-F1242

Research output: Contribution to journalArticle

7 Scopus citations

Renal carcinoma/kidney progenitor cell chimera organoid as a novel tumorigenesis gene discovery model

Xu, Q., Junttila, S., Scherer, A., Giri, K. R., Kivelä, O., Skovorodkin, I., Röning, J., Quaggin, S. E., Marti, H. P., Shan, J., Samoylenko, A. & Vainio, S. J., Dec 1 2017, In : DMM Disease Models and Mechanisms. 10, 12, p. 1503-1515 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Selective tubular activation of hypoxia-inducible factor-2α has dual effects on renal fibrosis

Kong, K. H., Oh, H. J., Lim, B. J., Kim, M., Han, K. H., Choi, Y. H., Kwon, K., Nam, B. Y., Park, K. S., Park, J. T., Han, S. H., Yoo, T. H., Lee, S., Kim, S. J., Kang, D. H., Choi, K. B., Eremina, V., Quaggin, S. E., Ryu, D. R. & Kang, S. W., Dec 1 2017, In : Scientific reports. 7, 1, 11351.

Research output: Contribution to journalArticle

9 Scopus citations

SuPAR and FSGS: Is the jury still out?

Gallon, L. & Quaggin, S. E., Sep 1 2017, In : Nature Reviews Nephrology. 13, 9, 1 p.

Research output: Contribution to journalLetter

2 Scopus citations
2016

Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity

Souma, T., Tompson, S. W., Thomson, B. R., Siggs, O. M., Kizhatil, K., Yamaguchi, S., Feng, L., Limviphuvadh, V., Whisenhunt, K. N., Maurer-Stroh, S., Yanovitch, T. L., Kalaydjieva, L., Azmanov, D. N., Finzi, S., Mauri, L., Javadiyan, S., Souzeau, E., Zhou, T., Hewitt, A. W., Kloss, B. & 15 others, Burdon, K. P., Mackey, D. A., Allen, K. F., Ruddle, J. B., Lim, S. H., Rozen, S., Tran-Viet, K. N., Liu, X., John, S., Wiggs, J. L., Pasutto, F., Craig, J. E., Jin, J., Quaggin, S. E. & Young, T. L., Jul 1 2016, In : Journal of Clinical Investigation. 126, 7, p. 2575-2587 13 p.

Research output: Contribution to journalArticle

57 Scopus citations

CD146+ cells are essential for kidney vasculature development

Halt, K. J., Pärssinen, H. E., Junttila, S. M., Saarela, U., Sims-Lucas, S., Koivunen, P., Myllyharju, J., Quaggin, S., Skovorodkin, I. N. & Vainio, S. J., Aug 1 2016, In : Kidney international. 90, 2, p. 311-324 14 p.

Research output: Contribution to journalArticle

25 Scopus citations

Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria

Higgins, S. J., Purcell, L. A., Silver, K. L., Tran, V., Crowley, V., Hawkes, M., Conroy, A. L., Opoka, R. O., Hay, J. G., Quaggin, S. E., Thurston, G., Liles, W. C. & Kain, K. C., Sep 28 2016, In : Science translational medicine. 8, 358, 358ra127.

Research output: Contribution to journalArticle

33 Scopus citations

Embryology of the Kidney

Scott, RP., Maezawa, Y., Kreidberg, J. & Quaggin, SE., 2016, Brenner and Rector's The Kidney, 10th Edition. Skorecki, K., Chertow, GM., Marsden, PA., Taal, MW. & Yu, ASL. (eds.). Philadelphia: Elsevier

Research output: Chapter in Book/Report/Conference proceedingChapter

Kindling the Kidney

Quaggin, S. E., Jan 21 2016, In : New England Journal of Medicine. 374, 3, p. 281-283 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Nephrin tyrosine phosphorylation is required to stabilize and restore podocyte foot process architecture

New, L. A., Martin, C. E., Scott, R. P., Platt, M. J., Chahi, A. K., Stringer, C. D., Lu, P., Samborska, B., Eremina, V., Takano, T., Simpson, J. A., Quaggin, S. E. & Jones, N., Jan 1 2016, In : Journal of the American Society of Nephrology. 27, 8, p. 2422-2435 14 p.

Research output: Contribution to journalArticle

37 Scopus citations

Podocyte-specific Nox4 deletion affords renoprotection in a mouse model of diabetic nephropathy

Jha, J. C., Thallas-Bonke, V., Banal, C., Gray, S. P., Chow, B. S. M., Ramm, G., Quaggin, S. E., Cooper, M. E., Schmidt, H. H. H. W. & Jandeleit-Dahm, K. A., Feb 1 2016, In : Diabetologia. 59, 2, p. 379-389 11 p.

