• 4049 Citations
1992 …2022

Research output per year

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Personal profile

Research Interests

Dr. Kume’s research interests focus on cardiovascular development, cardiovascular stem/progenitor cells, and angiogenesis. Current studies include the role of Foxc transcription factors in cardiovascular development and disease.

Education/Academic qualification

PhD, University of Tokyo

… → 1996

Research interests

  • Cardiovascular Diseases
  • Cardiovascular System
  • Developmental Biology
  • Developmental Genetics
  • Stem Cells
  • Vascular Biology

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  • Research Output

    Hemodynamic regulation of perivalvular endothelial gene expression prevents deep venous thrombosis

    Welsh, J. D., Hoofnagle, M. H., Bamezai, S., Oxendine, M., Lim, L., Hall, J. D., Yang, J., Schultz, S., Engel, J. D., Kume, T., Oliver, G., Jimenez, J. M. & Kahn, M. L., Dec 2 2019, In : Journal of Clinical Investigation. 129, 12, p. 5489-5500 12 p.

    Research output: Contribution to journalArticle

    Open Access
  • Organ/tissue-specific vascular endothelial cell heterogeneity in health and disease

    Minami, T., Muramatsu, M. & Kume, T., Jan 1 2019, In : Biological and Pharmaceutical Bulletin. 42, 10, p. 1609-1619 11 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells

    Adane, B., Ye, H., Khan, N., Pei, S., Minhajuddin, M., Stevens, B. M., Jones, C. L., D'Alessandro, A., Reisz, J. A., Zaberezhnyy, V., Gasparetto, M., Ho, T. C., Kelly, K. K., Myers, J. R., Ashton, J. M., Siegenthaler, J., Kume, T., Campbell, E. L., Pollyea, D. A., Becker, M. W. & 1 others, Jordan, C. T., Apr 2 2019, In : Cell reports. 27, 1, p. 238-254.e6

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations

    Endothelial immune activation programmes cell-fate decisions and angiogenesis by inducing angiogenesis regulator DLL4 through TLR4-ERK-FOXC2 signalling

    Xia, S., Menden, H. L., Korfhagen, T. R., Kume, T. & Sampath, V., Apr 15 2018, In : Journal of Physiology. 596, 8, p. 1397-1417 21 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion

    Inman, K. E., Caiaffa, C. D., Melton, K. R., Sandell, L. L., Achilleos, A., Kume, T. & Trainor, P. A., Dec 2018, In : Developmental Dynamics. 247, 12, p. 1286-1296 11 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations