• 21362 Citations
1975 …2023
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Personal profile

Research Interests

Research activities of our group focus on two major clinical areas: musculoskeletal pain and bone. In collaboration with Dr. A. Vania Apkarian in the Department of Physiology, our pain research focuses on understanding the basis for pain chronification, utilizing brain imaging and psychophysical methodologies. Current NIH-funded studies are evaluating the transition that occurs in individuals who progress from acute to chronic pain and attempting to modulate this by pharmacologic interventions. On a more applied level, the development and characterization of analgesic agents for the management of chronic musculoskeleletal pain has been a major focus for over the past decade. We have helped design and implement phase 2 studies of many of the major classes of drugs currently in use, including NSAIDs, cox-2 selective inhibitors, opioids, topical analgesic agents and novel approaches to pain including antibodies to NGF (nerve growth factor) and other agents active on the peripheral nervous system. Bone loss is known to be a major problem for individuals with disabilities, particularly those who are not able to ambulate or bear weight normally. Our group has initiated studies aimed at treating patients with acute spinal cord injury to attempt to maintain bone mass during their immediate post-injury period. In those individuals with SCI who have already lost significant bone mass, we have undertaken a second set of studies aimed at evaluating approaches to increase bone mass in these individuals, using physical and pharmacological interventions as well as attempting to assess the interaction between bone and the metabolic status of these individuals.

Certifications and Licenses

Internal Medicine
Rheumatology

Training Experience

1972Internship, Johns Hopkins Hospital
1973Residency, Johns Hopkins Hospital
1976Fellowship, MRC Rheumatology Unit, UK

Education/Academic qualification

PhD, Council for National Academic Awards

… → 1979

MD, Harvard Medical School

… → 1971

Keywords

  • Bones / Cartilage / Joints / Muscles
  • Clinical Trial Methodology
  • Osteoarthritis
  • Osteoporosis
  • Pain

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Grants 2002 2023

Research Output 1975 2018

Applications of Bayesian statistical methodology to clinical trial design: A case study of a phase 2 trial with an interim futility assessment in patients with knee osteoarthritis

Smith, C. L., Jin, Y., Raddad, E., McNearney, T. A., Ni, X., Monteith, D., Brown, R., Deeg, M. A. & Schnitzer, T. J., Jan 1 2018, (Accepted/In press) In : Pharmaceutical Statistics.

Research output: Contribution to journalArticle

Osteoarthritis
Medical Futility
Knee Osteoarthritis
Interim Analysis
Clinical Trials

Bone fragility after spinal cord injury: reductions in stiffness and bone mineral at the distal femur and proximal tibia as a function of time

Haider, I. T., Lobos, S. M., Simonian, N., Schnitzer, T. J. & Edwards, W. B., Jan 1 2018, (Accepted/In press) In : Osteoporosis International.

Research output: Contribution to journalArticle

Tibia
Spinal Cord Injuries
Femur
Minerals
Bone and Bones
1 Citations

Brain and psychological determinants of placebo pill response in chronic pain patients

Vachon-Presseau, E., Berger, S. E., Abdullah, T. B., Huang, L., Cecchi, G. A., Griffith, J. W., Schnitzer, T. J. & Apkarian, A., Dec 1 2018, In : Nature communications. 9, 1, 3397.

Research output: Contribution to journalArticle

pain
determinants
Chronic Pain
Magnetic resonance imaging
brain

CGRP blockade by galcanezumab was not associated with reductions in signs and symptoms of knee osteoarthritis in a randomized clinical trial

Jin, Y., Smith, C., Monteith, D., Brown, R., Camporeale, A., McNearney, T. A., Deeg, M. A., Raddad, E., Xiao, N., de la Peña, A., Kivitz, A. J. & Schnitzer, T. J., Dec 1 2018, In : Osteoarthritis and Cartilage. 26, 12, p. 1609-1618 10 p.

Research output: Contribution to journalArticle

Knee Osteoarthritis
Celecoxib
Signs and Symptoms
Randomized Controlled Trials
Placebos
2 Citations

Effects of Teriparatide and Vibration on Bone Mass and Bone Strength in People with Bone Loss and Spinal Cord Injury: A Randomized, Controlled Trial

Edwards, W. B., Simonian, N., Haider, I. T., Anschel, A. S., Chen, D., Gordon, K. E., Gregory, E. K., Kim, K. H., Parachuri, R., Troy, K. L. & Schnitzer, T. J., Oct 1 2018, In : Journal of Bone and Mineral Research. 33, 10, p. 1729-1740 12 p.

Research output: Contribution to journalArticle

Teriparatide
Vibration
Spinal Cord Injuries
Randomized Controlled Trials
Bone and Bones