Swati Bhattacharyya

  • 2101 Citations
1993 …2024

Research output per year

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Research Output

  • 2101 Citations
  • 30 Article
  • 10 Review article
  • 3 Comment/debate
2019

The JAK/STAT pathway is activated in systemic sclerosis and is effectively targeted by tofacitinib

Wang, W., Bhattacharyya, S., Goncalves Marangoni, R., Carns, M., Dennis-Aren, K., Yeldandi, A. V., Wei, J. & Varga, J., Jan 1 2019, (Accepted/In press) In : Journal of Scleroderma and Related Disorders.

Research output: Contribution to journalArticle

1 Scopus citations
2018
18 Scopus citations

Fibronectin EDA forms the chronic fibrotic scar after contusive spinal cord injury

Cooper, J. G., Jeong, S. J., McGuire, T. L., Sharma, S., Wang, W., Bhattacharyya, S., Varga, J. & Kessler, J. A., Aug 2018, In : Neurobiology of Disease. 116, p. 60-68 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Matrix protein tenascin-C expands and reversibly blocks maturation of murine eosinophil progenitors

Doan, T. C., Jeong, B. M., Coden, M. E., Loffredo, L. F., Bhattacharyya, S., Chiarella, S. E., Varga, J., Abdala-Valencia, H. & Berdnikovs, S., Aug 2018, In : Journal of Allergy and Clinical Immunology. 142, 2, p. 695-698.e4

Research output: Contribution to journalArticle

3 Scopus citations

Pharmacological inhibition of tolllike receptor-4 signaling by TAK242 prevents and induces regression of experimental organ fibrosis

Bhattacharyya, S., Wang, W., Tamaki, Z., Shi, B., Yeldandi, A., Tsukimi, Y., Yamasaki, M. & Varga, J., Oct 23 2018, In : Frontiers in immunology. 9, OCT, 2434.

Research output: Contribution to journalArticle

6 Scopus citations

Targeting TLRs and the inflammasome in systemic sclerosis

Henderson, J., Bhattacharyya, S., Varga, J. & O'Reilly, S., Dec 2018, In : Pharmacology and Therapeutics. 192, p. 163-169 7 p.

Research output: Contribution to journalReview article

8 Scopus citations

TLR4-dependent fibroblast activation drives persistent organ fibrosis in skin and lung

Bhattacharyya, S., Wang, W., Qin, W., Cheng, K., Coulup, S., Chavez, S., Jiang, S., Raparia, K., De Almeida, L. M. V., Stehlik, C., Tamaki, Z., Yin, H. & Varga, J., Jul 12 2018, In : JCI Insight. 3, 13

Research output: Contribution to journalArticle

Open Access
14 Scopus citations
2017

Toll-like receptor-4 signaling drives persistent fibroblast activation and prevents fibrosis resolution in scleroderma

Bhattacharyya, S., Midwood, K. S., Yin, H. & Varga, J., Oct 2017, In : Advances in Wound Care. 6, 10, p. 356-369 14 p.

Research output: Contribution to journalReview article

15 Scopus citations
2016
9 Scopus citations

Tenascin-C drives persistence of organ fibrosis

Bhattacharyya, S., Wang, W., Morales-Nebreda, L., Feng, G., Wu, M., Zhou, X., Lafyatis, R., Lee, J., Hinchcliff, M., Feghali-Bostwick, C., Lakota, K., Budinger, G. R. S., Raparia, K., Tamaki, Z. & Varga, J., Jun 3 2016, In : Nature communications. 7, 11703.

Research output: Contribution to journalArticle

70 Scopus citations

Toll-like Receptor 9 Signaling Is Augmented in Systemic Sclerosis and Elicits Transforming Growth Factor β–Dependent Fibroblast Activation

Fang, F., Goncalves Marangoni, R., Zhou, X., Yang, Y., Ye, B., Shangguang, A., Qin, W., Wang, W., Bhattacharyya, S., Wei, J., Tourtellotte, W. G. & Varga, J., Aug 1 2016, In : Arthritis and Rheumatology. 68, 8, p. 1989-2002 14 p.

Research output: Contribution to journalArticle

28 Scopus citations
2015
43 Scopus citations

Molecular characterization of systemic sclerosis esophageal pathology identifies inflammatory and proliferative signatures

Taroni, J. N., Martyanov, V., Huang, C. C., Mahoney, J. M., Hirano, I., Shetuni, B., Yang, G. Y., Brenner, D., Jung, B., Wood, T. A., Bhattacharyya, S., Almagor, O., Lee, J., Sirajuddin, A., Varga, J., Chang, R. W., Whitfield, M. L. & Hinchcliff, M., Jul 29 2015, In : Arthritis Research and Therapy. 17, 1, 194.

Research output: Contribution to journalArticle

16 Scopus citations
2014

Erratum to Imatinib mesylate causes genome-wide transcriptional changes in systemic sclerosis fibroblasts in vitro [Clin Exp Rheumatol, 30, 2 Suppl. 71, (2012) S86-S96]

Hinchcliff, M., Huang, C. C., Ishida, W., Fang, F., Lee, J., Jafari, N., Wilkes, M., Bhattacharyya, S., Leof, E. & Varga, J., Feb 25 2014, In : Clinical and Experimental Rheumatology. 32, 1, 1 p.

Research output: Contribution to journalComment/debate

FibronectinEDA promotes chronic cutaneous fibrosis through toll-like receptor signaling

Bhattacharyya, S., Tamaki, Z., Wang, W., Hinchcliff, M., Hoover, P., Getsios, S., White, E. S. & Varga, J., Apr 16 2014, In : Science translational medicine. 6, 232, 232ra50.

Research output: Contribution to journalArticle

102 Scopus citations
2013

A synthetic TLR3 ligand mitigates profibrotic fibroblast responses by inducing autocrine IFN signaling

Fang, F., Ooka, K., Sun, X., Shah, R., Bhattacharyya, S., Wei, J. & Varga, J., Sep 15 2013, In : Journal of Immunology. 191, 6, p. 2956-2966 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Early growth response 3 (Egr-3) is induced by transforming growth factor-β and regulates fibrogenic responses

Fang, F., Shangguan, A. J., Kelly, K., Wei, J., Gruner, K., Ye, B., Wang, W., Bhattacharyya, S., Hinchcliff, M. E., Tourtellotte, W. G. & Varga, J., Oct 1 2013, In : American Journal of Pathology. 183, 4, p. 1197-1208 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

Egr-1: New conductor for the tissue repair orchestra directs harmony (regeneration) or cacophony (fibrosis)

Bhattacharyya, S., Fang, F., Tourtellotte, W. & Varga, J., Jan 1 2013, In : Journal of Pathology. 229, 2, p. 286-297 12 p.

Research output: Contribution to journalReview article

80 Scopus citations

Molecular signatures in skin associated with clinical improvement during mycophenolate treatment in systemic sclerosis

Hinchcliff, M., Huang, C. C., Wood, T. A., Matthew Mahoney, J., Martyanov, V., Bhattacharyya, S., Tamaki, Z., Lee, J., Carns, M., Podlusky, S., Sirajuddin, A., Shah, S. J., Chang, R. W., Lafyatis, R., Varga, J. & Whitfield, M. L., Aug 2013, In : Journal of Investigative Dermatology. 133, 8, p. 1979-1989 11 p.

Research output: Contribution to journalArticle

69 Scopus citations
55 Scopus citations

Toll-like receptor 4 signaling augments transforming growth factor-β responses: A novel mechanism for maintaining and amplifying fibrosis in scleroderma

Bhattacharyya, S., Kelley, K., Melichian, D. S., Tamaki, Z., Fang, F., Su, Y., Feng, G., Pope, R. M., Budinger, GR. S., Mutlu, G. M., Lafyatis, R., Radstake, T., Feghali-Bostwick, C. & Varga, J., Jan 1 2013, In : American Journal of Pathology. 182, 1, p. 192-205 14 p.

Research output: Contribution to journalArticle

143 Scopus citations
2012

Fibrosis in systemic sclerosis: Common and unique pathobiology

Bhattacharyya, S., Wei, J., Tourtellotte, W. G., Hinchcliff, M., Gottardi, C. G. & Varga, J., Jun 6 2012, In : Fibrogenesis and Tissue Repair. 5, SUPPL.1, S18.

Research output: Contribution to journalArticle

26 Scopus citations

Imatinib mesylate causes genome-wide transcriptional changes in systemic sclerosis fibroblasts in vitro

Hinchcliff, M., Huang, C. C., Ishida, W., Fang, F., Lee, J., Jafari, N., Wilkes, M., Bhattacharyya, S., Leof, E. & Varga, J., May 1 2012, In : Clinical and experimental rheumatology. 30, SUPPL.71, p. S86-S96

Research output: Contribution to journalArticle

7 Scopus citations
29 Scopus citations

The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: Novel target for fibrosis therapy

Fang, F., Liu, L., Yang, Y., Tamaki, Z., Wei, J., Marangoni, R. G., Bhattacharyya, S., Summer, R. S., Ye, B. & Varga, J., Oct 23 2012, In : Arthritis Research and Therapy. 14, 5, R229.

Research output: Contribution to journalArticle

51 Scopus citations

Understanding fibrosis in systemic sclerosis: Shifting paradigms, emerging opportunities

Bhattacharyya, S., Wei, J. & Varga, J., Jan 1 2012, In : Nature Reviews Rheumatology. 8, 1, p. 42-54 13 p.

Research output: Contribution to journalReview article

206 Scopus citations
2011

Early growth response transcription factors: Key mediators of fibrosis and novel targets for anti-fibrotic therapy

Bhattacharyya, S., Wu, M., Fang, F., Tourtellotte, W., Feghali-Bostwick, C. & Varga, J., May 1 2011, In : Matrix Biology. 30, 4, p. 235-242 8 p.

Research output: Contribution to journalReview article

53 Scopus citations

Egr-1 induces a profibrotic injury/repair gene program associated with systemic sclerosis

Bhattacharyya, S., Sargent, J. L., Du, P., Lin, S., Tourtellotte, W. G., Takehara, K., Whitfield, M. L. & Varga, J., Sep 13 2011, In : PloS one. 6, 9, e23082.

Research output: Contribution to journalArticle

24 Scopus citations

Fibrosis in systemic sclerosis: Emerging concepts and implications for targeted therapy

Wei, J., Bhattacharyya, S., Tourtellotte, W. G. & Varga, J., Mar 1 2011, In : Autoimmunity Reviews. 10, 5, p. 267-275 9 p.

Research output: Contribution to journalReview article

118 Scopus citations
2010

A TGFΒ-responsive gene signature is associated with a subset of diffuse scleroderma with increased disease severity

Sargent, J. L., Milano, A., Bhattacharyya, S., Varga, J., Connolly, M. K., Chang, H. Y. & Whitfield, M. L., Mar 1 2010, In : Journal of Investigative Dermatology. 130, 3, p. 694-705 12 p.

Research output: Contribution to journalArticle

100 Scopus citations
52 Scopus citations
2009

A non-Smad mechanism of fibroblast activation by transforming growth factor-β via c-Abl and Egr-1: Selective modulation by imatinib mesylate

Bhattacharyya, S., Ishida, W., Wu, M., Wilkes, M., Mori, Y., Hinchcliff, M., Leof, E. & Varga, J., Mar 12 2009, In : Oncogene. 28, 10, p. 1285-1297 13 p.

Research output: Contribution to journalArticle

64 Scopus citations

Essential roles for early growth response transcription factor Egr-1 in tissue fibrosis and wound healing

Wu, M., Melichian, D. S., De La Garza, M., Gruner, K., Bhattacharyya, S., Barr, L., Nair, A., Shahrara, S., Sporn, P. H. S., Mustoe, T. A., Tourtellotte, W. G. & Varga, J., Jan 1 2009, In : American Journal of Pathology. 175, 3, p. 1041-1055 15 p.

Research output: Contribution to journalArticle

70 Scopus citations

Peroxisome proliferator-activated receptor-γ abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator

Ghosh, A. K., Bhattacharyya, S., Wei, J., Kim, S., Barak, Y., Mori, Y. & Varga, J., Sep 1 2009, In : FASEB Journal. 23, 9, p. 2968-2977 10 p.

Research output: Contribution to journalArticle

89 Scopus citations

The transcriptional cofactor Nab2 is induced by TGF-β and suppresses fibroblast activation: Physiological roles and impaired expression in scleroderma

Bhattacharyya, S., Wei, J., Melichian, D. S., Milbrandt, J., Takehara, K. & Varga, J., Oct 26 2009, In : PloS one. 4, 10, e7620.

Research output: Contribution to journalArticle

17 Scopus citations

Tyrosine kinase inhibitors in systemic sclerosis: The case for imatinib

Castelino, F. V., Bhattacharyya, S. & Varga, J., Jul 1 2009, In : Current Rheumatology Reports. 11, 3, p. 161-163 3 p.

Research output: Contribution to journalComment/debate

1 Scopus citations
2008

Smad-independent transforming growth factor-β regulation of early growth response-1 and sustained expression in fibrosis: Implications for scleroderma

Bhattacharyya, S., Chen, S. J., Wu, M., Warner-Blankenship, M., Ning, H., Lakos, G., Mori, Y., Chang, E., Nihijima, C., Takehara, K., Feghali-Bostwick, C. & Varga, J., Jan 1 2008, In : American Journal of Pathology. 173, 4, p. 1085-1099 15 p.

Research output: Contribution to journalArticle

68 Scopus citations
2006
29 Scopus citations
2005

Fibroblast expression of the coactivator p300 governs the intensity of profibrotic response to transforming growth factor β

Bhattacharyya, S., Ghosh, A. K., Pannu, J., Mori, Y., Takagawa, S., Chen, G., Trojanowska, M., Gilliam, A. C. & Varga, J., Apr 1 2005, In : Arthritis and rheumatism. 52, 4, p. 1248-1258 11 p.

Research output: Contribution to journalArticle

68 Scopus citations
2004
161 Scopus citations
86 Scopus citations
44 Scopus citations