Grants per year
Personal profile
Research Interests
My research interests involve using a systems biology approach to discover mechanisms of neurodegenerative diseases. This systems biology approach uses proteomics, genomics, and metabolomics data from both animal models of disease and patient derived cells/tissues to investigate disease mechanisms and discover new therapeutics. These methods are currently being applied to amyotrophic lateral sclerosis (ALS) Cayman's ataxia, Friedrich's ataxia, as well as hearing loss due to chemical and/or environmental insults.
Training Experience
| 1980 | Postdoctoral Fellowship, Rockefeller University |
Education/Academic qualification
PhD, Rutgers - The State University of New Jersey, New Brunswick
… → 1979
Research interests
- Biochemistry: Proteins
- Drug Discovery
- Molecular Pharmacology
- Neuroscience
- Proteomics
- Signal Transduction
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Grants
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A novel innate immunity risk factor for amyotrophic lateral sclerosis
Agency for Toxic Substances and Disease Registry
9/1/19 → 8/31/22
Project: Research project
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A Novel approach to therapy in ALS and ALS/Dementia using new insights from ALS5/SPG11
Deng, H., Lukas, T. J. & Siddique, T.
National Institute of Neurological Disorders and Stroke
9/1/18 → 8/31/21
Project: Research project
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Investigation of ALS caused by mutant CHCHD10
Deng, H., Kiskinis, E., Lukas, T. J. & Siddique, T.
National Institute of Neurological Disorders and Stroke
9/1/16 → 8/31/21
Project: Research project
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Ubiquitin pathway activation: A new strategy for treating ALS
Luan, C., Lukas, T. J. & Siddique, T.
U.S. Army Medical Research and Materiel Command
4/15/17 → 9/30/19
Project: Research project
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Med1 in Liver Metabolism, Regeneration and Cancer
Jia, Y., Lukas, T. J., Reddy, J. K., Thimmapaya, B. & Zhu, Y.
National Institute of Diabetes and Digestive and Kidney Diseases
7/1/16 → 12/31/18
Project: Research project
Research Output
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Compound heterozygote mutations in SPG7 in a family with adult-onset primary lateral sclerosis
Yang, Y., Zhang, L., Lynch, D. R., Lukas, T., Ahmeti, K., Sleiman, P. M. A., Ryan, E., Schadt, K. A., Newman, J. H., Deng, H. X., Siddique, N. & Siddique, T., Apr 1 2016, In: Neurology: Genetics. 2, 2, e60.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
ACTH (acthar gel) reduces toxic SOD1 protein linked to amyotrophic lateral sclerosis in transgenic mice: A novel observation
Arrat, H., Lukas, T. J. & Siddique, T., May 1 2015, In: PloS one. 10, 5, 0125638.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes
Ju, W. K., Kim, K. Y., Noh, Y. H., Hoshijima, M., Lukas, T. J., Ellisman, M. H., Weinreb, R. N. & Perkins, G. A., May 1 2015, In: Glia. 63, 5, p. 736-753 18 p.Research output: Contribution to journal › Article › peer-review
36 Scopus citations -
Phosphorylation regulates interaction of 210-kDa myosin light chain kinase N-terminal domain with actin cytoskeleton
Vilitkevich, E. L., Khapchaev, A. Y., Kudryashov, D. S., Nikashin, A. V., Schavocky, J. P., Lukas, T. J., Watterson, D. M. & Shirinsky, V. P., Oct 1 2015, In: Biochemistry (Moscow). 80, 10, p. 1288-1297 10 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Discovery of 1,3,4-oxidiazole scaffold compounds as inhibitors of superoxide dismutase expression
Lukas, T. J., Schiltz, G. E., Arrat, H., Scheidt, K. & Siddique, T., Mar 15 2014, In: Bioorganic and Medicinal Chemistry Letters. 24, 6, p. 1532-1537 6 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations