Grants per year
Personal profile
Research Interests
My research interests involve using a systems biology approach to discover mechanisms of neurodegenerative diseases. This systems biology approach uses proteomics, genomics, and metabolomics data from both animal models of disease and patient derived cells/tissues to investigate disease mechanisms and discover new therapeutics. These methods are currently being applied to amyotrophic lateral sclerosis (ALS) Cayman's ataxia, Friedrich's ataxia, as well as hearing loss due to chemical and/or environmental insults.
Training Experience
| 1980 | Postdoctoral Fellowship, Rockefeller University |
Education/Academic qualification
PhD, Rutgers University
… → 1979
Keywords
- Biochemistry: Proteins
- Drug Discovery
- Molecular Pharmacology
- Neuroscience
- Proteomics
- Signal Transduction
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Medicine & Life Sciences
Myosin-Light-Chain Kinase
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Protein Kinases
Medicine & Life Sciences
Calcium
Medicine & Life Sciences
Proteins
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Amino Acid Sequence
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Retinal Pigment Epithelium
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2003 2021
A Novel approach to therapy in ALS and ALS/Dementia using new insights from ALS5/SPG11
Deng, H., Lukas, T. J. & Siddique, T.
National Institute of Neurological Disorders and Stroke
9/1/18 → 8/31/20
Project: Research project
Secretory Vesicles
Dementia
Motor Neurons
Carisoprodol
Therapeutics
Investigation of ALS caused by mutant CHCHD10
Deng, H., Kiskinis, E., Lukas, T. J., Siddique, T. & Yang, Y.
National Institute of Neurological Disorders and Stroke
9/1/16 → 8/31/21
Project: Research project
Amyotrophic Lateral Sclerosis
Motor Neurons
Oxidation-Reduction
Clustered Regularly Interspaced Short Palindromic Repeats
Pathology
Ubiquitin pathway activation: A new strategy for treating ALS
Luan, C., Lukas, T. J. & Siddique, T.
U.S. Army Medical Research and Materiel Command
4/15/17 → 4/14/19
Project: Research project
Ubiquitin
Recycling
Neurodegenerative Diseases
Pharmaceutical Preparations
Libraries
Med1 in Liver Metabolism, Regeneration and Cancer
Jia, Y., Lukas, T. J., Reddy, J. K., Thimmapaya, B. & Zhu, Y.
National Institute of Diabetes, Digestive and Kidney Diseases
7/1/16 → 12/31/18
Project: Research project
Association of ALS to gene-environment mediated changes in HDL proteins
Deng, H., Lukas, T. J., Rademaker, A. W. & Siddique, T.
National Institute of Environmental Health Sciences
11/1/15 → 4/30/18
Project: Research project
Research Output 1977 2016
5
Citations
(Scopus)
Compound heterozygote mutations in SPG7 in a family with adult-onset primary lateral sclerosis
Yang, Y., Zhang, L., Lynch, D. R., Lukas, T. J., Ahmeti, K., Sleiman, P. M. A., Ryan, E., Schadt, K. A., Newman, J. H., Deng, H-X., Siddique, N. & Siddique, T., Apr 1 2016, In : Neurology: Genetics. 2, 2, e60.Research output: Contribution to journal › Article
Motor Neuron Disease
Heterozygote
Mutation
Exome
Siblings
ACTH (acthar gel) reduces toxic SOD1 protein linked to amyotrophic lateral sclerosis in transgenic mice: A novel observation
Arrat, H., Lukas, T. J. & Siddique, T., May 1 2015, In : PLoS One. 10, 5, 0125638.Research output: Contribution to journal › Article
Poisons
Amyotrophic Lateral Sclerosis
corticotropin
Adrenocorticotropic Hormone
Transgenic Mice
24
Citations
(Scopus)
Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes
Ju, W. K., Kim, K. Y., Noh, Y. H., Hoshijima, M., Lukas, T. J., Ellisman, M. H., Weinreb, R. N. & Perkins, G. A., Jan 1 2015, In : GLIA. 63, 5, p. 736-753 18 p.Research output: Contribution to journal › Article
Mitochondrial Dynamics
Mitochondrial Size
Optic Disk
Astrocytes
Glutamic Acid
2
Citations
(Scopus)
Phosphorylation regulates interaction of 210-kDa myosin light chain kinase N-terminal domain with actin cytoskeleton
Vilitkevich, E. L., Khapchaev, A. Y., Kudryashov, D. S., Nikashin, A. V., Schavocky, J. P., Lukas, T. J., Watterson, D. M. & Shirinsky, V. P., Oct 1 2015, In : Biochemistry (Moscow). 80, 10, p. 1288-1297 10 p.Research output: Contribution to journal › Article
Myosin-Light-Chain Kinase
Phosphorylation
Actin Cytoskeleton
Actins
Serine
8
Citations
(Scopus)
Discovery of 1,3,4-oxidiazole scaffold compounds as inhibitors of superoxide dismutase expression
Lukas, T. J., Schiltz, G. E., Arrat, H., Scheidt, K. & Siddique, T., Mar 15 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 6, p. 1532-1537 6 p.Research output: Contribution to journal › Article
Scaffolds
Superoxide Dismutase
Amyotrophic Lateral Sclerosis
Genes
Precipitating Factors