Swati Bhattacharyya

  • 1943 Citations
1993 …2024
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Research Output 2004 2019

  • 1943 Citations
  • 31 Article
  • 10 Review article
  • 3 Comment/debate
2019

The JAK/STAT pathway is activated in systemic sclerosis and is effectively targeted by tofacitinib

Wang, W., Bhattacharyya, S., Goncalves Marangoni, R., Carns, M., Dennis-Aren, K., Yeldandi, A. V., Wei, J. & Varga, J., Jan 1 2019, (Accepted/In press) In : Journal of Scleroderma and Related Disorders.

Research output: Contribution to journalArticle

Systemic Scleroderma
Fibrosis
Skin
Lung
Biopsy
2018
12 Citations (Scopus)
Systemic Scleroderma
Fibrosis
Ligands
Fibroblasts
Therapeutics
1 Citation (Scopus)

Fibronectin EDA forms the chronic fibrotic scar after contusive spinal cord injury

Cooper, J. G., Jeong, S. J., McGuire, T. L., Sharma, S., Wang, W., Bhattacharyya, S., Varga, J. & Kessler, J., Aug 1 2018, In : Neurobiology of Disease. 116, p. 60-68 9 p.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Fibronectins
Cicatrix
Fibrosis
Gliosis

Matrix protein tenascin-C expands and reversibly blocks maturation of murine eosinophil progenitors

Doan, T. C., Jeong, B. M., Coden, M. E., Loffredo, L. F., Bhattacharyya, S., Chiarella, S. E., Varga, J., Abdala-Valencia, H. & Berdnikovs, S., Aug 1 2018, In : Journal of Allergy and Clinical Immunology. 142, 2, p. 695-698.e4

Research output: Contribution to journalArticle

Tenascin
Protein C
Eosinophils
2 Citations (Scopus)

Pharmacological inhibition of tolllike receptor-4 signaling by TAK242 prevents and induces regression of experimental organ fibrosis

Bhattacharyya, S., Wang, W., Tamaki, Z., Shi, B., Yeldandi, A. V., Tsukimi, Y., Yamasaki, M. & Varga, J., Oct 23 2018, In : Frontiers in immunology. 9, OCT, 2434.

Research output: Contribution to journalArticle

Systemic Scleroderma
Fibrosis
Pharmacology
Toll-Like Receptors
Fibroblasts
5 Citations (Scopus)

Targeting TLRs and the inflammasome in systemic sclerosis

Henderson, J., Bhattacharyya, S., Varga, J. & O'Reilly, S., Dec 1 2018, In : Pharmacology and Therapeutics. 192, p. 163-169 7 p.

Research output: Contribution to journalReview article

Inflammasomes
Systemic Scleroderma
Toll-Like Receptors
Fibrosis
Extracellular Matrix Proteins
7 Citations (Scopus)

TLR4-dependent fibroblast activation drives persistent organ fibrosis in skin and lung

Bhattacharyya, S., Wang, W., Qin, W., Cheng, K., Coulup, S., Chavez, S., Jiang, S., Raparia, K., De Almeida, L. M. V., Stehlik, C., Tamaki, Z., Yin, H. & Varga, J., Jul 12 2018, In : JCI Insight. 3, 13

Research output: Contribution to journalArticle

Open Access
Systemic Scleroderma
Fibrosis
Fibroblasts
Lung
Skin

TLR4-dependent fibroblast activation drives persistent organ fibrosis in skin and lung.

Bhattacharyya, S., Wang, W., Qin, W., Cheng, K., Coulup, S., Chavez, S., Jiang, S., De, A. LMV., Stehlik, C., Tamaki, Z., Yin, H. & Varga, J., Jul 12 2018, In : JCI Insight.. 3, 13

Research output: Contribution to journalArticle

2017
8 Citations (Scopus)

Toll-like receptor-4 signaling drives persistent fibroblast activation and prevents fibrosis resolution in scleroderma

Bhattacharyya, S., Midwood, K. S., Yin, H. & Varga, J., Oct 1 2017, In : Advances in Wound Care. 6, 10, p. 356-369 14 p.

Research output: Contribution to journalReview article

Toll-Like Receptor 4
Fibrosis
Fibroblasts
Pattern Recognition Receptors
Systemic Scleroderma
2016
8 Citations (Scopus)
Transforming Growth Factors
Fibroblasts
Systemic Scleroderma
Toll-Like Receptors
Adiponectin
56 Citations (Scopus)

Tenascin-C drives persistence of organ fibrosis

Bhattacharyya, S., Wang, W., Morales-Nebreda, L., Feng, G., Wu, M., Zhou, X., Lafyatis, R., Lee, J., Hinchcliff, M., Feghali-Bostwick, C., Lakota, K., Budinger, G. R. S., Raparia, K., Tamaki, Z. & Varga, J., Jun 3 2016, In : Nature communications. 7, 11703.

