Grants per year
Personal profile
Research Interests
Research activities of our group focus on two major clinical areas: musculoskeletal pain and bone. In collaboration with Dr. A. Vania Apkarian in the Department of Physiology, our pain research focuses on understanding the basis for pain chronification, utilizing brain imaging and psychophysical methodologies. Current NIH-funded studies are evaluating the transition that occurs in individuals who progress from acute to chronic pain and attempting to modulate this by pharmacologic interventions. On a more applied level, the development and characterization of analgesic agents for the management of chronic musculoskeleletal pain has been a major focus for over the past decade. We have helped design and implement phase 2 studies of many of the major classes of drugs currently in use, including NSAIDs, cox-2 selective inhibitors, opioids, topical analgesic agents and novel approaches to pain including antibodies to NGF (nerve growth factor) and other agents active on the peripheral nervous system. Bone loss is known to be a major problem for individuals with disabilities, particularly those who are not able to ambulate or bear weight normally. Our group has initiated studies aimed at treating patients with acute spinal cord injury to attempt to maintain bone mass during their immediate post-injury period. In those individuals with SCI who have already lost significant bone mass, we have undertaken a second set of studies aimed at evaluating approaches to increase bone mass in these individuals, using physical and pharmacological interventions as well as attempting to assess the interaction between bone and the metabolic status of these individuals.
Certifications and Licenses
Internal Medicine | |
Rheumatology |
Training Experience
1972 | Internship, Johns Hopkins Hospital |
1973 | Residency, Johns Hopkins Hospital |
1976 | Fellowship, MRC Rheumatology Unit, UK |
Education/Academic qualification
PhD, Council for National Academic Awards
… → 1979
MD, Harvard Medical School
… → 1971
Research interests
- Bones
- Cartilage
- Clinical Trial Methodology
- Joints
- Muscles
- Osteoarthritis
- Osteoporosis
- Pain
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Grants
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Prot #20197268: Effects of Romosozumab on Bone Health in Women with Spinal Cord Injury and Osteoporosis
12/21/20 → 12/21/23
Project: Research project
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Prot #Cingal 19-01: A Randomized, Double-Blind, Placebo Controlled, Multi-Center Study of a Single Injection Cross-Linked Sodium Hyaluronate Combined with Triamcinolone Hexacetonide (Cingal) to Provide Symptomatic Relief of Osteoarthritis of the Knee
SynteractHCR, Inc., Anika Therapeutics, Inc.
9/11/20 → 9/11/23
Project: Research project
Research Output
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Bone Adaptation in Adult Women Is Related to Loading Dose: A 12-Month Randomized Controlled Trial
Troy, K. L., Mancuso, M. E., Johnson, J. E., Wu, Z., Schnitzer, T. J. & Butler, T. A., Jul 1 2020, In: Journal of Bone and Mineral Research. 35, 7, p. 1300-1312 13 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Onset and maintenance of efficacy of subcutaneous tanezumab in patients with moderate to severe osteoarthritis of the knee or hip: A 16-week dose-titration study
Schnitzer, T. J., Khan, A., Bessette, L., Davignon, I., Brown, M. T., Pixton, G., Prucka, W. R., Tive, L., Viktrup, L. & West, C. R., Jun 2020, In: Seminars in Arthritis and Rheumatism. 50, 3, p. 387-393 7 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Prognostics for pain in osteoarthritis: Do clinical measures predict pain after total joint replacement?
Barroso, J., Wakaizumi, K., Reckziegel, D., Pinto-Ramos, J., Schnitzer, T., Galhardo, V. & Apkarian, A. V., Jan 1 2020, In: PloS one. 15, 1, e0222370.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Reorganization of functional brain network architecture in chronic osteoarthritis pain
Barroso, J., Wakaizumi, K., Reis, A. M., Baliki, M. N., Schnitzer, T. J., Galhardo, V. & Apkarian, A., 2020, (Accepted/In press) In: Human Brain Mapping.Research output: Contribution to journal › Article › peer-review
Open Access -
Stiffness and Strength Predictions From Finite Element Models of the Knee are Associated with Lower-Limb Fractures After Spinal Cord Injury
Haider, I. T., Simonian, N., Schnitzer, T. J. & Edwards, W. B., 2020, (Accepted/In press) In: Annals of Biomedical Engineering.Research output: Contribution to journal › Article › peer-review