• 21678 Citations
1983 …2020

Research output per year

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Personal profile

Research Interests

My interest is in understanding mechanism of disease. Our approach is gene discovery, animal and cell culture modeling and therapeutic application in disorders of the nervous system. My specific emphasis is on neurodegenerative conditions and those affecting the neuromuscular system. We have focused on amyotrophic lateral sclerosis, the spastic paraparesis, primary lateral sclerosis and frontal-temporal lobe dementias as protoptypic neurodegenerative disorders. We have identified several genes that cause these disorders and have made animal models to study their pathogenesis. In addition I collabotate with colleagues in the study of mitochondrial disorder of muscle and the peripheral neuropathies.

Certifications and Licenses


Training Experience

1976Internship, Perth Amboy General Hospital
1979Residency, UMDNJ-University Hospital
1980Fellowship, Hospital for Special Surgery
1981Fellowship, National Institutes of Health

Education/Academic qualification

MD, Dow Medical College

… → 1973

Research interests

  • ALS
  • Dementia
  • Drug Discovery
  • Genomic Medicine/Personalized Medicine
  • Molecular Diagnostics
  • Molecular Genetics
  • Neuromuscular Disorders
  • Neuroscience

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  • Research Output

    Incidence and Clinical Features of TRPV4-Linked Axonal Neuropathies in a USA Cohort of Charcot–Marie–Tooth Disease Type 2

    Deng, S., Feely, S. M. E., Shi, Y., Zhai, H., Zhan, L., Siddique, T., Deng, H. X. & Shy, M. E., Mar 1 2020, In : Neuromolecular medicine. 22, 1, p. 68-72 5 p.

    Research output: Contribution to journalArticle

  • Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity

    Ortega, J. A., Daley, E. L., Kour, S., Samani, M., Tellez, L., Smith, H. S., Hall, E. A., Esengul, Y. T., Tsai, Y. H., Gendron, T. F., Donnelly, C. J., Siddique, T., Savas, J. N., Pandey, U. B. & Kiskinis, E., Apr 8 2020, In : Neuron. 106, 1, p. 90-107.e13

    Research output: Contribution to journalArticle

  • 2 Scopus citations
    3 Scopus citations

    A novel ALS-associated variant in UBQLN4 regulates motor axon morphogenesis

    Edens, B. M., Yan, J., Miller, N., Deng, H. X., Siddique, T. & Ma, Y. C., May 2 2017, In : eLife. 6, e25453.

    Research output: Contribution to journalArticle

  • 14 Scopus citations

    Defining SOD1 ALS natural history to guide therapeutic clinical trial design

    Bali, T., Self, W., Liu, J., Siddique, T., Wang, L. H., Bird, T. D., Ratti, E., Atassi, N., Boylan, K. B., Glass, J. D., Maragakis, N. J., Caress, J. B., McCluskey, L. F., Appel, S. H., Wymer, J. P., Gibson, S., Zinman, L., Mozaffar, T., Callaghan, B., McVey, A. L. & 7 others, Jockel-Balsarotti, J., Allred, P., Fisher, E. R., Lopate, G., Pestronk, A., Cudkowicz, M. E. & Miller, T. M., Feb 1 2017, In : Journal of Neurology, Neurosurgery and Psychiatry. 88, 2, p. 99-105 7 p.

    Research output: Contribution to journalArticle

  • 18 Scopus citations