Thomas John Lukas

Personal profile

Research Interests

My research interests involve using a systems biology approach to discover mechanisms of neurodegenerative diseases. This systems biology approach uses proteomics, genomics, and metabolomics data from both animal models of disease and patient derived cells/tissues to investigate disease mechanisms and discover new therapeutics. These methods are currently being applied to amyotrophic lateral sclerosis (ALS) Cayman's ataxia, Friedrich's ataxia, as well as hearing loss due to chemical and/or environmental insults.

Training Experience

1980	Postdoctoral Fellowship, Rockefeller University

Education/Academic qualification

PhD, Rutgers - The State University of New Jersey, New Brunswick

… → 1979

Research interests

Biochemistry: Proteins
Drug Discovery
Molecular Pharmacology
Neuroscience
Proteomics
Signal Transduction

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Grants

3 Active
10 Finished

A novel innate immunity risk factor for amyotrophic lateral sclerosis

Lukas, T. J. & Siddique, T.

Agency for Toxic Substances and Disease Registry

9/1/19 → 8/31/22

Project: Research project

A Novel approach to therapy in ALS and ALS/Dementia using new insights from ALS5/SPG11

Deng, H., Lukas, T. J. & Siddique, T.

National Institute of Neurological Disorders and Stroke

9/1/18 → 8/31/20

Project: Research project

Investigation of ALS caused by mutant CHCHD10

Deng, H., Kiskinis, E., Lukas, T. J., Siddique, T. & Yang, Y.

National Institute of Neurological Disorders and Stroke

9/1/16 → 8/31/21

Project: Research project

Ubiquitin pathway activation: A new strategy for treating ALS

Luan, C., Lukas, T. J. & Siddique, T.

U.S. Army Medical Research and Materiel Command

4/15/17 → 9/30/19

Project: Research project

Med1 in Liver Metabolism, Regeneration and Cancer

Jia, Y., Lukas, T. J., Reddy, J. K., Thimmapaya, B. & Zhu, Y.

National Institute of Diabetes, Digestive and Kidney Diseases

7/1/16 → 12/31/18

Project: Research project

Research Output

4282 Citations
101 Article
3 Chapter
2 Comment/debate

Compound heterozygote mutations in SPG7 in a family with adult-onset primary lateral sclerosis

Yang, Y., Zhang, L., Lynch, D. R., Lukas, T., Ahmeti, K., Sleiman, P. M. A., Ryan, E., Schadt, K. A., Newman, J. H., Deng, H. X., Siddique, N. & Siddique, T., Apr 1 2016, In : Neurology: Genetics. 2, 2, e60.