• 4135 Citations
1992 …2020

Research output per year

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Research Output

2020

Conditional inactivation of Foxc1 and Foxc2 in neural crest cells leads to cardiac abnormalities

Sanchez, J., Miyake, R., Cheng, A., Liu, T., Iseki, S. & Kume, T., Jan 1 2020, (Accepted/In press) In : Genesis.

Research output: Contribution to journalLetter

In vivo imaging of Schlemm’s canal and limbal vascular network in mouse using visible-light OCT

Zhang, X., Beckmann, L., Miller, D. A., Shao, G., Cai, Z., Sun, C., Sheibani, N., Liu, X., Schuman, J., Johnson, M., Kume, T. & Zhang, H. F., Feb 2020, In : Investigative Ophthalmology and Visual Science. 61, 2, 2761682.

Research output: Contribution to journalArticle

Open Access

The Role of Lymphatic Vascular Function in Metabolic Disorders

Norden, P. R. & Kume, T., May 5 2020, In : Frontiers in Physiology. 11, 404.

Research output: Contribution to journalReview article

Open Access
2019

Hemodynamic regulation of perivalvular endothelial gene expression prevents deep venous thrombosis

Welsh, J. D., Hoofnagle, M. H., Bamezai, S., Oxendine, M., Lim, L., Hall, J. D., Yang, J., Schultz, S., Engel, J. D., Kume, T., Oliver, G., Jimenez, J. M. & Kahn, M. L., Dec 2 2019, In : Journal of Clinical Investigation. 129, 12, p. 5489-5500 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Organ/tissue-specific vascular endothelial cell heterogeneity in health and disease

Minami, T., