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Tsutomu Kume

  • 4049 Citations
1992 …2022

Research output per year

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Personal profile

Research Interests

Dr. Kume’s research interests focus on cardiovascular development, cardiovascular stem/progenitor cells, and angiogenesis. Current studies include the role of Foxc transcription factors in cardiovascular development and disease.

Education/Academic qualification

PhD, University of Tokyo

… → 1996

Research interests

  • Cardiovascular Diseases
  • Cardiovascular System
  • Developmental Biology
  • Developmental Genetics
  • Stem Cells
  • Vascular Biology

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Grants

Molecular mechanisms of Foxc-mediated angiogenesis

Kume, T.

National Heart, Lung, and Blood Institute

7/1/18 → 6/30/22

Project: Research project

    • Mechanisms underlying the formation of the cornea and ocular surface epithelium

    Kume, T.

    Kennedy Institute - National Eye Clinic

    5/1/18 → 4/30/22

    Project: Research project

    • A-006 Potential Treatment of Corneal Vascularization

    Kume, T.

    Searle Funds at The Chicago Community Trust

    1/1/17 → 12/31/21

    Project: Research project

    Fox Transcription factors in lymphatic vessel development

    Kume, T.

    National Heart, Lung, and Blood Institute

    9/1/15 → 6/30/20

    Project: Research project

    • Predoctoral-Erin Lambers: The Role of Foxc1 During the Differentiation of Embryonic Stem Cells into Functional Cardiomyocytes

    Kume, T.

    American Heart Association Midwest Affiliate

    7/1/15 → 6/30/17

    Project: Research project

    • Research Output

    Hemodynamic regulation of perivalvular endothelial gene expression prevents deep venous thrombosis

    Welsh, J. D., Hoofnagle, M. H., Bamezai, S., Oxendine, M., Lim, L., Hall, J. D., Yang, J., Schultz, S., Engel, J. D., Kume, T., Oliver, G., Jimenez, J. M. & Kahn, M. L., Dec 2 2019, In : Journal of Clinical Investigation. 129, 12, p. 5489-5500 12 p.

    Research output: Contribution to journal › Article

    Open Access

    • Organ/tissue-specific vascular endothelial cell heterogeneity in health and disease

    Minami, T., Muramatsu, M. & Kume, T., Jan 1 2019, In : Biological and Pharmaceutical Bulletin. 42, 10, p. 1609-1619 11 p.

    Research output: Contribution to journal › Article

    Open Access
    • 1 Scopus citations

    The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells

    Adane, B., Ye, H., Khan, N., Pei, S., Minhajuddin, M., Stevens, B. M., Jones, C. L., D'Alessandro, A., Reisz, J. A., Zaberezhnyy, V., Gasparetto, M., Ho, T. C., Kelly, K. K., Myers, J. R., Ashton, J. M., Siegenthaler, J., Kume, T., Campbell, E. L., Pollyea, D. A., Becker, M. W. & 1 others, Jordan, C. T., Apr 2 2019, In : Cell reports. 27, 1, p. 238-254.e6

    Research output: Contribution to journal › Article

    Open Access
    • 3 Scopus citations

    Endothelial immune activation programmes cell-fate decisions and angiogenesis by inducing angiogenesis regulator DLL4 through TLR4-ERK-FOXC2 signalling

    Xia, S., Menden, H. L., Korfhagen, T. R., Kume, T. & Sampath, V., Apr 15 2018, In : Journal of Physiology. 596, 8, p. 1397-1417 21 p.

    Research output: Contribution to journal › Article

    • 2 Scopus citations

    Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion

    Inman, K. E., Caiaffa, C. D., Melton, K. R., Sandell, L. L., Achilleos, A., Kume, T. & Trainor, P. A., Dec 2018, In : Developmental Dynamics. 247, 12, p. 1286-1296 11 p.

    Research output: Contribution to journal › Article

    • 2 Scopus citations