Tatyana Simuni

  • Professor, Neurology
  • Arthur C. Nielsen, Jr. Research Professorship in Parkinson's Disease and Movement Disorders, Neurology
  • 6145 Citations
19982018
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Research Output 1998 2018

2018

Altered resting-state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease

Manes, J. L., Tjaden, K., Parrish, T., Simuni, T., Roberts, A., Greenlee, J. D., Corcos, D. M. & Kurani, A. S., Sep 1 2018, In : Brain and Behavior. 8, 9, e01073

Research output: Contribution to journalArticle

Globus Pallidus
Putamen
Parkinson Disease
Basal Ganglia
Parietal Lobe
3 Citations

Baseline prevalence and longitudinal evolution of non-motor symptoms in early Parkinson's disease: the PPMI cohort

Simuni, T., Caspell-Garcia, C., Coffey, C. S., Weintraub, D., Mollenhauer, B., Lasch, S., Tanner, C. M., Jennings, D., Kieburtz, K., Chahine, L. M. & Marek, K., Jan 1 2018, In : Journal of neurology, neurosurgery, and psychiatry. 89, 1, p. 78-88 11 p.

Research output: Contribution to journalArticle

Severity of Illness Index
Sex Factors
Age Factors
Amyloid beta-Peptides
Parkinson Disease

Cognition among individuals along a spectrum of increased risk for Parkinson’s disease

the Parkinson’s Progression Markers Initiative, Aug 1 2018, In : PloS one. 13, 8, e0201964

Research output: Contribution to journalArticle

cognition
Cognition
Parkinson Disease
dopamine
transporters

High priority publications on Parkinson's disease in 2017

Simuni, T. & Krainc, D., Jan 1 2018, In : The Lancet Neurology. 17, 1, p. 8-10 3 p.

Research output: Contribution to journalComment/debate

Parkinson Disease
Publications
1 Citations

Longitudinal Change of Clinical and Biological Measures in Early Parkinson's Disease: Parkinson's Progression Markers Initiative Cohort

the Parkinson's Progression Marker Initiative*, May 1 2018, In : Movement Disorders. 33, 5, p. 771-782 12 p.

Research output: Contribution to journalArticle

Dopamine Plasma Membrane Transport Proteins
Parkinson Disease
Disease Progression
Corpus Striatum
Movement Disorders

Predictors of clinically meaningful change in PDQ-39 in Parkinson's disease

the NPF QII Investigators, Jan 1 2018, (Accepted/In press) In : Parkinsonism and Related Disorders.

Research output: Contribution to journalArticle

Parkinson Disease
Quality of Life
Social Work
Counseling
Nootropic Agents

The spectrum of "off" in Parkinson's disease: What have we learned over 40 years?

Chou, K. L., Stacy, M., Simuni, T., Miyasaki, J., Oertel, W. H., Sethi, K., Fernandez, H. H. & Stocchi, F., Jan 1 2018, (Accepted/In press) In : Parkinsonism and Related Disorders.

Research output: Contribution to journalArticle

Parkinson Disease
Terminology
2017
2 Citations

Altered premotor cortical oscillations during repetitive movement in persons with Parkinson's disease

Stegemöller, E. L., Allen, D. P., Simuni, T. & MacKinnon, C. D., Jan 15 2017, In : Behavioural Brain Research. 317, p. 141-146 6 p.

Research output: Contribution to journalArticle

Motor Cortex
Parkinson Disease
Fingers
Electrodes
Research
15 Citations

Calcium, mitochondrial dysfunction and slowing the progression of Parkinson's disease

Surmeier, D. J., Halliday, G. M. & Simuni, T., Dec 1 2017, In : Experimental Neurology. 298, p. 202-209 8 p.

Research output: Contribution to journalReview article

Parkinson Disease
Calcium
Isradipine
Phase III Clinical Trials
Dopaminergic Neurons
2 Citations

Can loss of the swallow tail sign help distinguish between Parkinson Disease and the Parkinson-Plus syndromes?

Oustwani, C. S., Korutz, A. W., Lester, M. S., Kianirad, Y., Simuni, T. & Hijaz, T. A., Jul 1 2017, In : Clinical Imaging. 44, p. 66-69 4 p.

