Syamal Kumar Datta

  • 6539 Citations
1974 …2018
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Research Output 1974 2018

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Article
2018
8 Citations (Scopus)

Five year follow-up after autologous peripheral blood hematopoietic stem cell transplantation for refractory, chronic, corticosteroid-dependent systemic lupus erythematosus: Effect of conditioning regimen on outcome

Burt, R. K., Han, X., Gozdziak, P., Yaung, K., Morgan, A., Clendenan, A. M., Henry, J., Calvario, M. A., Datta, S. K., Helenowski, I. & Schroeder, J., Jun 1 2018, In : Bone Marrow Transplantation. 53, 6, p. 692-700 9 p.

Research output: Contribution to journalArticle

Peripheral Blood Stem Cell Transplantation
Hematopoietic Stem Cell Transplantation
Systemic Lupus Erythematosus
Adrenal Cortex Hormones
Cyclophosphamide
2016
3 Citations (Scopus)
Th17 Cells
Interleukin-17
Hematopoietic Stem Cells
Stem Cells
Bone Marrow
2015
13 Citations (Scopus)

CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis

Huang, Q. Q., Perlman, H., Birkett, R., Doyle, R., Fang, D., Haines, G. K., Robinson, W., Datta, S., Huang, Z., Li, Q. Z., Phee, H. & Pope, R. M., May 12 2015, In : Nature communications. 6, 7086.

Research output: Contribution to journalArticle

arthritis
deletion
Dendritic Cells
Arthritis
T-cells
9 Citations (Scopus)
Megakaryocyte Progenitor Cells
Hematopoietic Stem Cells
Extramedullary Hematopoiesis
Blood Platelets
T-Lymphocytes
2013
14 Citations (Scopus)

Major pathogenic steps in human lupus can be effectively suppressed by nucleosomal histone peptide epitope-induced regulatory immunity

Zhang, L., Bertucci, A. M., Ramsey-Goldman, R., Harsha-Strong, E. R., Burt, R. K. & Datta, S. K., Dec 2013, In : Clinical Immunology. 149, 3 PB, p. 365-378 14 p.

Research output: Contribution to journalArticle

Histones
Epitopes
Immunity
Peptides
Hydroxychloroquine
2012
9 Citations (Scopus)

Megakaryocyte progenitors are the main APCs inducing Th17 response to lupus autoantigens and foreign antigens

Kang, H. K., Chiang, M. Y., Ecklund, D., Zhang, L., Ramsey-Goldman, R. & Datta, S. K., Jun 15 2012, In : Journal of Immunology. 188, 12, p. 5970-5980 11 p.

Research output: Contribution to journalArticle

Megakaryocyte Progenitor Cells
Antigens
Autoantigens
Megakaryocyte-Erythroid Progenitor Cells
To autoantigen
2011
9 Citations (Scopus)

The histone peptide H4 71-94 alone is more effective than a cocktail of peptide epitopes in controlling lupus: Immunoregulatory mechanisms

Kang, H. K., Chiang, M. Y., Liu, M., Ecklund, D. & Datta, S. K., Jun 1 2011, In : Journal of Clinical Immunology. 31, 3, p. 379-394 16 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Histones
Epitopes
T-Lymphocytes
Peptides
2009
18 Citations (Scopus)
CD20 Antigens
Lymphocyte Depletion
Antibody-Dependent Cell Cytotoxicity
Immunosuppressive Agents
Anti-Idiotypic Antibodies
49 Citations (Scopus)
Apigenin
Th17 Cells
Th1 Cells
Autoantigens
Flavonoids
109 Citations (Scopus)
T-Lymphocyte Subsets
Stem Cell Transplantation
Regulatory T-Lymphocytes
T-Lymphocytes
Autoantigens
2008
32 Citations (Scopus)
Apigenin
Flavonoids
Cell Death
T-Lymphocytes
Cyclooxygenase 2
1 Citation (Scopus)

Signalling defects and cellular interactions (2)

Datta, S. K. & Mauri, C., May 1 2008, In : Lupus. 17, 3, p. 247-250 4 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Autoimmunity
Cell Communication
Systemic Lupus Erythematosus
Signal Transduction
2007
27 Citations (Scopus)
Celecoxib
Diet Therapy
Cyclooxygenase 2 Inhibitors
Cyclooxygenase 2
Systemic Lupus Erythematosus
155 Citations (Scopus)
Th17 Cells
Autoantigens
Regulatory T-Lymphocytes
Dendritic Cells
Peptides
2005
20 Citations (Scopus)

A defect in deletion of nucleosome-specific autoimmune T cells in lupus-prone thymus: Role of thymic dendritic cells

Michaels, M. A., Kang, H. K., Kaliyaperumal, A., Satyaraj, E., Shi, Y. & Datta, S. K., Nov 1 2005, In : Journal of Immunology. 175, 9, p. 5857-5865 9 p.

