• 13175 Citations
1991 …2020

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2019

Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium

Ricard, N., Scott, R. P., Booth, C. J., Velazquez, H., Cilfone, N. A., Baylon, J. L., Gulcher, J. R., Quaggin, S. E., Chittenden, T. W. & Simons, M., Aug 1 2019, In : Journal of Experimental Medicine. 216, 8, p. 1874-1890 17 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Forward genetic screen in human podocytes identifies diphthamide biosynthesis genes as regulators of adhesion

Cinà, D. P., Ketela, T., Brown, K. R., Chandrashekhar, M., Mero, P., Li, C., Onay, T., Fu, Y., Han, Z., Saleem, M., Moffat, J. & Quaggin, S. E., 2019, In : American Journal of Physiology - Renal Physiology. 317, 6, p. F1593-F1604

Research output: Contribution to journalArticle

Genetic Deletion of Emp2 Does Not Cause Proteinuric Kidney Disease in Mice

Donnan, M. D., Scott, R. P., Onay, T., Tarjus, A., Onay, U. V. & Quaggin, S. E., Aug 27 2019, In : Frontiers in Medicine. 6, 189.

Research output: Contribution to journalArticle

Open Access

Passive sweat collection and colorimetric analysis of biomarkers relevant to kidney disorders using a soft microfluidic system

Zhang, Y., Guo, H., Kim, S. B., Wu, Y., Ostojich, D., Park, S. H., Wang, X., Weng, Z., Li, R., Bandodkar, A. J., Sekine, Y., Choi, J., Xu, S., Quaggin, S., Ghaffari, R. & Rogers, J. A., May 7 2019, In : Lab on a Chip. 19, 9, p. 1545-1555 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function

Hurcombe, J. A., Hartley, P., Lay, A. C., Ni, L., Bedford, J. J., Leader, J. P., Singh, S., Murphy, A., Scudamore, C. L., Marquez, E., Barrington, A. F., Pinto, V., Marchetti, M., Wong, L. F., Uney, J., Saleem, M. A., Mathieson, P. W., Patel, S., Walker, R. J., Woodgett, J. R. & 3 others, Quaggin, S. E., Welsh, G. I. & Coward, R. J. M., Dec 1 2019, In : Nature communications. 10, 1, 403.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Targeting VE-PTP phosphatase protects the kidney from diabetic injury

Carota, I. A., Kenig-Kozlovsky, Y., Onay, T., Scott, R., Thomson, B. R., Souma, T., Bartlett, C. S., Li, Y., Procissi, D., Ramirez, V., Yamaguchi, S., Tarjus, A., Tanna, C. E., Li, C., Eremina, V., Vestweber, D., Oladipupo, S. S., Breyer, M. D. & Quaggin, S. E., Apr 1 2019, In : Journal of Experimental Medicine. 216, 4, p. 936-949 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Working title: Targeting the vascular-specific phosphatase ptprb protects against retinal ganglion cell loss in a pre-clinical model of glaucoma

Thomson, B. R., Carota, I. A., Souma, T., Soman, S., Vestweber, D. & Quaggin, S. E., Oct 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
2018

Angiopoietin-1 deficiency increases renal capillary rarefaction and tubulointerstitial fibrosis in mice

Loganathan, K., Said, E. S., Winterrowd, E., Orebrand, M., He, L., Vanlandewijck, M., Betsholtz, C., Quaggin, S. E. & Jeansson, M., Jan 2018, In : PloS one. 13, 1, e0189433.

Research output: Contribution to journalArticle

7 Scopus citations

Angiopoietins bind thrombomodulin and inhibit its function as a thrombin cofactor

Daly, C., Qian, X., Castanaro, C., Pasnikowski, E., Jiang, X., Thomson, B. R., Quaggin, S. E., Papadopoulos, N., Wei, Y., Rudge, J. S., Thurston, G., Yancopoulos, G. D. & Davis, S., Dec 1 2018, In : Scientific reports. 8, 1, 505.

