Syamal Kumar Datta

  • 6602 Citations
1974 …2018

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Article
2018

Five year follow-up after autologous peripheral blood hematopoietic stem cell transplantation for refractory, chronic, corticosteroid-dependent systemic lupus erythematosus: Effect of conditioning regimen on outcome

Burt, R. K., Han, X., Gozdziak, P., Yaung, K., Morgan, A., Clendenan, A. M., Henry, J., Calvario, M. A., Datta, S. K., Helenowski, I. & Schroeder, J., Jun 1 2018, In : Bone Marrow Transplantation. 53, 6, p. 692-700 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016
3 Scopus citations
2015

CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis

Huang, Q. Q., Perlman, H., Birkett, R., Doyle, R., Fang, D., Haines, G. K., Robinson, W., Datta, S., Huang, Z., Li, Q. Z., Phee, H. & Pope, R. M., May 12 2015, In : Nature communications. 6, 7086.

Research output: Contribution to journalArticle

13 Scopus citations
11 Scopus citations
2013

Major pathogenic steps in human lupus can be effectively suppressed by nucleosomal histone peptide epitope-induced regulatory immunity

Zhang, L., Bertucci, A. M., Ramsey-Goldman, R., Harsha-Strong, E. R., Burt, R. K. & Datta, S. K., Dec 2013, In : Clinical Immunology. 149, 3 PB, p. 365-378 14 p.

Research output: Contribution to journalArticle

15 Scopus citations
2012

Megakaryocyte progenitors are the main APCs inducing Th17 response to lupus autoantigens and foreign antigens

Kang, H. K., Chiang, M. Y., Ecklund, D., Zhang, L., Ramsey-Goldman, R. & Datta, S. K., Jun 15 2012, In : Journal of Immunology. 188, 12, p. 5970-5980 11 p.

Research output: Contribution to journalArticle

9 Scopus citations
2011

The histone peptide H4 71-94 alone is more effective than a cocktail of peptide epitopes in controlling lupus: Immunoregulatory mechanisms

Kang, H. K., Chiang, M. Y., Liu, M., Ecklund, D. & Datta, S. K., Jun 1 2011, In : Journal of Clinical Immunology. 31, 3, p. 379-394 16 p.

Research output: Contribution to journalArticle

11 Scopus citations
2009
18 Scopus citations
52 Scopus citations
112 Scopus citations
2008
33 Scopus citations

Signalling defects and cellular interactions (2)

Datta, S. K. & Mauri, C., May 1 2008, In : Lupus. 17, 3, p. 247-250 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
2007
29 Scopus citations
158 Scopus citations
2005

A defect in deletion of nucleosome-specific autoimmune T cells in lupus-prone thymus: Role of thymic dendritic cells

Michaels, M. A., Kang, H. K., Kaliyaperumal, A., Satyaraj, E., Shi, Y. & Datta, S. K., Nov 1 2005, In : Journal of Immunology. 175, 9, p. 5857-5865 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Genetic origin of lupus in NZB/SWR hybrids: Lessons from an intercross study

Xie, S., Li, L., Chang, S., Sharma, R., Kaliyaperumal, A., Datta, S. K. & Mohan, C., Feb 1 2005, In : Arthritis and rheumatism. 52, 2, p. 659-667 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Very low-dose tolerance with nucleosomal peptides controls lupus and induces potent regulatory T cell subsets

Kang, H. K., Michaels, M. A., Berner, B. R. & Datta, S. K., Mar 15 2005, In : Journal of Immunology. 174, 6, p. 3247-3255 9 p.

Research output: Contribution to journalArticle

147 Scopus citations
2004

Human lupus T cells resist inactivation and escape death by upregulating COX-2

Xu, L., Zhang, L., Yi, Y., Kang, H. K. & Datta, S. K., Apr 1 2004, In : Nature Medicine. 10, 4, p. 411-415 5 p.

Research output: Contribution to journalArticle

121 Scopus citations
2003
64 Scopus citations
2002

B cell stimulatory effects of α-enolase that is differentially expressed in NZB mouse B cells

Babu, J. S., Sun, T., Xu, L. & Datta, S. K., Jan 1 2002, In : Clinical Immunology. 104, 3, p. 293-304 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Dominant NZB contributions to lupus in the (SWR×NZB)F1 model

Xie, S., Chang, S. H., Sedrak, P., Kaliyaperumal, A., Datta, S. K. & Mohan, C., Jan 1 2002, In : Genes and Immunity. 3, p. S13-S20

Research output: Contribution to journalArticle

18 Scopus citations

Naturally processed chromatin peptides reveal a major autoepitope that primes pathogenic T and B cells of lupus

Kaliyaperumal, A., Michaels, M. A. & Datta, S. K., Mar 1 2002, In : Journal of Immunology. 168, 5, p. 2530-2537 8 p.

Research output: Contribution to journalArticle

66 Scopus citations
2001

Genetic contributions of nonautoimmune SWR mice toward lupus nephritis

Xie, S., Chang, S., Yang, P., Jacob, C., Kaliyaperumal, A., Datta, S. K. & Mohan, C., Dec 15 2001, In : Journal of Immunology. 167, 12, p. 7141-7149 9 p.

Research output: Contribution to journalArticle

20 Scopus citations
2000
91 Scopus citations
1999

Antigen-specific therapy of murine lupus nephritis using nucleosomal peptides: Tolerance spreading impairs pathogenic function of autoimmune T and B cells

Kaliyaperumal, A., Michaels, M. A. & Datta, S. K., May 15 1999, In : Journal of Immunology. 162, 10, p. 5775-5783 9 p.

Research output: Contribution to journalArticle

138 Scopus citations

Major peptide autoepitopes for nucleosome-specific T cells of human lupus

Lu, L., Kaliyaperumal, A., Boumpas, D. T. & Datta, S. K., Aug 1999, In : Journal of Clinical Investigation. 104, 3, p. 345-355 11 p.

Research output: Contribution to journalArticle

147 Scopus citations
1998

Anti-CD40 ligand antibody treatment of SNF1 mice with established nephritis: Preservation of kidney function

Kalled, S. L., Cutler, A. H., Datta, S. K. & Thomas, D. W., Mar 1 1998, In : Journal of Immunology. 160, 5, p. 2158-2165 8 p.

Research output: Contribution to journalArticle

165 Scopus citations

Promiscuous presentation and recognition of nucleosomal autoepitopes in lupus: Role of autoimmune T cell receptor α chain

Shi, Y., Kaliyaperumal, A., Lu, L., Southwood, S., Sette, A., Michaels, M. A. & Datta, S. K., Feb 2 1998, In : Journal of Experimental Medicine. 187, 3, p. 367-378 12 p.

Research output: Contribution to journalArticle

65 Scopus citations
1997

Characteristics of T cells that participate in the pathogenesis of SLE

Hahn, B. H. & Datta, S. K., Jan 1 1997, In : Lupus. 6, 3, p. 330-332 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Nucleosome-driven autoimmune response in lupus. Pathogenic T helper cell epitopes and costimulatory signals

Datta, S. K. & Kaliyaperumal, A., Jan 1 1997, In : Annals of the New York Academy of Sciences. 815, p. 155-170 16 p.

Research output: Contribution to journalArticle

22 Scopus citations

T helper cells driving pathogenic anti-DNA autoantibody production in lupus: Nucleosomal epitopes and CD40 ligand signals

Datta, S. K., Kaliyaperumal, A., Mohan, C. & Desai-Mehta, A., Jan 1 1997, In : Lupus. 6, 3, p. 333-336 4 p.

Research output: Contribution to journalArticle

13 Scopus citations
1996

Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production

Desai-Mehta, A., Lu, L., Ramsey-Goldman, R. & Datta, S. K., May 1 1996, In : Journal of Clinical Investigation. 97, 9, p. 2063-2073 11 p.

Research output: Contribution to journalArticle

428 Scopus citations

Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus

Kaliyaperumal, A., Mohan, C., Wu, W. & Datta, S. K., Jun 1 1996, In : Journal of Experimental Medicine. 183, 6, p. 2459-2469 11 p.

