Timothy J Searl

  • 436 Citations
1989 …2019
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Research Output 1989 2018

  • 436 Citations
  • 23 Article
  • 3 Review article
  • 1 Short survey
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Article
2018
3 Citations (Scopus)
Interstitial Cystitis
Urothelium
Tumor Necrosis Factor-alpha
Urinary Bladder
Cystitis
2016
2 Citations (Scopus)

A1 Adenosine Receptor-Mediated Inhibition of Parasympathetic Neuromuscular Transmission in Human and Murine Urinary Bladder

Searl, T. J., Dynda, D. I., Alanee, S. R., El-Zawahry, A. M., McVary, K. T. & Silinsky, E. M., Jan 1 2016, In : The Journal of pharmacology and experimental therapeutics. 356, 1, p. 116-122 7 p.

Research output: Contribution to journalArticle

2-chloro-N(6)cyclopentyladenosine
Adenosine A1 Receptors
Adenosine
Urinary Bladder
Electric Stimulation
2012
5 Citations (Scopus)

Evidence for constitutively-active adenosine receptors at mammalian motor nerve endings

Searl, T. J. & Silinsky, E. M., Jun 15 2012, In : European Journal of Pharmacology. 685, 1-3, p. 38-41 4 p.

Research output: Contribution to journalArticle

Purinergic P1 Receptors
Nerve Endings
Acetylcholine
Adenosine Deaminase
Purinergic P1 Receptor Antagonists
1 Citation (Scopus)
Protein Kinase C
Urinary Bladder
Protein Kinase Inhibitors
Purinergic Receptors
Staurosporine
2010
1 Citation (Scopus)
Neuromuscular Blocking Agents
Neuromuscular Junction
Ethanol
Tubocurarine
Vecuronium Bromide
2 Citations (Scopus)
Neurotransmitter Agents
Ethanol
Neuromuscular Junction
Nerve Endings
Synapses
2008
6 Citations (Scopus)

Mechanisms of neuromodulation as dissected using Sr2+ at motor nerve endings

Searl, T. J. & Silinsky, E. M., Jun 1 2008, In : Journal of Neurophysiology. 99, 6, p. 2779-2788 10 p.

Research output: Contribution to journalArticle

Nerve Endings
Cyclic AMP
Cyclic AMP-Dependent Protein Kinases
Synaptotagmin II
Synaptotagmins
2006
3 Citations (Scopus)
Bioelectric potentials
Adenosine
Acetylcholine
Animals
Modulation
2005
6 Citations (Scopus)
Casein Kinase II
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
Purinergic P1 Receptors
1-Phosphatidylinositol 4-Kinase
Adenosine
14 Citations (Scopus)
Phorbol Esters
Anura
Adenosine
Calcium
R-SNARE Proteins
2002
15 Citations (Scopus)
Strontium
Binomial Distribution
Acetylcholine
Neurotransmitter Agents
Calcium
15 Citations (Scopus)

Regulation of Rab3A of an endogeneous modulator of neurotransmitter release at mouse motor nerve endings

Hirsh, J. K., Searl, T. J. & Silinsky, E. M., Dec 1 2002, In : Journal of Physiology. 545, 2, p. 337-343 7 p.

Research output: Contribution to journalArticle

Nerve Endings
Neurotransmitter Agents
Acetylcholine
Adenosine
Adenosine A1 Receptor Antagonists
2001
5 Citations (Scopus)

Release and effects of ATP and its derivatives at cholinergic synapses

Silinsky, E. M., Searl, T. J., Redman, R. S. & Hirsh, J. K., May 15 2001, In : Drug Development Research. 52, 1-2, p. 22-33 12 p.

Research output: Contribution to journalArticle

Adenosine
Synapses
Cholinergic Agents
Adenosine Triphosphate
Derivatives
2000
11 Citations (Scopus)
N-Type Calcium Channels
1-Phosphatidylinositol 4-Kinase
Neurotransmitter Agents
Calcium
Dimercaprol
1998
22 Citations (Scopus)
Nerve Endings
Phorbol Esters
Phorbol 12,13-Dibutyrate
Protein Kinase C
Acetylcholine
61 Citations (Scopus)

Mutual occlusion of P2X ATP receptors and nicotinic receptors on sympathetic neurons of the guinea-pig

Searl, T. J., Redman, R. S. & Silinsky, E. M., Aug 1 1998, In : Journal of Physiology. 510, 3, p. 783-791 9 p.

Research output: Contribution to journalArticle

Nicotinic Agonists
Purinergic P2 Receptors
Nicotinic Receptors
Guinea Pigs
Adenosine Triphosphate
1997
41 Citations (Scopus)

Opposing effects of phorbol esters on transmitter release and calcium currents at frog motor nerve endings

Redman, R. S., Searl, T. J., Hirsh, J. K. & Silinsky, E. M., May 15 1997, In : Journal of Physiology. 501, 1, p. 41-48 8 p.

Research output: Contribution to journalArticle

Nerve Endings
Phorbol Esters
Anura
Calcium
Acetylcholine
1994
11 Citations (Scopus)

Neurotransmitter release mechanisms in autonomic nerve terminals

Cunnane, T. C. & Searl, T. J., Jan 1 1994, In : Advances in second messenger and phosphoprotein research. 29, C, p. 425-459 35 p.

Research output: Contribution to journalArticle

Postganglionic Sympathetic Fibers
Autonomic Pathways
Nerve Endings
Autonomic Nervous System
Synapses
1993
1 Citation (Scopus)

Neurotransmitter release mechanisms in sympathetic and parasympathetic nerve terminals

Searl, T. J. & Cunnane, T. C., Jan 1 1993, In : Biochemical Society Transactions. 21, 2, p. 416-420 5 p.

Research output: Contribution to journalArticle

Neurotransmitter Agents
1991
44 Citations (Scopus)

Acetylcholine recycling and release at rat motor nerve terminals studied using (‐)‐vesamicol and troxpyrrolium.

Searl, T., Prior, C. & Marshall, I. G., Dec 1 1991, In : The Journal of Physiology. 444, 1, p. 99-116 18 p.

Research output: Contribution to journalArticle

Recycling
Acetylcholine
Synaptic Vesicles
Motor Endplate
Choline
1990
2 Citations (Scopus)

The effects of (-)-vesamicol on miniature endplate current amplitudes in the rat hemidiaphragm

Marshall, I. G., Prior, C. & Searl, T., Jan 1 1990, In : Journal of Physiology. 424

Research output: Contribution to journalArticle

vesamicol
30 Citations (Scopus)

The effects of l-vesamicol, an inhibitor of vesicular acetylcholine uptake, on two populations of miniature endplate currents at the snake neuromuscular junction

Searl, T., Prior, C. & Marshall, I. G., Jan 1 1990, In : Neuroscience. 35, 1, p. 145-156 12 p.

Research output: Contribution to journalArticle

Snakes
Neuromuscular Junction
Acetylcholine
Population
Colubridae
1989
3 Citations (Scopus)

The effects of l-vesamicol on transmitter release from rat motor nerve terminals at high frequencies of nerve stimulation.

Prior, C., Searl, T. & Marshall, I. G., Dec 1 1989, In : British Journal of Pharmacology. 98 Suppl

Research output: Contribution to journalArticle

Neuromuscular Depolarizing Agents
Phencyclidine
Nerve Endings
Motor Neurons
Electric Stimulation