Research output: Contribution to journalArticle

9 Scopus citations

Ascending vasa recta are angiopoietin/Tie2-dependent lymphatic-like vessels

Kenig-Kozlovsky, Y., Scott, R. P., Onay, T., Carota, I. A., Thomson, B. R., Gil, H. J., Ramirez, V., Yamaguchi, S., Tanna, C. E., Heinen, S., Wu, C., Stan, R. V., Klein, J. D., Sands, J. M., Oliver, G. & Quaggin, S. E., Apr 2018, In : Journal of the American Society of Nephrology. 29, 4, p. 1097-1107 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Endothelial mineralocorticoid receptor ablation does not alter blood pressure, kidney function or renal vessel contractility

Laursen, S. B., Finsen, S., Marcussen, N., Quaggin, S. E., Hansen, P. B. L. & Dimke, H., Feb 2018, In : PloS one. 13, 2, e0193032.

Research output: Contribution to journalArticle

9 Scopus citations

Glomerular endothelial cell maturation depends on ADAM10, a key regulator of Notch signaling

Farber, G., Hurtado, R., Loh, S., Monette, S., Mtui, J., Kopan, R., Quaggin, S. E., Meyer-Schwesinger, C., Herzlinger, D., Scott, R. P. & Blobel, C. P., May 1 2018, In : Angiogenesis. 21, 2, p. 335-347 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Inverse correlation between vascular endothelial growth factor back-filtration and capillary filtration pressures

Kuppe, C., Rohlfs, W., Grepl, M., Schulte, K., Veron, D., Elger, M., Sanden, S. K., Saritas, T., Andrae, J., Betsholtz, C., Trautwein, C., Hausmann, R., Quaggin, S., Bachmann, S., Kriz, W., Tufro, A., Floege, J. & Moeller, M. J., Sep 1 2018, In : Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 33, 9, p. 1514-1525 12 p.

Research output: Contribution to journalArticle

3 Scopus citations
9 Scopus citations

Plasma Vascular Endothelial Growth Factor Concentrations after Intravitreous Anti–Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema

Diabetic Retinopathy Clinical Research Network, Jul 1 2018, In : Ophthalmology. 125, 7, p. 1054-1063 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
5 Scopus citations

ShcA adaptor protein promotes nephrin endocytosis and is upregulated in proteinuric nephropathies

Martin, C. E., Petersen, K. A., Aoudjit, L., Tilak, M., Eremina, V., Rod Hardy, W., Quaggin, S. E., Takano, T. & Jones, N., Jan 2018, In : Journal of the American Society of Nephrology. 29, 1, p. 92-103 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Transcription factor 21 is required for branching morphogenesis and regulates the Gdnf-Axis in kidney development

Ide, S., Finer, G., Maezawa, Y., Onay, T., Souma, T., Scott, R. P., Ide, K., Akimoto, Y., Li, C., Ye, M., Zhao, X., Baba, Y., Minamizuka, T., Jin, J., Takemoto, M., Yokote, K. & Quaggin, S. E., Dec 2018, In : Journal of the American Society of Nephrology. 29, 12, p. 2795-2808 14 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Angiopoietin-1 deficiency increases tumor metastasis in mice

Michael, I. P., Orebrand, M., Lima, M., Pereira, B., Volpert, O., Quaggin, S. E. & Jeansson, M., Jan 1 2017, In : BMC cancer. 17, 1, 539.

Research output: Contribution to journalArticle

8 Scopus citations

Angiopoietin-1 is required for Schlemm’s canal development in mice and humans

Thomson, B. R., Souma, T., Tompson, S. W., Onay, T., Kizhatil, K., Siggs, O. M., Feng, L., Whisenhunt, K. N., Yanovitch, T. L., Kalaydjieva, L., Azmanov, D. N., Finzi, S., Tanna, C. E., Hewitt, A. W., Mackey, D. A., Bradfield, Y. S., Souzeau, E., Javadiyan, S., Wiggs, J. L., Pasutto, F. & 6 others, Liu, X., John, S. W. M., Craig, J. E., Jin, J., Young, T. L. & Quaggin, S. E., Dec 1 2017, In : Journal of Clinical Investigation. 127, 12, p. 4421-4436 16 p.

Research output: Contribution to journalArticle

16 Scopus citations

A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis

Rai, R., Verma, S. K., Kim, D., Ramirez, V., Lux, E., Li, C., Sahoo, S., Wilsbacher, L. D., Vaughan, D. E., Quaggin, S. E. & Ghosh, A. K., Nov 2 2017, In : Epigenetics. 12, 11, p. 1004-1013 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

A novel assay to assess the effect of pharmaceutical compounds on the differentiation of podocytes

Kindt, F., Hammer, E., Kemnitz, S., Blumenthal, A., Klemm, P., Schlüter, R., Quaggin, S. E., van den Brandt, J., Fuellen, G., Völker, U., Endlich, K. & Endlich, N., Jan 1 2017, In : British journal of pharmacology. 174, 2, p. 163-176 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Beneficial effects of myo-inositol oxygenase deficiency in cisplatin-induced AKI

Dutta, R. K., Kondeti, V. K., Sharma, I., Chandel, N. S., Quaggin, S. E. & Kanwar, Y. S., May 2017, In : Journal of the American Society of Nephrology. 28, 5, p. 1421-1436 16 p.

Research output: Contribution to journalArticle

16 Scopus citations

Glomerular mesangial cell recruitment and function require the co-receptor neuropilin-1

Bartlett, C. S., Scott, R. P., Carota, I. A., Wnuk, M. L., Kanwar, Y. S., Miner, J. H. & Quaggin, S. E., Dec 2017, In : American Journal of Physiology - Renal Physiology. 313, 6, p. F1232-F1242

Research output: Contribution to journalArticle

7 Scopus citations

Renal carcinoma/kidney progenitor cell chimera organoid as a novel tumorigenesis gene discovery model

Xu, Q., Junttila, S., Scherer, A., Giri, K. R., Kivelä, O., Skovorodkin, I., Röning, J., Quaggin, S. E., Marti, H. P., Shan, J., Samoylenko, A. & Vainio, S. J., Dec 1 2017, In : DMM Disease Models and Mechanisms. 10, 12, p. 1503-1515 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Selective tubular activation of hypoxia-inducible factor-2α has dual effects on renal fibrosis

Kong, K. H., Oh, H. J., Lim, B. J., Kim, M., Han, K. H., Choi, Y. H., Kwon, K., Nam, B. Y., Park, K. S., Park, J. T., Han, S. H., Yoo, T. H., Lee, S., Kim, S. J., Kang, D. H., Choi, K. B., Eremina, V., Quaggin, S. E., Ryu, D. R. & Kang, S. W., Dec 1 2017, In : Scientific reports. 7, 1, 11351.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity

Souma, T., Tompson, S. W., Thomson, B. R., Siggs, O. M., Kizhatil, K., Yamaguchi, S., Feng, L., Limviphuvadh, V., Whisenhunt, K. N., Maurer-Stroh, S., Yanovitch, T. L., Kalaydjieva, L., Azmanov, D. N., Finzi, S., Mauri, L., Javadiyan, S., Souzeau, E., Zhou, T., Hewitt, A. W., Kloss, B. & 15 others, Burdon, K. P., Mackey, D. A., Allen, K. F., Ruddle, J. B., Lim, S. H., Rozen, S., Tran-Viet, K. N., Liu, X., John, S., Wiggs, J. L., Pasutto, F., Craig, J. E., Jin, J., Quaggin, S. E. & Young, T. L., Jul 1 2016, In : Journal of Clinical Investigation. 126, 7, p. 2575-2587 13 p.

Research output: Contribution to journalArticle

57 Scopus citations

CD146+ cells are essential for kidney vasculature development

Halt, K. J., Pärssinen, H. E., Junttila, S. M., Saarela, U., Sims-Lucas, S., Koivunen, P., Myllyharju, J., Quaggin, S., Skovorodkin, I. N. & Vainio, S. J., Aug 1 2016, In : Kidney international. 90, 2, p. 311-324 14 p.

Research output: Contribution to journalArticle

25 Scopus citations

Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria

Higgins, S. J., Purcell, L. A., Silver, K. L., Tran, V., Crowley, V., Hawkes, M., Conroy, A. L., Opoka, R. O., Hay, J. G., Quaggin, S. E., Thurston, G., Liles, W. C. & Kain, K. C., Sep 28 2016, In : Science translational medicine. 8, 358, 358ra127.

Research output: Contribution to journalArticle

33 Scopus citations

Kindling the Kidney

Quaggin, S. E., Jan 21 2016, In : New England Journal of Medicine. 374, 3, p. 281-283 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Nephrin tyrosine phosphorylation is required to stabilize and restore podocyte foot process architecture

New, L. A., Martin, C. E., Scott, R. P., Platt, M. J., Chahi, A. K., Stringer, C. D., Lu, P., Samborska, B., Eremina, V., Takano, T., Simpson, J. A., Quaggin, S. E. & Jones, N., Jan 1 2016, In : Journal of the American Society of Nephrology. 27, 8, p. 2422-2435 14 p.

Research output: Contribution to journalArticle

37 Scopus citations

Podocyte-specific Nox4 deletion affords renoprotection in a mouse model of diabetic nephropathy

Jha, J. C., Thallas-Bonke, V., Banal, C., Gray, S. P., Chow, B. S. M., Ramm, G., Quaggin, S. E., Cooper, M. E., Schmidt, H. H. H. W. & Jandeleit-Dahm, K. A., Feb 1 2016, In : Diabetologia. 59, 2, p. 379-389 11 p.

Research output: Contribution to journalArticle

55 Scopus citations

Synthesis of cationized nanofibrillated cellulose and its antimicrobial properties

Littunen, K., Snoei De Castro, J., Samoylenko, A., Xu, Q., Quaggin, S., Vainio, S. & Seppälä, J., Feb 1 2016, In : European Polymer Journal. 75, p. 116-124 9 p.

Research output: Contribution to journalArticle

36 Scopus citations
2015

ATGme: Open-source web application for rare codon identification and custom DNA sequence optimization

Daniel, E., Onwukwe, G. U., Wierenga, R. K., Quaggin, S. E., Vainio, S. J. & Krause, M., Sep 21 2015, In : BMC bioinformatics. 16, 1, 303.

Research output: Contribution to journalArticle

11 Scopus citations

Identification of the genes regulated by Wnt-4, a critical signal for commitment of the ovary

Naillat, F., Yan, W., Karjalainen, R., Liakhovitskaia, A., Samoylenko, A., Xu, Q., Sun, Z., Shen, B., Medvinsky, A., Quaggin, S. & Vainio, S. J., Mar 15 2015, In : Experimental Cell Research. 332, 2, p. 163-178 16 p.

Research output: Contribution to journalArticle

14 Scopus citations

Nephrology crossword: Genetics and glomerulopathies

Relia, N., Cheema, Y. R., Mehta, R. C. & Quaggin, S. E., Apr 8 2015, In : Kidney international. 87, 4, p. 867-868 2 p.

Research output: Contribution to journalArticle

Thioredoxin-interacting protein deficiency protects against diabetic nephropathy

Shah, A., Xia, L., Masson, E. A. Y., Gui, C., Momen, A., Shikatani, E. A., Husain, M., Quaggin, S., John, R. & Fantus, I. G., Dec 2015, In : Journal of the American Society of Nephrology. 26, 12, p. 2963-2977 15 p.

Research output: Contribution to journalArticle

31 Scopus citations

Tubulovascular cross-talk by vascular endothelial growth factor a maintains peritubular microvasculature in kidney

Dimke, H., Sparks, M. A., Thomson, B. R., Frische, S., Coffman, T. M. & Quaggin, S. E., May 1 2015, In : Journal of the American Society of Nephrology. 26, 5, p. 1027-1038 12 p.

Research output: Contribution to journalArticle

75 Scopus citations
2014

A lymphatic defect causes ocular hypertension and glaucoma in mice

Thomson, B. R., Heinen, S., Jeansson, M., Ghosh, A. K., Fatima, A., Sung, H. K., Onay, T., Chen, H., Yamaguchi, S., Economides, A. N., Flenniken, A., Gale, N. W., Hong, Y. K., Fawzi, A., Liu, X., Kume, T. & Quaggin, S. E., Oct 1 2014, In : Journal of Clinical Investigation. 124, 10, p. 4320-4324 5 p.

