Thomas Patrick Shanley

  • 7752 Citations
19952019
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Research Output 1995 2019

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2007
133 Citations (Scopus)

Tristetraprolin (TTP)-14-3-3 complex formation protects TTP from dephosphorylation by protein phosphatase 2a and stabilizes tumor necrosis factor-α mRNA

Sun, L., Stoecklin, G., Van Way, S., Hinkovska-Galcheva, V., Guo, R. F., Anderson, P. & Shanley, T. P., Jan 9 2007, In : Journal of Biological Chemistry. 282, 6, p. 3766-3777 12 p.

Research output: Contribution to journalArticle

Tristetraprolin
Protein Phosphatase 2
Phosphorylation
Tumor Necrosis Factor-alpha
Messenger RNA
2006
23 Citations (Scopus)

Approach to management of malignant hyperthermia-like syndrome in pediatric diabetes mellitus

Kilbane, B. J., Mehta, S., Backeljauw, P. F., Shanley, T. P. & Crimmins, N. A., Mar 1 2006, In : Pediatric Critical Care Medicine. 7, 2, p. 169-173 5 p.

Research output: Contribution to journalArticle

Malignant Hyperthermia
Hyperglycemic Hyperosmolar Nonketotic Coma
Diabetes Mellitus
Pediatrics
Dantrolene
9 Citations (Scopus)

Characteristics and outcomes of interhospital transfers from level II to level I pediatric intensive care units

Odetola, F. O., Shanley, T. P., Gurney, J. G., Clark, S. J., Dechert, R. E., Freed, G. L. & Davis, M. M., Nov 1 2006, In : Pediatric Critical Care Medicine. 7, 6, p. 536-540 5 p.

Research output: Contribution to journalArticle

Pediatric Intensive Care Units
Mortality
Length of Stay
Extracorporeal Membrane Oxygenation
Renal Replacement Therapy
89 Citations (Scopus)

Extracellular heat shock protein-70 induces endotoxin tolerance in THP-1 cells

Aneja, R., Odoms, K., Dunsmore, K., Shanley, T. P. & Wong, H. R., Nov 15 2006, In : Journal of Immunology. 177, 10, p. 7184-7192 9 p.

Research output: Contribution to journalArticle

HSP70 Heat-Shock Proteins
Endotoxins
Monocytes
Volunteers
2005
54 Citations (Scopus)

Contribution of MKP-1 regulation of p38 to endotoxin tolerance

Nimah, M., Zhao, B., Denenberg, A. G., Bueno, O., Molkentin, J., Wong, H. R. & Shanley, T. P., Jan 1 2005, In : Shock. 23, 1, p. 80-87 8 p.

Research output: Contribution to journalArticle

Endotoxins
Dual Specificity Phosphatase 1
Peritoneal Macrophages
p38 Mitogen-Activated Protein Kinases
Nuclear Proteins
33 Citations (Scopus)

Heat shock-mediated regulation of MKP-1

Wong, H. R., Dunsmore, K. E., Page, K. & Shanley, T. P., Nov 1 2005, In : American Journal of Physiology - Cell Physiology. 289, 5 58-5

Research output: Contribution to journalArticle

Dual Specificity Phosphatase 1
Shock
Phosphotransferases
Hot Temperature
Gene expression
32 Citations (Scopus)

Immunoregulatory effects of regulated, lung-targeted expression of IL-10 in vivo

Spight, D., Zhao, B., Haas, M., Wert, S., Denenberg, A. & Shanley, T. P., Feb 1 2005, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 288, 2 32-2

Research output: Contribution to journalArticle

Interleukin-10
Lung
Cytokines
Anti-Inflammatory Agents
CC Chemokines
2004
18 Citations (Scopus)

Heat shock inhibition of lipopolysaccharide-mediated tumor necrosis factor expression is associated with nuclear induction of MKP-1 and inhibition of mitogen-activated protein kinase activation

Sanlorenzo, L., Zhao, B., Spight, D., Denenberg, A. G., Page, K., Wong, H. R. & Shanley, T. P., Nov 1 2004, In : Critical Care Medicine. 32, 11, p. 2284-2292 9 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinases
Lipopolysaccharides
Shock
Tumor Necrosis Factor-alpha
Hot Temperature
11 Citations (Scopus)
Hyperoxia
Interleukin-1
Phosphotransferases
Gene Expression
Signal Transduction
2003
119 Citations (Scopus)

Combined steroid treatment for congenital heart surgery improves oxygen delivery and reduces postbypass inflammatory mediator expression

Schroeder, V. A., Pearl, J. M., Schwartz, S. M., Shanley, T. P., Manning, P. B. & Nelson, D. P., Jun 10 2003, In : Circulation. 107, 22, p. 2823-2828 6 p.

Research output: Contribution to journalArticle

Methylprednisolone
Thoracic Surgery
Steroids
Oxygen
Interleukin-6
2002
37 Citations (Scopus)

Heat shock inhibits activation of NF-κB in the absence of heat shock factor-1

Malhotra, V., Eaves-Pyles, T., Odoms, K., Quaid, G., Shanley, T. P. & Wong, H. R., Jan 1 2002, In : Biochemical and Biophysical Research Communications. 291, 3, p. 453-457 5 p.

Research output: Contribution to journalArticle

Shock
Hot Temperature
Chemical activation
Heat-Shock Response
Gene Expression
48 Citations (Scopus)

Heat shock inhibits TNF-induced ICAM-1 expression in human endothelial cells via I kappa kinase inhibition

Kohn, G., Wong, H. R., Bshesh, K., Zhao, B., Vasi, N., Denenberg, A., Morris, C., Stark, J. & Shanley, T. P., Jan 1 2002, In : Shock. 17, 2, p. 91-97 7 p.

Research output: Contribution to journalArticle

Intercellular Adhesion Molecule-1
Shock
Phosphotransferases
Endothelial Cells
Hot Temperature
10 Citations (Scopus)

Hyperoxia prolongs tumor necrosis factor-α-mediated activation of Nf-κB: Role of IκB kinase

Wong, H. R., Odoms, K. K., Denenberg, A. G., Allen, G. L. & Shanley, T. P., Jan 1 2002, In : Shock. 17, 4, p. 274-279 6 p.

Research output: Contribution to journalArticle

Hyperoxia
Phosphotransferases
Tumor Necrosis Factor-alpha
Intercellular Adhesion Molecule-1
Lung
56 Citations (Scopus)

Inhaled nitric oxide increases endothelin-1 levels: A potential cause of rebound pulmonary hypertension

Pearl, J. M., Nelson, D. P., Raake, J. L., Manning, P. B., Schwartz, S. M., Koons, L., Shanley, T. P., Wong, H. R. & Duffy, J. Y., Jan 1 2002, In : Critical Care Medicine. 30, 1, p. 89-93 5 p.

Research output: Contribution to journalArticle

Endothelin-1
Pulmonary Hypertension
Nitric Oxide
Heart Diseases
Therapeutics
10 Citations (Scopus)

Phosphatase inhibition leads to activation of IκB kinase in murine macrophages

Grossman, B. J., Shanley, T. P., Denenberg, A. G., Zhao, B. & Wong, H. R., Nov 6 2002, In : Biochemical and Biophysical Research Communications. 297, 5, p. 1264-1269 6 p.

Research output: Contribution to journalArticle

Macrophages
Phosphoric Monoester Hydrolases
Phosphotransferases
Chemical activation
Heat-Shock Response
24 Citations (Scopus)

Phosphatases: Counterregulatory role in inflammatory cell signaling

Shanley, T. P., Feb 18 2002, In : Critical Care Medicine. 30, 1 SUPPL. B

Research output: Contribution to journalArticle

Phosphoric Monoester Hydrolases
Phosphotransferases
Signal Transduction
Phosphorylation
Biological Phenomena
40 Citations (Scopus)

Role of nitric oxide in acute lung inflammation: Lessons learned from the inducible nitric oxide synthase knockout mouse

Shanley, T. P., Zhao, B., Macariola, D. R., Denenberg, A., Salzman, A. L. & Ward, P. A., Sep 1 2002, In : Critical Care Medicine. 30, 9, p. 1960-1968 9 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type II
Knockout Mice
Pneumonia
Nitric Oxide
Cytokines
22 Citations (Scopus)

Temporal and mechanistic effects of heat shock on LPS-mediated degradation of IκBα in macrophages

Grossman, B. J., Shanley, T. P., Odoms, K., Dunsmore, K. E., Denenberg, A. G. & Wong, H. R., Jun 17 2002, In : Inflammation. 26, 3, p. 129-137 9 p.

