Grants per year
Personal profile
Research Interests
Dr. Kume’s research interests focus on cardiovascular development, cardiovascular stem/progenitor cells, and angiogenesis. Current studies include the role of Foxc transcription factors in cardiovascular development and disease.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Molecular Biology, PhD, University of Tokyo
… → 1996
Research interests keywords
- Cardiovascular Diseases
- Cardiovascular System
- Developmental Biology
- Developmental Genetics
- Stem Cells
- Vascular Biology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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The Lymphatic Forum 2025
Kume, T. (PD/PI)
National Heart, Lung, and Blood Institute
1/8/25 → 12/31/25
Project: Research project
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Novel ocular imaging and molecular analysis of anterior eye segment for glaucoma
Kume, T. (PD/PI), Kume, T. (PD/PI), Zhang, H. F. (PD/PI), Zhang, H. F. (PD/PI) & Tan, C. (Other)
3/1/23 → 2/29/28
Project: Research project
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Administrative Supplement to Encourage Research in Valvular Heart Disease (CAROL Act),
Kume, T. (PD/PI)
National Heart, Lung, and Blood Institute
4/1/22 → 3/31/26
Project: Research project
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New roles of endothelial regrowth in ischemic tissue recovery and regeneration
Kume, T. (PD/PI) & Kume, T. (PD/PI)
National Heart, Lung, and Blood Institute
4/1/22 → 3/31/26
Project: Research project
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The identification and pathophysiology of non-infarcted but injured myocardium in the post-ischemic heart
Arora, R. K. (PD/PI), Arora, R. K. (PD/PI), Arora, R. K. (PD/PI), Zhao, M. (PD/PI), Zhao, M. (PD/PI), Zhao, M. (PD/PI), Arora, R. K. (Co-PD/PI), Jin, J. (Co-Investigator), Jin, J. (Co-Investigator), Jin, J. (Co-Investigator), Kume, T. (Co-Investigator), Kume, T. (Co-Investigator), Kume, T. (Co-Investigator), Kwasny, M. J. (Co-Investigator), Kwasny, M. J. (Co-Investigator), Kwasny, M. J. (Co-Investigator), Lomasney, J. W. (Co-Investigator), Lomasney, J. W. (Co-Investigator) & Lomasney, J. W. (Co-Investigator)
National Heart, Lung, and Blood Institute
1/1/21 → 12/31/25
Project: Research project
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FOXC1 and FOXC2 Ablation Causes Abnormal Valvular Endothelial Cell Junctions and Lymphatic Vessel Formation in Myxomatous Mitral Valve Degeneration
Tan, C., Ge, Z. D., Kurup, S., Dyakiv, Y., Liu, T., Muller, W. A. & Kume, T., Sep 1 2024, In: Arteriosclerosis, thrombosis, and vascular biology. 44, 9, p. 1944-1959 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
FOXC1 and FOXC2 regulate growth plate chondrocyte maturation towards hypertrophy in the embryonic mouse limb skeleton
Almubarak, A., Zhang, Q., Zhang, C. H., Abdelwahab, N., Kume, T., Lassar, A. B. & Berry, F. B., Aug 2024, In: Development (Cambridge). 151, 16, dev202798.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
FOXC1 and retinopathy: targeting molecular mechanisms in retinal blood vessel growth
Kume, T., 2024, In: Expert Opinion on Therapeutic Targets. 28, 12, p. 1017-1020 4 p.Research output: Contribution to journal › Editorial › peer-review
Open Access -
FOXC1 regulates endothelial CD98 (LAT1/4F2hc) expression in retinal angiogenesis and blood-retina barrier formation
Bhakuni, T., Norden, P. R., Ujiie, N., Tan, C., Lee, S. K., Tedeschi, T., Hsieh, Y. W., Wang, Y., Liu, T., Fawzi, A. A. & Kume, T., Dec 2024, In: Nature communications. 15, 1, 4097.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Pleiotropy in FOXC1-attributable phenotypes involves altered ciliation and cilia-dependent signaling
Havrylov, S., Chrystal, P., van Baarle, S., French, C. R., MacDonald, I. M., Avasarala, J., Rogers, R. C., Berry, F. B., Kume, T., Waskiewicz, A. J. & Lehmann, O. J., Dec 2024, In: Scientific reports. 14, 1, 20278.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Supplementary Material for: Characterization of Kidney and Skeleton Phenotypes of Mice Double Heterozygous for Foxc1 and Foxc2
Motojima, M. (Creator), Tanimoto, S. (Creator), Ohtsuka, M. (Creator), Matsusaka, T. (Creator), Kume, T. (Creator) & Abe, K. (Creator), Karger Publishers, 2016
DOI: 10.6084/m9.figshare.5129671.v1, https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Characterization_of_Kidney_and_Skeleton_Phenotypes_of_Mice_Double_Heterozygous_for_Foxc1_and_Foxc2/5129671/1
Dataset