• 21274 Citations
1983 …2022
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Personal profile

Research Interests

My interest is in understanding mechanism of disease. Our approach is gene discovery, animal and cell culture modeling and therapeutic application in disorders of the nervous system. My specific emphasis is on neurodegenerative conditions and those affecting the neuromuscular system. We have focused on amyotrophic lateral sclerosis, the spastic paraparesis, primary lateral sclerosis and frontal-temporal lobe dementias as protoptypic neurodegenerative disorders. We have identified several genes that cause these disorders and have made animal models to study their pathogenesis. In addition I collabotate with colleagues in the study of mitochondrial disorder of muscle and the peripheral neuropathies.

Certifications and Licenses


Training Experience

1976Internship, Perth Amboy General Hospital
1979Residency, UMDNJ-University Hospital
1980Fellowship, Hospital for Special Surgery
1981Fellowship, National Institutes of Health

Education/Academic qualification

MD, Dow Medical College, Pakistan

… → 1973

Research interests

  • ALS
  • Dementia
  • Drug Discovery
  • Genomic Medicine/Personalized Medicine
  • Molecular Diagnostics
  • Molecular Genetics
  • Neuromuscular Disorders
  • Neuroscience

Fingerprint Dive into the research topics where Teepu Siddique is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 7 Similar Profiles
Amyotrophic Lateral Sclerosis Medicine & Life Sciences
Motor Neurons Medicine & Life Sciences
Mutation Medicine & Life Sciences
Genes Medicine & Life Sciences
Motor Neuron Disease Medicine & Life Sciences
Transgenic Mice Medicine & Life Sciences
Chromosomes Medicine & Life Sciences
Neurodegenerative Diseases Medicine & Life Sciences

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Grants 1996 2022

Amyotrophic Lateral Sclerosis
Innate Immunity
Interferon Type I
Trypanocidal Agents
Secretory Vesicles
Motor Neurons
Parkinson Disease
Chromosomes, Human, Pair 20
Genetic Loci
Neurodegenerative Diseases
Amyotrophic Lateral Sclerosis
Motor Neurons
Clustered Regularly Interspaced Short Palindromic Repeats

Research Output 1983 2019

Incidence and Clinical Features of TRPV4-Linked Axonal Neuropathies in a USA Cohort of Charcot–Marie–Tooth Disease Type 2

Deng, S., Feely, S. M. E., Shi, Y., Zhai, H., Zhan, L., Siddique, T., Deng, H. X. & Shy, M. E., Jan 1 2019, (Accepted/In press) In : Neuromolecular medicine.

Research output: Contribution to journalArticle

Spinal Muscular Atrophy
Vocal Cord Paralysis
Hearing Loss
1 Citation (Scopus)
Parkinsonian Disorders
Parkinson Disease
11 Citations (Scopus)

A novel ALS-associated variant in UBQLN4 regulates motor axon morphogenesis

Edens, B. M., Yan, J., Miller, N., Deng, H. X., Siddique, T. & Ma, Y. C., May 2 2017, In : eLife. 6, e25453.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
beta Catenin
Wnt Signaling Pathway
16 Citations (Scopus)

Defining SOD1 ALS natural history to guide therapeutic clinical trial design

Bali, T., Self, W., Liu, J., Siddique, T., Wang, L. H., Bird, T. D., Ratti, E., Atassi, N., Boylan, K. B., Glass, J. D., Maragakis, N. J., Caress, J. B., McCluskey, L. F., Appel, S. H., Wymer, J. P., Gibson, S., Zinman, L., Mozaffar, T., Callaghan, B., McVey, A. L. & 7 others, Jockel-Balsarotti, J., Allred, P., Fisher, E. R., Lopate, G., Pestronk, A., Cudkowicz, M. E. & Miller, T. M., Feb 1 2017, In : Journal of Neurology, Neurosurgery and Psychiatry. 88, 2, p. 99-105 7 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Natural History
Clinical Trials
8 Citations (Scopus)

Nuclear export of misfolded SOD1 mediated by a normally buried NES-like sequence reduces proteotoxicity in the nucleus

Zhong, Y., Wang, J., Henderson, M. J., Yang, P., Hagen, B. M., Siddique, T., Vogel, B. E., Deng, H. X. & Fang, S., May 2 2017, In : eLife. 6, e23759.

Research output: Contribution to journalArticle

Nuclear Export Signals
Cell Nucleus Active Transport
Protein Sorting Signals
Gene encoding