Thomas Patrick Shanley

  • 8175 Citations
19952019

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2014

Post-ICU admission fluid balance and pediatric septic shock outcomes: A risk-stratified analysis

Abulebda, K., Cvijanovich, N. Z., Thomas, N. J., Allen, G. L., Anas, N., Bigham, M. T., Hall, M., Freishtat, R. J., Sen, A., Meyer, K., Checchia, P. A., Shanley, T. P., Nowak, J., Quasney, M., Weiss, S. L., Chopra, A., Banschbach, S., Beckman, E., Lindsell, C. J. & Wong, H. R., Feb 1 2014, In : Critical care medicine. 42, 2, p. 397-403 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

Refractory hypoxemia caused by hepatopulmonary syndrome: A case report

Govindan, M. L., Kuo, K. W., Mahani, M. G. & Shanley, T. P., Dec 10 2014, In : Journal of Medical Case Reports. 8, 1, 418.

Research output: Contribution to journalArticle

Relationship between the functional status scale and the pediatric overall performance category and pediatric cerebral performance category scales

Pollack, M. M., Holubkov, R., Funai, T., Clark, A., Moler, F., Shanley, T., Meert, K., Newth, C. J. L., Carcillo, J., Berger, J. T., Doctor, A., Berg, R. A., Dalton, H., Wessel, D. L., Harrison, R. E., Dean, J. M. & Jenkins, T. L., Jul 2014, In : JAMA Pediatrics. 168, 7, p. 671-676 6 p.

Research output: Contribution to journalArticle

65 Scopus citations

Testing the prognostic accuracy of the updated pediatric sepsis biomarker risk model

Wong, H. R., Weiss, S. L., Giuliano, J. S., Wainwright, M. S., Cvijanovich, N. Z., Thomas, N. J., Allen, G. L., Anas, N., Bigham, M. T., Hall, M., Freishtat, R. J., Sen, A., Meyer, K., Checchia, P. A., Shanley, T. P., Nowak, J., Quasney, M., Chopra, A., Fitzgerald, J. C., Gedeit, R. & 5 others, Banschbach, S., Beckman, E., Lahn, P., Hart, K. & Lindsell, C. J., Jan 29 2014, In : PLoS One. 9, 1, e86242.

Research output: Contribution to journalArticle

47 Scopus citations

The temporal version of the pediatric sepsis biomarker risk model

Wong, H. R., Weiss, S. L., Giuliano, J. S., Wainwright, M. S., Cvijanovich, N. Z., Thomas, N. J., Allen, G. L., Anas, N., Bigham, M. T., Hall, M., Freishtat, R. J., Sen, A., Meyer, K., Checchia, P. A., Shanley, T. P., Nowak, J., Quasney, M., Chopra, A., Fitzgerald, J. C., Gedeit, R. & 5 others, Banschbach, S., Beckman, E., Harmon, K., Lahni, P. & Lindsell, C. J., Mar 13 2014, In : PloS one. 9, 3, e92121.

Research output: Contribution to journalArticle

28 Scopus citations

Validation of the KDIGO acute kidney injury criteria in a pediatric critical care population

Selewski, D. T., Cornell, T. T., Heung, M., Troost, J. P., Ehrmann, B. J., Lombel, R. M., Blatt, N. B., Luckritz, K., Hieber, S., Gajarski, R., Kershaw, D. B., Shanley, T. P. & Gipson, D. S., Sep 26 2014, In : Intensive Care Medicine. 40, 10, p. 1481-1488 8 p.

Research output: Contribution to journalArticle

90 Scopus citations
2013

Critical pertussis illness in children: A multicenter prospective cohort study

Berger, J. T., Carcillo, J. A., Shanley, T. P., Wessel, D. L., Clark, A., Holubkov, R., Meert, K. L., Newth, C. J. L., Berg, R. A., Heidemann, S., Harrison, R., Pollack, M., Dalton, H., Harvill, E., Karanikas, A., Liu, T., Burr, J. S., Doctor, A., Dean, J. M., Jenkins, T. L. & 1 others, Nicholson, C. E., May 1 2013, In : Pediatric Critical Care Medicine. 14, 4, p. 356-365 10 p.

Research output: Contribution to journalArticle

63 Scopus citations

Dual role of interleukin-10 in the regulation of respiratory syncitial virus (RSV)-induced lung inflammation

Sun, L., Cornell, T. T., Levine, A., Berlin, A. A., Hinkovska-Galcheva, V., Fleszar, A. J., Lukacs, N. W. & Shanley, T. P., May 1 2013, In : Clinical and Experimental Immunology. 172, 2, p. 263-279 17 p.

Research output: Contribution to journalArticle

22 Scopus citations

Improving delivery of continuous renal replacement therapy: Impact of a simulation-based educational intervention

Mottes, T., Owens, T., Niedner, M., Juno, J., Shanley, T. P. & Heung, M., Oct 1 2013, In : Pediatric Critical Care Medicine. 14, 8, p. 747-754 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Public Participation in, and Awareness about, Medical Research Opportunities in the Era of Clinical and Translational Research

Davis, M. M., Clark, S. J., Butchart, A. T., Singer, D. C., Shanley, T. P. & Gipson, D. S., Apr 1 2013, In : Clinical and Translational Science. 6, 2, p. 88-93 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Ratio of PICU versus ward cardiopulmonary resuscitation events is increasing

Berg, R. A., Sutton, R. M., Holubkov, R., Nicholson, C. E., Dean, J. M., Harrison, R., Heidemann, S., Meert, K., Newth, C., Moler, F., Pollack, M., Dalton, H., Doctor, A., Wessel, D., Berger, J., Shanley, T., Carcillo, J. & Nadkarni, V. M., Oct 1 2013, In : Critical care medicine. 41, 10, p. 2292-2297 6 p.

Research output: Contribution to journalArticle

58 Scopus citations

Surface-Micromachined Microfiltration Membranes for Efficient Isolation and Functional Immunophenotyping of Subpopulations of Immune Cells

Chen, W., Huang, N. T., Oh, B., Lam, R. H. W., Fan, R., Cornell, T. T., Shanley, T. P., Kurabayashi, K. & Fu, J., Jul 2013, In : Advanced Healthcare Materials. 2, 7, p. 965-975 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

The ideal time interval for critical care severity-of-illness assessment.

Pollack, M. M., Dean, J. M., Butler, J., Holubkov, R., Doctor, A., Meert, K. L., Newth, C. J. L., Berg, R. A., Moler, F., Dalton, H., Wessel, D. L., Berger, J., Harrison, R. E., Carcillo, J. A., Shanley, T. P. & Nicholson, C. E., Jun 2013, In : Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 14, 5, p. 448-453 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

The use of extracorporeal membrane oxygenation in pediatric patients with sickle cell disease

Kuo, K. W., Cornell, T. T., Shanley, T. P., Odetola, F. O. & Annich, G. M., Sep 1 2013, In : Perfusion (United Kingdom). 28, 5, p. 424-432 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Tristetraprolin Mediates Radiation-Induced TNF-α Production in Lung Macrophages

Ray, D., Shukla, S., Allam, U. S., Helman, A., Ramanand, S. G., Tran, L., Bassetti, M., Krishnamurthy, P. M., Rumschlag, M., Paulsen, M., Sun, L., Shanley, T. P., Ljungman, M., Nyati, M. K., Zhang, M. & Lawrence, T. S., Feb 28 2013, In : PloS one. 8, 2, e57290.

