Syamal Kumar Datta

  • 6537 Citations
1974 …2018
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Research Output 1974 2018

2018
8 Citations (Scopus)

Five year follow-up after autologous peripheral blood hematopoietic stem cell transplantation for refractory, chronic, corticosteroid-dependent systemic lupus erythematosus: Effect of conditioning regimen on outcome

Burt, R. K., Han, X., Gozdziak, P., Yaung, K., Morgan, A., Clendenan, A. M., Henry, J., Calvario, M. A., Datta, S. K., Helenowski, I. & Schroeder, J., Jun 1 2018, In : Bone Marrow Transplantation. 53, 6, p. 692-700 9 p.

Research output: Contribution to journalArticle

Peripheral Blood Stem Cell Transplantation
Hematopoietic Stem Cell Transplantation
Systemic Lupus Erythematosus
Adrenal Cortex Hormones
Cyclophosphamide
2016
3 Citations (Scopus)
Th17 Cells
Interleukin-17
Hematopoietic Stem Cells
Stem Cells
Bone Marrow
2015
13 Citations (Scopus)

CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis

Huang, Q-Q., Perlman, H. R., Birkett, R., Doyle, R., Fang, D., Haines, G. K., Robinson, W., Datta, S. K., Huang, Z., Li, Q. Z., Phee, H. & Pope, R. M., May 12 2015, In : Nature communications. 6, 7086.

Research output: Contribution to journalArticle

arthritis
deletion
Dendritic Cells
Arthritis
T-cells
9 Citations (Scopus)
Megakaryocyte Progenitor Cells
Hematopoietic Stem Cells
Extramedullary Hematopoiesis
Blood Platelets
T-Lymphocytes
2014

Prospects for a peptide vaccine for human lupus

Zhang, L. & Datta, S. K., Jan 1 2014, In : International Journal of Clinical Rheumatology. 9, 3, p. 229-232 4 p.

Research output: Contribution to journalReview article

Subunit Vaccines
Nucleosomes
Regulatory T-Lymphocytes
Autoimmunity
Systemic Lupus Erythematosus
2013
14 Citations (Scopus)

Major pathogenic steps in human lupus can be effectively suppressed by nucleosomal histone peptide epitope-induced regulatory immunity

Zhang, L., Bertucci, A. M., Ramsey-Goldman, R., Harsha-Strong, E. R., Burt, R. K. & Datta, S. K., Dec 2013, In : Clinical Immunology. 149, 3 PB, p. 365-378 14 p.

Research output: Contribution to journalArticle

Histones
Epitopes
Immunity
Peptides
Hydroxychloroquine
2012
9 Citations (Scopus)

Megakaryocyte progenitors are the main APCs inducing Th17 response to lupus autoantigens and foreign antigens

Kang, H. K., Chiang, M. Y., Ecklund, D., Zhang, L., Ramsey-Goldman, R. & Datta, S. K., Jun 15 2012, In : Journal of Immunology. 188, 12, p. 5970-5980 11 p.

Research output: Contribution to journalArticle

Megakaryocyte Progenitor Cells
Antigens
Autoantigens
Megakaryocyte-Erythroid Progenitor Cells
To autoantigen
2011
9 Citations (Scopus)

The histone peptide H4 71-94 alone is more effective than a cocktail of peptide epitopes in controlling lupus: Immunoregulatory mechanisms

Kang, H. K., Chiang, M. Y., Liu, M., Ecklund, D. & Datta, S. K., Jun 1 2011, In : Journal of Clinical Immunology. 31, 3, p. 379-394 16 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Histones
Epitopes
T-Lymphocytes
Peptides
2009
18 Citations (Scopus)
CD20 Antigens
Lymphocyte Depletion
Antibody-Dependent Cell Cytotoxicity
Immunosuppressive Agents
Anti-Idiotypic Antibodies
49 Citations (Scopus)
Apigenin
Th17 Cells
Th1 Cells
Autoantigens
Flavonoids
108 Citations (Scopus)
T-Lymphocyte Subsets
Stem Cell Transplantation
Regulatory T-Lymphocytes
T-Lymphocytes
Autoantigens
2008
32 Citations (Scopus)
Apigenin
Flavonoids
Cell Death
T-Lymphocytes
Cyclooxygenase 2
1 Citation (Scopus)

