Syamal Kumar Datta

  • 6618 Citations
1974 …2018

Research output per year

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Research Output

2018

Five year follow-up after autologous peripheral blood hematopoietic stem cell transplantation for refractory, chronic, corticosteroid-dependent systemic lupus erythematosus: Effect of conditioning regimen on outcome

Burt, R. K., Han, X., Gozdziak, P., Yaung, K., Morgan, A., Clendenan, A. M., Henry, J., Calvario, M. A., Datta, S. K., Helenowski, I. & Schroeder, J., Jun 1 2018, In : Bone Marrow Transplantation. 53, 6, p. 692-700 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016
3 Scopus citations
2015

CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis

Huang, Q. Q., Perlman, H., Birkett, R., Doyle, R., Fang, D., Haines, G. K., Robinson, W., Datta, S., Huang, Z., Li, Q. Z., Phee, H. & Pope, R. M., May 12 2015, In : Nature communications. 6, 7086.

Research output: Contribution to journalArticle

13 Scopus citations
11 Scopus citations
2014

Prospects for a peptide vaccine for human lupus

Zhang, L. & Datta, S. K., Jan 1 2014, In : International Journal of Clinical Rheumatology. 9, 3, p. 229-232 4 p.

Research output: Contribution to journalReview article

2013

Major pathogenic steps in human lupus can be effectively suppressed by nucleosomal histone peptide epitope-induced regulatory immunity

Zhang, L., Bertucci, A. M., Ramsey-Goldman, R., Harsha-Strong, E. R., Burt, R. K. & Datta, S. K., Dec 2013, In : Clinical Immunology. 149, 3 PB, p. 365-378 14 p.

Research output: Contribution to journalArticle

15 Scopus citations
2012

Megakaryocyte progenitors are the main APCs inducing Th17 response to lupus autoantigens and foreign antigens

Kang, H. K., Chiang, M. Y., Ecklund, D., Zhang, L., Ramsey-Goldman, R. & Datta, S. K., Jun 15 2012, In : Journal of Immunology. 188, 12, p. 5970-5980 11 p.

Research output: Contribution to journalArticle

9 Scopus citations
2011

The histone peptide H4 71-94 alone is more effective than a cocktail of peptide epitopes in controlling lupus: Immunoregulatory mechanisms

Kang, H. K., Chiang, M. Y., Liu, M., Ecklund, D. & Datta, S. K., Jun 1 2011, In : Journal of Clinical Immunology. 31, 3, p. 379-394 16 p.

Research output: Contribution to journalArticle

12 Scopus citations
2009
18 Scopus citations
52 Scopus citations
113 Scopus citations
2008
33 Scopus citations

Signalling defects and cellular interactions (2)

Datta, S. K. & Mauri, C., May 1 2008, In : Lupus. 17, 3, p. 247-250 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
2007
30 Scopus citations
158 Scopus citations
2006

Regulatory T cells in lupus

Kang, H. K. & Datta, S. K., Jan 1 2006, In : International Reviews of Immunology. 25, 1-2, p. 5-25 21 p.

Research output: Contribution to journalReview article

18 Scopus citations
2005

A defect in deletion of nucleosome-specific autoimmune T cells in lupus-prone thymus: Role of thymic dendritic cells

Michaels, M. A., Kang, H. K., Kaliyaperumal, A., Satyaraj, E., Shi, Y. & Datta, S. K., Nov 1 2005, In : Journal of Immunology. 175, 9, p. 5857-5865 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Genetic origin of lupus in NZB/SWR hybrids: Lessons from an intercross study

Xie, S., Li, L., Chang, S., Sharma, R., Kaliyaperumal, A., Datta, S. K. & Mohan, C., Feb 1 2005, In : Arthritis and rheumatism. 52, 2, p. 659-667 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

T-helper cell intrinsic defects in lupus that break peripheral tolerance to nuclear autoantigens

Datta, S. K., Zhang, L. & Xu, L., Apr 1 2005, In : Journal of Molecular Medicine. 83, 4, p. 267-278 12 p.

Research output: Contribution to journalReview article

29 Scopus citations

Very low-dose tolerance with nucleosomal peptides controls lupus and induces potent regulatory T cell subsets

Kang, H. K., Michaels, M. A., Berner, B. R. & Datta, S. K., Mar 15 2005, In : Journal of Immunology. 174, 6, p. 3247-3255 9 p.

Research output: Contribution to journalArticle

148 Scopus citations
2004

Human lupus T cells resist inactivation and escape death by upregulating COX-2

Xu, L., Zhang, L., Yi, Y., Kang, H. K. & Datta, S. K., Apr 1 2004, In : Nature Medicine. 10, 4, p. 411-415 5 p.

Research output: Contribution to journalArticle

122 Scopus citations
2003
64 Scopus citations
2002

B cell stimulatory effects of α-enolase that is differentially expressed in NZB mouse B cells

Babu, J. S., Sun, T., Xu, L. & Datta, S. K., 2002, In : Clinical Immunology. 104, 3, p. 293-304 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Dominant NZB contributions to lupus in the (SWR×NZB)F1 model

Xie, S., Chang, S. H., Sedrak, P., Kaliyaperumal, A., Datta, S. K. & Mohan, C., Jan 1 2002, In : Genes and Immunity. 3, p. S13-S20

Research output: Contribution to journalArticle

18 Scopus citations

Naturally processed chromatin peptides reveal a major autoepitope that primes pathogenic T and B cells of lupus

Kaliyaperumal, A., Michaels, M. A. & Datta, S. K., Mar 1 2002, In : Journal of Immunology. 168, 5, p. 2530-2537 8 p.

Research output: Contribution to journalArticle

66 Scopus citations
2001

Genetic contributions of nonautoimmune SWR mice toward lupus nephritis

Xie, S., Chang, S., Yang, P., Jacob, C., Kaliyaperumal, A., Datta, S. K. & Mohan, C., Dec 15 2001, In : Journal of Immunology. 167, 12, p. 7141-7149 9 p.

Research output: Contribution to journalArticle

20 Scopus citations
2000

Positive selection for autoimmunity

Datta, S. K., Mar 1 2000, In : Nature Medicine. 6, 3, p. 259-261 3 p.

Research output: Contribution to journalShort survey

12 Scopus citations
91 Scopus citations
1999

Antigen-specific therapy of murine lupus nephritis using nucleosomal peptides: Tolerance spreading impairs pathogenic function of autoimmune T and B cells

Kaliyaperumal, A., Michaels, M. A. & Datta, S. K., May 15 1999, In : Journal of Immunology. 162, 10, p. 5775-5783 9 p.

Research output: Contribution to journalArticle

138 Scopus citations

Major peptide autoepitopes for nucleosome-specific T cells of human lupus

Lu, L., Kaliyaperumal, A., Boumpas, D. T. & Datta, S. K., Aug 1999, In : Journal of Clinical Investigation. 104, 3, p. 345-355 11 p.

Research output: Contribution to journalArticle

147 Scopus citations
1998

Anti-CD40 ligand antibody treatment of SNF1 mice with established nephritis: Preservation of kidney function

Kalled, S. L., Cutler, A. H., Datta, S. K. & Thomas, D. W., Mar 1 1998, In : Journal of Immunology. 160, 5, p. 2158-2165 8 p.

Research output: Contribution to journalArticle

165 Scopus citations

Mechanisms of pathogenic autoimmune response in lupus: From mouse models to human disease.

Datta, S. K., 1998, Lupus: Molecular and Cellular Pathogenesis. Tsokos, G. C. & Kammer, G. (eds.). New Jersey: Humana Press Inc.

Research output: Chapter in Book/Report/Conference proceedingChapter

Production of pathogenic antibodies: Cognate interactions between autoimmune T and B cells

Datta, S. K., Dec 1 1998, In : Lupus. 7, 9, p. 591-596 6 p.

Research output: Contribution to journalReview article

35 Scopus citations

Promiscuous presentation and recognition of nucleosomal autoepitopes in lupus: Role of autoimmune T cell receptor α chain

Shi, Y., Kaliyaperumal, A., Lu, L., Southwood, S., Sette, A., Michaels, M. A. & Datta, S. K., Feb 2 1998, In : Journal of Experimental Medicine. 187, 3, p. 367-378 12 p.

Research output: Contribution to journalArticle

66 Scopus citations

Systemic lupus:basic mechanisms of autoimmunity and specific immunotherapy.

Datta, S. K., Kaliyaperumal, A., Michaels, M. A., Desai-Mehta, A., Rao, K. V. S., Mohan, C. & Shi, Y., 1998, Proceedings of The 10th International Congress of Immunology. Talwar, G. P., Nath, I. & Ganguly, N. K. (eds.). Bologna, Italy: Monduzzi Editore S.p.A., p. 2:1311-1319

Research output: Chapter in Book/Report/Conference proceedingChapter

1997

CD40-CD40 ligand interaction in autoimmune disease

Datta, S. K. & Kalled, S. L., Nov 1 1997, In : Arthritis and rheumatism. 40, 10, p. 1735-1745 11 p.

