Tracy S Gertler

  • 1188 Citations

Research output per year

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Personal profile

Research Interests

Dr. Gertler completed her undergraduate degree in molecular biology and neuroscience at Princeton University, her medical school degree at Northwestern University Feinberg school of medicine, her graduate degree studying neuromodulation in altered dopamingeric states in the basal ganglia at Northwestern University in the lab of Dr. D. James Surmeier, and her pediatrics/child neurology residency at Lurie Children's Hospital in Chicago.

The goal of my basic science research is to understand the mechanisms by which genetic ion channel variants identified in patients with early-onset epilepsy translate to altered channel biophysics when isolated in an expression system, to abnormal intrinsic neuronal excitability when studied in patient-derived neurons (made from induced pluripotent stem cell lines), and to circuit-level disruption resulting in epileptogenesis in transgenic animal models. This three-pronged approach shares a common pathophysiologic protein, and is intended to identify new therapeutic targets by complementary ion channel, neuronal, and synaptic modulation.

My clinical time is split between inpatient attending on the general neurology service, and a dedicated outpatient general neurology/neurogenetics clinic increasingly focused on patients with new-onset genetic epilepsy, epilepsy with multiple family members affected, chromosomal abnormalities including CNVs complicated by epilepsy, and genetic variants of unknown significance requiring careful consideration of rational therapies and integration of translational bench-bedside research approaches.

Training Experience

2013Residency, Northwestern University, McGaw Medical Center (Lurie Children's Hospital)
2016Residency, Northwestern University, McGaw Medical Center (Lurie Children's Hospital)
2017Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine

Education/Academic qualification

MD, Northwestern University Feinberg School of Medicine

… → 2011

PhD, Northwestern University Feinberg School of Medicine

… → 2009

Research interests

  • Epilepsy
  • Genetics: Medical
  • Ion Channels
  • Neurobiology
  • Neurogenetics
  • Pediatric Neurology

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Research Output

  • 1188 Citations
  • 16 Article
  • 5 Chapter
  • 1 Review article

A single-center, retrospective analysis of genotype-phenotype correlations in children with Dravet syndrome

Gertler, T. S., Calhoun, J. & Laux, L., Feb 2020, In : Seizure. 75, p. 1-6 6 p.

Research output: Contribution to journalArticle

  • 1 Scopus citations
    Open Access
  • SCN8A: When Neurons Are So Excited, They Just Can’t Hide It

    Gertler, T. S. & Carvill, G. L., Jul 1 2019, In : Epilepsy Currents. 19, 4, p. 269-271 3 p.

    Research output: Contribution to journalArticle

    Open Access
  • Treatment Responsiveness in KCNT1-Related Epilepsy

    Fitzgerald, M. P., Fiannacca, M., Smith, D. M., Gertler, T. S., Gunning, B., Syrbe, S., Verbeek, N., Stamberger, H., Weckhuysen, S., Ceulemans, B., Schoonjans, A. S., Rossi, M., Demarquay, G., Lesca, G., Olofsson, K., Koolen, D. A., Hornemann, F., Baulac, S., Rubboli, G., Minks, K. Q. & 5 others, Lee, B., Helbig, I., Dlugos, D., Møller, R. S. & Bearden, D., Jul 15 2019, In : Neurotherapeutics. 16, 3, p. 848-857 10 p.

    Research output: Contribution to journalArticle

  • 8 Scopus citations

    KCNT1-associated epilepsy

    Bean, A. MP. A. HH. P. RA. W. SE. & Gertler, TS., 2018, Genereviews. Seattle: University of Washington, p. 6

    Research output: Chapter in Book/Report/Conference proceedingChapter