Signalling defects and cellular interactions (2)

Datta, S. K. & Mauri, C., May 1 2008, In : Lupus. 17, 3, p. 247-250 4 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Autoimmunity
Cell Communication
Systemic Lupus Erythematosus
Signal Transduction
2007
27 Citations (Scopus)
Celecoxib
Diet Therapy
Cyclooxygenase 2 Inhibitors
Cyclooxygenase 2
Systemic Lupus Erythematosus
155 Citations (Scopus)
Th17 Cells
Autoantigens
Regulatory T-Lymphocytes
Dendritic Cells
Peptides
2006
18 Citations (Scopus)

Regulatory T cells in lupus

Kang, H. K. & Datta, S. K., Jan 1 2006, In : International Reviews of Immunology. 25, 1-2, p. 5-25 21 p.

Research output: Contribution to journalReview article

Regulatory T-Lymphocytes
Autoantigens
Lupus Nephritis
Autoimmunity
Autoantibodies
2005
20 Citations (Scopus)

A defect in deletion of nucleosome-specific autoimmune T cells in lupus-prone thymus: Role of thymic dendritic cells

Michaels, M. A., Kang, H. K., Kaliyaperumal, A., Satyaraj, E., Shi, Y. & Datta, S. K., Nov 1 2005, In : Journal of Immunology. 175, 9, p. 5857-5865 9 p.

Research output: Contribution to journalArticle

Nucleosomes
Dendritic Cells
Thymus Gland
Inbred NZB Mouse
T-Lymphocytes
8 Citations (Scopus)

Genetic origin of lupus in NZB/SWR hybrids: Lessons from an intercross study

Xie, S., Li, L., Chang, S., Sharma, R., Kaliyaperumal, A., Datta, S. K. & Mohan, C., Feb 1 2005, In : Arthritis and rheumatism. 52, 2, p. 659-667 9 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 2
Antibodies
29 Citations (Scopus)

T-helper cell intrinsic defects in lupus that break peripheral tolerance to nuclear autoantigens

Datta, S. K., Zhang, L. & Xu, L., Apr 1 2005, In : Journal of Molecular Medicine. 83, 4, p. 267-278 12 p.

Research output: Contribution to journalReview article

Peripheral Tolerance
Helper-Inducer T-Lymphocytes
Epitopes
Cyclooxygenase 2 Inhibitors
Cyclooxygenase 2
144 Citations (Scopus)

Very low-dose tolerance with nucleosomal peptides controls lupus and induces potent regulatory T cell subsets

Kang, H. K., Michaels, M. A., Berner, B. R. & Datta, S. K., Mar 15 2005, In : Journal of Immunology. 174, 6, p. 3247-3255 9 p.

Research output: Contribution to journalArticle

T-Lymphocyte Subsets
Regulatory T-Lymphocytes
Peptides
T-Lymphocytes
Autoantibodies
2004
120 Citations (Scopus)

Human lupus T cells resist inactivation and escape death by upregulating COX-2

Xu, L., Zhang, L., Yi, Y., Kang, H. K. & Datta, S. K., Apr 1 2004, In : Nature Medicine. 10, 4, p. 411-415 5 p.

Research output: Contribution to journalArticle

T-cells
Cyclooxygenase 2
T-Lymphocytes
Apoptosis
Gene encoding
2003
64 Citations (Scopus)
Nucleosomes
Cell Communication
B-Lymphocytes
Cells
T-Lymphocytes
2002
3 Citations (Scopus)

B cell stimulatory effects of α-enolase that is differentially expressed in NZB mouse B cells

Babu, J. S., Sun, T., Xu, L. & Datta, S. K., Jan 1 2002, In : Clinical Immunology. 104, 3, p. 293-304 12 p.

