• 18197 Citations
1978 …2020

Research output per year

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Personal profile

Research Interests

Dr. O’Halloran’s research interests center on the regulatory biology and chemistry of transition metal receptors involved homeostasis and oxidative stress pathways. His work focuses on the intracellular chemistry of elements essential for growth and proliferation, (i.e. zinc, copper and iron), nanoscale drug delivery mechanisms and on the mechanisms of clinically important anticancer agents that are based on arsenic, molybdenum and platinum chemistry. His discoveries have established the function and structures of two new classes of soluble receptors: metalloregulatory proteins that govern metal responsive gene expression and metallochaperone proteins that control intracellular trafficking pathways.

Education/Academic qualification

Bioinorganic Chemistry, PhD, Columbia University

… → 1985

Bioinorganic Chemistry, MA, University of Missouri

… → 1980

Chemistry, BS, University of Missouri

… → 1979

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Grants

Research Output

Zinc exocytosis is sensitive to myosin light chain kinase inhibition in mouse and human eggs

Lee, H. C., Edmonds, M. E., Duncan, F. E., O'Halloran, T. V. & Woodruff, T. K., Apr 15 2020, In : Molecular human reproduction. 26, 4, p. 228-239 12 p.

Research output: Contribution to journalArticle

  • Arsenoplatin-1 Is a Dual Pharmacophore Anticancer Agent

    Miodragović, D., Merlino, A., Swindell, E. P., Bogachkov, A., Ahn, R. W., Abuhadba, S., Ferraro, G., Marzo, T., Mazar, A. P., Messori, L. & O'Halloran, T. V., Apr 24 2019, In : Journal of the American Chemical Society. 141, 16, p. 6453-6457 5 p.

    Research output: Contribution to journalArticle

  • 7 Scopus citations

    Beyond cisplatin: Combination therapy with arsenic trioxide

    Miodragović, Ð., Swindell, E. P., Sattar Waxali, Z., Bogachkov, A. & O'Halloran, T. V., Oct 1 2019, In : Inorganica Chimica Acta. 496, 119030.

    Research output: Contribution to journalReview article

  • 5 Scopus citations

    Bovine eggs release zinc in response to parthenogenetic and sperm-induced egg activation

    Que, E. L., Duncan, F. E., Lee, H. C., Hornick, J. E., Vogt, S., Fissore, R. A., O'Halloran, T. V. & Woodruff, T. K., Mar 15 2019, In : Theriogenology. 127, p. 41-48 8 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    Interrogating Intracellular Zinc Chemistry with a Long Stokes Shift Zinc Probe ZincBY-4

    Garwin, S. A., Kelley, M. S., Sue, A. C., Que, E. L., Schatz, G. C., Woodruff, T. K. & O'Halloran, T. V., Jan 1 2019, In : Journal of the American Chemical Society. 141, 42, p. 16696-16705 10 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations