Thomas J Schnitzer

Personal profile

Research Interests

Research activities of our group focus on two major clinical areas: musculoskeletal pain and bone. In collaboration with Dr. A. Vania Apkarian in the Department of Physiology, our pain research focuses on understanding the basis for pain chronification, utilizing brain imaging and psychophysical methodologies. Current NIH-funded studies are evaluating the transition that occurs in individuals who progress from acute to chronic pain and attempting to modulate this by pharmacologic interventions. On a more applied level, the development and characterization of analgesic agents for the management of chronic musculoskeleletal pain has been a major focus for over the past decade. We have helped design and implement phase 2 studies of many of the major classes of drugs currently in use, including NSAIDs, cox-2 selective inhibitors, opioids, topical analgesic agents and novel approaches to pain including antibodies to NGF (nerve growth factor) and other agents active on the peripheral nervous system. Bone loss is known to be a major problem for individuals with disabilities, particularly those who are not able to ambulate or bear weight normally. Our group has initiated studies aimed at treating patients with acute spinal cord injury to attempt to maintain bone mass during their immediate post-injury period. In those individuals with SCI who have already lost significant bone mass, we have undertaken a second set of studies aimed at evaluating approaches to increase bone mass in these individuals, using physical and pharmacological interventions as well as attempting to assess the interaction between bone and the metabolic status of these individuals.

Certifications and Licenses

	Internal Medicine
	Rheumatology

Training Experience

1972	Internship, Johns Hopkins Hospital
1973	Residency, Johns Hopkins Hospital
1976	Fellowship, MRC Rheumatology Unit, UK

Education/Academic qualification

PhD, Council for National Academic Awards

… → 1979

MD, Harvard Medical School

… → 1971

Research interests

Bones
Cartilage
Clinical Trial Methodology
Joints
Muscles
Osteoarthritis
Osteoporosis
Pain

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Grants

18 Active
74 Finished

Prot #R475-OA-1816: Study to Evaluate Arthroplasty Specimens in the Phase 3 Fasinumab Program for Osteoarthritis of the Knee and Hip

Schnitzer, T. J.

ICON Clinical Research Limited, Regeneron Pharmaceuticals, Inc.

5/14/19 → 5/14/22

Project: Research project

Prot #R475-OA-1758: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Effects of Fasinumab on Peripheral Nerve Function in Patients with Pain due to Osteoarthritis of the Hip or Knee

Schnitzer, T. J.

inVentiv Health Clinical, Regeneron Pharmaceuticals, Inc.

2/21/19 → 2/21/22

Project: Research project

Prot #FX006-2018-015: A Randomized, Double-Blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy and Safety of FX006 in Patients with Hip Osteoarthritis

Schnitzer, T. J.

Flexion Therapeutics, Inc.

2/6/19 → 2/6/22

Project: Research project

Brain Pathophysiology of Osteoarthritis Pain

Apkarian, A., Griffith, J. W., Kahnt, T., Manning, D. W., Parrish, T. B. & Schnitzer, T. J.

National Institute of Arthritis and Musculoskeletal and Skin Diseases

2/1/19 → 12/31/23

Project: Research project

Prot #TGC-15302/KTG-15302: A Randomized, Double-Blind, Placebo-Controlled, Multi-Center, Phase 3 Study to Determine the Efficacy and Effectiveness of TG-C in Subjects with Kellgren and Lawrence Grade 2 or 3 Osteoarthritis of the Knee

Schnitzer, T. J.

Parexel, Kolon TissueGene, Inc.

1/28/19 → 1/28/24

Project: Research project