Grants per year
Personal profile
Research Interests
I received my PhD in immunology from the University of Chicago where I discovered the function of CTLA-4, the first checkpoint inhibitor. Following my MS in computer science, I worked in microbial genomics developing informatics tools to understand biochemical pathways in microorganisms. I joined the Nortwestern faculty to focus on medical informatics and am Associate Director for the Center for Health Information Partnerships and Director of the Chicago Health IT Regional Extension Center.
My goal is to improve health for people with autoimmune disease, using immunological, genomics, informatics and implementation science methods to study the development of autoimmunity. My research focuses on using electronic health records, intersected with genetic, social and environmental data to 1) develop translational models to elucidate the molecular and environmental mechanisms of human autoimmune disease and 2) develop EHR-based tools to improve care for people with autoimmunity.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
MS, Computer Science, DePaul University
… → 2004
Immunology, PhD, The University of Chicago
… → 1997
Research interests keywords
- Autoimmune Diseases
- Big Data
- Bioinformatics
- Genomic Medicine/Personalized Medicine
- Healthcare Quality
- Immunology
- Implementation Science
- Medical Informatics
- Systemic Lupus Erythematosus
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Collaborations and top research areas from the last five years
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Disparities in diabetes management: before and during the COVID-19 era
Furmanchuk, A., Ackermann, R. T., Kho, A. N., McHugh, M. C., Wallia, A. & Walunas, T. L.
11/15/22 → 11/14/25
Project: Research project
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Using systems dynamics modeling and implementation research to improve hypertension management in primary care
Washington University St. Louis
9/1/22 → 11/21/23
Project: Research project
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Identification of Risk Factors for predicting outcomes of COVID-19-Related Multisystem Inflammatory Syndrome in Children (MISC) using Real World Clinical Data
Walunas, T. L., Furmanchuk, A., Kho, A. N., Luo, Y. & Rasmussen-Torvik, L. J.
National Institute of Child Health and Human Development
8/8/22 → 7/31/24
Project: Research project
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Healthy Hearts in Michigan (H2M)
Walunas, T. L., Ciolino, J. D., Hitsman, B. L., Kho, A. N., McHugh, M. C. & Smith, J. D.
Altarum Institute, Agency for Healthcare Research and Quality
1/1/21 → 12/31/23
Project: Research project
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A metadata framework for computational phenotypes
Spotnitz, M., Acharya, N., Cimino, J. J., Murphy, S., Namjou, B., Crimmins, N., Walunas, T., Liu, C., Crosslin, D., Benoit, B., Rosenthal, E., Pacheco, J. A., Ostropolets, A., Nieva, H. R., Patterson, J. S., Richter, L. R., Callahan, T. J., Elhussein, A., Pang, C., Kiryluk, K., & 8 others , Jul 1 2023, In: JAMIA Open. 6, 2, ooad032.Research output: Contribution to journal › Article › peer-review
Open Access -
An Approach to Evaluating Multisector Partnerships to Support Evidence-Based Quality Improvement in Primary Care
McHugh, M., Philbin, S., Carroll, A. J., Vu, M. H., Ciolino, J. D., Maki, B., Day, A., Smith, J. D. & Walunas, T., Apr 2023, In: Joint Commission Journal on Quality and Patient Safety. 49, 4, p. 199-206 8 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Author Correction: Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits (Nature Communications, (2022), 13, 1, (6859), 10.1038/s41467-022-34456-6)
Liu, L., Khan, A., Sanchez-Rodriguez, E., Zanoni, F., Li, Y., Steers, N., Balderes, O., Zhang, J., Krithivasan, P., LeDesma, R. A., Fischman, C., Hebbring, S. J., Harley, J. B., Moncrieffe, H., Kottyan, L. C., Namjou-Khales, B., Walunas, T. L., Knevel, R., Raychaudhuri, S., Karlson, E. W., & 32 others , Dec 2023, In: Nature communications. 14, 1, 655.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Characterizing variability of electronic health record-driven phenotype definitions