Research output: Contribution to journalArticle

Deglutition
Parkinson Disease

Erratum to: Inaugural Conference on Incorporating Patient-Reported Outcomes and Patient Preference Information into Clinical Research, Clinical Care, and Risk-Benefit Assessments for Neurodegenerative Diseases (The Patient - Patient-Centered Outcomes Research, (2017), 10, 5, (541-544), 10.1007/s40271-017-0257-5)

Purks, J. L., Wilhelm, E. E., Shoulson, I., Creveling, J., Dorsey, E. R., Irony, T., LoCastro, T. M., Pagan, F., Ravina, B., Simuni, T., Sterling, M. A., Tariot, P. & Anderson, K. E., Oct 1 2017, In : Patient. 10, 5, p. 667-668 2 p.

Research output: Contribution to journalComment/debate

Patient Outcome Assessment
Patient Preference
Neurodegenerative Diseases
Publications
Research

Inaugural Conference on Incorporating Patient-Reported Outcomes and Patient Preference Information into Clinical Research, Clinical Care, and Risk-Benefit Assessments for Neurodegenerative Diseases

Purks, J. L., Wilhelm, E. E., Shoulson, I., Creveling, J., Dorsey, E. R., Irony, T., LoCastro, T. M., Pagan, F., Ravina, B., Simuni, T., Sterling, M. A., Tariot, P. & Anderson, K. E., Oct 1 2017, In : Patient. 10, 5, p. 541-544 4 p.

Research output: Contribution to journalLetter

1 Citations

Increasing Efficiency of Recruitment in Early Parkinson's Disease Trials: A Case Study Examination of the STEADY-PD III Trial

Berk, S., Greco, B. L., Biglan, K., Kopil, C. M., Holloway, R. G., Meunier, C. & Simuni, T., Jan 1 2017, In : Journal of Parkinson's Disease. 7, 4, p. 685-693 9 p.

Research output: Contribution to journalArticle

Parkinson Disease
Referral and Consultation
National Institute of Neurological Disorders and Stroke
Clinical Trials
Personnel Selection
2 Citations

Laughter is the best medicine: The Second City® improvisation as an intervention for Parkinson's disease

Bega, D., Palmentera, P., Wagner, A., Hovde, M., Barish, B., Kwasny, M. J. & Simuni, T., Jan 1 2017, In : Parkinsonism and Related Disorders. 34, p. 62-65 4 p.

Research output: Contribution to journalArticle

Laughter
Parkinson Disease
Medicine
Activities of Daily Living
Cross-Over Studies
3 Citations

Longitudinal assessment of excessive daytime sleepiness in early Parkinson's disease

Parkinson's Progression Markers Initiative, Aug 1 2017, In : Journal of Neurology, Neurosurgery and Psychiatry. 88, 8, p. 653-662 10 p.

Research output: Contribution to journalArticle

Parkinson Disease
Parkinson's Disease
Mental Disorders
Cerebrospinal Fluid
Cohort Studies
Medical Marijuana
Cannabis
Parkinson Disease
Physicians
Drug Approval
13 Citations

Multiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease

Caspell-Garcia, C. , Simuni, T. , Tosun-Turgut, D. , Wu, I. W. , Zhang, Y. , Nalls, M. , Singleton, A. , Shaw, L. A. , Kang, J. H. , Trojanowski, J. Q. , Siderowf, A. , Coffey, C. , Lasch, S. , Aarsland, D. , Burn, D. , Chahine, L. M. , Espay, A. J. , Foster, E. D. , Hawkins, K. A. , Litvan, I. & 2 others Richard, I. & Weintraub, D., May 1 2017, In : PloS one. 12, 5, e0175674

Research output: Contribution to journalArticle

Parkinson disease
Biomarkers
dopamine
Parkinson Disease
biomarkers

Pimavanserin, a novel antipsychotic for management of Parkinson’s disease psychosis

Kianirad, Y. & Simuni, T., Nov 2 2017, In : Expert Review of Clinical Pharmacology. 10, 11, p. 1161-1168 8 p.

Research output: Contribution to journalArticle

Psychotic Disorders
Antipsychotic Agents
Parkinson Disease
Drug Labeling
Pharmaceutical Preparations
9 Citations

Regular Exercise, Quality of Life, and Mobility in Parkinson's Disease: A Longitudinal Analysis of National Parkinson Foundation Quality Improvement Initiative Data

Rafferty, M. R., Schmidt, P. N., Luo, S. T., Li, K., Marras, C., Davis, T. L., Guttman, M., Cubillos, F. & Simuni, T., Jan 1 2017, In : Journal of Parkinson's Disease. 7, 1, p. 193-202 10 p.

Research output: Contribution to journalArticle

Quality Improvement
Parkinson Disease
Quality of Life
Habits
Observational Studies
2016
34 Citations

Cognition in individuals at risk for Parkinson's: Parkinson associated risk syndrome (PARS) study findings

PARS Investigators, Jan 1 2016, In : Movement Disorders. 31, 1, p. 86-94 9 p.

Research output: Contribution to journalArticle

Dopamine Plasma Membrane Transport Proteins
Executive Function
Short-Term Memory
Cognition
Parkinson Disease
37 Citations

CSF biomarkers associated with disease heterogeneity in early Parkinson’s disease: the Parkinson’s Progression Markers Initiative study

Kang, J. H. , Mollenhauer, B. , Coffey, C. S. , Toledo, J. B. , Weintraub, D. , Galasko, D. R. , Irwin, D. J. , Van Deerlin, V. , Chen-Plotkin, A. S. , Caspell-Garcia, C. , Waligórska, T. , Taylor, P. , Shah, N. , Pan, S. , Zero, P. , Frasier, M. , Marek, K. , Kieburtz, K. , Jennings, D. , Tanner, C. M. & 6 others Simuni, T., Singleton, A., Toga, A. W., Chowdhury, S., Trojanowski, J. Q. & Shaw, L. M., Jun 1 2016, In : Acta Neuropathologica. 131, 6, p. 935-949 15 p.

Research output: Contribution to journalArticle

Parkinson Disease
Cerebrospinal Fluid
Biomarkers
Phenotype
alpha-Synuclein
22 Citations

How stable are Parkinson's disease subtypes in de novo patients: Analysis of the PPMI cohort?

PPMI Investigators, Jul 1 2016, In : Parkinsonism and Related Disorders. 28, p. 62-67 6 p.

Research output: Contribution to journalArticle

Gait
Tremor
Parkinson Disease
Case-Control Studies
Biomarkers
19 Citations

Longitudinal changes in cognition in early Parkinson's disease patients with REM sleep behavior disorder

Chahine, L. M., Xie, S. X., Simuni, T., Tran, B., Postuma, R., Amara, A., Oertel, W. H., Iranzo, A., Scordia, C., Fullard, M., Linder, C., Purri, R., Darin, A., Rennert, L., Videnovic, A., Del Riva, P. & Weintraub, D., Jan 1 2016, In : Parkinsonism and Related Disorders. 27, p. 102-106 5 p.

Research output: Contribution to journalArticle

REM Sleep Behavior Disorder
Cognition
Parkinson Disease
Verbal Learning
Sex Education
4 Citations

Motor cortical oscillations are abnormally suppressed during repetitive movement in patients with Parkinson's disease

Stegemöller, E. L., Allen, D. P., Simuni, T. & MacKinnon, C. D., Jan 1 2016, In : Clinical Neurophysiology. 127, 1, p. 664-674 11 p.

Research output: Contribution to journalArticle

Parkinson Disease
Fingers
5 Citations

Neuro-QoL health-related quality of life measurement system: Validation in Parkinson's disease

Nowinski, C. J., Siderowf, A., Simuni, T., Wortman, C., Moy, C. & Cella, D., May 1 2016, In : Movement Disorders. 31, 5, p. 725-733 9 p.

Research output: Contribution to journalArticle

Parkinson Disease
Quality of Life
Neurology
Aptitude
Reproducibility of Results
7 Citations

Novel Approaches to Optimization of Levodopa Therapy for Parkinson’s Disease

Kianirad, Y. & Simuni, T., Apr 1 2016, In : Current Neurology and Neuroscience Reports. 16, 4, p. 1-6 6 p., 34

Research output: Contribution to journalReview article

Levodopa
Parkinson Disease
Therapeutics
Drug-Induced Dyskinesia
Phase III Clinical Trials
7 Citations

Predictors of time to initiation of symptomatic therapy in early Parkinson’s disease

the PPMI Investigators, Jul 1 2016, In : Annals of Clinical and Translational Neurology. p. 482-494 13 p.

