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Personal profile

Research Interests

Dr. Kume’s research interests focus on cardiovascular development, cardiovascular stem/progenitor cells, and angiogenesis. Current studies include the role of Foxc transcription factors in cardiovascular development and disease.

Education/Academic qualification

PhD, University of Tokyo

… → 1996

Research interests

  • Cardiovascular Diseases
  • Cardiovascular System
  • Developmental Biology
  • Developmental Genetics
  • Stem Cells
  • Vascular Biology

Fingerprint Dive into the research topics where Tsutomu Kume is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 4 Similar Profiles
Forkhead Transcription Factors Medicine & Life Sciences
Blood Vessels Medicine & Life Sciences
Endothelial Cells Medicine & Life Sciences
Transcription Factors Medicine & Life Sciences
Neural Crest Medicine & Life Sciences
Winged-Helix Transcription Factors Medicine & Life Sciences
Endothelial cells Chemical Compounds
Leukemia, Erythroblastic, Acute Medicine & Life Sciences

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Grants 2009 2022

Blood Vessels
Physiologic Neovascularization
Pathologic Neovascularization
Endothelial Cells
Neural Crest
Meibomian Glands
Epithelial Cells
Forkhead Transcription Factors
Lymphatic Vessels
Lymphatic System
Cardiac Myocytes
Cell Differentiation
Stem Cells
Small Interfering RNA
Transcription Factors

Research Output 1992 2019

Hemodynamic regulation of perivalvular endothelial gene expression prevents deep venous thrombosis

Welsh, J. D., Hoofnagle, M. H., Bamezai, S., Oxendine, M., Lim, L., Hall, J. D., Yang, J., Schultz, S., Engel, J. D., Kume, T., Oliver, G., Jimenez, J. M. & Kahn, M. L., Dec 2 2019, In : Journal of Clinical Investigation. 129, 12, p. 5489-5500 12 p.

Research output: Contribution to journalArticle

Open Access
Venous Thrombosis
Gene Expression
Pulmonary Embolism
Endothelial Cells
1 Citation (Scopus)

Organ/tissue-specific vascular endothelial cell heterogeneity in health and disease

Minami, T., Muramatsu, M. & Kume, T., Jan 1 2019, In : Biological and Pharmaceutical Bulletin. 42, 10, p. 1609-1619 11 p.

Research output: Contribution to journalArticle

Open Access
Endothelial Cells
Blood Vessels
Lymphatic System
1 Citation (Scopus)

The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells

Adane, B., Ye, H., Khan, N., Pei, S., Minhajuddin, M., Stevens, B. M., Jones, C. L., D'Alessandro, A., Reisz, J. A., Zaberezhnyy, V., Gasparetto, M., Ho, T. C., Kelly, K. K., Myers, J. R., Ashton, J. M., Siegenthaler, J., Kume, T., Campbell, E. L., Pollyea, D. A., Becker, M. W. & 1 others, Jordan, C. T., Apr 2 2019, In : Cell reports. 27, 1, p. 238-254.e6

Research output: Contribution to journalArticle

Open Access
Stem cells
NADPH Oxidase
1 Citation (Scopus)

Endothelial immune activation programmes cell-fate decisions and angiogenesis by inducing angiogenesis regulator DLL4 through TLR4-ERK-FOXC2 signalling

Xia, S., Menden, H. L., Korfhagen, T. R., Kume, T. & Sampath, V., Apr 15 2018, In : Journal of Physiology. 596, 8, p. 1397-1417 21 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Extracellular Signal-Regulated MAP Kinases
Endothelial Cells
Toll-Like Receptors
2 Citations (Scopus)

Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion

Inman, K. E., Caiaffa, C. D., Melton, K. R., Sandell, L. L., Achilleos, A., Kume, T. & Trainor, P. A., Dec 2018, In : Developmental Dynamics. 247, 12, p. 1286-1296 11 p.

Research output: Contribution to journalArticle

Neural Crest
Cell Movement
Persistent Truncus Arteriosus
Parasympathetic Ganglia
Forkhead Transcription Factors