Research output: Contribution to journalReview article

104 Scopus citations

Characteristics of T cells that participate in the pathogenesis of SLE

Hahn, B. H. & Datta, S. K., Jan 1 1997, In : Lupus. 6, 3, p. 330-332 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Nucleosome-driven autoimmune response in lupus. Pathogenic T helper cell epitopes and costimulatory signals

Datta, S. K. & Kaliyaperumal, A., Jan 1 1997, In : Annals of the New York Academy of Sciences. 815, p. 155-170 16 p.

Research output: Contribution to journalArticle

22 Scopus citations

Systemic lupus: Basic mechanisms and prospects for specific immunotherapy

Datta, S. K., Jan 1 1997, In : Japanese Journal of Rheumatology. 7, 4, p. 247-261 15 p.

Research output: Contribution to journalReview article

T cells of lupus and molecular targets for immunotherapy

Datta, S. K., Kaliyaperumal, A. & Desai-Mehta, A., Feb 28 1997, In : Journal of Clinical Immunology. 17, 1, p. 11-20 10 p.

Research output: Contribution to journalReview article

22 Scopus citations

T helper cells driving pathogenic anti-DNA autoantibody production in lupus: Nucleosomal epitopes and CD40 ligand signals

Datta, S. K., Kaliyaperumal, A., Mohan, C. & Desai-Mehta, A., Jan 1 1997, In : Lupus. 6, 3, p. 333-336 4 p.

Research output: Contribution to journalArticle

13 Scopus citations
1996

Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production

Desai-Mehta, A., Lu, L., Ramsey-Goldman, R. & Datta, S. K., May 1 1996, In : Journal of Clinical Investigation. 97, 9, p. 2063-2073 11 p.

Research output: Contribution to journalArticle

430 Scopus citations

Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus

Kaliyaperumal, A., Mohan, C., Wu, W. & Datta, S. K., Jun 1 1996, In : Journal of Experimental Medicine. 183, 6, p. 2459-2469 11 p.

Research output: Contribution to journalArticle

188 Scopus citations
1995

Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis

Mohan, C., Shi, Y., Laman, J. D. & Datta, S. K., Jan 1 1995, In : Journal of Immunology. 154, 3, p. 1470-1480 11 p.

Research output: Contribution to journalArticle

347 Scopus citations

Lupus: Key pathogenic mechanisms and contributing factors

Mohan, C. & Datta, S. K., Dec 1995, In : Clinical Immunology and Immunopathology. 77, 3, p. 209-220 12 p.

Research output: Contribution to journalReview article

103 Scopus citations

Mechanisms of the pathogenic autoimmune response in lupus: Prospects for specific immunotherapy

Datta, S. K., Mohan, C. & Desai-Mehta, A., Jun 1 1995, In : Immunologic Research. 14, 2, p. 132-147 16 p.

Research output: Contribution to journalArticle

10 Scopus citations

Structure and specificity of T cell receptors expressed by potentially pathogenic anti-DNA autoantibody-inducing T cells in human lupus

Desai-Mehta, A., Mao, C., Rajagopalan, S., Robinson, T. & Datta, S. K., Jan 1 1995, In : Journal of Clinical Investigation. 95, 2, p. 531-541 11 p.

Research output: Contribution to journalArticle

159 Scopus citations
1994

Mechanisms of autoimmunization: Perspective from the mid-90s

Sercarz, E. E. & Datta, S. K., Dec 1994, In : Current Opinion in Immunology. 6, 6, p. 875-881 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

T cell receptor α-chain repertoire of pathogenic autoantibody-inducing T cells in lupus mice

Mao, C., Osman, G. E., Adams, S. & Datta, S. K., Feb 1 1994, In : Journal of Immunology. 152, 3, p. 1462-1470 9 p.

Research output: Contribution to journalArticle

34 Scopus citations
1993

Nucleosome: A major immunogen for pathogenic autoantibody-inducing T cells of lupus

Mohan, C., Adams, S., Stanik, V. & Datta, S. K., May 1 1993, In : Journal of Experimental Medicine. 177, 5, p. 1367-1381 15 p.

Research output: Contribution to journalArticle

602 Scopus citations