Research output: Contribution to journalArticle

Shock
Hot Temperature
Macrophages
Phosphoric Monoester Hydrolases
Heat-Shock Response
76 Citations (Scopus)

The A2A receptor mediates an endogenous regulatory pathway of cytokine expression in THP-1 cells

Bshesh, K., Zhao, B., Spight, D., Biaggioni, I., Feokistov, I., Denenberg, A., Wong, H. R. & Shanley, T. P., Nov 1 2002, In : Journal of Leukocyte Biology. 72, 5, p. 1027-1036 10 p.

Research output: Contribution to journalArticle

Adenosine
Lipopolysaccharides
Cytokines
Tumor Necrosis Factor-alpha
Cyclic AMP
2001
34 Citations (Scopus)

Geldanamycin inhibits NF-κB activation and interleukin-8 gene expression in cultured human respiratory epithelium

Malhotra, V., Shanley, T. P., Pittet, J. F., Welch, W. J. & Wong, H. R., Jan 1 2001, In : American Journal of Respiratory Cell and Molecular Biology. 25, 1, p. 92-97 6 p.

Research output: Contribution to journalArticle

Respiratory Mucosa
Interleukin-8
Gene expression
Chemical activation
Gene Expression
116 Citations (Scopus)

The serine/threonine phosphatase, PP2A: Endogenous regulator of inflammatory cell signaling

Shanley, T. P., Vasi, N., Denenberg, A. & Wong, H. R., Jan 15 2001, In : Journal of Immunology. 166, 2, p. 966-972 7 p.

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
Phosphoprotein Phosphatases
Transcriptional Activation
Proto-Oncogene Proteins c-jun
Okadaic Acid
109 Citations (Scopus)

Usefulness of corticosteroid therapy in decreasing epinephrine requirements in critically ill infants with congenital heart disease

Shore, S., Nelson, D. P., Pearl, J. M., Manning, P. B., Wong, H., Shanley, T. P., Keyser, T. & Schwartz, S. M., Sep 1 2001, In : American Journal of Cardiology. 88, 5, p. 591-594 4 p.

Research output: Contribution to journalArticle

2000
50 Citations (Scopus)

Heat shock inhibits phosphorylation of I-κBα

Shanley, T. P., Ryan, M. A., Eaves-Pyles, T. & Wong, H. R., Jan 1 2000, In : Shock. 14, 4, p. 447-450 4 p.

Research output: Contribution to journalArticle

Shock
Hot Temperature
Phosphorylation
Ubiquitination
Heat-Shock Response
67 Citations (Scopus)

Regulation of chemokine expression by IL-10 in lung inflammation

Shanley, T. P., Vasi, N. & Denenberg, A., Jan 1 2000, In : Cytokine. 12, 7, p. 1054-1064 11 p.

Research output: Contribution to journalArticle

Chemokines
Interleukin-10
Pneumonia
Lung
Neutrophil Infiltration
114 Citations (Scopus)

Role of CC chemokines (macrophage inflammatory protein-1β, monocyte chemoattractant protein-1, RANTES) in acute lung injury in rats

Bless, N. M., Huber-Lang, M., Guo, R. F., Warner, R. L., Schmal, H., Czermak, B. J., Shanley, T. P., Crouch, L. D., Lentsch, A. B., Sarma, V., Mulligan, M. S., Friedl, H. P. & Ward, P. A., Mar 1 2000, In : Journal of Immunology. 164, 5, p. 2650-2659 10 p.