Research output: Contribution to journalArticle

71 Scopus citations

Heparin binding VEGF isoforms attenuate hyperoxic embryonic lung growth retardation via a FLK1-neuropilin-1-PKC dependent pathway

Esquibies, A. E., Karihaloo, A., Quaggin, S. E., Bazzy-Asaad, A. & Cantley, L. G., Mar 19 2014, In : Respiratory Research. 15, 1, 32.

Research output: Contribution to journalArticle

8 Scopus citations

Loss of the podocyte-expressed transcription factor Tcf21/Pod1 Results in podocyte differentiation defects and FSGS

Maezawa, Y., Onay, T., Scott, R. P., Keir, L. S., Dimke, H., Li, C., Eremina, V., Maezawa, Y., Jeansson, M., Shan, J., Binnie, M., Lewin, M., Ghosh, A., Miner, J. H., Vainio, S. J. & Quaggin, S. E., Nov 1 2014, In : Journal of the American Society of Nephrology. 25, 11, p. 2459-2470 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Murine Notch1 is required for lymphatic vascular morphogenesis during development

Fatima, A., Culver, A., Culver, F., Liu, T., Dietz, W. H., Thomson, B. R., Hadjantonakis, A. K., Quaggin, S. E. & Kume, T., Jul 2014, In : Developmental Dynamics. 243, 7, p. 957-964 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice

Eren, M., Boe, A. E., Murphy, S. B., Place, A. T., Nagpal, V., Morales-Nebreda, L., Urich, D., Quaggin, S. E., Scott Budinger, G. R., Mutlu, G. M., Miyata, T. & Vaughan, D. E., May 13 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 19, p. 7090-7095 6 p.

Research output: Contribution to journalArticle

77 Scopus citations

The glomerulus: The sphere of influence

Pollak, M. R., Quaggin, S. E., Hoenig, M. P. & Dworkin, L. D., Jan 1 2014, In : Clinical Journal of the American Society of Nephrology. 9, 8, p. 1461-1469 9 p.

Research output: Contribution to journalArticle

37 Scopus citations
2013

GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure

Kim, M., Platt, M. J., Shibasaki, T., Quaggin, S. E., Backx, P. H., Seino, S., Simpson, J. A. & Drucker, D. J., May 1 2013, In : Nature Medicine. 19, 5, p. 567-575 9 p.

Research output: Contribution to journalArticle

279 Scopus citations

Monitoring and modeling treatment of atypical hemolytic uremic syndrome

Heinen, S., Pluthero, F. G., van Eimeren, V. F., Quaggin, S. E. & Licht, C., May 1 2013, In : Molecular Immunology. 54, 1, p. 84-88 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Rapid and sensitive MRM-based mass spectrometry approach for systematically exploring ganglioside-protein interactions

Tian, R., Jin, J., Taylor, L., Larsen, B., Quaggin, S. E. & Pawson, T., Apr 1 2013, In : Proteomics. 13, 8, p. 1334-1338 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Regulation of hypoxia-inducible factor 2-a is essential for integrity of the glomerular barrier

Ding, M., Coward, R. J., Jeansson, M., Kim, W. & Quaggin, S. E., Jan 1 2013, In : American Journal of Physiology - Renal Physiology. 304, 1, p. F120-F126

Research output: Contribution to journalArticle

7 Scopus citations

Thioredoxin-interacting protein mediates high glucose-induced reactive oxygen species generation by mitochondria and the nadph oxidase, Nox4, in mesangial cells

Shah, A., Xia, L., Goldberg, H., Lee, K. W., Quaggin, S. E. & Fantus, I. G., Mar 8 2013, In : Journal of Biological Chemistry. 288, 10, p. 6835-6848 14 p.

Research output: Contribution to journalArticle

85 Scopus citations
2012

A new Cre driver mouse line, Tcf21/Pod1-Cre, targets metanephric mesenchyme

Maezawa, Y., Binnie, M., Li, C., Thorner, P., Hui, C. C., Alman, B., Taketo, M. M. & Quaggin, S. E., Jul 6 2012, In : PloS one. 7, 7, e40547.

Research output: Contribution to journalArticle

13 Scopus citations