• 20771 Citations
1983 …2022
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Personal profile

Research Interests

My interest is in understanding mechanism of disease. Our approach is gene discovery, animal and cell culture modeling and therapeutic application in disorders of the nervous system. My specific emphasis is on neurodegenerative conditions and those affecting the neuromuscular system. We have focused on amyotrophic lateral sclerosis, the spastic paraparesis, primary lateral sclerosis and frontal-temporal lobe dementias as protoptypic neurodegenerative disorders. We have identified several genes that cause these disorders and have made animal models to study their pathogenesis. In addition I collabotate with colleagues in the study of mitochondrial disorder of muscle and the peripheral neuropathies.

Certifications and Licenses

Neurology

Training Experience

1976Internship, Perth Amboy General Hospital
1979Residency, UMDNJ-University Hospital
1980Fellowship, Hospital for Special Surgery
1981Fellowship, National Institutes of Health

Education/Academic qualification

MD, Dow Medical College, Pakistan

… → 1973

Keywords

  • ALS
  • Dementia
  • Drug Discovery
  • Genomic Medicine/Personalized Medicine
  • Molecular Diagnostics
  • Molecular Genetics
  • Neuromuscular Disorders
  • Neuroscience

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Grants 1996 2022

Secretory Vesicles
Dementia
Motor Neurons
Carisoprodol
Therapeutics
Ubiquitin
Recycling
Neurodegenerative Diseases
Pharmaceutical Preparations
Libraries
Parkinson Disease
Chromosomes, Human, Pair 20
Genetic Loci
Neurodegenerative Diseases
Genes
Amyotrophic Lateral Sclerosis
Motor Neurons
Oxidation-Reduction
Clustered Regularly Interspaced Short Palindromic Repeats
Pathology

Research Output 1983 2019

1 Citation (Scopus)
Parkinsonian Disorders
Parkinson Disease
Genes
9 Citations (Scopus)

A novel ALS-associated variant in UBQLN4 regulates motor axon morphogenesis

Edens, B. M., Yan, J., Miller, N., Deng, H-X., Siddique, T. & Ma, Y., May 2 2017, In : eLife. 6, e25453.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Morphogenesis
Axons
beta Catenin
Wnt Signaling Pathway
13 Citations (Scopus)

Defining SOD1 ALS natural history to guide therapeutic clinical trial design

Bali, T., Self, W., Liu, J., Siddique, T., Wang, L. H., Bird, T. D., Ratti, E., Atassi, N., Boylan, K. B., Glass, J. D., Maragakis, N. J., Caress, J. B., McCluskey, L. F., Appel, S. H., Wymer, J. P., Gibson, S., Zinman, L., Mozaffar, T., Callaghan, B., McVey, A. L. & 7 othersJockel-Balsarotti, J., Allred, P., Fisher, E. R., Lopate, G., Pestronk, A., Cudkowicz, M. E. & Miller, T. M., Feb 1 2017, In : Journal of Neurology, Neurosurgery and Psychiatry. 88, 2, p. 99-105 7 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Natural History
Clinical Trials
Mutation
Survival
7 Citations (Scopus)

Nuclear export of misfolded SOD1 mediated by a normally buried NES-like sequence reduces proteotoxicity in the nucleus

Zhong, Y., Wang, J., Henderson, M. J., Yang, P., Hagen, B. M., Siddique, T., Vogel, B. E., Deng, H-X. & Fang, S., May 2 2017, In : eLife. 6, e23759.

Research output: Contribution to journalArticle

Nuclear Export Signals
Cell Nucleus Active Transport
Cytotoxicity
Protein Sorting Signals
Gene encoding
7 Citations (Scopus)
Tidal Volume
Amyotrophic Lateral Sclerosis
Pressure
Noninvasive Ventilation
Aptitude