Research output: Contribution to journalArticle

Tenascin
fibrosis
Systemic Scleroderma
organs
Skin
25 Citations (Scopus)

Toll-like Receptor 9 Signaling Is Augmented in Systemic Sclerosis and Elicits Transforming Growth Factor β–Dependent Fibroblast Activation

Fang, F., Goncalves Marangoni, R., Zhou, X., Yang, Y., Ye, B., Shangguang, A., Qin, W., Wang, W., Bhattacharyya, S., Wei, J., Tourtellotte, W. G. & Varga, J., Aug 1 2016, In : Arthritis and Rheumatology. 68, 8, p. 1989-2002 14 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 9
Systemic Scleroderma
Transforming Growth Factors
Fibroblasts
Skin
2015
39 Citations (Scopus)
Systemic Scleroderma
Toll-Like Receptors
Fibrosis
Fibroblasts
Ligands
13 Citations (Scopus)

Molecular characterization of systemic sclerosis esophageal pathology identifies inflammatory and proliferative signatures

Taroni, J. N., Martyanov, V., Huang, C. C., Mahoney, J. M., Hirano, I., Shetuni, B., Yang, G. Y., Brenner, D., Jung, B., Wood, T. A., Bhattacharyya, S., Almagor, O., Lee, J., Sirajuddin, A., Varga, J., Chang, R. W., Whitfield, M. L. & Hinchcliff, M., Jul 29 2015, In : Arthritis Research and Therapy. 17, 1, 194.

Research output: Contribution to journalArticle

Systemic Scleroderma
Pathology
Biopsy
Gene Expression
Smooth Muscle
2014

Erratum to Imatinib mesylate causes genome-wide transcriptional changes in systemic sclerosis fibroblasts in vitro [Clin Exp Rheumatol, 30, 2 Suppl. 71, (2012) S86-S96]

Hinchcliff, M., Huang, C. C., Ishida, W., Fang, F., Lee, J., Jafari, N., Wilkes, M., Bhattacharyya, S., Leof, E. & Varga, J., Feb 25 2014, In : Clinical and Experimental Rheumatology. 32, 1, 1 p.

Research output: Contribution to journalComment/debate

Systemic Scleroderma
Fibroblasts
Genome
Imatinib Mesylate
In Vitro Techniques
91 Citations (Scopus)

FibronectinEDA promotes chronic cutaneous fibrosis through toll-like receptor signaling

Bhattacharyya, S., Tamaki, Z., Wang, W., Hinchcliff, M., Hoover, P., Getsios, S., White, E. S. & Varga, J., Apr 16 2014, In : Science translational medicine. 6, 232, 232ra50.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Toll-Like Receptors
Fibrosis
Fibronectins
Skin
2013
24 Citations (Scopus)

A synthetic TLR3 ligand mitigates profibrotic fibroblast responses by inducing autocrine IFN signaling

Fang, F., Ooka, K., Sun, X., Shah, R., Bhattacharyya, S., Wei, J. & Varga, J., Sep 15 2013, In : Journal of Immunology. 191, 6, p. 2956-2966 11 p.

Research output: Contribution to journalArticle

Autocrine Communication
Fibroblasts
Ligands
Genes
Poly C
28 Citations (Scopus)

Early growth response 3 (Egr-3) is induced by transforming growth factor-β and regulates fibrogenic responses

Fang, F., Shangguan, A. J., Kelly, K., Wei, J., Gruner, K., Ye, B., Wang, W., Bhattacharyya, S., Hinchcliff, M. E., Tourtellotte, W. G. & Varga, J., Oct 1 2013, In : American Journal of Pathology. 183, 4, p. 1197-1208 12 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Growth
Skin
Fibrosis
Fibroblasts
72 Citations (Scopus)

Egr-1: New conductor for the tissue repair orchestra directs harmony (regeneration) or cacophony (fibrosis)

Bhattacharyya, S., Fang, F., Tourtellotte, W. & Varga, J., Jan 1 2013, In : Journal of Pathology. 229, 2, p. 286-297 12 p.

Research output: Contribution to journalReview article

Regeneration
Fibrosis
Growth
Early Growth Response Protein 1
Fibroblasts
62 Citations (Scopus)

Molecular signatures in skin associated with clinical improvement during mycophenolate treatment in systemic sclerosis

Hinchcliff, M. E., Huang, C. C., Wood, T. A., Matthew Mahoney, J., Martyanov, V., Bhattacharyya, S., Tamaki, Z., Lee, J., Carns, M., Podlusky, S., Sirajuddin, A., Shah, S. J., Chang, R. W., Lafyatis, R., Varga, J. & Whitfield, M. L., Jan 1 2013, In : Journal of Investigative Dermatology. 133, 8, p. 1979-1989 11 p.

