Tracy S Gertler

  • 1099 Citations
20082023
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Personal profile

Research Interests

Dr. Gertler completed her undergraduate degree in molecular biology and neuroscience at Princeton University, her medical school degree at Northwestern University Feinberg school of medicine, her graduate degree studying neuromodulation in altered dopamingeric states in the basal ganglia at Northwestern University in the lab of Dr. D. James Surmeier, and her pediatrics/child neurology residency at Lurie Children's Hospital in Chicago.

The goal of my basic science research is to understand the mechanisms by which genetic ion channel variants identified in patients with early-onset epilepsy translate to altered channel biophysics when isolated in an expression system, to abnormal intrinsic neuronal excitability when studied in patient-derived neurons (made from induced pluripotent stem cell lines), and to circuit-level disruption resulting in epileptogenesis in transgenic animal models. This three-pronged approach shares a common pathophysiologic protein, and is intended to identify new therapeutic targets by complementary ion channel, neuronal, and synaptic modulation.

My clinical time is split between inpatient attending on the general neurology service, and a dedicated outpatient general neurology/neurogenetics clinic increasingly focused on patients with new-onset genetic epilepsy, epilepsy with multiple family members affected, chromosomal abnormalities including CNVs complicated by epilepsy, and genetic variants of unknown significance requiring careful consideration of rational therapies and integration of translational bench-bedside research approaches.

Training Experience

2013Residency, Northwestern University, McGaw Medical Center (Lurie Children's Hospital)
2016Residency, Northwestern University, McGaw Medical Center (Lurie Children's Hospital)
2017Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine

Education/Academic qualification

MD, Northwestern University Feinberg School of Medicine

… → 2011

PhD, Northwestern University Feinberg School of Medicine

… → 2009

Research interests

  • Epilepsy
  • Genetics: Medical
  • Ion Channels
  • Neurobiology
  • Neurogenetics
  • Pediatric Neurology

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Grants 2015 2023

Research Output 2008 2019

  • 1099 Citations
  • 16 Article
  • 4 Chapter
  • 1 Review article
Open Access
Dystonia
Brain Diseases
Electrophysiology
Movement Disorders
Cricetulus

SCN8A: When Neurons Are So Excited, They Just Can’t Hide It

Gertler, T. S. & Carvill, G. L., Jul 1 2019, In : Epilepsy Currents. 19, 4, p. 269-271 3 p.

Research output: Contribution to journalArticle

Open Access
Seizures
Neurons
Mutation
Brain Diseases
Sodium Channels

Treatment Responsiveness in KCNT1-Related Epilepsy

Fitzgerald, M. P., Fiannacca, M., Smith, D. M., Gertler, T. S., Gunning, B., Syrbe, S., Verbeek, N., Stamberger, H., Weckhuysen, S., Ceulemans, B., Schoonjans, A. S., Rossi, M., Demarquay, G., Lesca, G., Olofsson, K., Koolen, D. A., Hornemann, F., Baulac, S., Rubboli, G., Minks, K. Q. & 5 others, Lee, B., Helbig, I., Dlugos, D., Møller, R. S. & Bearden, D., Jul 15 2019, In : Neurotherapeutics. 16, 3, p. 848-857 10 p.

Research output: Contribution to journalArticle

Epilepsy
Quinidine
Seizures
Therapeutics
NADP

KCNT1-associated epilepsy

Bean, A. MP. A. HH. P. RA. W. SE. & Gertler, TS., 2018, Genereviews. Seattle: University of Washington, p. 6

Research output: Chapter in Book/Report/Conference proceedingChapter

KCNT1-Related Epilepsy

Gertler, T., Bearden, D., Bhattacharjee, A. & Carvill, G., 2018, GeneReviews((R)). Adam, M. P., Ardinger, H. H., Pagon, R. A., Wallace, S. E., Bean, L. J. H., Stephens, K. & Amemiya, A. (eds.). Seattle (WA): University of Washington, Seattle University of Washington, Seattle. GeneReviews is a registered trademark of the University of Washington, Seattle. All rights reserved.

Research output: Chapter in Book/Report/Conference proceedingChapter