Thomas V O'Halloran

Professor, Chemistry
Morrison Professor, Chemistry
Professor, Medicine, Endocrinology Division
Professor, Molecular Biosciences
Chemistry PhD Program
Interdisciplinary Biological Sciences PhD Program
Director, Chemistry of Life Processes Institute, Chemistry of Life Processes Institute

Phone847/491-5060
Emailt-ohalloran@northwestern.edu

17474 Citations

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Personal profile

Education/Academic qualification

Bioinorganic Chemistry, PhD, Columbia University

… → 1985

Bioinorganic Chemistry, MA, University of Missouri, Columbia

… → 1980

Chemistry, BS, University of Missouri, Columbia

… → 1979

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Platinum Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 1998 2022

25 Active
56 Finished

Laser Ablation Inductively Coupled Plasma Time-of-Flight Mass Spectrometer for Advanced Bioelement Imaging Applications

O'Halloran, T. V.

Office of the Director, National Institutes of Health

8/1/19 → 7/31/22

Project: Research project

mass spectrometers

laser ablation

ablation

inductively coupled plasma mass spectrometry

acquisition

Mechanisms of Cadmium Induced Dysglycemia and Type 2 Diabetes Mellitus

Allen, N. B., El Muayed, M. & O'Halloran, T. V.

National Institute of Environmental Health Sciences

9/15/17 → 5/31/22

Project: Research project

Cadmium

Type 2 Diabetes Mellitus

Insulin

Prediabetic State

Reticulum

Metalloregulation by MerR and Fur Protein Families

Bleher, R. & O'Halloran, T. V.

National Institute of General Medical Sciences

1/1/17 → 11/30/20

Project: Research project

Metals

Physiology

Proteins

Metal ions

Escherichia coli

Regulatory Roles of Zinc Fluxes in Metalloprotein Occupancy and Cell Cycle Progression

O'Halloran, T. V.

National Institute of General Medical Sciences

7/1/15 → 4/30/20

Project: Research project

Metalloproteins

Zinc

Cell Cycle

Proteins

Metals

Dr. Woodruff's Subproject for Regulatory Roles of Zinc Fluxes in Metalloprotein Occupancy and Cell Cycle Progression

O'Halloran, T. V., Woodruff, T. K. & Woodruff, T. K.

National Institute of General Medical Sciences

7/1/15 → 4/30/20

Project: Research project

Metalloproteins

Zinc

Cell Cycle

Proteins

Metals

Research Output 1978 2019

17474 Citations
145 Article
15 Chapter
10 Review article
5 Patent
10 More

2 Citations (Scopus)

Arsenoplatin-1 Is a Dual Pharmacophore Anticancer Agent

Miodragović, D., Merlino, A., Swindell, E. P., Bogachkov, A., Ahn, R. W., Abuhadba, S., Ferraro, G., Marzo, T., Mazar, A. P., Messori, L. & O'Halloran, T. V., Apr 24 2019, In : Journal of the American Chemical Society. 141, 16, p. 6453-6457 5 p.

Research output: Contribution to journal › Article

Antineoplastic Agents

DNA

Arsenic

Cisplatin

Tumors

Bovine eggs release zinc in response to parthenogenetic and sperm-induced egg activation

Que, E. L., Duncan, F. E., Lee, H. C., Hornick, J. E., Vogt, S., Fissore, R. A., O'Halloran, T. V. & Woodruff, T. K., Mar 15 2019, In : Theriogenology. 127, p. 41-48 8 p.

Research output: Contribution to journal › Article

Eggs

Ovum

Spermatozoa

Zinc

zinc

Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation

Stephens, A. D., Liu, P. Z., Kandula, V., Chen, H., Almassalha, L. M., Herman, C., Backman, V., O'Halloran, T. V., Adam, S. A., Goldman, R., Banigan, E. J. & Marko, J. F., Aug 1 2019, In : Molecular biology of the cell. 30, 17, p. 2320-2330 11 p.

Research output: Contribution to journal › Article

Open Access

Heterochromatin

Mechanics

Chromatin

Ion Channels

Cations

1 Citation (Scopus)

Whole-body imaging of cell death provides a systemic, minimally invasive, dynamic, and near-real time indicator for chemotherapeutic drug toxicity

Johnson, S. E., Ugolkov, A., Haney, C. R., Bondarenko, G., Li, L., Waters, E. A., Bergan, R., Tran, A., O'Halloran, T. V., Mazar, A. & Zhao, M., Feb 15 2019, In : Clinical Cancer Research. 25, 4, p. 1331-1342 12 p.

Research output: Contribution to journal › Article

Whole Body Imaging

Drug-Related Side Effects and Adverse Reactions

Cell Death

Drug Therapy

Toxicology

2 Citations (Scopus)

9-ING-41, a small-molecule glycogen synthase kinase-3 inhibitor, is active in neuroblastoma

Ugolkov, A. V., Bondarenko, G. I., Dubrovskyi, O., Berbegall, A. P., Navarro, S., Noguera, R., O'Halloran, T. V., Hendrix, M. J., Giles, F. J. & Mazar, A. P., Sep 1 2018, In : Anti-Cancer Drugs. 29, 8, p. 717-724 8 p.

Research output: Contribution to journal › Article

Glycogen Synthase Kinase 3

Neuroblastoma

irinotecan

Heterografts

Pediatrics