Grants per year
Personal profile
Research Interests
Research activities of our group focus on two major clinical areas: musculoskeletal pain and bone. In collaboration with Dr. A. Vania Apkarian in the Department of Physiology, our pain research focuses on understanding the basis for pain chronification, utilizing brain imaging and psychophysical methodologies. Current NIH-funded studies are evaluating the transition that occurs in individuals who progress from acute to chronic pain and attempting to modulate this by pharmacologic interventions. On a more applied level, the development and characterization of analgesic agents for the management of chronic musculoskeleletal pain has been a major focus for over the past decade. We have helped design and implement phase 2 studies of many of the major classes of drugs currently in use, including NSAIDs, cox-2 selective inhibitors, opioids, topical analgesic agents and novel approaches to pain including antibodies to NGF (nerve growth factor) and other agents active on the peripheral nervous system. Bone loss is known to be a major problem for individuals with disabilities, particularly those who are not able to ambulate or bear weight normally. Our group has initiated studies aimed at treating patients with acute spinal cord injury to attempt to maintain bone mass during their immediate post-injury period. In those individuals with SCI who have already lost significant bone mass, we have undertaken a second set of studies aimed at evaluating approaches to increase bone mass in these individuals, using physical and pharmacological interventions as well as attempting to assess the interaction between bone and the metabolic status of these individuals.
Certifications and Licenses
Internal Medicine | |
Rheumatology |
Training Experience
1972 | Internship, Johns Hopkins Hospital |
1973 | Residency, Johns Hopkins Hospital |
1976 | Fellowship, MRC Rheumatology Unit, UK |
Education/Academic qualification
PhD, Council for National Academic Awards
… → 1979
MD, Harvard Medical School
… → 1971
Keywords
- Clinical Trial Methodology
- Osteoarthritis
- Osteoporosis
- Pain
- Bones
- Cartilage
- Joints
- Muscles
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Grants 2002 2023
Prot #CL2-201086-002/GLPG1972-CL-201: Efficacy and safety of 3 doses of S201086/GLPG1972 administered orally once daily in patients with knee osteoarthritis. A 52-week international, multi-regional, multi-center, randomized, double-blind, placebo-controll
Medpace Clinical Research LLC, Galapagos NV
12/4/18 → 12/4/21
Project: Research project
Center for chronic pain and drug abuse
Apkarian, A., Awatramani, R., Drenan, R. M., Graves, S. M., Griffith, J. W., Huang, L., Jovasevic, V., Martina, M., Miller, R. J., Parrish, T. B., Procissi, D., Radulovic, J., Rodes, M. E., Schnitzer, T. J. & Surmeier Jr, D. J.
National Institute on Drug Abuse
9/1/18 → 6/30/23
Project: Research project
Prot #R475-OA-1611: A Phase 3 Randomized, Double-Blind, Multi-Dose, Placebo and Naproxen-Controlled Study to Evaluate the Efficacy and Safety of Fasinumab in Patients with Pain Due to Osteoarthritis of the Knee or Hip
ICON Clinical Research Limited, Regeneron Pharmaceuticals, Inc.
10/25/17 → 10/25/20
Project: Research project
D-Cycloserine for the Treatment of Chronic, Refractory Low Back Pain
Apkarian, A., Griffith, J. W. & Schnitzer, T. J.
U.S. Army Medical Research and Materiel Command
9/30/17 → 9/29/21
Project: Research project
Research Output 1975 2019
Applications of Bayesian statistical methodology to clinical trial design: A case study of a phase 2 trial with an interim futility assessment in patients with knee osteoarthritis
Smith, C. L., Jin, Y., Raddad, E., McNearney, T. A., Ni, X., Monteith, D., Brown, R., Deeg, M. A. & Schnitzer, T. J., Jan 1 2019, In : Pharmaceutical Statistics. 18, 1, p. 39-53 15 p.Research output: Contribution to journal › Article
Bone fragility after spinal cord injury: reductions in stiffness and bone mineral at the distal femur and proximal tibia as a function of time
Haider, I. T., Lobos, S. M., Simonian, N., Schnitzer, T. J. & Edwards, W. B., Dec 1 2018, In : Osteoporosis International. 29, 12, p. 2703-2715 13 p.Research output: Contribution to journal › Article
Brain and psychological determinants of placebo pill response in chronic pain patients
Vachon-Presseau, E., Berger, S. E., Abdullah, T. B., Huang, L., Cecchi, G. A., Griffith, J. W., Schnitzer, T. J. & Apkarian, A., Dec 1 2018, In : Nature communications. 9, 1, 3397.Research output: Contribution to journal › Article
CGRP blockade by galcanezumab was not associated with reductions in signs and symptoms of knee osteoarthritis in a randomized clinical trial
Jin, Y., Smith, C., Monteith, D., Brown, R., Camporeale, A., McNearney, T. A., Deeg, M. A., Raddad, E., Xiao, N., de la Peña, A., Kivitz, A. J. & Schnitzer, T. J., Dec 1 2018, In : Osteoarthritis and Cartilage. 26, 12, p. 1609-1618 10 p.Research output: Contribution to journal › Article
Effects of Teriparatide and Vibration on Bone Mass and Bone Strength in People with Bone Loss and Spinal Cord Injury: A Randomized, Controlled Trial
Edwards, W. B., Simonian, N., Haider, I. T., Anschel, A. S., Chen, D., Gordon, K. E., Gregory, E. K., Kim, K. H., Parachuri, R., Troy, K. L. & Schnitzer, T. J., Oct 1 2018, In : Journal of Bone and Mineral Research. 33, 10, p. 1729-1740 12 p.Research output: Contribution to journal › Article