Grants per year
Personal profile
Research Interests
Dr. O’Halloran’s research interests center on the regulatory biology and chemistry of transition metal receptors involved homeostasis and oxidative stress pathways. His work focuses on the intracellular chemistry of elements essential for growth and proliferation, (i.e. zinc, copper and iron), nanoscale drug delivery mechanisms and on the mechanisms of clinically important anticancer agents that are based on arsenic, molybdenum and platinum chemistry. His discoveries have established the function and structures of two new classes of soluble receptors: metalloregulatory proteins that govern metal responsive gene expression and metallochaperone proteins that control intracellular trafficking pathways.
Education/Academic qualification
Bioinorganic Chemistry, PhD, Columbia University
… → 1985
Bioinorganic Chemistry, MA, University of Missouri
… → 1980
Chemistry, BS, University of Missouri
… → 1979
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Grants
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Acquisition of an MD3-UP microdiffractometer for macromolecular crystallography
Anderson, S. M., Brister, K., Brunzelle, J. S., Mondragon, A., O'Halloran, T. V., Pinkett, H. W., Rosenzweig, A. C., Satchell, K. J. F. & Wawrzak, Z.
Office of the Director, National Institutes of Health
8/26/20 → 8/25/21
Project: Research project
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Acquisition of an Eiger2 X 16M pixel array detector for macromolecular crystallography
Anderson, S. M., Brister, K., Brunzelle, J. S., Mondragon, A., O'Halloran, T. V., Pinkett, H. W., Rosenzweig, A. C., Satchell, K. J. F. & Wawrzak, Z.
Office of the Director, National Institutes of Health
8/15/20 → 8/14/21
Project: Research project
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TR&D1 - Resource for Quantitative Elemental Mapping for the Life Sciences
National Institute of General Medical Sciences
7/1/20 → 5/31/25
Project: Research project
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Resource for Quantitative Elemental Mapping for the Life Sciences
Jacobsen, C., Judge, S. M. & O'Halloran, T. V.
National Institute of General Medical Sciences
7/1/20 → 5/31/25
Project: Research project
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Driving Biomedical Projects (DBP) - Resource for Quantitative Elemental Mapping for the Life Sciences
National Institute of General Medical Sciences
7/1/20 → 5/31/25
Project: Research project
Research Output
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CueR activates transcription through a DNA distortion mechanism
Fang, C., Philips, S. J., Wu, X., Chen, K., Shi, J., Shen, L., Xu, J., Feng, Y., O’Halloran, T. V. & Zhang, Y., Jan 2021, In: Nature Chemical Biology. 17, 1, p. 57-64 8 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Zinc Dynamics during Drosophila Oocyte Maturation and Egg Activation
Hu, Q., Duncan, F. E., Nowakowski, A. B., Antipova, O. A., Woodruff, T. K., O'Halloran, T. V. & Wolfner, M. F., Jul 24 2020, In: iScience. 23, 7, 101275.Research output: Contribution to journal › Article › peer-review
Open Access -
Zinc exocytosis is sensitive to myosin light chain kinase inhibition in mouse and human eggs
Lee, H. C., Edmonds, M. E., Duncan, F. E., O'Halloran, T. V. & Woodruff, T. K., Apr 15 2020, In: Molecular human reproduction. 26, 4, p. 228-239 12 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Arsenoplatin-1 Is a Dual Pharmacophore Anticancer Agent
Miodragović, D., Merlino, A., Swindell, E. P., Bogachkov, A., Ahn, R. W., Abuhadba, S., Ferraro, G., Marzo, T., Mazar, A. P., Messori, L. & O'Halloran, T. V., Apr 24 2019, In: Journal of the American Chemical Society. 141, 16, p. 6453-6457 5 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Beyond cisplatin: Combination therapy with arsenic trioxide
Miodragović, Ð., Swindell, E. P., Sattar Waxali, Z., Bogachkov, A. & O'Halloran, T. V., Oct 1 2019, In: Inorganica Chimica Acta. 496, 119030.Research output: Contribution to journal › Review article › peer-review
5 Scopus citations