Research output: Contribution to journalArticle

Parkinson Disease
Therapeutics
Survival
Neurology
Activities of Daily Living
69 Citations

Technology in Parkinson's disease: Challenges and opportunities

on behalf of the Movement Disorders Society Task Force on Technology, Sep 1 2016, In : Movement Disorders. 31, 9, p. 1272-1282 11 p.

Research output: Contribution to journalArticle

Parkinson Disease
Technology
Advisory Committees
Miniaturization
Therapeutics

Yoga Versus Resistance Training in Mild to Moderate Severity Parkinson’s Disease: A 12-Week Pilot Study

Bega, D., Stein, J., Zadikoff, C., Simuni, T., Victorson, D., Ring, M., Jovanovic, B. & Corcos, D., 2016, In : J Yoga Phys Ther. 6

Research output: Contribution to journalArticle

2015
82 Citations

Cognitive performance and neuropsychiatric symptoms in early, untreated Parkinson's disease

Parkinson's Progression Markers Initiative, Jan 1 2015, In : Movement Disorders. 30, 7, p. 919-927 9 p.

Research output: Contribution to journalArticle

Parkinson Disease
Disruptive, Impulse Control, and Conduct Disorders
Apathy
Psychotic Disorders
Anxiety
20 Citations

Correlates of excessive daytime sleepiness in de novo Parkinson's disease: A case control study

PPMI Sleep Working group on behalf of the PPMI Investigators, Sep 1 2015, In : Movement Disorders. 30, 10, p. 1371-1381 11 p.

Research output: Contribution to journalArticle

Parkinson Disease
Case-Control Studies
alpha-Synuclein
Movement Disorders
Hypnotics and Sedatives
17 Citations

Diffusion imaging of nigral alterations in early Parkinson's disease with dopaminergic deficits

Schuff, N. , Wu, I. W. , Buckley, S. , Foster, E. D. , Coffey, C. S. , Gitelman, D. R. , Mendick, S. , Seibyl, J. , Simuni, T. , Zhang, Y. , Jankovic, J. , Hunter, C. , Tanner, C. M. , Rees, L. , Factor, S. , Berg, D. , Wurster, I. , Gauss, K. , Sprenger, F. , Seppi, K. & 7 others Poewe, W., Mollenhauer, B., Knake, S., Mari, Z., Mccoy, A., Ranola, M. & Marek, K., Dec 1 2015, In : Movement Disorders. 30, 14, p. 1885-1892 8 p.

Research output: Contribution to journalArticle

Substantia Nigra
Parkinson Disease
Anisotropy
Dopamine Plasma Membrane Transport Proteins
Diffusion Tensor Imaging
70 Citations

Effect of creatine monohydrate on clinical progression in patients with parkinson disease: A randomized clinical trial

Kieburtz, K. , Tilley, B. C. , Elm, J. J. , Babcock, D. , Hauser, R. , Ross, G. W. , Augustine, A. H. , Augustine, E. U. , Aminoff, M. J. , Bodis-Wollner, I. G. , Boyd, J. , Cambi, F. , Chou, K. , Christine, C. W. , Cines, M. , Dahodwala, N. , Derwent, L. , Dewey, R. B. , Hawthorne, K. , Houghton, D. J. & 23 others Kamp, C., Leehey, M., Lew, M. F., Lin Liang, G. S., Luo, S. T., Mari, Z., Morgan, J. C., Parashos, S., Pérez, A., Petrovitch, H., Rajan, S., Reichwein, S., Roth, J. T., Schneider, J. S., Shannon, K. M., Simon, D. K., Simuni, T., Singer, C., Sudarsky, L., Tanner, C. M., Umeh, C. C., Williams, K. & Wills, A. M., Jan 1 2015, In : JAMA - Journal of the American Medical Association. 313, 6, p. 584-593 10 p.