Research output: Contribution to journalArticle

Systemic Scleroderma
Skin
Mycophenolic Acid
Gene expression
Gene Expression
50 Citations (Scopus)
Systemic Scleroderma
Transforming Growth Factors
Epigenomics
Amplification
Fibrosis
132 Citations (Scopus)

Toll-like receptor 4 signaling augments transforming growth factor-β responses: A novel mechanism for maintaining and amplifying fibrosis in scleroderma

Bhattacharyya, S., Kelley, K., Melichian, D. S., Tamaki, Z., Fang, F., Su, Y., Feng, G., Pope, R. M., Budinger, GR. S., Mutlu, G. M., Lafyatis, R., Radstake, T., Feghali-Bostwick, C. & Varga, J., Jan 1 2013, In : American Journal of Pathology. 182, 1, p. 192-205 14 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Transforming Growth Factors
Fibrosis
Fibroblasts
Ligands
2012
25 Citations (Scopus)

Fibrosis in systemic sclerosis: Common and unique pathobiology

Bhattacharyya, S., Wei, J., Tourtellotte, W. G., Hinchcliff, M., Gottardi, C. G. & Varga, J., Jun 6 2012, In : Fibrogenesis and Tissue Repair. 5, SUPPL.1, S18.

Research output: Contribution to journalArticle

Systemic Scleroderma
Peroxisome Proliferator-Activated Receptors
Fibrosis
Drug Repositioning
Fibroblasts
7 Citations (Scopus)

Imatinib mesylate causes genome-wide transcriptional changes in systemic sclerosis fibroblasts in vitro

Hinchcliff, M., Huang, C. C., Ishida, W., Fang, F., Lee, J., Jafari, N., Wilkes, M., Bhattacharyya, S., Leof, E. & Varga, J., May 1 2012, In : Clinical and experimental rheumatology. 30, SUPPL.71

Research output: Contribution to journalArticle

Systemic Scleroderma
Fibroblasts
Genome
Gene Expression
Fibrosis
26 Citations (Scopus)
Peroxisome Proliferator-Activated Receptors
Fibrosis
Systemic Scleroderma
Rodentia
Cytoplasmic and Nuclear Receptors
49 Citations (Scopus)

The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: Novel target for fibrosis therapy

Fang, F., Liu, L., Yang, Y., Tamaki, Z., Wei, J., Goncalves Marangoni, R., Bhattacharyya, S., Summer, R. S., Ye, B. & Varga, J., Oct 23 2012, In : Arthritis Research and Therapy. 14, 5, R229.

Research output: Contribution to journalArticle

Adipokines
Adiponectin
Adenosine Monophosphate
Protein Kinases
Fibrosis
196 Citations (Scopus)

Understanding fibrosis in systemic sclerosis: Shifting paradigms, emerging opportunities

Bhattacharyya, S., Wei, J. & Varga, J., Jan 1 2012, In : Nature Reviews Rheumatology. 8, 1, p. 42-54 13 p.

Research output: Contribution to journalReview article

Systemic Scleroderma
Fibrosis
Fibroblasts
Drug Repositioning
Pericytes
2011
50 Citations (Scopus)

Early growth response transcription factors: Key mediators of fibrosis and novel targets for anti-fibrotic therapy

Bhattacharyya, S., Wu, M., Fang, F., Tourtellotte, W., Feghali-Bostwick, C. & Varga, J., May 1 2011, In : Matrix Biology. 30, 4, p. 235-242 8 p.

Research output: Contribution to journalReview article

Early Growth Response Transcription Factors
Fibrosis
Transforming Growth Factors
Transcription Factors
Therapeutics
22 Citations (Scopus)

Egr-1 induces a profibrotic injury/repair gene program associated with systemic sclerosis

Bhattacharyya, S., Sargent, J. L., Du, P., Lin, S., Tourtellotte, W. G., Takehara, K., Whitfield, M. L. & Varga, J., Sep 13 2011, In : PloS one. 6, 9, e23082.

Research output: Contribution to journalArticle

Systemic Scleroderma
sclerosis
Repair
Genes
Transforming Growth Factors
114 Citations (Scopus)

Fibrosis in systemic sclerosis: Emerging concepts and implications for targeted therapy

Wei, J., Bhattacharyya, S., Tourtellotte, W. G. & Varga, J., Mar 1 2011, In : Autoimmunity Reviews. 10, 5, p. 267-275 9 p.

