Grants per year
Personal profile
Research Interests
Research activities of our group focus on two major clinical areas: musculoskeletal pain and bone. In collaboration with Dr. A. Vania Apkarian in the Department of Physiology, our pain research focuses on understanding the basis for pain chronification, utilizing brain imaging and psychophysical methodologies. Current NIH-funded studies are evaluating the transition that occurs in individuals who progress from acute to chronic pain and attempting to modulate this by pharmacologic interventions. On a more applied level, the development and characterization of analgesic agents for the management of chronic musculoskeleletal pain has been a major focus for over the past decade. We have helped design and implement phase 2 studies of many of the major classes of drugs currently in use, including NSAIDs, cox-2 selective inhibitors, opioids, topical analgesic agents and novel approaches to pain including antibodies to NGF (nerve growth factor) and other agents active on the peripheral nervous system. Bone loss is known to be a major problem for individuals with disabilities, particularly those who are not able to ambulate or bear weight normally. Our group has initiated studies aimed at treating patients with acute spinal cord injury to attempt to maintain bone mass during their immediate post-injury period. In those individuals with SCI who have already lost significant bone mass, we have undertaken a second set of studies aimed at evaluating approaches to increase bone mass in these individuals, using physical and pharmacological interventions as well as attempting to assess the interaction between bone and the metabolic status of these individuals.
Certifications and Licenses
Internal Medicine | |
Rheumatology |
Training Experience
1972 | Internship, Johns Hopkins Hospital |
1973 | Residency, Johns Hopkins Hospital |
1976 | Fellowship, MRC Rheumatology Unit, UK |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Molecular Virology, Council for National Academic Awards
… → 1979
MD, Medicine, Harvard Medical School
… → 1971
Research interests keywords
- Bones
- Cartilage
- Clinical Trial Methodology
- Joints
- Muscles
- Osteoarthritis
- Osteoporosis
- Pain
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Prot #VX24-548-110: A Phase 3, Randomized, Double-blind, Placebo- and Active-Controlled Study of the Efficacy and Safety of Suzetrigine in Subjects with Pain Associated with Diabetic Peripheral Neuropathy
Schnitzer, T. J. (PD/PI)
Vertex Pharmaceuticals Incorporated
12/13/24 → 12/13/27
Project: Research project
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Denosumab and sequential zoledronic acid to prevent bone loss and maintain bone mass after spinal cord injury
Schnitzer, T. J. (PD/PI) & Andrei, A. (Co-Investigator)
National Institute of Arthritis and Musculoskeletal and Skin Diseases
8/1/24 → 7/31/26
Project: Research project
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Prot #TGC-B106727: Long-Term Safety Follow-up of Study Subjects Who Were Previously Enrolled in a Kolon TissueGene TG-C Clinical Trial
Schnitzer, T. J. (PD/PI)
Medpace Clinical Research LLC, Kolon TissueGene, Inc.
6/27/24 → 6/27/27
Project: Research project
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A phase III study to evaluate the long-term safety and efficacy of fasinumab in patients with pain due to osteoarthritis of the knee or hip
DiMartino, S. J., Mei, J., Schnitzer, T. J., Gao, H., Eng, S., Winslow, C., Ho, T., Turner, K. C., Hassan, H. E., Patel, Y., Davis, J. D., Trinh, N., Manley, A., Manvelian, G., Fetell, M., Braunstein, N., Geba, G. P. & Dakin, P., Dec 2024, In: Osteoarthritis and Cartilage Open. 6, 4, 100533.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Does sex affect the efficacy of systemic pharmacological treatments of pain in knee osteoarthritis? A systematic review
Espinosa-Salas, S., Bagherzadeh, L., Wafford, Q. E., Witte, G. & Schnitzer, T. J., Mar 2024, In: Osteoarthritis and Cartilage Open. 6, 1, 100438.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
Effect size varies based on calculation method and may affect interpretation of treatment effect: an illustration using randomised clinical trials in osteoarthritis
Schnitzer, T. J., Conaghan, P. G., Berenbaum, F., Abraham, L., Cappelleri, J. C., Bushmakin, A. G., Viktrup, L., Yang, R. & Brown, M. T., Dec 2024, In: Advances in Rheumatology. 64, 1, 31.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Monthly treatment with romosozumab for 1 year increases bone mineral at the hip, but not the knee, in women with chronic spinal cord injury
Crack, L. E., Simonian, N., Schnitzer, T. J. & Edwards, W. B., Jul 2024, In: JBMR Plus. 8, 7, ziae077.Research output: Contribution to journal › Article › peer-review
Open Access -
Use of patient-reported global assessment measures in clinical trials of chronic pain treatments: ACTTION systematic review and considerations
Langford, D. J., Mark, R. P., France, F. O., Nishtar, M., Park, M., Sharma, S., Shklyar, I. C., Schnitzer, T. J., Conaghan, P. G., Amtmann, D., Reeve, B. B., Turk, D. C., Dworkin, R. H. & Gewandter, J. S., Nov 1 2024, In: Pain. 165, 11, p. 2445-2454 10 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations
Datasets
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Psychosocial, Functional, and Emotional Correlates of Long-Term Opioid Use in Patients with Chronic Back Pain: A Cross-Sectional Case–Control Study
Wakaizumi, K. (Creator), Vigotsky, A. D. (Creator), Jabakhanji, R. (Creator), Abdallah, M. (Creator), Barroso, J. (Creator), Schnitzer, T. J. (Creator), Apkarian, A. V. (Contributor) & Baliki, M. N. (Creator), Adis Journals, 2021
DOI: 10.6084/m9.figshare.14207990.v1, https://adisjournals.figshare.com/articles/media/Psychosocial_Functional_and_Emotional_Correlates_of_Long-Term_Opioid_Use_in_Patients_with_Chronic_Back_Pain_A_Cross-Sectional_Case_Control_Study/14207990/1
Dataset
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Effect size varies based on calculation method and may affect interpretation of treatment effect: an illustration using randomised clinical trials in osteoarthritis
Schnitzer, T. J. (Creator), Conaghan, P. G. (Creator), Berenbaum, F. (Creator), Abraham, L. (Creator), Cappelleri, J. C. (Creator), Bushmakin, A. G. (Creator), Viktrup, L. (Creator), Yang, R. (Creator) & Brown, M. T. (Creator), figshare, 2024
DOI: 10.6084/m9.figshare.c.7195208, https://springernature.figshare.com/collections/Effect_size_varies_based_on_calculation_method_and_may_affect_interpretation_of_treatment_effect_an_illustration_using_randomised_clinical_trials_in_osteoarthritis/7195208
Dataset
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Factors associated with physician-reported treatment status of patients with osteoarthritis pain
Schnitzer, T. J. (Creator), Robinson, R. L. (Creator), Tive, L. (Creator), Cappelleri, J. C. (Creator), Bushmakin, A. G. (Creator), Jackson, J. (Creator), Berry, M. (Creator), Barlow, S. (Creator), Walker, C. (Creator) & Viktrup, L. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.c.6017479, https://springernature.figshare.com/collections/Factors_associated_with_physician-reported_treatment_status_of_patients_with_osteoarthritis_pain/6017479
Dataset