Research output: Contribution to journalArticle

Creatine
Parkinson Disease
Randomized Controlled Trials
Placebos
National Institute of Neurological Disorders and Stroke
2 Citations
Cerebrovascular Circulation
L-dopa
Parkinson disease
Levodopa
Labeling
20 Citations

Effects of endurance exercise training on the motor and non-motor features of Parkinson's disease: A review

Lamotte, G., Rafferty, M. R., Prodoehl, J., Kohrt, W. M., Comella, C. L., Simuni, T. & Corcos, D. M., Jan 1 2015, In : Journal of Parkinson's disease. 5, 1, p. 21-41 21 p.

Research output: Contribution to journalReview article

Parkinson Disease
Exercise
Parkinsonian Disorders
Gait
Randomized Controlled Trials
1 Citations

Effects of endurance exercise training on the motor and non-motor features of Parkinson's Disease: A Review(Journal of Parkinsons Disease 5(1) 2015 21-41))

Lamotte, G., Rafferty, M. R., Prodoehl, J., Kohrt, W. M., Comella, C. L., Simuni, T. & Corcos, D. M., Nov 21 2015, In : Journal of Parkinson's disease. 5, 4, 1 p.

Research output: Contribution to journalComment/debate

Parkinson Disease
Exercise
Parkinson Disease 5
1 Citations

Erratum: Effects of endurance exercise training on the motor and non-motor features of Parkinson's disease: A review (Journal of Parkinson's Disease (2015) 5:1 (21-41) DOI: 10.3233/JPD-140425)

Lamotte, G., Rafferty, M. R., Prodoehl, J., Kohrt, W. M., Comella, C. L., Simuni, T. & Corcos, D. M., Jan 1 2015, In : Journal of Parkinson's disease. 5, 3, 1 p.

Research output: Contribution to journalComment/debate

Parkinson Disease
Exercise
Parkinson Disease 5

Impact of Depression on Progression of Impairment and Disability in Early Parkinson’s Disease

Bega, D., Luo, S., Fernandez, H., Chou, K., Aminoff, M., Parashos, S., Walker, H., Russell, D., Christine, C., Dhall, R., Singer, C., Bodis-Wollner, I., Hamill, R., Truong, D., Mari, Z., Glazzman, S., Huang, M., Houston, E. & Simuni, T., 2015, In : Movement Disorders Clinical Practice. 2, 4, p. 371-378 8 p.

Research output: Contribution to journalArticle

6 Citations

Is there a role for DAT-SPECT imaging in a specialty movement disorders practice?

Bega, D., Gonzalez-Latapi, P., Zadikoff, C., Spies, W. & Simuni, T., Jan 1 2015, In : Neurodegenerative Diseases. 15, 2, p. 81-86 6 p.

Research output: Contribution to journalArticle

Movement Disorders
Single-Photon Emission-Computed Tomography
Parkinson Disease
Parkinsonian Disorders
Essential Tremor
10 Citations

Peripheral Biomarkers of Parkinson's disease progression and pioglitazone Effects

Simon, D. K., Simuni, T., Elm, J., Clark-Matott, J., Graebner, A. K., Baker, L., Dunlop, S. R., Emborg, M., Kamp, C., Morgan, J. C., Ross, G. W., Sharma, S. & Ravina, B., Nov 21 2015, In : Journal of Parkinson's disease. 5, 4, p. 731-736 6 p.

Research output: Contribution to journalArticle

pioglitazone
Parkinson Disease
Disease Progression
Biomarkers
Hypoglycemic Agents
66 Citations

Pioglitazone in early Parkinson's disease: A phase 2, multicentre, double-blind, randomised trial

Simuni, T. , Kieburtz, K. , Tilley, B. , J Elm, J. , Ravina, B. , Babcock, D. , Emborg, M. , Hauser, R. , Kamp, C. , Morgan, J. C. , Webster Ross, G. , K Simon, D. , Bainbridge, J. , Baker, L. , Bodis-Wollner, I. , Boyd, J. , Cambi, F. , Carter, J. , Chou, K. , Dahodwala, N. & 28 others Dewey, R. B., Dhall, R., Fang, J., Farrow, B., Feigin, A., Glazman, S., Goudreau, J., LeBlanc, P., Lee, S., Leehey, M., Lew, M. F., Lowenhaupt, S., Luo, S., Pahwa, R., Perez, A., Schneider, J., Scott, B., Shah, B., Shannon, K. M., Sharma, S., Singer, C., Truong, D., Wagner, R., Williams, K., Marie Wills, A., Shieen Wong, P., Zadikoff, C. & Zweig, R., Aug 1 2015, In : The Lancet Neurology. 14, 8, p. 795-803 9 p.