Research output: Contribution to journalArticle

Inbred NZB Mouse
Phosphopyruvate Hydratase
B-Lymphocytes
Chromosomes, Human, Pair 4
Genes
18 Citations (Scopus)

Dominant NZB contributions to lupus in the (SWR×NZB)F1 model

Xie, S., Chang, S. H., Sedrak, P., Kaliyaperumal, A., Datta, S. K. & Mohan, C., Jan 1 2002, In : Genes and Immunity. 3, p. S13-S20

Research output: Contribution to journalArticle

Lupus Nephritis
Antinuclear Antibodies
Antibody Formation
Mortality
66 Citations (Scopus)

Naturally processed chromatin peptides reveal a major autoepitope that primes pathogenic T and B cells of lupus

Kaliyaperumal, A., Michaels, M. A. & Datta, S. K., Mar 1 2002, In : Journal of Immunology. 168, 5, p. 2530-2537 8 p.

Research output: Contribution to journalArticle

Chromatin
Epitopes
B-Lymphocytes
T-Lymphocytes
Peptides
2001
20 Citations (Scopus)

Genetic contributions of nonautoimmune SWR mice toward lupus nephritis

Xie, S., Chang, S., Yang, P., Jacob, C., Kaliyaperumal, A., Datta, S. K. & Mohan, C., Dec 15 2001, In : Journal of Immunology. 167, 12, p. 7141-7149 9 p.

Research output: Contribution to journalArticle

Lupus Nephritis
New Zealand
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 14
Genetic Crosses
2000
12 Citations (Scopus)

Positive selection for autoimmunity

Datta, S. K., Mar 1 2000, In : Nature Medicine. 6, 3, p. 259-261 3 p.

Research output: Contribution to journalShort survey

Central Tolerance
Thymus
Autoantigens
Autoimmunity
Thymus Gland
91 Citations (Scopus)
CD40 Ligand
Mitogen-Activated Protein Kinases
Phosphotransferases
T-Lymphocytes
Extracellular Signal-Regulated MAP Kinases
1999
135 Citations (Scopus)

Antigen-specific therapy of murine lupus nephritis using nucleosomal peptides: Tolerance spreading impairs pathogenic function of autoimmune T and B cells

Kaliyaperumal, A., Michaels, M. A. & Datta, S. K., May 15 1999, In : Journal of Immunology. 162, 10, p. 5775-5783 9 p.

Research output: Contribution to journalArticle

Lupus Nephritis
B-Lymphocytes
Inbred NZB Mouse
T-Lymphocytes
Antigens
145 Citations (Scopus)

Major peptide autoepitopes for nucleosome-specific T cells of human lupus

Lu, L., Kaliyaperumal, A., Boumpas, D. T. & Datta, S. K., Aug 1999, In : Journal of Clinical Investigation. 104, 3, p. 345-355 11 p.

Research output: Contribution to journalArticle

Nucleosomes
T-Lymphocytes
Peptides
Histones
Autoantibodies
1998
163 Citations (Scopus)

Anti-CD40 ligand antibody treatment of SNF1 mice with established nephritis: Preservation of kidney function

Kalled, S. L., Cutler, A. H., Datta, S. K. & Thomas, D. W., Mar 1 1998, In : Journal of Immunology. 160, 5, p. 2158-2165 8 p.

Research output: Contribution to journalArticle

Inbred NZB Mouse
CD40 Ligand
Nephritis
Kidney
Antibodies

Mechanisms of pathogenic autoimmune response in lupus: From mouse models to human disease.

Datta, S. K., 1998, Lupus: Molecular and Cellular Pathogenesis. Tsokos, G. C. & Kammer, G. (eds.). New Jersey: Humana Press Inc.

Research output: Chapter in Book/Report/Conference proceedingChapter

34 Citations (Scopus)

Production of pathogenic antibodies: Cognate interactions between autoimmune T and B cells

Datta, S. K., Dec 1 1998, In : Lupus. 7, 9, p. 591-596 6 p.

Research output: Contribution to journalReview article

Helper-Inducer T-Lymphocytes
CD40 Ligand
Antibody Formation
B-Lymphocytes
T-Lymphocytes
65 Citations (Scopus)

Promiscuous presentation and recognition of nucleosomal autoepitopes in lupus: Role of autoimmune T cell receptor α chain

Shi, Y., Kaliyaperumal, A., Lu, L., Southwood, S., Sette, A., Michaels, M. A. & Datta, S. K., Feb 2 1998, In : Journal of Experimental Medicine. 187, 3, p. 367-378 12 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Clone Cells
Epitopes
Nucleosomes
T-Lymphocytes

Systemic lupus:basic mechanisms of autoimmunity and specific immunotherapy.

Datta, S. K., Kaliyaperumal, A., Michaels, M. A., Desai-Mehta, A., Rao, K. V. S., Mohan, C. & Shi, Y., 1998, Proceedings of The 10th International Congress of Immunology. Talwar, G. P., Nath, I. & Ganguly, N. K. (eds.). Bologna, Italy: Monduzzi Editore S.p.A., p. 2:1311-1319

Research output: Chapter in Book/Report/Conference proceedingChapter

1997
104 Citations (Scopus)

CD40-CD40 ligand interaction in autoimmune disease

Datta, S. K. & Kalled, S. L., Nov 1 1997, In : Arthritis and rheumatism. 40, 10, p. 1735-1745 11 p.

Research output: Contribution to journalReview article

CD40 Antigens
CD40 Ligand
Membrane Glycoproteins
Systemic Lupus Erythematosus
Autoimmune Diseases
3 Citations (Scopus)

Characteristics of T cells that participate in the pathogenesis of SLE

Hahn, B. H. & Datta, S. K., Jan 1 1997, In : Lupus. 6, 3, p. 330-332 3 p.

Research output: Contribution to journalArticle

Immune Tolerance
Nucleosomes
Helper-Inducer T-Lymphocytes
T-Lymphocytes
22 Citations (Scopus)

Nucleosome-driven autoimmune response in lupus. Pathogenic T helper cell epitopes and costimulatory signals

Datta, S. K. & Kaliyaperumal, A., Jan 1 1997, In : Annals of the New York Academy of Sciences. 815, p. 155-170 16 p.

Research output: Contribution to journalArticle

T-Lymphocyte Epitopes
Nucleosomes
Autoimmunity
Cells

Systemic lupus: Basic mechanisms and prospects for specific immunotherapy

Datta, S. K., Dec 1 1997, In : Japanese Journal of Rheumatology. 7, 4, p. 247-261 15 p.

Research output: Contribution to journalReview article

Nucleosomes
Immunotherapy
Helper-Inducer T-Lymphocytes
Histones
CD40 Ligand
22 Citations (Scopus)

T cells of lupus and molecular targets for immunotherapy

Datta, S. K., Kaliyaperumal, A. & Desai-Mehta, A., Feb 28 1997, In : Journal of Clinical Immunology. 17, 1, p. 11-20 10 p.

Research output: Contribution to journalReview article

Nucleosomes
Immunotherapy
Histones
T-Lymphocytes
CD40 Ligand
13 Citations (Scopus)

T helper cells driving pathogenic anti-DNA autoantibody production in lupus: Nucleosomal epitopes and CD40 ligand signals

Datta, S. K., Kaliyaperumal, A., Mohan, C. & Desai-Mehta, A., Jan 1 1997, In : Lupus. 6, 3, p. 333-336 4 p.

