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Thomas V O'Halloran

  • 18197 Citations
1978 …2020

Research output per year

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Personal profile

Research Interests

Dr. O’Halloran’s research interests center on the regulatory biology and chemistry of transition metal receptors involved homeostasis and oxidative stress pathways. His work focuses on the intracellular chemistry of elements essential for growth and proliferation, (i.e. zinc, copper and iron), nanoscale drug delivery mechanisms and on the mechanisms of clinically important anticancer agents that are based on arsenic, molybdenum and platinum chemistry. His discoveries have established the function and structures of two new classes of soluble receptors: metalloregulatory proteins that govern metal responsive gene expression and metallochaperone proteins that control intracellular trafficking pathways.

Education/Academic qualification

Bioinorganic Chemistry, PhD, Columbia University

… → 1985

Bioinorganic Chemistry, MA, University of Missouri

… → 1980

Chemistry, BS, University of Missouri

… → 1979

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Grants

TR&D1 - Resource for Quantitative Elemental Mapping for the Life Sciences

O'Halloran, T. V.

National Institute of General Medical Sciences

12/1/19 → 11/30/24

Project: Research project

    • Driving Biomedical Projects (DBP) - Resource for Quantitative Elemental Mapping for the Life Sciences

    O'Halloran, T. V.

    National Institute of General Medical Sciences

    12/1/19 → 11/30/24

    Project: Research project

    • Laser Ablation Inductively Coupled Plasma Time-of-Flight Mass Spectrometer for Advanced Bioelement Imaging Applications

    O'Halloran, T. V.

    Office of the Director, National Institutes of Health

    8/1/19 → 7/31/22

    Project: Research project

    • Mechanisms of Cadmium Induced Dysglycemia and Type 2 Diabetes Mellitus

    Allen, N. B., El Muayed, M. & O'Halloran, T. V.

    National Institute of Environmental Health Sciences

    9/15/17 → 5/31/22

    Project: Research project

    • Metalloregulation by MerR and Fur Protein Families

    Bleher, R. & O'Halloran, T. V.

    National Institute of General Medical Sciences

    1/1/17 → 11/30/20

    Project: Research project

    • Research Output

    Zinc exocytosis is sensitive to myosin light chain kinase inhibition in mouse and human eggs

    Lee, H. C., Edmonds, M. E., Duncan, F. E., O'Halloran, T. V. & Woodruff, T. K., Apr 15 2020, In : Molecular human reproduction. 26, 4, p. 228-239 12 p.

    Research output: Contribution to journal › Article

    • Arsenoplatin-1 Is a Dual Pharmacophore Anticancer Agent

    Miodragović, D., Merlino, A., Swindell, E. P., Bogachkov, A., Ahn, R. W., Abuhadba, S., Ferraro, G., Marzo, T., Mazar, A. P., Messori, L. & O'Halloran, T. V., Apr 24 2019, In : Journal of the American Chemical Society. 141, 16, p. 6453-6457 5 p.

    Research output: Contribution to journal › Article

    • 7 Scopus citations

    Beyond cisplatin: Combination therapy with arsenic trioxide

    Miodragović, Ð., Swindell, E. P., Sattar Waxali, Z., Bogachkov, A. & O'Halloran, T. V., Oct 1 2019, In : Inorganica Chimica Acta. 496, 119030.

    Research output: Contribution to journal › Review article

    • 5 Scopus citations

    Bovine eggs release zinc in response to parthenogenetic and sperm-induced egg activation

    Que, E. L., Duncan, F. E., Lee, H. C., Hornick, J. E., Vogt, S., Fissore, R. A., O'Halloran, T. V. & Woodruff, T. K., Mar 15 2019, In : Theriogenology. 127, p. 41-48 8 p.

    Research output: Contribution to journal › Article

    • 6 Scopus citations

    Interrogating Intracellular Zinc Chemistry with a Long Stokes Shift Zinc Probe ZincBY-4

    Garwin, S. A., Kelley, M. S., Sue, A. C., Que, E. L., Schatz, G. C., Woodruff, T. K. & O'Halloran, T. V., Jan 1 2019, In : Journal of the American Chemical Society. 141, 42, p. 16696-16705 10 p.

    Research output: Contribution to journal › Article

    • 2 Scopus citations