Thomas Patrick Shanley

  • 8283 Citations
19952020

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2007

Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome

Wong, H. R., Shanley, T. P., Sakthivel, B., Cvijanovich, N., Lin, R., Allen, G. L., Thomas, N. J., Doctor, A., Kalyanaraman, M., Tofil, N. M., Penfil, S., Monaco, M., Tagavilla, M. A., Odoms, K., Dunsmore, K., Barnes, M. & Aronow, B. J., Jul 18 2007, In : Physiological genomics. 30, 2, p. 146-155 10 p.

Research output: Contribution to journalArticle

161 Scopus citations

Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock

Shanley, T. P., Cvijanovich, N., Lin, R., Allen, G. L., Thomas, N. J., Doctor, A., Kalyanaraman, M., Tofil, N. M., Penfil, S., Monaco, M., Odoms, K., Barnes, M., Sakthivel, B., Aronow, B. J. & Wong, H. R., Sep 1 2007, In : Molecular Medicine. 13, 9-10, p. 495-508 14 p.

Research output: Contribution to journalArticle

99 Scopus citations

Going back for more: An evaluation of clinical outcomes and characteristics of readmissions to a pediatric intensive care unit

Odetola, F. O., Clark, S. J., Dechert, R. E. & Shanley, T. P., Jul 2007, In : Pediatric Critical Care Medicine. 8, 4, p. 343-347 5 p.

Research output: Contribution to journalArticle

27 Scopus citations

Tristetraprolin (TTP)-14-3-3 complex formation protects TTP from dephosphorylation by protein phosphatase 2a and stabilizes tumor necrosis factor-α mRNA

Sun, L., Stoecklin, G., Van Way, S., Hinkovska-Galcheva, V., Guo, R. F., Anderson, P. & Shanley, T. P., Jan 9 2007, In : Journal of Biological Chemistry. 282, 6, p. 3766-3777 12 p.

Research output: Contribution to journalArticle

140 Scopus citations
2006

Approach to management of malignant hyperthermia-like syndrome in pediatric diabetes mellitus

Kilbane, B. J., Mehta, S., Backeljauw, P. F., Shanley, T. P. & Crimmins, N. A., Mar 1 2006, In : Pediatric Critical Care Medicine. 7, 2, p. 169-173 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

Characteristics and outcomes of interhospital transfers from level II to level I pediatric intensive care units

Odetola, F. O., Shanley, T. P., Gurney, J. G., Clark, S. J., Dechert, R. E., Freed, G. L. & Davis, M. M., Nov 1 2006, In : Pediatric Critical Care Medicine. 7, 6, p. 536-540 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Extracellular heat shock protein-70 induces endotoxin tolerance in THP-1 cells

Aneja, R., Odoms, K., Dunsmore, K., Shanley, T. P. & Wong, H. R., Nov 15 2006, In : Journal of Immunology. 177, 10, p. 7184-7192 9 p.

Research output: Contribution to journalArticle

92 Scopus citations
2005

Contribution of MKP-1 regulation of p38 to endotoxin tolerance

Nimah, M., Zhao, B., Denenberg, A. G., Bueno, O., Molkentin, J., Wong, H. R. & Shanley, T. P., Jan 1 2005, In : Shock. 23, 1, p. 80-87 8 p.

Research output: Contribution to journalArticle

55 Scopus citations

Heat shock-mediated regulation of MKP-1

Wong, H. R., Dunsmore, K. E., Page, K. & Shanley, T. P., Nov 1 2005, In : American Journal of Physiology - Cell Physiology. 289, 5 58-5, p. C1152-C1158

Research output: Contribution to journalArticle

34 Scopus citations

Immunoregulatory effects of regulated, lung-targeted expression of IL-10 in vivo

Spight, D., Zhao, B., Haas, M., Wert, S., Denenberg, A. & Shanley, T. P., Feb 1 2005, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 288, 2 32-2, p. L251-L265

Research output: Contribution to journalArticle

33 Scopus citations

Signal transduction overview

Cornell, T. T. & Shanley, T. P., Dec 2005, In : Critical care medicine. 33, 12 SUPPL., p. S410-S413

Research output: Contribution to journalArticle

3 Scopus citations
2004

Heat shock inhibition of lipopolysaccharide-mediated tumor necrosis factor expression is associated with nuclear induction of MKP-1 and inhibition of mitogen-activated protein kinase activation

Sanlorenzo, L., Zhao, B., Spight, D., Denenberg, A. G., Page, K., Wong, H. R. & Shanley, T. P., Nov 1 2004, In : Critical Care Medicine. 32, 11, p. 2284-2292 9 p.

