Grants per year
Personal profile
Research Interests
Dr. Kume’s research interests focus on cardiovascular development, cardiovascular stem/progenitor cells, and angiogenesis. Current studies include the role of Foxc transcription factors in cardiovascular development and disease.
Education/Academic qualification
PhD, University of Tokyo
… → 1996
Research interests
- Cardiovascular Diseases
- Cardiovascular System
- Developmental Biology
- Developmental Genetics
- Stem Cells
- Vascular Biology
Fingerprint Dive into the research topics where Tsutomu Kume is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 4 Similar Profiles
Forkhead Transcription Factors
Medicine & Life Sciences
Blood Vessels
Medicine & Life Sciences
Endothelial Cells
Medicine & Life Sciences
Transcription Factors
Medicine & Life Sciences
Neural Crest
Medicine & Life Sciences
Winged-Helix Transcription Factors
Medicine & Life Sciences
Endothelial cells
Chemical Compounds
Leukemia, Erythroblastic, Acute
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2009 2022
Molecular mechanisms of Foxc-mediated angiogenesis
National Heart, Lung, and Blood Institute
7/1/18 → 6/30/22
Project: Research project
Blood Vessels
Physiologic Neovascularization
Pathologic Neovascularization
Endothelial Cells
Sirolimus
Mechanisms underlying the formation of the cornea and ocular surface epithelium
Kennedy Institute - National Eye Clinic
5/1/18 → 4/30/22
Project: Research project
Cornea
Epithelium
Neural Crest
Meibomian Glands
Epithelial Cells
A-006 Potential Treatment of Corneal Vascularization
Searle Funds at The Chicago Community Trust
1/1/17 → 12/31/21
Project: Research project
Fox Transcription factors in lymphatic vessel development
National Heart, Lung, and Blood Institute
9/1/15 → 6/30/20
Project: Research project
Forkhead Transcription Factors
Lymphatic Vessels
Lymphangiogenesis
Lymphatic System
Lymphedema
Predoctoral-Erin Lambers: The Role of Foxc1 During the Differentiation of Embryonic Stem Cells into Functional Cardiomyocytes
American Heart Association Midwest Affiliate
7/1/15 → 6/30/17
Project: Research project
Cardiac Myocytes
Cell Differentiation
Stem Cells
Small Interfering RNA
Transcription Factors
Research Output 1992 2019
Hemodynamic regulation of perivalvular endothelial gene expression prevents deep venous thrombosis
Welsh, J. D., Hoofnagle, M. H., Bamezai, S., Oxendine, M., Lim, L., Hall, J. D., Yang, J., Schultz, S., Engel, J. D., Kume, T., Oliver, G., Jimenez, J. M. & Kahn, M. L., Dec 2 2019, In : Journal of Clinical Investigation. 129, 12, p. 5489-5500 12 p.Research output: Contribution to journal › Article
Open Access
Venous Thrombosis
Hemodynamics
Gene Expression
Pulmonary Embolism
Endothelial Cells
1
Citation
(Scopus)
Organ/tissue-specific vascular endothelial cell heterogeneity in health and disease
Minami, T., Muramatsu, M. & Kume, T., Jan 1 2019, In : Biological and Pharmaceutical Bulletin. 42, 10, p. 1609-1619 11 p.Research output: Contribution to journal › Article
Open Access
Endothelial Cells
Blood Vessels
Health
Lymphatic System
Neoplasms
1
Citation
(Scopus)
The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells
Adane, B., Ye, H., Khan, N., Pei, S., Minhajuddin, M., Stevens, B. M., Jones, C. L., D'Alessandro, A., Reisz, J. A., Zaberezhnyy, V., Gasparetto, M., Ho, T. C., Kelly, K. K., Myers, J. R., Ashton, J. M., Siegenthaler, J., Kume, T., Campbell, E. L., Pollyea, D. A., Becker, M. W. & 1 others, , Apr 2 2019, In : Cell reports. 27, 1, p. 238-254.e6Research output: Contribution to journal › Article
Open Access
Stem cells
Oxidoreductases
NADPH Oxidase
NADP
Metabolism
1
Citation
(Scopus)
Endothelial immune activation programmes cell-fate decisions and angiogenesis by inducing angiogenesis regulator DLL4 through TLR4-ERK-FOXC2 signalling
Xia, S., Menden, H. L., Korfhagen, T. R., Kume, T. & Sampath, V., Apr 15 2018, In : Journal of Physiology. 596, 8, p. 1397-1417 21 p.Research output: Contribution to journal › Article
Toll-Like Receptor 4
Extracellular Signal-Regulated MAP Kinases
Lipopolysaccharides
Endothelial Cells
Toll-Like Receptors
2
Citations
(Scopus)
Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion
Inman, K. E., Caiaffa, C. D., Melton, K. R., Sandell, L. L., Achilleos, A., Kume, T. & Trainor, P. A., Dec 2018, In : Developmental Dynamics. 247, 12, p. 1286-1296 11 p.Research output: Contribution to journal › Article
Neural Crest
Cell Movement
Persistent Truncus Arteriosus
Parasympathetic Ganglia
Forkhead Transcription Factors