Research output: Contribution to journalArticle

Nucleosomes
Dendritic Cells
Thymus Gland
Inbred NZB Mouse
T-Lymphocytes
8 Citations (Scopus)

Genetic origin of lupus in NZB/SWR hybrids: Lessons from an intercross study

Xie, S., Li, L., Chang, S., Sharma, R., Kaliyaperumal, A., Datta, S. K. & Mohan, C., Feb 1 2005, In : Arthritis and rheumatism. 52, 2, p. 659-667 9 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 2
Antibodies
144 Citations (Scopus)

Very low-dose tolerance with nucleosomal peptides controls lupus and induces potent regulatory T cell subsets

Kang, H. K., Michaels, M. A., Berner, B. R. & Datta, S. K., Mar 15 2005, In : Journal of Immunology. 174, 6, p. 3247-3255 9 p.

Research output: Contribution to journalArticle

T-Lymphocyte Subsets
Regulatory T-Lymphocytes
Peptides
T-Lymphocytes
Autoantibodies
2004
120 Citations (Scopus)

Human lupus T cells resist inactivation and escape death by upregulating COX-2

Xu, L., Zhang, L., Yi, Y., Kang, H. K. & Datta, S. K., Apr 1 2004, In : Nature Medicine. 10, 4, p. 411-415 5 p.

Research output: Contribution to journalArticle

T-cells
Cyclooxygenase 2
T-Lymphocytes
Apoptosis
Gene encoding
2003
64 Citations (Scopus)
Nucleosomes
Cell Communication
B-Lymphocytes
Cells
T-Lymphocytes
2002
3 Citations (Scopus)

B cell stimulatory effects of α-enolase that is differentially expressed in NZB mouse B cells

Babu, J. S., Sun, T., Xu, L. & Datta, S. K., Jan 1 2002, In : Clinical Immunology. 104, 3, p. 293-304 12 p.

Research output: Contribution to journalArticle

Inbred NZB Mouse
Phosphopyruvate Hydratase
B-Lymphocytes
Chromosomes, Human, Pair 4
Genes
18 Citations (Scopus)

Dominant NZB contributions to lupus in the (SWR×NZB)F1 model

Xie, S., Chang, S. H., Sedrak, P., Kaliyaperumal, A., Datta, S. K. & Mohan, C., Jan 1 2002, In : Genes and Immunity. 3, p. S13-S20

Research output: Contribution to journalArticle

Lupus Nephritis
Antinuclear Antibodies
Antibody Formation
Mortality
66 Citations (Scopus)

Naturally processed chromatin peptides reveal a major autoepitope that primes pathogenic T and B cells of lupus

Kaliyaperumal, A., Michaels, M. A. & Datta, S. K., Mar 1 2002, In : Journal of Immunology. 168, 5, p. 2530-2537 8 p.

Research output: Contribution to journalArticle

Chromatin
Epitopes
B-Lymphocytes
T-Lymphocytes
Peptides
2001
20 Citations (Scopus)

Genetic contributions of nonautoimmune SWR mice toward lupus nephritis

Xie, S., Chang, S., Yang, P., Jacob, C., Kaliyaperumal, A., Datta, S. K. & Mohan, C., Dec 15 2001, In : Journal of Immunology. 167, 12, p. 7141-7149 9 p.

Research output: Contribution to journalArticle

Lupus Nephritis
New Zealand
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 14
Genetic Crosses
2000
91 Citations (Scopus)
CD40 Ligand
Mitogen-Activated Protein Kinases
Phosphotransferases
T-Lymphocytes
Extracellular Signal-Regulated MAP Kinases
1999
135 Citations (Scopus)

Antigen-specific therapy of murine lupus nephritis using nucleosomal peptides: Tolerance spreading impairs pathogenic function of autoimmune T and B cells

Kaliyaperumal, A., Michaels, M. A. & Datta, S. K., May 15 1999, In : Journal of Immunology. 162, 10, p. 5775-5783 9 p.

Research output: Contribution to journalArticle

Lupus Nephritis
B-Lymphocytes
Inbred NZB Mouse
T-Lymphocytes
Antigens
145 Citations (Scopus)

Major peptide autoepitopes for nucleosome-specific T cells of human lupus

Lu, L., Kaliyaperumal, A., Boumpas, D. T. & Datta, S. K., Aug 1999, In : Journal of Clinical Investigation. 104, 3, p. 345-355 11 p.

Research output: Contribution to journalArticle

Nucleosomes
T-Lymphocytes
Peptides
Histones
Autoantibodies
1998
163 Citations (Scopus)

Anti-CD40 ligand antibody treatment of SNF1 mice with established nephritis: Preservation of kidney function

Kalled, S. L., Cutler, A. H., Datta, S. K. & Thomas, D. W., Mar 1 1998, In : Journal of Immunology. 160, 5, p. 2158-2165 8 p.

Research output: Contribution to journalArticle

Inbred NZB Mouse
CD40 Ligand
Nephritis
Kidney
Antibodies
65 Citations (Scopus)

Promiscuous presentation and recognition of nucleosomal autoepitopes in lupus: Role of autoimmune T cell receptor α chain

Shi, Y., Kaliyaperumal, A., Lu, L., Southwood, S., Sette, A., Michaels, M. A. & Datta, S. K., Feb 2 1998, In : Journal of Experimental Medicine. 187, 3, p. 367-378 12 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Clone Cells
Epitopes
Nucleosomes
T-Lymphocytes
1997
3 Citations (Scopus)

Characteristics of T cells that participate in the pathogenesis of SLE

Hahn, B. H. & Datta, S. K., Jan 1 1997, In : Lupus. 6, 3, p. 330-332 3 p.

Research output: Contribution to journalArticle

Immune Tolerance
Nucleosomes
Helper-Inducer T-Lymphocytes
T-Lymphocytes
22 Citations (Scopus)

Nucleosome-driven autoimmune response in lupus. Pathogenic T helper cell epitopes and costimulatory signals

Datta, S. K. & Kaliyaperumal, A., Jan 1 1997, In : Annals of the New York Academy of Sciences. 815, p. 155-170 16 p.

Research output: Contribution to journalArticle

T-Lymphocyte Epitopes
Nucleosomes
Autoimmunity
Cells
13 Citations (Scopus)

T helper cells driving pathogenic anti-DNA autoantibody production in lupus: Nucleosomal epitopes and CD40 ligand signals

Datta, S. K., Kaliyaperumal, A., Mohan, C. & Desai-Mehta, A., Jan 1 1997, In : Lupus. 6, 3, p. 333-336 4 p.

Research output: Contribution to journalArticle

Lymphocyte Cooperation
Genetic Crosses
Inbred NZB Mouse
Immunoglobulin Variable Region
Animal Disease Models
1996
424 Citations (Scopus)

Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production

Desai-Mehta, A., Lu, L., Ramsey-Goldman, R. & Datta, S. K., May 1 1996, In : Journal of Clinical Investigation. 97, 9, p. 2063-2073 11 p.

Research output: Contribution to journalArticle

CD40 Ligand
Autoantibodies
B-Lymphocytes
T-Lymphocytes
Mitogens
185 Citations (Scopus)

Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus

Kaliyaperumal, A., Mohan, C., Wu, W. & Datta, S. K., Jun 1 1996, In : Journal of Experimental Medicine. 183, 6, p. 2459-2469 11 p.

Research output: Contribution to journalArticle

Nucleosomes
Nephritis
Helper-Inducer T-Lymphocytes
Epitopes
Histones
1995
345 Citations (Scopus)

Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis

Mohan, C., Shi, Y., Laman, J. D. & Datta, S. K., Jan 1 1995, In : Journal of Immunology. 154, 3, p. 1470-1480 11 p.

Research output: Contribution to journalArticle

CD40 Ligand
Lupus Nephritis
Autoantibodies
B-Lymphocytes
Clone Cells
10 Citations (Scopus)

Mechanisms of the pathogenic autoimmune response in lupus: Prospects for specific immunotherapy

Datta, S. K., Mohan, C. & Desai-Mehta, A., Jun 1 1995, In : Immunologic Research. 14, 2, p. 132-147 16 p.

Research output: Contribution to journalArticle

Autoimmunity
Systemic Lupus Erythematosus
Immunotherapy
B-Lymphocytes
Nucleosomes
159 Citations (Scopus)

Structure and specificity of T cell receptors expressed by potentially pathogenic anti-DNA autoantibody-inducing T cells in human lupus

Desai-Mehta, A., Mao, C., Rajagopalan, S., Robinson, T. & Datta, S. K., Jan 1 1995, In : Journal of Clinical Investigation. 95, 2, p. 531-541 11 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor Specificity
Autoantibodies
T-Lymphocytes
DNA
Helper-Inducer T-Lymphocytes
1994
11 Citations (Scopus)

Mechanisms of autoimmunization: Perspective from the mid-90s

Sercarz, E. E. & Datta, S. K., Dec 1994, In : Current Opinion in Immunology. 6, 6, p. 875-881 7 p.

Research output: Contribution to journalArticle

Helper-Inducer T-Lymphocytes
Autoimmunity
Autoantibodies
Autoimmune Diseases
34 Citations (Scopus)

T cell receptor α-chain repertoire of pathogenic autoantibody-inducing T cells in lupus mice

Mao, C., Osman, G. E., Adams, S. & Datta, S. K., Feb 1 1994, In : Journal of Immunology. 152, 3, p. 1462-1470 9 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Autoantibodies
Clone Cells
T-Lymphocytes
Genes
1993
598 Citations (Scopus)

Nucleosome: A major immunogen for pathogenic autoantibody-inducing T cells of lupus

Mohan, C., Adams, S., Stanik, V. & Datta, S. K., May 1 1993, In : Journal of Experimental Medicine. 177, 5, p. 1367-1381 15 p.

Research output: Contribution to journalArticle

Nucleosomes
Autoantibodies
T-Lymphocytes
Clone Cells
Helper-Inducer T-Lymphocytes
1992
185 Citations (Scopus)

Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites

Vlahakos, D. V., Foster, M. H., Adams, S., Katz, M., Ucci, A. A., Barrett, K. J., Datta, S. K. & Madaio, M. P., Jan 1 1992, In : Kidney international. 41, 6, p. 1690-1700 11 p.

Research output: Contribution to journalArticle

Antinuclear Antibodies
Proteinuria
Blood Vessels
Nephritis
Autoantigens
43 Citations (Scopus)

Cationic residues in pathogenic anti‐DNA autoantibodies arise by mutations of a germ‐line gene that belongs to a large VH gene subfamily

O'Keefe, T. L., Datta, S. K. & Imanishi‐Kari, T., Jan 1 1992, In : European Journal of Immunology. 22, 3, p. 619-624 6 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Autoantibodies
Genes
Inbred NZB Mouse
Basic Amino Acids
153 Citations (Scopus)

Murine monoclonal anti-DNA antibodies penetrate cells, bind to nuclei, and induce glomerular proliferation and proteinuria in vivo

Vlahakos, D., Foster, M. H., Ucci, A. A., Barrett, K. J., Datta, S. K. & Madaio, M. P., Feb 1 1992, In : Journal of the American Society of Nephrology. 2, 8, p. 1345-1354 10 p.

Research output: Contribution to journalArticle

Antinuclear Antibodies
Proteinuria
Monoclonal Antibodies
Autoantibodies
DNA
19 Citations (Scopus)

Pathogenic autoantibody-inducing γ δ T helper cells from patients with lupus nephritis express unusual T cell receptors

Rajagopalan, S., Mao, C. & Datta, S. K., Jan 1 1992, In : Clinical Immunology and Immunopathology. 62, 3, p. 344-350 7 p.

Research output: Contribution to journalArticle

Lupus Nephritis
Helper-Inducer T-Lymphocytes
T-Cell Antigen Receptor
Autoantibodies
Clone Cells
1991
88 Citations (Scopus)
Autoantigens
Helper-Inducer T-Lymphocytes
T-Cell Antigen Receptor
Autoantibodies
Clone Cells
1990
169 Citations (Scopus)
Lupus Nephritis
T-Cell Antigen Receptor
Autoantibodies
Heat-Shock Proteins
T-Lymphocytes
6 Citations (Scopus)

Selective strain distribution pattern of a germline VH gene for a pathogenic anti-DNA autoantibody family

Ghatak, S., O'keefe, T. L., Imanishi-kari, T. & Datta, S. K., Oct 1 1990, In : International Immunology. 2, 10, p. 1003-1012 10 p.

Research output: Contribution to journalArticle

Autoantibodies
DNA
Genes
Nephritis
5' Flanking Region
40 Citations (Scopus)
Inbred NZB Mouse
T-Cell Receptor Genes
Lupus Nephritis
T-Cell Antigen Receptor
Immunoglobulin G
63 Citations (Scopus)

V region sequences of an idiotypically connected family of pathogenic anti-dna autoantibodies

O'Keefe, T. L., Bandyopadhyay, S., Datta, S. K. & Imanishi-Kari, T., Jun 1 1990, In : Journal of Immunology. 144, 11, p. 4275-4283 9 p.

Research output: Contribution to journalArticle

Autoantibodies
Inbred NZB Mouse
Antinuclear Antibodies
DNA
Nephritis
1989
306 Citations (Scopus)
Lupus Nephritis
Helper-Inducer T-Lymphocytes
T-Cell Antigen Receptor
Autoantibodies
DNA
1988
72 Citations (Scopus)
Lupus Nephritis
Autoantibodies
T-Lymphocytes
Cell Line
DNA