Research output: Contribution to journalArticle

18 Scopus citations
12 Scopus citations
2003

Combined steroid treatment for congenital heart surgery improves oxygen delivery and reduces postbypass inflammatory mediator expression

Schroeder, V. A., Pearl, J. M., Schwartz, S. M., Shanley, T. P., Manning, P. B. & Nelson, D. P., Jun 10 2003, In : Circulation. 107, 22, p. 2823-2828 6 p.

Research output: Contribution to journalArticle

122 Scopus citations
2002

Heat shock inhibits activation of NF-κB in the absence of heat shock factor-1

Malhotra, V., Eaves-Pyles, T., Odoms, K., Quaid, G., Shanley, T. P. & Wong, H. R., Jan 1 2002, In : Biochemical and Biophysical Research Communications. 291, 3, p. 453-457 5 p.

Research output: Contribution to journalArticle

37 Scopus citations

Heat shock inhibits TNF-induced ICAM-1 expression in human endothelial cells via I kappa kinase inhibition

Kohn, G., Wong, H. R., Bshesh, K., Zhao, B., Vasi, N., Denenberg, A., Morris, C., Stark, J. & Shanley, T. P., Jan 1 2002, In : Shock. 17, 2, p. 91-97 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Hyperoxia prolongs tumor necrosis factor-α-mediated activation of Nf-κB: Role of IκB kinase

Wong, H. R., Odoms, K. K., Denenberg, A. G., Allen, G. L. & Shanley, T. P., Jan 1 2002, In : Shock. 17, 4, p. 274-279 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Inhaled nitric oxide increases endothelin-1 levels: A potential cause of rebound pulmonary hypertension

Pearl, J. M., Nelson, D. P., Raake, J. L., Manning, P. B., Schwartz, S. M., Koons, L., Shanley, T. P., Wong, H. R. & Duffy, J. Y., Jan 1 2002, In : Critical care medicine. 30, 1, p. 89-93 5 p.

Research output: Contribution to journalArticle

56 Scopus citations

Phosphatase inhibition leads to activation of IκB kinase in murine macrophages

Grossman, B. J., Shanley, T. P., Denenberg, A. G., Zhao, B. & Wong, H. R., Nov 6 2002, In : Biochemical and Biophysical Research Communications. 297, 5, p. 1264-1269 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Phosphatases: Counterregulatory role in inflammatory cell signaling

Shanley, T. P., Feb 18 2002, In : Critical Care Medicine. 30, 1 SUPPL. B

Research output: Contribution to journalArticle

24 Scopus citations

Role of nitric oxide in acute lung inflammation: Lessons learned from the inducible nitric oxide synthase knockout mouse

Shanley, T. P., Zhao, B., Macariola, D. R., Denenberg, A., Salzman, A. L. & Ward, P. A., Sep 1 2002, In : Critical care medicine. 30, 9, p. 1960-1968 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Temporal and mechanistic effects of heat shock on LPS-mediated degradation of IκBα in macrophages

Grossman, B. J., Shanley, T. P., Odoms, K., Dunsmore, K. E., Denenberg, A. G. & Wong, H. R., Jun 17 2002, In : Inflammation. 26, 3, p. 129-137 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

The A2A receptor mediates an endogenous regulatory pathway of cytokine expression in THP-1 cells

Bshesh, K., Zhao, B., Spight, D., Biaggioni, I., Feokistov, I., Denenberg, A., Wong, H. R. & Shanley, T. P., Nov 1 2002, In : Journal of Leukocyte Biology. 72, 5, p. 1027-1036 10 p.

Research output: Contribution to journalArticle

79 Scopus citations
2001

Geldanamycin inhibits NF-κB activation and interleukin-8 gene expression in cultured human respiratory epithelium

Malhotra, V., Shanley, T. P., Pittet, J. F., Welch, W. J. & Wong, H. R., Jan 1 2001, In : American Journal of Respiratory Cell and Molecular Biology. 25, 1, p. 92-97 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

The serine/threonine phosphatase, PP2A: Endogenous regulator of inflammatory cell signaling

Shanley, T. P., Vasi, N., Denenberg, A. & Wong, H. R., Jan 15 2001, In : Journal of Immunology. 166, 2, p. 966-972 7 p.

Research output: Contribution to journalArticle

119 Scopus citations

Usefulness of corticosteroid therapy in decreasing epinephrine requirements in critically ill infants with congenital heart disease

Shore, S., Nelson, D. P., Pearl, J. M., Manning, P. B., Wong, H., Shanley, T. P., Keyser, T. & Schwartz, S. M., Sep 1 2001, In : American Journal of Cardiology. 88, 5, p. 591-594 4 p.

Research output: Contribution to journalArticle

111 Scopus citations
2000

Heat shock inhibits phosphorylation of I-κBα

Shanley, T. P., Ryan, M. A., Eaves-Pyles, T. & Wong, H. R., Jan 1 2000, In : Shock. 14, 4, p. 447-450 4 p.

Research output: Contribution to journalArticle

51 Scopus citations

Regulation of chemokine expression by IL-10 in lung inflammation

Shanley, T. P., Vasi, N. & Denenberg, A., Jul 2000, In : Cytokine. 12, 7, p. 1054-1064 11 p.

Research output: Contribution to journalArticle

67 Scopus citations

Role of CC chemokines (macrophage inflammatory protein-1β, monocyte chemoattractant protein-1, RANTES) in acute lung injury in rats

Bless, N. M., Huber-Lang, M., Guo, R. F., Warner, R. L., Schmal, H., Czermak, B. J., Shanley, T. P., Crouch, L. D., Lentsch, A. B., Sarma, V., Mulligan, M. S., Friedl, H. P. & Ward, P. A., Mar 1 2000, In : Journal of Immunology. 164, 5, p. 2650-2659 10 p.

Research output: Contribution to journalArticle

115 Scopus citations

Role of macrophage inflammatory protein-2 in aspiration-induced lung injury

Shanley, T. P., Vasi, N., Davidson, B. A., Nader, N. D., Knight, P. R., Bless, N., Ward, P. A. & Johnson, K. J., Jan 1 2000, In : Critical care medicine. 28, 7, p. 2437-2444 8 p.

Research output: Contribution to journalArticle

45 Scopus citations

Role of RANTES in experimental cardiac allograft rejection

Mulligan, M. S., McDuffie, J. E., Shanley, T. P., Guo, R. F., Vidya Sarma, J., Warner, R. L. & Ward, P. A., Jan 1 2000, In : Experimental and Molecular Pathology. 69, 3, p. 167-174 8 p.

Research output: Contribution to journalArticle

33 Scopus citations
1999

Anti-thrombin III deficiency primes the endothelial inflam matory response via upregulation of adhesion molecules

Shanley, T. P., Vasi, N., Stark, J. & Morris, C., Dec 1 1999, In : Critical care medicine. 27, 1 SUPPL.

Research output: Contribution to journalArticle

2 Scopus citations

Regulatory effects of endogenous protease inhibitors in acute lung inflammatory injury

Gipson, T. S., Bless, N. M., Shanley, T. P., Crouch, L. D., Bleavins, M. R., Younkin, E. M., Sarma, V., Gibbs, D. F., Tefera, W., McConnell, P. C., Mueller, W. T., Johnson, K. J. & Ward, P. A., Mar 15 1999, In : Journal of Immunology. 162, 6, p. 3653-3662 10 p.

Research output: Contribution to journalArticle

81 Scopus citations

Role of matrix metalloproteinases in models of macrophage-dependent acute lung injury: Evidence for alveolar macrophage as source of proteinases

Gibbs, D. F., Shanley, T. P., Warner, R. L., Murphy, H. S., Varani, J. & Johnson, K. J., Jan 1 1999, In : American journal of respiratory cell and molecular biology. 20, 6, p. 1145-1154 10 p.

Research output: Contribution to journalArticle

104 Scopus citations

The heat shock response inhibits phosphorylation of I-KBA

Wong, H. R., Menendez, I. Y. & Shanley, T. P., Dec 1 1999, In : Critical Care Medicine. 27, 12 SUPPL.

Research output: Contribution to journalArticle

The role of tumor necrosis factor-α in the pathogenesis of aspiration pneumonitis in rats

Davidson, B. A., Knight, P. R., Helinski, J. D., Nader, N. D., Shanley, T. P. & Johnson, K. J., Aug 1 1999, In : Anesthesiology. 91, 2, p. 486-499 14 p.

Research output: Contribution to journalArticle

73 Scopus citations

The serine/threonine phosphatase, PP2A: An endogenous regulator of inflammation?

