• 23139 Citations
1975 …2020

Research output per year

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Personal profile

Research Interests

Research activities of our group focus on two major clinical areas: musculoskeletal pain and bone. In collaboration with Dr. A. Vania Apkarian in the Department of Physiology, our pain research focuses on understanding the basis for pain chronification, utilizing brain imaging and psychophysical methodologies. Current NIH-funded studies are evaluating the transition that occurs in individuals who progress from acute to chronic pain and attempting to modulate this by pharmacologic interventions. On a more applied level, the development and characterization of analgesic agents for the management of chronic musculoskeleletal pain has been a major focus for over the past decade. We have helped design and implement phase 2 studies of many of the major classes of drugs currently in use, including NSAIDs, cox-2 selective inhibitors, opioids, topical analgesic agents and novel approaches to pain including antibodies to NGF (nerve growth factor) and other agents active on the peripheral nervous system. Bone loss is known to be a major problem for individuals with disabilities, particularly those who are not able to ambulate or bear weight normally. Our group has initiated studies aimed at treating patients with acute spinal cord injury to attempt to maintain bone mass during their immediate post-injury period. In those individuals with SCI who have already lost significant bone mass, we have undertaken a second set of studies aimed at evaluating approaches to increase bone mass in these individuals, using physical and pharmacological interventions as well as attempting to assess the interaction between bone and the metabolic status of these individuals.

Certifications and Licenses

Internal Medicine
Rheumatology

Training Experience

1972Internship, Johns Hopkins Hospital
1973Residency, Johns Hopkins Hospital
1976Fellowship, MRC Rheumatology Unit, UK

Education/Academic qualification

PhD, Council for National Academic Awards

… → 1979

MD, Harvard Medical School

… → 1971

Research interests

  • Bones
  • Cartilage
  • Clinical Trial Methodology
  • Joints
  • Muscles
  • Osteoarthritis
  • Osteoporosis
  • Pain

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Grants

Research Output

Bone Adaptation in Adult Women Is Related to Loading Dose: A 12-Month Randomized Controlled Trial

Troy, K. L., Mancuso, M. E., Johnson, J. E., Wu, Z., Schnitzer, T. J. & Butler, T. A., Jan 1 2020, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Open Access
  • Onset and maintenance of efficacy of subcutaneous tanezumab in patients with moderate to severe osteoarthritis of the knee or hip: A 16-week dose-titration study

    Schnitzer, T. J., Khan, A., Bessette, L., Davignon, I., Brown, M. T., Pixton, G., Prucka, W. R., Tive, L., Viktrup, L. & West, C. R., Jan 1 2020, (Accepted/In press) In : Seminars in Arthritis and Rheumatism.

    Research output: Contribution to journalArticle

    Open Access
  • Prognostics for pain in osteoarthritis: Do clinical measures predict pain after total joint replacement?

    Barroso, J., Wakaizumi, K., Reckziegel, D., Pinto-Ramos, J., Schnitzer, T., Galhardo, V. & Apkarian, A. V., Jan 1 2020, In : PloS one. 15, 1, e0222370.

    Research output: Contribution to journalArticle

    Open Access
  • Temporal Factors Associated With Opioid Prescriptions for Patients With Pain Conditions in an Urban Emergency Department

    Smith, B. C., Vigotsky, A. D., Apkarian, A. V. & Schnitzer, T. J., Mar 2 2020, In : JAMA network open. 3, 3, p. e200802

    Research output: Contribution to journalArticle

    Open Access
  • A Phase II Trial of Lutikizumab, an Anti–Interleukin-1α/β Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis

    Fleischmann, R. M., Bliddal, H., Blanco, F. J., Schnitzer, T. J., Peterfy, C., Chen, S., Wang, L., Feng, S., Conaghan, P. G., Berenbaum, F., Pelletier, J. P., Martel-Pelletier, J., Vaeterlein, O., Kaeley, G. S., Liu, W., Kosloski, M. P., Levy, G., Zhang, L., Medema, J. K. & Levesque, M. C., Jul 2019, In : Arthritis and Rheumatology. 71, 7, p. 1056-1069 14 p.

    Research output: Contribution to journalArticle

  • 13 Scopus citations