Thomas John Lukas

  • 4142 Citations
1977 …2021
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Personal profile

Research Interests

My research interests involve using a systems biology approach to discover mechanisms of neurodegenerative diseases. This systems biology approach uses proteomics, genomics, and metabolomics data from both animal models of disease and patient derived cells/tissues to investigate disease mechanisms and discover new therapeutics. These methods are currently being applied to amyotrophic lateral sclerosis (ALS) Cayman's ataxia, Friedrich's ataxia, as well as hearing loss due to chemical and/or environmental insults.

Training Experience

1980Postdoctoral Fellowship, Rockefeller University

Education/Academic qualification

PhD, Rutgers University

… → 1979

Research interests

  • Biochemistry: Proteins
  • Drug Discovery
  • Molecular Pharmacology
  • Neuroscience
  • Proteomics
  • Signal Transduction

Fingerprint Dive into the research topics where Thomas John Lukas is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Grants 2003 2021

Secretory Vesicles
Dementia
Motor Neurons
Carisoprodol
Therapeutics
Ubiquitin
Recycling
Neurodegenerative Diseases
Pharmaceutical Preparations
Libraries
Amyotrophic Lateral Sclerosis
Motor Neurons
Oxidation-Reduction
Clustered Regularly Interspaced Short Palindromic Repeats
Pathology

Research Output 1977 2016

  • 4142 Citations
  • 101 Article
  • 3 Chapter
  • 2 Comment/debate
6 Citations (Scopus)

Compound heterozygote mutations in SPG7 in a family with adult-onset primary lateral sclerosis

Yang, Y., Zhang, L., Lynch, D. R., Lukas, T. J., Ahmeti, K., Sleiman, P. M. A., Ryan, E., Schadt, K. A., Newman, J. H., Deng, H-X., Siddique, N. & Siddique, T., Apr 1 2016, In : Neurology: Genetics. 2, 2, e60.

Research output: Contribution to journalArticle

Motor Neuron Disease
Heterozygote
Mutation
Exome
Siblings
Poisons
Amyotrophic Lateral Sclerosis
corticotropin
Adrenocorticotropic Hormone
Transgenic Mice
26 Citations (Scopus)

Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes

Ju, W. K., Kim, K. Y., Noh, Y. H., Hoshijima, M., Lukas, T. J., Ellisman, M. H., Weinreb, R. N. & Perkins, G. A., Jan 1 2015, In : GLIA. 63, 5, p. 736-753 18 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Mitochondrial Size
Optic Disk
Astrocytes
Glutamic Acid
2 Citations (Scopus)

Phosphorylation regulates interaction of 210-kDa myosin light chain kinase N-terminal domain with actin cytoskeleton

Vilitkevich, E. L., Khapchaev, A. Y., Kudryashov, D. S., Nikashin, A. V., Schavocky, J. P., Lukas, T. J., Watterson, D. M. & Shirinsky, V. P., Oct 1 2015, In : Biochemistry (Moscow). 80, 10, p. 1288-1297 10 p.

Research output: Contribution to journalArticle

Myosin-Light-Chain Kinase
Phosphorylation
Actin Cytoskeleton
Actins
Serine
8 Citations (Scopus)
Scaffolds
Superoxide Dismutase
Amyotrophic Lateral Sclerosis
Genes
Precipitating Factors