Brandt, P. S., Kho, A., Luo, Y., Pacheco, J. A., Walunas, T. L., Hakonarson, H., Hripcsak, G., Liu, C., Shang, N., Weng, C., Walton, N., Carrell, D. S., Crane, P. K., Larson, E. B., Chute, C. G., Kullo, I. J., Carroll, R., Denny, J., Ramirez, A., Wei, W. Q., & 5 others , Mar 1 2023, In: Journal of the American Medical Informatics Association. 30, 3, p. 427-437 11 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Evaluation of the portability of computable phenotypes with natural language processing in the eMERGE network
Pacheco, J. A., Rasmussen, L. V., Wiley, K., Person, T. N., Cronkite, D. J., Sohn, S., Murphy, S., Gundelach, J. H., Gainer, V., Castro, V. M., Liu, C., Mentch, F., Lingren, T., Sundaresan, A. S., Eickelberg, G., Willis, V., Furmanchuk, A., Patel, R., Carrell, D. S., Deng, Y., & 19 others , Dec 2023, In: Scientific reports. 13, 1, 1971.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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sj-xlsx-1-lup-10.1177_09612033211014952 - Supplemental material for Pleiotropy of systemic lupus erythematosus risk alleles and cardiometabolic disorders: A phenome-wide association study and inverse-variance weighted meta-analysis
Kawai, V. K. (Creator), Shi, M. (Contributor), Liu, G. (Creator), Feng, Q. (Creator), Wei, W. (Creator), Chung, C. P. (Creator), Walunas, T. L. (Creator), Gordon, A. S. (Creator), Linneman, J. G. (Creator), Hebbring, S. J. (Creator), Harley, J. B. (Creator), Cox, N. J. (Creator), Roden, D. M. (Creator), Stein, C. M. (Contributor) & Mosley, J. D. (Creator), SAGE Journals, 2021
DOI: 10.25384/sage.14588139, https://sage.figshare.com/articles/dataset/sj-xlsx-1-lup-10_1177_09612033211014952_-_Supplemental_material_for_Pleiotropy_of_systemic_lupus_erythematosus_risk_alleles_and_cardiometabolic_disorders_A_phenome-wide_association_study_and_inverse-variance_weighted_meta-analysis/14588139
Dataset
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Electronic health record data use in the assessment of quality indicators for glucocorticoid osteoporosis screening in systemic lupus erythematosus
Ko, D. (Creator), Forrest, N. (Creator), Mai, Q. (Creator), Pawlowski, A. (Creator), Balsley, K. (Creator), Chung, A. (Creator), Ramsey-Goldman, R. (Creator), Walunas, T. L. (Creator) & Pawlowski, A. (Creator), SAGE Journals, 2022
DOI: 10.25384/sage.c.6235403.v1, https://sage.figshare.com/collections/Electronic_health_record_data_use_in_the_assessment_of_quality_indicators_for_glucocorticoid_osteoporosis_screening_in_systemic_lupus_erythematosus/6235403/1
Dataset
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A metadata framework for electronic phenotypes
Spotnitz, M. (Contributor), Acharya, N. (Contributor), Cimino, J. J. (Contributor), Murphy, S. (Contributor), Namjou-Khales, B. (Contributor), Crimmins, N. (Contributor), Walunas, T. L. (Contributor), Liu, C. (Contributor), Crosslin, D. (Contributor), Benoit, B. (Contributor), Rosenthal, E. (Contributor), Pacheco, J. (Contributor), Ostropolets, A. (Contributor), Reyes Nieva, H. (Contributor), Patterson, J. (Contributor), Richter, L. (Contributor), Callahan, T. (Contributor), Elhussein, A. (Contributor), Pang, C. (Contributor), Kiryluk, K. (Contributor), Nestor, J. (Contributor), Mohan, S. (Contributor), Minty, E. (Contributor), Wei, W. (Contributor), Natarajan, K. (Contributor) & Weng, C. (Contributor), ZENODO, May 1 2023
DOI: 10.5061/dryad.rn8pk0ph3, https://zenodo.org/record/7883685
Dataset
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Pleiotropy of systemic lupus erythematosus risk alleles and cardiometabolic disorders: A phenome-wide association study and inverse-variance weighted meta-analysis
Kawai, V. K. (Creator), Shi, M. (Contributor), Liu, G. (Creator), Feng, Q. (Creator), Wei, W. (Creator), Chung, C. P. (Creator), Walunas, T. L. (Creator), Gordon, A. S. (Creator), Linneman, J. G. (Creator), Hebbring, S. J. (Creator), Harley, J. B. (Creator), Cox, N. J. (Creator), Roden, D. M. (Creator), Stein, C. M. (Contributor), Mosley, J. D. (Creator), Liu, G. (Creator), Harley, J. B. (Creator), Cox, N. J. (Creator), Roden, D. M. (Creator) & Mosley, J. D. (Creator), SAGE Journals, 2021
DOI: 10.25384/sage.c.5423292.v1, https://sage.figshare.com/collections/Pleiotropy_of_systemic_lupus_erythematosus_risk_alleles_and_cardiometabolic_disorders_A_phenome-wide_association_study_and_inverse-variance_weighted_meta-analysis/5423292/1
Dataset