Thomas John Lukas

  • 4282 Citations
1977 …2019

Research output per year

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Personal profile

Research Interests

My research interests involve using a systems biology approach to discover mechanisms of neurodegenerative diseases. This systems biology approach uses proteomics, genomics, and metabolomics data from both animal models of disease and patient derived cells/tissues to investigate disease mechanisms and discover new therapeutics. These methods are currently being applied to amyotrophic lateral sclerosis (ALS) Cayman's ataxia, Friedrich's ataxia, as well as hearing loss due to chemical and/or environmental insults.

Training Experience

1980Postdoctoral Fellowship, Rockefeller University

Education/Academic qualification

PhD, Rutgers - The State University of New Jersey, New Brunswick

… → 1979

Research interests

  • Biochemistry: Proteins
  • Drug Discovery
  • Molecular Pharmacology
  • Neuroscience
  • Proteomics
  • Signal Transduction

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Grants

  • Research Output

    • 4282 Citations
    • 101 Article
    • 3 Chapter
    • 2 Comment/debate

    Compound heterozygote mutations in SPG7 in a family with adult-onset primary lateral sclerosis

    Yang, Y., Zhang, L., Lynch, D. R., Lukas, T., Ahmeti, K., Sleiman, P. M. A., Ryan, E., Schadt, K. A., Newman, J. H., Deng, H. X., Siddique, N. & Siddique, T., Apr 1 2016, In : Neurology: Genetics. 2, 2, e60.

    Research output: Contribution to journalArticle

  • 7 Scopus citations
  • Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes

    Ju, W. K., Kim, K. Y., Noh, Y. H., Hoshijima, M., Lukas, T. J., Ellisman, M. H., Weinreb, R. N. & Perkins, G. A., May 1 2015, In : Glia. 63, 5, p. 736-753 18 p.

    Research output: Contribution to journalArticle

  • 32 Scopus citations

    Phosphorylation regulates interaction of 210-kDa myosin light chain kinase N-terminal domain with actin cytoskeleton

    Vilitkevich, E. L., Khapchaev, A. Y., Kudryashov, D. S., Nikashin, A. V., Schavocky, J. P., Lukas, T. J., Watterson, D. M. & Shirinsky, V. P., Oct 1 2015, In : Biochemistry (Moscow). 80, 10, p. 1288-1297 10 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations
  • 9 Scopus citations