Research output: Contribution to journalArticle

Macrophage Inflammatory Proteins
Chemokine CCL5
CC Chemokines
Acute Lung Injury
Chemokine CCL2
43 Citations (Scopus)

Role of macrophage inflammatory protein-2 in aspiration-induced lung injury

Shanley, T. P., Vasi, N., Davidson, B. A., Nader, N. D., Knight, P. R., Bless, N., Ward, P. A. & Johnson, K. J., Jan 1 2000, In : Critical Care Medicine. 28, 7, p. 2437-2444 8 p.

Research output: Contribution to journalArticle

Chemokine CXCL2
Lung Injury
Bronchoalveolar Lavage Fluid
Lung
Neutrophils
33 Citations (Scopus)

Role of RANTES in experimental cardiac allograft rejection

Mulligan, M. S., McDuffie, J. E., Shanley, T. P., Guo, R. F., Vidya Sarma, J., Warner, R. L. & Ward, P. A., Jan 1 2000, In : Experimental and Molecular Pathology. 69, 3, p. 167-174 8 p.

Research output: Contribution to journalArticle

T-cells
Allografts
Chemical activation
T-Lymphocytes
Rats
1999
2 Citations (Scopus)

Anti-thrombin III deficiency primes the endothelial inflam matory response via upregulation of adhesion molecules

Shanley, T. P., Vasi, N., Stark, J. & Morris, C., Dec 1 1999, In : Critical care medicine. 27, 1 SUPPL.

Research output: Contribution to journalArticle

Thrombin
Intercellular Adhesion Molecule-1
Up-Regulation
Human Umbilical Vein Endothelial Cells
Vascular Cell Adhesion Molecule-1
80 Citations (Scopus)

Regulatory effects of endogenous protease inhibitors in acute lung inflammatory injury

Gipson, T. S., Bless, N. M., Shanley, T. P., Crouch, L. D., Bleavins, M. R., Younkin, E. M., Sarma, V., Gibbs, D. F., Tefera, W., McConnell, P. C., Mueller, W. T., Johnson, K. J. & Ward, P. A., Mar 15 1999, In : Journal of Immunology. 162, 6, p. 3653-3662 10 p.

Research output: Contribution to journalArticle

Acute Lung Injury
Metalloproteases
Protease Inhibitors
Lung Injury
Lung
104 Citations (Scopus)

Role of matrix metalloproteinases in models of macrophage-dependent acute lung injury: Evidence for alveolar macrophage as source of proteinases

Gibbs, D. F., Shanley, T. P., Warner, R. L., Murphy, H. S., Varani, J. & Johnson, K. J., Jan 1 1999, In : American Journal of Respiratory Cell and Molecular Biology. 20, 6, p. 1145-1154 10 p.

Research output: Contribution to journalArticle

Acute Lung Injury
Macrophages
Alveolar Macrophages
Matrix Metalloproteinases
Peptide Hydrolases

The heat shock response inhibits phosphorylation of I-KBA

Wong, H. R., Menendez, I. Y. & Shanley, T. P., Dec 1 1999, In : Critical Care Medicine. 27, 12 SUPPL.

Research output: Contribution to journalArticle

Heat-Shock Response
Phosphorylation
Endotoxins
Ubiquitination
Western Blotting
72 Citations (Scopus)

The role of tumor necrosis factor-α in the pathogenesis of aspiration pneumonitis in rats

Davidson, B. A., Knight, P. R., Helinski, J. D., Nader, N. D., Shanley, T. P. & Johnson, K. J., Aug 1 1999, In : Anesthesiology. 91, 2, p. 486-499 14 p.

Research output: Contribution to journalArticle

Pneumonia
Tumor Necrosis Factor-alpha
Wounds and Injuries
Permeability
Gastric Acid

The serine/threonine phosphatase, PP2A: An endogenous regulator of inflammation?

Shanley, T. P., Vasi, N. & Denenberg, A., Dec 1 1999, In : Critical care medicine. 27, 12 SUPPL.

Research output: Contribution to journalArticle

Phosphoprotein Phosphatases
Transcription Factor AP-1
Phosphotransferases
Inflammation
Interleukin-1
1998
4 Citations (Scopus)

Adenosine receptor agonists inhibit Macrophage Inflammatory Protein (MIP)-1α production in immunostimulated macrophages

Shanley, T. P., Haskó, G., Egnaczyk, G., Salzman, A. L. & Szabó, C., Mar 20 1998, In : FASEB Journal. 12, 5

Research output: Contribution to journalArticle

Purinergic P1 Receptor Agonists
Macrophage Inflammatory Proteins
Macrophages
adenosine
agonists
8 Citations (Scopus)

Cytokine and adhesion molecule requirements for lung injury induced by anti-glomerular basement membrane antibody

Mulligan, M. S., Lentsch, A. B., Shanley, T. P., Miyasaka, M., Johnson, K. J. & Ward, P. A., Aug 26 1998, In : Inflammation. 22, 4, p. 403-417 15 p.

Research output: Contribution to journalArticle

Glomerular Basement Membrane
Lung Injury
Cytokines
Neutrophils
Antibodies
5 Citations (Scopus)
Cytokines
76 Citations (Scopus)

Exogenous and endogenous catecholamines inhibit the production of macrophage inflammatory protein (MIP) 1α via a β adrenoceptor mediated mechanism

Haskó, G., Shanley, T. P., Egnaczyk, G., Németh, Z. H., Salzman, A. L., Vizi, E. S. & Szabó, C., Jan 1 1998, In : British Journal of Pharmacology. 125, 6, p. 1297-1303 7 p.

Research output: Contribution to journalArticle

Macrophage Inflammatory Proteins
Adrenergic Receptors
Catecholamines
Rolipram
Norepinephrine
42 Citations (Scopus)

Induction of the stress response with prostaglandin increases A1 increases I-κBα, gene expression

Thomas, S. C., Ryan, M. A., Shanley, T. P. & Wong, H. R., Oct 28 1998, In : FASEB Journal. 12, 13, p. 1371-1378 8 p.

Research output: Contribution to journalArticle

Gene expression
prostaglandins
Prostaglandins
stress response
Gene Expression
25 Citations (Scopus)

Requirements for αd in IgG immune complex-induced rat lung injury

Shanley, T. P., Warner, R. L., Crouch, L. D., Dietsch, G. N., Clark, D. L., O'Brien, M. M., Gallatin, W. M. & Ward, P. A., Jan 15 1998, In : Journal of Immunology. 160, 2, p. 1014-1020 7 p.

Research output: Contribution to journalArticle

Lung Injury
Antigen-Antibody Complex
Immunoglobulin G
Lung
Bronchoalveolar Lavage Fluid
151 Citations (Scopus)

Suppression of macrophage inflammatory protein (MIP)-1α production and collagen-induced arthritis by adenosine receptor agonists

Szabó, C., Scott, G. S., Virág, L., Egnaczyk, G., Salzman, A. L., Shanley, T. P. & Haskó, G., Sep 25 1998, In : British Journal of Pharmacology. 125, 2, p. 379-387 9 p.

Research output: Contribution to journalArticle

Purinergic P1 Receptor Agonists
Macrophage Inflammatory Proteins
Experimental Arthritis
Neutrophil Infiltration
Adenosine A2 Receptors
1997

Interleukin-10 protects against IgG immune complex-induced lung injury through suppression of NF-κB

Lentsch, A. B., Shanley, T. P. & Ward, P. A., Dec 1 1997, In : FASEB Journal. 11, 3

Research output: Contribution to journalArticle

antigen-antibody complex
Lung Injury
interleukin-10
Antigen-Antibody Complex
Interleukin-10
269 Citations (Scopus)

In vivo suppression of NF-κB and preservation of IκBα by interleukin- 10 and interleukin-13

Lentsch, A. B., Shanley, T. P., Sarma, V. & Ward, P. A., Nov 15 1997, In : Journal of Clinical Investigation. 100, 10, p. 2443-2448 6 p.

