Thomas John Lukas

  • 4107 Citations
1977 …2021
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Personal profile

Research Interests

My research interests involve using a systems biology approach to discover mechanisms of neurodegenerative diseases. This systems biology approach uses proteomics, genomics, and metabolomics data from both animal models of disease and patient derived cells/tissues to investigate disease mechanisms and discover new therapeutics. These methods are currently being applied to amyotrophic lateral sclerosis (ALS) Cayman's ataxia, Friedrich's ataxia, as well as hearing loss due to chemical and/or environmental insults.

Training Experience

1980Postdoctoral Fellowship, Rockefeller University

Education/Academic qualification

PhD, Rutgers University

… → 1979


  • Biochemistry: Proteins
  • Drug Discovery
  • Molecular Pharmacology
  • Neuroscience
  • Proteomics
  • Signal Transduction

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Grants 2003 2021

Secretory Vesicles
Motor Neurons
Amyotrophic Lateral Sclerosis
Motor Neurons
Clustered Regularly Interspaced Short Palindromic Repeats
Neurodegenerative Diseases
Pharmaceutical Preparations

Research Output 1977 2016

  • 4107 Citations
  • 101 Article
  • 3 Chapter
  • 2 Comment/debate
5 Citations (Scopus)

Compound heterozygote mutations in SPG7 in a family with adult-onset primary lateral sclerosis

Yang, Y., Zhang, L., Lynch, D. R., Lukas, T. J., Ahmeti, K., Sleiman, P. M. A., Ryan, E., Schadt, K. A., Newman, J. H., Deng, H-X., Siddique, N. & Siddique, T., Apr 1 2016, In : Neurology: Genetics. 2, 2, e60.

Research output: Contribution to journalArticle

Motor Neuron Disease
Amyotrophic Lateral Sclerosis
Adrenocorticotropic Hormone
Transgenic Mice
24 Citations (Scopus)

Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes

Ju, W. K., Kim, K. Y., Noh, Y. H., Hoshijima, M., Lukas, T. J., Ellisman, M. H., Weinreb, R. N. & Perkins, G. A., Jan 1 2015, In : GLIA. 63, 5, p. 736-753 18 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Mitochondrial Size
Optic Disk
Glutamic Acid
2 Citations (Scopus)

Phosphorylation regulates interaction of 210-kDa myosin light chain kinase N-terminal domain with actin cytoskeleton

Vilitkevich, E. L., Khapchaev, A. Y., Kudryashov, D. S., Nikashin, A. V., Schavocky, J. P., Lukas, T. J., Watterson, D. M. & Shirinsky, V. P., Oct 1 2015, In : Biochemistry (Moscow). 80, 10, p. 1288-1297 10 p.

Research output: Contribution to journalArticle

Myosin-Light-Chain Kinase
Actin Cytoskeleton
8 Citations (Scopus)
Superoxide Dismutase
Amyotrophic Lateral Sclerosis
Precipitating Factors