Research output: Contribution to journalArticle

188 Scopus citations
1995

Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis

Mohan, C., Shi, Y., Laman, J. D. & Datta, S. K., Jan 1 1995, In : Journal of Immunology. 154, 3, p. 1470-1480 11 p.

Research output: Contribution to journalArticle

346 Scopus citations

Mechanisms of the pathogenic autoimmune response in lupus: Prospects for specific immunotherapy

Datta, S. K., Mohan, C. & Desai-Mehta, A., Jun 1 1995, In : Immunologic Research. 14, 2, p. 132-147 16 p.

Research output: Contribution to journalArticle

10 Scopus citations

Structure and specificity of T cell receptors expressed by potentially pathogenic anti-DNA autoantibody-inducing T cells in human lupus

Desai-Mehta, A., Mao, C., Rajagopalan, S., Robinson, T. & Datta, S. K., Jan 1 1995, In : Journal of Clinical Investigation. 95, 2, p. 531-541 11 p.

Research output: Contribution to journalArticle

159 Scopus citations
1994

Mechanisms of autoimmunization: Perspective from the mid-90s

Sercarz, E. E. & Datta, S. K., Dec 1994, In : Current Opinion in Immunology. 6, 6, p. 875-881 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

T cell receptor α-chain repertoire of pathogenic autoantibody-inducing T cells in lupus mice

Mao, C., Osman, G. E., Adams, S. & Datta, S. K., Feb 1 1994, In : Journal of Immunology. 152, 3, p. 1462-1470 9 p.

Research output: Contribution to journalArticle

34 Scopus citations
1993

Nucleosome: A major immunogen for pathogenic autoantibody-inducing T cells of lupus

Mohan, C., Adams, S., Stanik, V. & Datta, S. K., May 1 1993, In : Journal of Experimental Medicine. 177, 5, p. 1367-1381 15 p.

Research output: Contribution to journalArticle

600 Scopus citations
1992

Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites

Vlahakos, D. V., Foster, M. H., Adams, S., Katz, M., Ucci, A. A., Barrett, K. J., Datta, S. K. & Madaio, M. P., Jan 1 1992, In : Kidney international. 41, 6, p. 1690-1700 11 p.

Research output: Contribution to journalArticle

187 Scopus citations

Cationic residues in pathogenic anti‐DNA autoantibodies arise by mutations of a germ‐line gene that belongs to a large VH gene subfamily

O'Keefe, T. L., Datta, S. K. & Imanishi‐Kari, T., Jan 1 1992, In : European Journal of Immunology. 22, 3, p. 619-624 6 p.

Research output: Contribution to journalArticle

44 Scopus citations

Murine monoclonal anti-DNA antibodies penetrate cells, bind to nuclei, and induce glomerular proliferation and proteinuria in vivo

Vlahakos, D., Foster, M. H., Ucci, A. A., Barrett, K. J., Datta, S. K. & Madaio, M. P., Feb 1 1992, In : Journal of the American Society of Nephrology. 2, 8, p. 1345-1354 10 p.

Research output: Contribution to journalArticle

156 Scopus citations

Pathogenic autoantibody-inducing γ δ T helper cells from patients with lupus nephritis express unusual T cell receptors

Rajagopalan, S., Mao, C. & Datta, S. K., Jan 1 1992, In : Clinical Immunology and Immunopathology. 62, 3, p. 344-350 7 p.

Research output: Contribution to journalArticle

19 Scopus citations
1991
89 Scopus citations
1990
169 Scopus citations

Selective strain distribution pattern of a germline VH gene for a pathogenic anti-DNA autoantibody family

Ghatak, S., O'keefe, T. L., Imanishi-kari, T. & Datta, S. K., Oct 1 1990, In : International Immunology. 2, 10, p. 1003-1012 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
40 Scopus citations

V region sequences of an idiotypically connected family of pathogenic anti-dna autoantibodies

O'Keefe, T. L., Bandyopadhyay, S., Datta, S. K. & Imanishi-Kari, T., Jun 1 1990, In : Journal of Immunology. 144, 11, p. 4275-4283 9 p.

Research output: Contribution to journalArticle

64 Scopus citations
1989
309 Scopus citations
1988
72 Scopus citations