Research output: Contribution to journalArticle

Interleukin-13
NF-kappa B
Interleukin-10
Antigen-Antibody Complex
Lung Injury

Molecular cloning and in vivo transcriptional expression of rat SLPI in lung inflammation

Gipson, T. S., Shanley, T. P., Bleavins, M. R., Tefera, W., Johnson, K. S. & Ward, P. A., Dec 1 1997, In : FASEB Journal. 11, 3

Research output: Contribution to journalArticle

Cloning
Molecular Cloning
Rats
Pneumonia
Leukocytes
82 Citations (Scopus)

Protective Effects of IL-4, IL-10, IL-12, and IL-13 in IgG Immune Complex-Induced Lung Injury Role of Endogenous IL-12

Mulligan, M. S., Warner, R. L., Foreback, J. L., Shanley, T. P. & Ward, P. A., Oct 1 1997, In : Journal of Immunology. 159, 7, p. 3483-3489 7 p.

Research output: Contribution to journalArticle

Interleukin-13
Lung Injury
Interleukin-12
Antigen-Antibody Complex
Interleukin-4
43 Citations (Scopus)

Regulatory effects of interleukin-6 in immunoglobulin G immune-complex- induced lung injury

Shanley, T. P., Foreback, J. L., Remick, D. G., Ulich, T. R., Kunkel, S. L. & Ward, P. A., Jul 18 1997, In : American Journal of Pathology. 151, 1, p. 193-203 11 p.

Research output: Contribution to journalArticle

Lung Injury
Antigen-Antibody Complex
Interleukin-6
Immunoglobulin G
Tumor Necrosis Factor-alpha
166 Citations (Scopus)

Requirement for C-X-C Chemokines (Macrophage Inflammatory Protein-2 and Cytokine-Induced Neutrophil Chemoattractant) in IgG Immune Complex-Induced Lung Injury

Shanley, T. P., Schmal, H., Warner, R. L., Schmid, E., Friedl, H. P. & Ward, P. A., Apr 1 1997, In : Journal of Immunology. 158, 7, p. 3439-3448 10 p.

Research output: Contribution to journalArticle

Chemokine CXCL2
CXC Chemokines
Chemotactic Factors
Lung Injury
Antigen-Antibody Complex
60 Citations (Scopus)

Role of Kupffer cells in gut ischemia/reperfusion-induced hepatic microvascular dysfunction in mice

Horie, Y., Wolf, R., Russell, J., Shanley, T. P. & Granger, D. N., Jan 1 1997, In : Hepatology. 26, 6, p. 1499-1505 7 p.

Research output: Contribution to journalArticle

Kupffer Cells
Reperfusion
Leukostasis
Ischemia
Liver
169 Citations (Scopus)

Sublytic concentrations of the membrane attack complex of complement induce endothelial interleukin-8 and monocyte chemoattractant protein-1 through nuclear factor-κB activation

Kilgore, K. S., Schmidt, E., Shanley, T. P., Flory, C. M., Maheswari, V., Tramontini, N. L., Cohen, H., Ward, P. A., Friedl, H. P. & Warren, J. S., Jun 16 1997, In : American Journal of Pathology. 150, 6, p. 2019-2031 13 p.

Research output: Contribution to journalArticle

Complement Membrane Attack Complex
Complement Factor B
Chemokine CCL2
Interleukin-8
Human Umbilical Vein Endothelial Cells
1996
107 Citations (Scopus)

Glomerular inflammation induces resistance to tubular injury in the rat. A novel form of acquired, heme oxygenase-dependent resistance to renal injury

Vogt, B. A., Shanley, T. P., Croatt, A., Alam, J., Johnson, K. J. & Nath, K. A., Nov 1 1996, In : Journal of Clinical Investigation. 98, 9, p. 2139-2145 7 p.

Research output: Contribution to journalArticle

Heme Oxygenase (Decyclizing)
Inflammation
Kidney
Acute Kidney Injury
Wounds and Injuries
2 Citations (Scopus)

IL-13 is transcriptionally expressed in IgG-immune complex-induced lung injury

Crouch, L. D., Shanley, T. P., Johnson, K. J. & Ward, P. A., Dec 1 1996, In : FASEB Journal. 10, 6

Research output: Contribution to journalArticle

antigen-antibody complex
Interleukin-13
Lung Injury
Antigen-Antibody Complex
Immunoglobulin G