Tatyana Simuni

  • Professor, Neurology
  • Arthur C. Nielsen, Jr. Research Professorship in Parkinson's Disease and Movement Disorders, Neurology
  • 6894 Citations
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Personal profile

Research Interests

Dr Simuni joined the faculty of the Northwestern University Feinberg school of Medicine in 2000 to build and lead a multidisciplinary movement disorders center that is recognized by the National Parkinson’s Foundation as a Center of Excellence and serves as a training model in the region. Her research interests are focused on development of disease modifying ( neuroprotective ) interventions in Parkinson’s disease (PD). She is the lead investigator of a number of clinical trials on experimental pharmacology, non-motor manifestations, and pharmacological and surgical management of PD. As the Principal Investigator of the multicenter Parkinson Study Group (PSG) Phase II study of isradipine as potential disease modifying agent in early PD (STEADY PD) and more recently NET PD FS-Zone studies as well as a member of the Steering Committees on a number of national studies including PPMI, she has developed expertise in design and coordination of multicenter studies. She is actively involved with the PSG where she is an active member of three PSG working groups and Chair of the Classic Motor group. She serves on the Steering Committees for the National Parkinson Foundation.

Certifications and Licenses


Training Experience

1994Residency, Temple University Hospital
1995Fellowship, Temple University Hospital

Education/Academic qualification

MD, Leningrad Medical School

… → 1985


  • Clinical Trial Methodology
  • Drug Discovery
  • Movement Control

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Grants 2001 2023

Parkinson Disease
Clinical Trials
Parkinson Disease
Clinical Trials
Parkinson Disease
Clinical Trials

Research Output 1998 2019

Clinical trial highlights: Targetting alpha-synuclein

McFarthing, K. & Simuni, T., Jan 1 2019, In : Journal of Parkinson's disease. 9, 1, p. 5-16 12 p.

Research output: Contribution to journalReview article

Clinical Trials

Clinical trial highlights: Phase III study in spotlight

McFarthing, K. & Simuni, T., Jan 1 2019, In : Journal of Parkinson's disease. 9, 1, p. 3-4 2 p.

Research output: Contribution to journalComment/debate

Phase III Clinical Trials

Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI)

The Parkinson's Progression Markers InitiativeSteering Committee, Study Cores, Site Investigators, Coordinators & Industry and Scientific Advisory Board, Jan 1 2019, In : Parkinsonism and Related Disorders.

Research output: Contribution to journalArticle

Spinal Puncture
Parkinson Disease
1 Citation (Scopus)
Globus Pallidus
Parkinson Disease
Basal Ganglia
Parietal Lobe
7 Citations (Scopus)

Baseline prevalence and longitudinal evolution of non-motor symptoms in early Parkinson's disease: The PPMI cohort

Simuni, T., Caspell-Garcia, C., Coffey, C. S., Weintraub, D., Mollenhauer, B., Lasch, S., Tanner, C. M., Jennings, D., Kieburtz, K., Chahine, L. M. & Marek, K., Jan 1 2018, In : Journal of Neurology, Neurosurgery and Psychiatry. 89, 1, p. 78-88 11 p.

Research output: Contribution to journalArticle

Parkinson Disease
Movement Disorders
Cerebrospinal Fluid
Healthy Volunteers
Dopamine Plasma Membrane Transport Proteins