Tatjana Paunesku

  • 2894 Citations
1989 …2022
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Personal profile

Research Interests

My current research interests include radiation biology and nanotechnology and development of a new instrument for high resolution microscopy--Bionanoprobe. In the field of radiation biology, my primary focus is on mechanisms underlying development of genomic instability caused by ionizing irradiation. This investigation includes work with cells in culture and animal models as well as exploration of archival animal tissues collected from large scale animal experiments, currently located in Woloschak laboratory. My efforts in the field of biomedical nanotechnology include development and investigation of nanoconstructs suitable for biomedical imaging and cancer therapy. Different metals and metal oxides are combined to form the compact center of nanocomposites; their outer layer(s) are made by conjugation of biomolecules and small molecules which enable nanoconstruct targeting and use in vitro and in vivo. Study of interactions between nanoconstructs and cells and tissues requires high throughput and high resolution imaging that co-registers both biological material and nanoconstructs. Only technique that can fulfill all of these requirements is X-ray fluorescence microscopy. A grant awarded to our laboratory was used for custom construction of unique new instrument--Bionanoprobe. This instrument is now installed at the Advanced Photon Source synchrotron and will be used for imaging for bio-nanotechnology.

Education/Academic qualification

PhD, Illinois Institute Of Technology

… → 1997

Research interests

  • Cancer Biology
  • Gene Regulation
  • Microscopy
  • Molecular Biology
  • Nanotechnology
  • Radiation Oncology

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  • 3 Similar Profiles
Nanoconjugates Chemical Compounds
Nanoparticles Engineering & Materials Science
Radiation Medicine & Life Sciences
X-Rays Medicine & Life Sciences
Fluorescence Microscopy Medicine & Life Sciences
DNA Engineering & Materials Science
Fluorescence microscopy Engineering & Materials Science
Imaging techniques Engineering & Materials Science

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2001 2022

Research Output 1989 2019

4 Citations (Scopus)

Funding for radiation research: past, present and future

Cho, K., Imaoka, T., Klokov, D., Paunesku, T., Salomaa, S., Birschwilks, M., Bouffler, S., Brooks, A. L., Hei, T. K., Iwasaki, T., Ono, T., Sakai, K., Wojcik, A., Woloschak, G. E., Yamada, Y. & Hamada, N., Jul 3 2019, In : International Journal of Radiation Biology. 95, 7, p. 816-840 25 p.

Research output: Contribution to journalReview article

Open Access
Radiation
Research
Education
Republic of Korea
Radiation Effects

Neuroprotective Role of Selected Antioxidant Agents in Preventing Cisplatin-Induced Damage of Human Neurons In Vitro

Popović, J., Klajn, A., Paunesku, T., Ma, Q., Chen, S., Lai, B., Stevanović, M. & Woloschak, G. E., Jan 1 2019, In : Cellular and molecular neurobiology.

Research output: Contribution to journalArticle

Open Access
Cisplatin
Antioxidants
Neurons
Amifostine
Sodium Azide

Optimization-based simultaneous alignment and reconstruction in multi-element tomography

Di, Z., Chen, S., Gursoy, D., Paunesku, T., Leyffer, S., Wild, S. M. & Vogt, S., Sep 1 2019, In : Optics Letters. 44, 17, p. 4331-4334 4 p.

Research output: Contribution to journalArticle

tomography
alignment
x ray fluorescence
optimization
x ray sources
1 Citation (Scopus)

Radiation databases and archives–examples and comparisons

Zander, A., Paunesku, T. & Woloschak, G., Oct 3 2019, In : International Journal of Radiation Biology. 95, 10, p. 1378-1389 12 p.

Research output: Contribution to journalReview article

Ionizing Radiation
Databases
Radiation
Radioactive Hazard Release
Radiobiology

The Transition from Metal-Based to Metal-Free Contrast Agents for T1 Magnetic Resonance Imaging Enhancement

Akakuru, O. U., Iqbal, M. Z., Saeed, M., Liu, C., Paunesku, T., Woloschak, G. E., Hosmane, N. S. & Wu, A., Jan 1 2019, (Accepted/In press) In : Bioconjugate Chemistry.

Research output: Contribution to journalArticle

Contrast Media
Metals
Magnetic Resonance Imaging
Magnetic resonance imaging
Blood Circulation Time