Research output: Contribution to journalReview article

Systemic Scleroderma
Fibrosis
Transforming Growth Factors
Fibroblasts
Peroxisome Proliferator-Activated Receptors
2010
94 Citations (Scopus)

A TGFΒ-responsive gene signature is associated with a subset of diffuse scleroderma with increased disease severity

Sargent, J. L., Milano, A., Bhattacharyya, S., Varga, J., Connolly, M. K., Chang, H. Y. & Whitfield, M. L., Mar 1 2010, In : Journal of Investigative Dermatology. 130, 3, p. 694-705 12 p.

Research output: Contribution to journalArticle

Diffuse Scleroderma
Transforming Growth Factors
Genes
Systemic Scleroderma
Skin
49 Citations (Scopus)
Peroxisome Proliferator-Activated Receptors
Systemic Scleroderma
Fibrosis
Pulmonary Hypertension
Ligands
2009
63 Citations (Scopus)

A non-Smad mechanism of fibroblast activation by transforming growth factor-β via c-Abl and Egr-1: Selective modulation by imatinib mesylate

Bhattacharyya, S., Ishida, W., Wu, M., Wilkes, M., Mori, Y., Hinchcliff, M. E., Leof, E. & Varga, J., Mar 12 2009, In : Oncogene. 28, 10, p. 1285-1297 13 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Intercellular Signaling Peptides and Proteins
Fibroblasts
Fibrosis
Phosphotransferases
68 Citations (Scopus)

Essential roles for early growth response transcription factor Egr-1 in tissue fibrosis and wound healing

Wu, M., Melichian, D. S., De La Garza, M., Gruner, K., Bhattacharyya, S., Barr, L., Nair, A., Shahrara, S., Sporn, P. H. S., Mustoe, T. A., Tourtellotte, W. G. & Varga, J., Jan 1 2009, In : American Journal of Pathology. 175, 3, p. 1041-1055 15 p.

Research output: Contribution to journalArticle

Early Growth Response Protein 1
Wound Healing
Fibrosis
Fibroblasts
Transforming Growth Factors
86 Citations (Scopus)

Peroxisome proliferator-activated receptor-γ abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator

Ghosh, A. K., Bhattacharyya, S., Wei, J., Kim, S., Barak, Y., Mori, Y. & Varga, J., Sep 1 2009, In : FASEB Journal. 23, 9, p. 2968-2977 10 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Collagen
Transforming Growth Factor beta
Fibroblasts
Histone Acetyltransferases
15 Citations (Scopus)

The transcriptional cofactor Nab2 is induced by TGF-β and suppresses fibroblast activation: Physiological roles and impaired expression in scleroderma

Bhattacharyya, S., Wei, J., Melichian, D. S., Milbrandt, J., Takehara, K. & Varga, J., Oct 26 2009, In : PloS one. 4, 10, e7620.

Research output: Contribution to journalArticle

transforming growth factors
Transforming Growth Factors
Fibroblasts
fibroblasts
binding proteins
1 Citation (Scopus)

Tyrosine kinase inhibitors in systemic sclerosis: The case for imatinib

Castelino, F. V., Bhattacharyya, S. & Varga, J., Jul 1 2009, In : Current Rheumatology Reports. 11, 3, p. 161-163 3 p.

Research output: Contribution to journalComment/debate

Systemic Scleroderma
Protein-Tyrosine Kinases
Imatinib Mesylate
2008
63 Citations (Scopus)

Smad-independent transforming growth factor-β regulation of early growth response-1 and sustained expression in fibrosis: Implications for scleroderma

Bhattacharyya, S., Chen, S. J., Wu, M., Warner-Blankenship, M., Ning, H., Lakos, G., Mori, Y., Chang, E., Nihijima, C., Takehara, K., Feghali-Bostwick, C. & Varga, J., Jan 1 2008, In : American Journal of Pathology. 173, 4, p. 1085-1099 15 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Fibrosis
Early Growth Response Protein 1
Growth
Fibroblasts
2006
29 Citations (Scopus)
CCAAT-Enhancer-Binding Proteins
Gene expression
Interferons
Collagen
Gene Expression
2005
65 Citations (Scopus)

Fibroblast expression of the coactivator p300 governs the intensity of profibrotic response to transforming growth factor β

Bhattacharyya, S., Ghosh, A. K., Pannu, J., Mori, Y., Takagawa, S., Chen, G., Trojanowska, M., Gilliam, A. C. & Varga, J., Apr 1 2005, In : Arthritis and rheumatism. 52, 4, p. 1248-1258 11 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Fibroblasts
Catalytic RNA
Skin
Systemic Scleroderma
2004
159 Citations (Scopus)
Peroxisome Proliferator-Activated Receptors
Transforming Growth Factors
Fibroblasts
Skin
Myofibroblasts
84 Citations (Scopus)
Transforming Growth Factors
Fibroblasts
Skin
Systemic Scleroderma
TGF-beta type I receptor
43 Citations (Scopus)
Transforming Growth Factors
Tumors
Collagen
Genes
Fibroblasts