Personal profile

Research Interests

Dr. Kume’s research interests focus on cardiovascular development, cardiovascular stem/progenitor cells, and angiogenesis. Current studies include the role of Foxc transcription factors in cardiovascular development and disease.


  • Stem Cells
  • Cardiovascular Diseases
  • Developmental genetics
  • Developmental biology
  • Vascular Biology
  • Cardiovascular System

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 3 Similar Profiles
Genes Medicine & Life Sciences
Endothelial Cells Medicine & Life Sciences
Blood Vessels Medicine & Life Sciences
Transcription Factors Medicine & Life Sciences
Forkhead Transcription Factors Medicine & Life Sciences
Mutation Medicine & Life Sciences
Embryonic Structures Medicine & Life Sciences
Endothelial cells Chemical Compounds

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Research Output 1992 2017

1 Citations

Foxc1 Ablated Mice Are Anhidrotic and Recapitulate Features of Human Miliaria Sweat Retention Disorder

Cui, C. Y., Ishii, R., Campbell, D. P., Michel, M., Piao, Y., Kume, T. & Schlessinger, D. Jan 1 2017 In : Journal of Investigative Dermatology. 137, 1, p. 38-45 8 p.

Research output: Research - peer-reviewArticle

Sweat Glands

Foxc1 and Foxc2 are necessary to maintain glomerular podocytes

Motojima, M., Kume, T. & Matsusaka, T. Mar 15 2017 In : Experimental Cell Research. 352, 2, p. 265-272 8 p.

Research output: Research - peer-reviewArticle

Gene Expression
Wounds and Injuries

Foxc1 and foxc2 in the neural crest are required for ocular anterior segment development

Seo, S., Chen, L., Liu, W., Zhao, D., Schultz, K. M., Sasman, A., Liu, T., Zhang, H. F., Gage, P. J. & Kume, T. Mar 1 2017 In : Investigative Ophthalmology and Visual Science. 58, 3, p. 1368-1377 10 p.

Research output: Research - peer-reviewArticle

Neural Crest
Forkhead Transcription Factors
Epithelial Cells

Foxc2CreERT2 knock-in mice mark stage-specific Foxc2-expressing cells during mouse organogenesis

Amin, M. B., Miura, N., Uddin, M. K. M., Islam, M. J., Yoshida, N., Iseki, S., Kume, T., Trainor, P. A., Saitsu, H. & Aoto, K. Jan 1 2017 In : Congenital Anomalies. 57, 1, p. 24-31 8 p.

Research output: Research - peer-reviewArticle

Neural Crest
Embryonic Development
2 Citations

Human venous valve disease caused by mutations in FOXC2 and GJC2

Lyons, O. , Saha, P. , Seet, C. , Kuchta, A. , Arnold, A. , Grover, S. , Rashbrook, V. , Sabine, A. , Vizcay-Barrena, G. , Patel, A. , Ludwinski, F. , Padayachee, S. , Kume, T. , Kwak, B. R. , Brice, G. , Mansour, S. , Ostergaard, P. , Mortimer, P. , Jeffery, S. , Brown, N. & 4 others Makinen, T., Petrova, T. V., Modarai, B. & Smith, A. Aug 1 2017 In : Journal of Experimental Medicine. 214, 8, p. 2437-2452 16 p.

Research output: Research - peer-reviewArticle

Venous Valves
Transcription Factors