My current research interests include radiation biology and nanotechnology and development of a new instrument for high resolution microscopy--Bionanoprobe. In the field of radiation biology, my primary focus is on mechanisms underlying development of genomic instability caused by ionizing irradiation. This investigation includes work with cells in culture and animal models as well as exploration of archival animal tissues collected from large scale animal experiments, currently located in Woloschak laboratory. My efforts in the field of biomedical nanotechnology include development and investigation of nanoconstructs suitable for biomedical imaging and cancer therapy. Different metals and metal oxides are combined to form the compact center of nanocomposites; their outer layer(s) are made by conjugation of biomolecules and small molecules which enable nanoconstruct targeting and use in vitro and in vivo. Study of interactions between nanoconstructs and cells and tissues requires high throughput and high resolution imaging that co-registers both biological material and nanoconstructs. Only technique that can fulfill all of these requirements is X-ray fluorescence microscopy. A grant awarded to our laboratory was used for custom construction of unique new instrument--Bionanoprobe. This instrument is now installed at the Advanced Photon Source synchrotron and will be used for imaging for bio-nanotechnology.