Research output: Contribution to journalArticle

pioglitazone
Parkinson Disease
Placebos
Medical Futility
National Institute of Neurological Disorders and Stroke
2 Citations

Predictors of functional decline in early Parkinson's Disease: NET-PD LS1 Cohort

Bega, D., Kim, S., Zhang, Y., Elm, J., Schneider, J., Hauser, R., Fraser, A. & Simuni, T., Nov 21 2015, In : Journal of Parkinson's Disease. 5, 4, p. 773-782 10 p.

Research output: Contribution to journalArticle

National Institute of Neurological Disorders and Stroke
Parkinson Disease
Cohort Studies
Age of Onset
Cognition
12 Citations

The profile of long-term Parkinson's disease survivors with 20 years of disease duration and beyond

Hassan, A., Wu, S. S., Schmidt, P., Simuni, T., Giladi, N., Miyasaki, J. M., Bloem, B. R., Malaty, I. A. & Okun, M. S., Jan 1 2015, In : Journal of Parkinson's Disease. 5, 2, p. 313-319 7 p.

Research output: Contribution to journalArticle

Parkinson Disease
Survivors
Caregivers
Quality of Life
Activities of Daily Living
17 Citations

Thiazolidinediones under preclinical and early clinical development for the treatment of Parkinson's disease

Carta, A. R. & Simuni, T., Feb 1 2015, In : Expert Opinion on Investigational Drugs. 24, 2, p. 219-227 9 p.

Research output: Contribution to journalReview article

Thiazolidinediones
pioglitazone
Parkinson Disease
PPAR gamma
Safety
2014
20 Citations
Complementary Therapies
Parkinson Disease
Dietary Supplements
Biological Products
Dance Therapy
27 Citations

Back to the basics: Regular exercise matters in Parkinson's disease: Results from the National Parkinson Foundation QII registry study

Oguh, O., Eisenstein, A., Kwasny, M. & Simuni, T., Jan 1 2014, In : Parkinsonism and Related Disorders. 20, 11, p. 1221-1225 5 p.

Research output: Contribution to journalArticle

Parkinson Disease
Registries
Exercise
Caregivers
Demography
86 Citations

Circadian melatonin rhythm and excessive daytime sleepiness in Parkinson disease

Videnovic, A., Noble, C., Reid, K. J., Peng, J., Turek, F. W., Marconi, A., Rademaker, A. W., Simuni, T., Zadikoff, C. & Zee, P. C., Jan 1 2014, In : JAMA Neurology. 71, 4, p. 463-469 7 p.

Research output: Contribution to journalArticle

Melatonin
Circadian Rhythm
Parkinson Disease
Sleep
Area Under Curve
15 Citations

Cost of deep brain stimulation for the treatment of Parkinson's disease by surgical stimulation sites

Stroupe, K. T., Weaver, F. M., Cao, L., Ippolito, D., Barton, B. R., Burnett-Zeigler, I. E., Holloway, R. G., Vickrey, B. G., Simuni, T. & Follett, K. A., Nov 1 2014, In : Movement Disorders. 29, 13, p. 1666-1674 9 p.

Research output: Contribution to journalArticle

Globus Pallidus
Deep Brain Stimulation
Subthalamic Nucleus
Parkinson Disease
Quality-Adjusted Life Years
4 Citations

Is exenatide the next big thing in Parkinson's disease?

Simuni, T. & Brundin, P., Jan 1 2014, In : Journal of Parkinson's Disease. 4, 3, p. 345-347 3 p.

Research output: Contribution to journalComment/debate

Parkinson Disease
Placebos
Neurobehavioral Manifestations
Placebo Effect
Withholding Treatment