Research output: Contribution to journalArticle

55 Scopus citations

Synthesis of cationized nanofibrillated cellulose and its antimicrobial properties

Littunen, K., Snoei De Castro, J., Samoylenko, A., Xu, Q., Quaggin, S., Vainio, S. & Seppälä, J., Feb 1 2016, In : European Polymer Journal. 75, p. 116-124 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Vascular Growth Factors and Glomerular Disease

Bartlett, C. S., Jeansson, M. & Quaggin, S. E., Feb 10 2016, In : Annual review of physiology. 78, p. 437-461 25 p.

Research output: Contribution to journalReview article

32 Scopus citations
2015

ATGme: Open-source web application for rare codon identification and custom DNA sequence optimization

Daniel, E., Onwukwe, G. U., Wierenga, R. K., Quaggin, S. E., Vainio, S. J. & Krause, M., Sep 21 2015, In : BMC bioinformatics. 16, 1, 303.

Research output: Contribution to journalArticle

11 Scopus citations

Crosstalk in glomerular injury and repair

Dimke, H., Maezawa, Y. & Quaggin, S. E., May 27 2015, In : Current opinion in nephrology and hypertension. 24, 3, p. 231-238 8 p.

Research output: Contribution to journalReview article

29 Scopus citations

Formation and Maintenance of a Functional Glomerulus

Scott, R. P. & Quaggin, S. E., Jan 1 2015, Kidney Development, Disease, Repair and Regeneration. Little, MH. (ed.). London: Elsevier Science Ltd., p. 103-119 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Identification of the genes regulated by Wnt-4, a critical signal for commitment of the ovary

Naillat, F., Yan, W., Karjalainen, R., Liakhovitskaia, A., Samoylenko, A., Xu, Q., Sun, Z., Shen, B., Medvinsky, A., Quaggin, S. & Vainio, S. J., Mar 15 2015, In : Experimental Cell Research. 332, 2, p. 163-178 16 p.

Research output: Contribution to journalArticle

14 Scopus citations

Nephrology crossword: Genetics and glomerulopathies

Relia, N., Cheema, Y. R., Mehta, R. C. & Quaggin, S. E., Apr 8 2015, In : Kidney international. 87, 4, p. 867-868 2 p.

Research output: Contribution to journalArticle

Signaling during kidney development

Krause, M., Rak-Raszewska, A., Pietilä, I., Quaggin, S. E. & Vainio, S., Apr 10 2015, In : Cells. 4, 2, p. 112-132 21 p.

Research output: Contribution to journalReview article

The cell biology of renal filtration

Scott, R. P. & Quaggin, S. E., Jan 1 2015, In : Journal of Cell Biology. 209, 2, p. 199-210 12 p.

Research output: Contribution to journalReview article

132 Scopus citations

Therapies on the Horizon for Diabetic Kidney Disease

Khan, S. S. & Quaggin, S. E., Dec 1 2015, In : Current diabetes reports. 15, 12, 111.

Research output: Contribution to journalReview article

16 Scopus citations

Thioredoxin-interacting protein deficiency protects against diabetic nephropathy

Shah, A., Xia, L., Masson, E. A. Y., Gui, C., Momen, A., Shikatani, E. A., Husain, M., Quaggin, S., John, R. & Fantus, I. G., Dec 2015, In : Journal of the American Society of Nephrology. 26, 12, p. 2963-2977 15 p.

Research output: Contribution to journalArticle

31 Scopus citations

Tubulovascular cross-talk by vascular endothelial growth factor a maintains peritubular microvasculature in kidney

Dimke, H., Sparks, M. A., Thomson, B. R., Frische, S., Coffman, T. M. & Quaggin, S. E., May 1 2015, In : Journal of the American Society of Nephrology. 26, 5, p. 1027-1038 12 p.

Research output: Contribution to journalArticle

75 Scopus citations
2014

A lymphatic defect causes ocular hypertension and glaucoma in mice

Thomson, B. R., Heinen, S., Jeansson, M., Ghosh, A. K., Fatima, A., Sung, H. K., Onay, T., Chen, H., Yamaguchi, S., Economides, A. N., Flenniken, A., Gale, N. W., Hong, Y. K., Fawzi, A., Liu, X., Kume, T. & Quaggin, S. E., Oct 1 2014, In : Journal of Clinical Investigation. 124, 10, p. 4320-4324 5 p.

Research output: Contribution to journalArticle

71 Scopus citations