Research output: Contribution to journalArticle

4 Scopus citations
2012

Clinical implications and molecular mechanisms of immunoparalysis after cardiopulmonary bypass

Cornell, T. T., Sun, L., Hall, M. W., Gurney, J. G., Ashbrook, M. J., Ohye, R. G. & Shanley, T. P., May 2012, In : Journal of Thoracic and Cardiovascular Surgery. 143, 5, p. 1160-1166.e1

Research output: Contribution to journalArticle

36 Scopus citations

Critical care for pediatric asthma: Wide care variability and challenges for study

Bratton, S. L., Newth, C. J. L., Zuppa, A. F., Moler, F. W., Meert, K. L., Berg, R. A., Berger, J., Wessel, D., Pollack, M., Harrison, R., Carcillo, J. A., Shanley, T. P., Liu, T., Holubkov, R., Dean, J. M. & Nicholson, C. E., Jul 1 2012, In : Pediatric Critical Care Medicine. 13, 4, p. 407-414 8 p.

Research output: Contribution to journalArticle

49 Scopus citations

Fatal and near-fatal asthma in children: The critical care perspective

Newth, C. J. L., Meert, K. L., Clark, A. E., Moler, F. W., Zuppa, A. F., Berg, R. A., Pollack, M. M., Sward, K. A., Berger, J. T., Wessel, D. L., Harrison, R. E., Reardon, J., Carcillo, J. A., Shanley, T. P., Holubkov, R., Dean, J. M., Doctor, A. & Nicholson, C. E., Aug 2012, In : Journal of Pediatrics. 161, 2, p. 214-221.e3

Research output: Contribution to journalArticle

42 Scopus citations

Fluid overload and fluid removal in pediatric patients on extracorporeal membrane oxygenation requiring continuous renal replacement therapy

Selewski, D. T., Cornell, T. T., Blatt, N. B., Han, Y. Y., Mottes, T., Kommareddi, M., Gaies, M. G., Annich, G. M., Kershaw, D. B., Shanley, T. P. & Heung, M., Sep 1 2012, In : Critical care medicine. 40, 9, p. 2694-2699 6 p.

Research output: Contribution to journalArticle

101 Scopus citations

Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children

Wong, H. R., Cvijanovich, N. Z., Hall, M., Allen, G. L., Thomas, N. J., Freishtat, R. J., Anas, N., Meyer, K., Checchia, P. A., Lin, R., Bigham, M. T., Sen, A., Nowak, J., Quasney, M., Henricksen, J. W., Chopra, A., Banschbach, S., Beckman, E., Harmon, K., Lahni, P. & 1 others, Shanley, T. P., Oct 26 2012, In : Critical Care. 16, 5, R213.

Research output: Contribution to journalArticle

56 Scopus citations

Mitogen-activated protein kinase phosphatase 2, MKP-2, regulates early inflammation in acute lung injury

Cornell, T. T., Fleszar, A., McHugh, W., Blatt, N. B., LeVine, A. M. & Shanley, T. P., Aug 1 2012, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 303, 3, p. L251-L258

Research output: Contribution to journalArticle

21 Scopus citations
13 Scopus citations

The pediatric sepsis biomarker risk model

Wong, H. R., Salisbury, S., Xiao, Q., Cvijanovich, N. Z., Hall, M., Allen, G. L., Thomas, N. J., Freishtat, R. J., Anas, N., Meyer, K., Checchia, P. A., Lin, R., Shanley, T. P., Bigham, M. T., Sen, A., Nowak, J., Quasney, M., Henricksen, J. W., Chopra, A., Banschbach, S. & 4 others, Beckman, E., Harmon, K., Lahni, P. & Lindsell, C. J., Oct 1 2012, In : Critical Care. 16, 5, R174.

Research output: Contribution to journalArticle

97 Scopus citations

Tracking the impact of the national institutes of health clinical and translational science awards on child health research: Developing and evaluating a measurement strategy

Huskins, W. C., Sullivan, C. D., Wang, J., Aitken, M., Alexander, S. R., Epstein, L. G., Hoberman, A., Neufeld, E., Philipps, A., Shanley, T. P., Szilagyi, P., Purucker, M. & Barkin, S. L., May 1 2012, In : Pediatric research. 71, 5, p. 619-624 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
2011

Clinical course of sepsis in children with acute leukemia admitted to the pediatric intensive care unit

Singer, K., Subbaiah, P., Hutchinson, R., Odetola, F. & Shanley, T. P., Nov 2011, In : Pediatric Critical Care Medicine. 12, 6, p. 649-654 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Identification of candidate serum biomarkers for severe septic shock-associated kidney injury via microarray

Basu, R. K., Standage, S. W., Cvijanovich, N. Z., Allen, G. L., Thomas, N. J., Freishtat, R. J., Anas, N., Meyer, K., Checchia, P. A., Lin, R., Shanley, T. P., Bigham, M. T., Wheeler, D. S., Devarajan, P., Goldstein, S. L. & Wong, H. R., Nov 18 2011, In : Critical Care. 15, 6, R273.

Research output: Contribution to journalArticle

29 Scopus citations

IL-17Induced pulmonary pathogenesis during respiratory viral infection and exacerbation of allergic disease

Mukherjee, S., Lindell, D. M., Berlin, A. A., Morris, S. B., Shanley, T. P., Hershenson, M. B. & Lukacs, N. W., Jul 1 2011, In : American Journal of Pathology. 179, 1, p. 248-258 11 p.

Research output: Contribution to journalArticle

137 Scopus citations

Inpatient health care utilization for children dependent on long-term mechanical ventilation

Benneyworth, B. D., Gebremariam, A., Clark, S. J., Shanley, T. P. & Davis, M. M., Jun 1 2011, In : Pediatrics. 127, 6

Research output: Contribution to journalArticle

51 Scopus citations

New concepts of IL-10-induced lung fibrosis: Fibrocyte recruitment and M2 activation in a CCL2/CCR2 axis

Sun, L., Louie, M. C., Vannella, K. M., Wilke, C. A., Levine, A. M., Moore, B. B. & Shanley, T. P., Mar 1 2011, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 300, 3

Research output: Contribution to journalArticle

124 Scopus citations

The influence of developmental age on the early transcriptomic response of children with septic shock

Wynn, J. L., Cvijanovich, N. Z., Allen, G. L., Thomas, N. J., Freishtat, R. J., Anas, N., Meyer, K., Checchia, P. A., Lin, R., Shanley, T. P., Bigham, M. T., Banschbach, S., Beckman, E. & Wong, H. R., Nov 1 2011, In : Molecular Medicine. 17, 11, p. 1146-1156 11 p.

Research output: Contribution to journalArticle

70 Scopus citations

Validation of a gene expression-based subclassification strategy for pediatric septic shock

Wong, H. R., Cvijanovich, N. Z., Allen, G. L., Thomas, N. J., Freishtat, R. J., Anas, N., Meyer, K., Checchia, P. A., Lin, R., Shanley, T. P., Bigham, M. T., Wheeler, D. S., Doughty, L. A., Tegtmeyer, K., Poynter, S. E., Kaplan, J. M., Chima, R. S., Stalets, E., Basu, R. K., Varisco, B. M. & 1 others, Barr, F. E., Nov 2011, In : Critical care medicine. 39, 11, p. 2511-2517 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Weight-based determination of fluid overload status and mortality in pediatric intensive care unit patients requiring continuous renal replacement therapy

Selewski, D. T., Cornell, T. T., Lombel, R. M., Blatt, N. B., Han, Y. Y., Mottes, T., Kommareddi, M., Kershaw, D. B., Shanley, T. P. & Heung, M., Jul 1 2011, In : Intensive Care Medicine. 37, 7, p. 1166-1173 8 p.

Research output: Contribution to journalArticle

91 Scopus citations
2010

Leukocyte subset-derived genomewide expression profiles in pediatric septic shock

Wong, H. R., Freishtat, R. J., Monaco, M., Odoms, K. & Shanley, T. P., May 2010, In : Pediatric Critical Care Medicine. 11, 3, p. 349-355 7 p.

Research output: Contribution to journalArticle

46 Scopus citations

Mitogen-activated protein kinase phosphatase 2 regulates the inflammatory response in sepsis

Cornell, T. T., Rodenhouse, P., Cai, Q., Sun, L. & Shanley, T. P., Jun 1 2010, In : Infection and immunity. 78, 6, p. 2868-2876 9 p.

Research output: Contribution to journalArticle

40 Scopus citations
2009

Ceramide-dependent PP2A regulation of TNFα-induced IL-8 production in respiratory epithelial cells

Cornell, T. T., Hinkovska-Galcheva, V., Sun, L., Cai, Q., Hershenson, M. B., Vanway, S. & Shanley, T. P., May 1 2009, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 296, 5, p. L849-L856

Research output: Contribution to journalArticle

36 Scopus citations

Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine

Brierley, J., Carcillo, J. A., Choong, K., Cornell, T., Decaen, A., Deymann, A., Doctor, A., Davis, A., Duff, J., Dugas, M. A., Duncan, A., Evans, B., Feldman, J., Felmet, K., Fisher, G., Frankel, L., Jeffries, H., Greenwald, B., Gutierrez, J., Hall, M. & 33 others, Han, Y. Y., Hanson, J., Hazelzet, J., Hernan, L., Kiff, J., Kissoon, N., Kon, A., Irazusta, J., Lin, J., Lorts, A., Mariscalco, M., Mehta, R., Nadel, S., Nguyen, T., Nicholson, C., Peters, M., Okhuysen-Cawley, R., Poulton, T., Relves, M., Rodriguez, A., Rozenfeld, R., Schnitzler, E., Shanley, T., Skache, S., Skippen, P., Torres, A., Von Dessauer, B., Weingarten, J., Yeh, T., Zaritsky, A., Stojadinovic, B., Zimmerman, J. & Zuckerberg, A., Feb 2009, In : Critical care medicine. 37, 2, p. 666-688 23 p.

Research output: Contribution to journalArticle

663 Scopus citations

Effect of IL-10 on neutrophil recruitment and survival after Pseudomonas aeruginosa challenge

Sun, L., Guo, R. F., Newstead, M. W., Standiford, T. J., Macariola, D. R. & Shanley, T. P., Jul 1 2009, In : American journal of respiratory cell and molecular biology. 41, 1, p. 76-84 9 p.

Research output: Contribution to journalArticle

52 Scopus citations

Effect of interhospital transfer on resource utilization and outcomes at a tertiary pediatric intensive care unit

Odetola, F. O., Clark, S. J., Gurney, J. G., Dechert, R. E., Shanley, T. P. & Freed, G. L., Sep 1 2009, In : Journal of Critical Care. 24, 3, p. 379-386 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum

Wong, H. R., Cvijanovich, N., Allen, G. L., Lin, R., Anas, N., Meyer, K., Freishtat, R. J., Monaco, M., Odoms, K., Sakthivel, B. & Shanley, T. P., May 2009, In : Critical care medicine. 37, 5, p. 1558-1566 9 p.

Research output: Contribution to journalArticle

129 Scopus citations

Identification of pediatric septic shock subclasses based on genome-wide expression profiling

Wong, H. R., Cvijanovich, N., Lin, R., Allen, G. L., Thomas, N. J., Willson, D. F., Freishtat, R. J., Anas, N., Meyer, K., Checchia, P. A., Monaco, M., Odom, K. & Shanley, T. P., Jul 22 2009, In : BMC Medicine. 7, 34.

Research output: Contribution to journalArticle

117 Scopus citations
2008

Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells

Hinkovska-Galcheva, V., Clark, A., VanWay, S., Huang, J. B., Hiraoka, M., Abe, A., Borofsky, M., Kunkel, R. G., Shanley, T., Shayman, J. A., Lanni, F., Petty, H. R. & Boxer, L. A., Mar 1 2008, In : Journal of Lipid Research. 49, 3, p. 531-542 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Do outcomes vary according to the source of admission to the pediatric intensive care unit?

Odetola, F. O., Rosenberg, A. L., Davis, M. M., Clark, S. J., Dechert, R. E. & Shanley, T. P., Jan 2008, In : Pediatric Critical Care Medicine. 9, 1, p. 20-25 6 p.

Research output: Contribution to journalArticle

58 Scopus citations

Extracorporeal life support for severe respiratory failure in children with immune compromised conditions

Gupta, M., Shanley, T. P. & Moler, F. W., Jul 2008, In : Pediatric Critical Care Medicine. 9, 4, p. 380-385 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

Granulocyte-macrophage-colony-stimulating factor-dependent peritoneal macrophage responses determine survival in experimentally induced peritonitis and sepsis in mice

Spight, D., Trapnell, B., Zhao, B., Berclaz, P. & Shanley, T. P., Oct 1 2008, In : Shock. 30, 4, p. 434-442 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

PP2A regulates upstream members of the c-jun N-terminal kinase mitogen-activated protein kinase signaling pathway

Zhao, B., Sun, L., Haas, M., Denenberg, A. G., Wong, H. R. & Shanley, T. P., Feb 1 2008, In : Shock. 29, 2, p. 181-188 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Validating the genomic signature of pediatric septic shock

Cvijanovich, N., Shanley, T. P., Lin, R., Allen, G. L., Thomas, N. J., Checchia, P., Anas, N., Freishtat, R. J., Monaco, M., Odoms, K., Sakthivel, B. & Wong, H. R., Jun 1 2008, In : Physiological genomics. 34, 1, p. 127-134 8 p.

Research output: Contribution to journalArticle

65 Scopus citations
2007

Epstein-Barr virus-induced hemophagocytic lymphohistiocytosis and X-linked lymphoproliferative disease: A mimicker of sepsis in the Pediatric Intensive Care Unit

Mischler, M., Fleming, G. M., Shanley, T. P., Madden, L., Levine, J., Castle, V., Filipovich, A. H. & Cornell, T. T., May 1 2007, In : Pediatrics. 119, 5, p. e1212-e1218

Research output: Contribution to journalArticle

24 Scopus citations

Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome

Wong, H. R., Shanley, T. P., Sakthivel, B., Cvijanovich, N., Lin, R., Allen, G. L., Thomas, N. J., Doctor, A., Kalyanaraman, M., Tofil, N. M., Penfil, S., Monaco, M., Tagavilla, M. A., Odoms, K., Dunsmore, K., Barnes, M. & Aronow, B. J., Jul 18 2007, In : Physiological genomics. 30, 2, p. 146-155 10 p.

Research output: Contribution to journalArticle

160 Scopus citations

Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock

Shanley, T. P., Cvijanovich, N., Lin, R., Allen, G. L., Thomas, N. J., Doctor, A., Kalyanaraman, M., Tofil, N. M., Penfil, S., Monaco, M., Odoms, K., Barnes, M., Sakthivel, B., Aronow, B. J. & Wong, H. R., Sep 1 2007, In : Molecular Medicine. 13, 9-10, p. 495-508 14 p.

Research output: Contribution to journalArticle

99 Scopus citations

Going back for more: An evaluation of clinical outcomes and characteristics of readmissions to a pediatric intensive care unit

Odetola, F. O., Clark, S. J., Dechert, R. E. & Shanley, T. P., Jul 2007, In : Pediatric Critical Care Medicine. 8, 4, p. 343-347 5 p.

Research output: Contribution to journalArticle

27 Scopus citations