Shanley, T. P., Vasi, N. & Denenberg, A., Jan 1 1999, In : Critical care medicine. 27, 12 SUPPL., p. A25

Research output: Contribution to journalArticle

1998

Adenosine receptor agonists inhibit Macrophage Inflammatory Protein (MIP)-1α production in immunostimulated macrophages

Shanley, T. P., Haskó, G., Egnaczyk, G., Salzman, A. L. & Szabó, C., Mar 20 1998, In : FASEB Journal. 12, 5

Research output: Contribution to journalArticle

4 Scopus citations

Cytokine and adhesion molecule requirements for lung injury induced by anti-glomerular basement membrane antibody

Mulligan, M. S., Lentsch, A. B., Shanley, T. P., Miyasaka, M., Johnson, K. J. & Ward, P. A., Aug 26 1998, In : Inflammation. 22, 4, p. 403-417 15 p.

Research output: Contribution to journalArticle

8 Scopus citations
5 Scopus citations

Exogenous and endogenous catecholamines inhibit the production of macrophage inflammatory protein (MIP) 1α via a β adrenoceptor mediated mechanism

Haskó, G., Shanley, T. P., Egnaczyk, G., Németh, Z. H., Salzman, A. L., Vizi, E. S. & Szabó, C., Jan 1 1998, In : British journal of pharmacology. 125, 6, p. 1297-1303 7 p.

Research output: Contribution to journalArticle

79 Scopus citations

Induction of the stress response with prostaglandin increases A1 increases I-κBα, gene expression

Thomas, S. C., Ryan, M. A., Shanley, T. P. & Wong, H. R., Oct 28 1998, In : FASEB Journal. 12, 13, p. 1371-1378 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Requirements for αd in IgG immune complex-induced rat lung injury

Shanley, T. P., Warner, R. L., Crouch, L. D., Dietsch, G. N., Clark, D. L., O'Brien, M. M., Gallatin, W. M. & Ward, P. A., Jan 15 1998, In : Journal of Immunology. 160, 2, p. 1014-1020 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Suppression of macrophage inflammatory protein (MIP)-1α production and collagen-induced arthritis by adenosine receptor agonists

Szabó, C., Scott, G. S., Virág, L., Egnaczyk, G., Salzman, A. L., Shanley, T. P. & Haskó, G., Sep 25 1998, In : British journal of pharmacology. 125, 2, p. 379-387 9 p.

Research output: Contribution to journalArticle

155 Scopus citations
1997

Interleukin-10 protects against IgG immune complex-induced lung injury through suppression of NF-κB

Lentsch, A. B., Shanley, T. P. & Ward, P. A., Dec 1 1997, In : FASEB Journal. 11, 3

Research output: Contribution to journalArticle

In vivo suppression of NF-κB and preservation of IκBα by interleukin- 10 and interleukin-13

Lentsch, A. B., Shanley, T. P., Sarma, V. & Ward, P. A., Nov 15 1997, In : Journal of Clinical Investigation. 100, 10, p. 2443-2448 6 p.

Research output: Contribution to journalArticle

270 Scopus citations

Molecular cloning and in vivo transcriptional expression of rat SLPI in lung inflammation

Gipson, T. S., Shanley, T. P., Bleavins, M. R., Tefera, W., Johnson, K. S. & Ward, P. A., Dec 1 1997, In : FASEB Journal. 11, 3

Research output: Contribution to journalArticle

Protective Effects of IL-4, IL-10, IL-12, and IL-13 in IgG Immune Complex-Induced Lung Injury Role of Endogenous IL-12

Mulligan, M. S., Warner, R. L., Foreback, J. L., Shanley, T. P. & Ward, P. A., Oct 1 1997, In : Journal of Immunology. 159, 7, p. 3483-3489 7 p.

Research output: Contribution to journalArticle

82 Scopus citations

Regulatory effects of interleukin-6 in immunoglobulin G immune-complex- induced lung injury

Shanley, T. P., Foreback, J. L., Remick, D. G., Ulich, T. R., Kunkel, S. L. & Ward, P. A., Jul 18 1997, In : American Journal of Pathology. 151, 1, p. 193-203 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Requirement for C-X-C Chemokines (Macrophage Inflammatory Protein-2 and Cytokine-Induced Neutrophil Chemoattractant) in IgG Immune Complex-Induced Lung Injury

Shanley, T. P., Schmal, H., Warner, R. L., Schmid, E., Friedl, H. P. & Ward, P. A., Apr 1 1997, In : Journal of Immunology. 158, 7, p. 3439-3448 10 p.

Research output: Contribution to journalArticle

166 Scopus citations