• 17992 Citations
1978 …2024

Research output per year

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Personal profile

Research Interests

Dr. O’Halloran’s research interests center on the regulatory biology and chemistry of transition metal receptors involved homeostasis and oxidative stress pathways. His work focuses on the intracellular chemistry of elements essential for growth and proliferation, (i.e. zinc, copper and iron), nanoscale drug delivery mechanisms and on the mechanisms of clinically important anticancer agents that are based on arsenic, molybdenum and platinum chemistry. His discoveries have established the function and structures of two new classes of soluble receptors: metalloregulatory proteins that govern metal responsive gene expression and metallochaperone proteins that control intracellular trafficking pathways.

Education/Academic qualification

Bioinorganic Chemistry, PhD, Columbia University

… → 1985

Bioinorganic Chemistry, MA, University of Missouri

… → 1980

Chemistry, BS, University of Missouri

… → 1979

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Grants

Research Output

Arsenoplatin-1 Is a Dual Pharmacophore Anticancer Agent

Miodragović, D., Merlino, A., Swindell, E. P., Bogachkov, A., Ahn, R. W., Abuhadba, S., Ferraro, G., Marzo, T., Mazar, A. P., Messori, L. & O'Halloran, T. V., Apr 24 2019, In : Journal of the American Chemical Society. 141, 16, p. 6453-6457 5 p.

Research output: Contribution to journalArticle

  • 5 Scopus citations

    Bovine eggs release zinc in response to parthenogenetic and sperm-induced egg activation

    Que, E. L., Duncan, F. E., Lee, H. C., Hornick, J. E., Vogt, S., Fissore, R. A., O'Halloran, T. V. & Woodruff, T. K., Mar 15 2019, In : Theriogenology. 127, p. 41-48 8 p.

    Research output: Contribution to journalArticle

  • 4 Scopus citations

    Interrogating Intracellular Zinc Chemistry with a Long Stokes Shift Zinc Probe ZincBY-4

    Garwin, S. A., Kelley, M. S., Sue, A. C., Que, E. L., Schatz, G. C., Woodruff, T. K. & O'Halloran, T. V., Jan 1 2019, In : Journal of the American Chemical Society. 141, 42, p. 16696-16705 10 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation

    Stephens, A. D., Liu, P. Z., Kandula, V., Chen, H., Almassalha, L. M., Herman, C., Backman, V., O'Halloran, T., Adam, S. A., Goldman, R. D., Banigan, E. J. & Marko, J. F., Aug 1 2019, In : Molecular biology of the cell. 30, 17, p. 2320-2330 11 p.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Whole-body imaging of cell death provides a systemic, minimally invasive, dynamic, and near-real time indicator for chemotherapeutic drug toxicity

    Johnson, S. E., Ugolkov, A., Haney, C. R., Bondarenko, G., Li, L., Waters, E. A., Bergan, R., Tran, A., O'Halloran, T. V., Mazar, A. & Zhao, M., Feb 15 2019, In : Clinical Cancer Research. 25, 4, p. 1331-1342 12 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations