Tatjana Paunesku

  • 3021 Citations
1989 …2020

Research output per year

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Personal profile

Research Interests

My current research interests include radiation biology and nanotechnology and development of a new instrument for high resolution microscopy--Bionanoprobe. In the field of radiation biology, my primary focus is on mechanisms underlying development of genomic instability caused by ionizing irradiation. This investigation includes work with cells in culture and animal models as well as exploration of archival animal tissues collected from large scale animal experiments, currently located in Woloschak laboratory. My efforts in the field of biomedical nanotechnology include development and investigation of nanoconstructs suitable for biomedical imaging and cancer therapy. Different metals and metal oxides are combined to form the compact center of nanocomposites; their outer layer(s) are made by conjugation of biomolecules and small molecules which enable nanoconstruct targeting and use in vitro and in vivo. Study of interactions between nanoconstructs and cells and tissues requires high throughput and high resolution imaging that co-registers both biological material and nanoconstructs. Only technique that can fulfill all of these requirements is X-ray fluorescence microscopy. A grant awarded to our laboratory was used for custom construction of unique new instrument--Bionanoprobe. This instrument is now installed at the Advanced Photon Source synchrotron and will be used for imaging for bio-nanotechnology.

Education/Academic qualification

PhD, Illinois Institute of Technology

… → 1997

Research interests

  • Cancer Biology
  • Gene Regulation
  • Microscopy
  • Molecular Biology
  • Nanotechnology
  • Radiation Oncology

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Grants

Research Output

Activation of DNA damage repair factors in HPV positive oropharyngeal cancers

Kono, T., Hoover, P., Poropatich, K., Paunesku, T., Mittal, B. B., Samant, S. & Laimins, L. A., Aug 2020, In : Virology. 547, p. 27-34 8 p.

Research output: Contribution to journalArticle

  • Insights into platinum-induced peripheral neuropathy-current perspective

    Lazic, A., Popović, J., Paunesku, T., Woloschak, G. E. & Stevanović, M., Sep 1 2020, In : Neural Regeneration Research. 15, 9, p. 1623-1630 8 p.

    Research output: Contribution to journalReview article

    Open Access
  • 1 Scopus citations

    Funding for radiation research: past, present and future

    Cho, K., Imaoka, T., Klokov, D., Paunesku, T., Salomaa, S., Birschwilks, M., Bouffler, S., Brooks, A. L., Hei, T. K., Iwasaki, T., Ono, T., Sakai, K., Wojcik, A., Woloschak, G. E., Yamada, Y. & Hamada, N., Jul 3 2019, In : International Journal of Radiation Biology. 95, 7, p. 816-840 25 p.

    Research output: Contribution to journalReview article

    Open Access
  • 4 Scopus citations

    Genome effects and mutational risk of radiation

    Paunesku, T. & Woloschak, G. E., Jan 1 2019, Encyclopedia of Environmental Health. Elsevier, p. 233-244 12 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • Neuroprotective Role of Selected Antioxidant Agents in Preventing Cisplatin-Induced Damage of Human Neurons In Vitro

    Popović, J., Klajn, A., Paunesku, T., Ma, Q., Chen, S., Lai, B., Stevanović, M. & Woloschak, G. E., Jan 1 2019, In : Cellular and molecular neurobiology.

    Research output: Contribution to journalArticle

    Open Access
  • 6 Scopus citations