• 22780 Citations
1975 …2024

Research output per year

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Personal profile

Research Interests

Research activities of our group focus on two major clinical areas: musculoskeletal pain and bone. In collaboration with Dr. A. Vania Apkarian in the Department of Physiology, our pain research focuses on understanding the basis for pain chronification, utilizing brain imaging and psychophysical methodologies. Current NIH-funded studies are evaluating the transition that occurs in individuals who progress from acute to chronic pain and attempting to modulate this by pharmacologic interventions. On a more applied level, the development and characterization of analgesic agents for the management of chronic musculoskeleletal pain has been a major focus for over the past decade. We have helped design and implement phase 2 studies of many of the major classes of drugs currently in use, including NSAIDs, cox-2 selective inhibitors, opioids, topical analgesic agents and novel approaches to pain including antibodies to NGF (nerve growth factor) and other agents active on the peripheral nervous system. Bone loss is known to be a major problem for individuals with disabilities, particularly those who are not able to ambulate or bear weight normally. Our group has initiated studies aimed at treating patients with acute spinal cord injury to attempt to maintain bone mass during their immediate post-injury period. In those individuals with SCI who have already lost significant bone mass, we have undertaken a second set of studies aimed at evaluating approaches to increase bone mass in these individuals, using physical and pharmacological interventions as well as attempting to assess the interaction between bone and the metabolic status of these individuals.

Certifications and Licenses

Internal Medicine

Training Experience

1972Internship, Johns Hopkins Hospital
1973Residency, Johns Hopkins Hospital
1976Fellowship, MRC Rheumatology Unit, UK

Education/Academic qualification

PhD, Council for National Academic Awards

… → 1979

MD, Harvard Medical School

… → 1971

Research interests

  • Bones
  • Cartilage
  • Clinical Trial Methodology
  • Joints
  • Muscles
  • Osteoarthritis
  • Osteoporosis
  • Pain

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Research Output

Prognostics for pain in osteoarthritis: Do clinical measures predict pain after total joint replacement?

Barroso, J., Wakaizumi, K., Reckziegel, D., Pinto-Ramos, J., Schnitzer, T., Galhardo, V. & Apkarian, A. V., Jan 1 2020, In : PloS one. 15, 1, e0222370.

Research output: Contribution to journalArticle

Open Access
  • A Phase II Trial of Lutikizumab, an Anti–Interleukin-1α/β Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis

    Fleischmann, R. M., Bliddal, H., Blanco, F. J., Schnitzer, T. J., Peterfy, C., Chen, S., Wang, L., Feng, S., Conaghan, P. G., Berenbaum, F., Pelletier, J. P., Martel-Pelletier, J., Vaeterlein, O., Kaeley, G. S., Liu, W., Kosloski, M. P., Levy, G., Zhang, L., Medema, J. K. & Levesque, M. C., Jul 1 2019, In : Arthritis and Rheumatology. 71, 7, p. 1056-1069 14 p.

    Research output: Contribution to journalArticle

  • 11 Scopus citations

    Applications of Bayesian statistical methodology to clinical trial design: A case study of a phase 2 trial with an interim futility assessment in patients with knee osteoarthritis

    Smith, C. L., Jin, Y., Raddad, E., McNearney, T. A., Ni, X., Monteith, D., Brown, R., Deeg, M. A. & Schnitzer, T., Jan 1 2019, In : Pharmaceutical Statistics. 18, 1, p. 39-53 15 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Deconstructing biomarkers for chronic pain: context- and hypothesis-dependent biomarker types in relation to chronic pain

    Reckziegel, D., Vachon-Presseau, E., Petre, B., Schnitzer, T. J., Baliki, M. N. & Apkarian, A. V., May 1 2019, In : Pain. 160, p. S37-S48

    Research output: Contribution to journalReview article

  • 2 Scopus citations

    Effect of Tanezumab on Joint Pain, Physical Function, and Patient Global Assessment of Osteoarthritis among Patients with Osteoarthritis of the Hip or Knee: A Randomized Clinical Trial

    Schnitzer, T. J., Easton, R., Pang, S., Levinson, D. J., Pixton, G., Viktrup, L., Davignon, I., Brown, M. T., West, C. R. & Verburg, K. M., Jul 2 2019, In : JAMA - Journal of the American Medical Association. 322, 1, p. 37-48 12 p.

    Research output: Contribution to journalArticle

  • 9 Scopus citations