Research output: Contribution to journalArticle

Lymphocyte Cooperation
Genetic Crosses
Inbred NZB Mouse
Immunoglobulin Variable Region
Animal Disease Models
1996
424 Citations (Scopus)

Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production

Desai-Mehta, A., Lu, L., Ramsey-Goldman, R. & Datta, S. K., May 1 1996, In : Journal of Clinical Investigation. 97, 9, p. 2063-2073 11 p.

Research output: Contribution to journalArticle

CD40 Ligand
Autoantibodies
B-Lymphocytes
T-Lymphocytes
Mitogens
185 Citations (Scopus)

Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus

Kaliyaperumal, A., Mohan, C., Wu, W. & Datta, S. K., Jun 1 1996, In : Journal of Experimental Medicine. 183, 6, p. 2459-2469 11 p.

Research output: Contribution to journalArticle

Nucleosomes
Nephritis
Helper-Inducer T-Lymphocytes
Epitopes
Histones
1995
344 Citations (Scopus)

Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis

Mohan, C., Shi, Y., Laman, J. D. & Datta, S. K., Jan 1 1995, In : Journal of Immunology. 154, 3, p. 1470-1480 11 p.

Research output: Contribution to journalArticle

CD40 Ligand
Lupus Nephritis
Autoantibodies
B-Lymphocytes
Clone Cells
103 Citations (Scopus)

Lupus: Key pathogenic mechanisms and contributing factors

Mohan, C. & Datta, S. K., Dec 1995, In : Clinical Immunology and Immunopathology. 77, 3, p. 209-220 12 p.

Research output: Contribution to journalReview article

B-Lymphocytes
Nucleosomes
Antinuclear Antibodies
Antigen-Antibody Complex
Systemic Lupus Erythematosus
10 Citations (Scopus)

Mechanisms of the pathogenic autoimmune response in lupus: Prospects for specific immunotherapy

Datta, S. K., Mohan, C. & Desai-Mehta, A., Jun 1 1995, In : Immunologic Research. 14, 2, p. 132-147 16 p.

Research output: Contribution to journalArticle

Autoimmunity
Systemic Lupus Erythematosus
Immunotherapy
B-Lymphocytes
Nucleosomes
159 Citations (Scopus)

Structure and specificity of T cell receptors expressed by potentially pathogenic anti-DNA autoantibody-inducing T cells in human lupus

Desai-Mehta, A., Mao, C., Rajagopalan, S., Robinson, T. & Datta, S. K., Jan 1 1995, In : Journal of Clinical Investigation. 95, 2, p. 531-541 11 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor Specificity
Autoantibodies
T-Lymphocytes
DNA
Helper-Inducer T-Lymphocytes
1994
11 Citations (Scopus)

Mechanisms of autoimmunization: Perspective from the mid-90s

Sercarz, E. E. & Datta, S. K., Dec 1994, In : Current Opinion in Immunology. 6, 6, p. 875-881 7 p.

Research output: Contribution to journalArticle

Helper-Inducer T-Lymphocytes
Autoimmunity
Autoantibodies
Autoimmune Diseases
34 Citations (Scopus)

T cell receptor α-chain repertoire of pathogenic autoantibody-inducing T cells in lupus mice

Mao, C., Osman, G. E., Adams, S. & Datta, S. K., Feb 1 1994, In : Journal of Immunology. 152, 3, p. 1462-1470 9 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Autoantibodies
Clone Cells
T-Lymphocytes
Genes
1993
598 Citations (Scopus)

Nucleosome: A major immunogen for pathogenic autoantibody-inducing T cells of lupus

Mohan, C., Adams, S., Stanik, V. & Datta, S. K., May 1 1993, In : Journal of Experimental Medicine. 177, 5, p. 1367-1381 15 p.

Research output: Contribution to journalArticle

Nucleosomes
Autoantibodies
T-Lymphocytes
Clone Cells
Helper-Inducer T-Lymphocytes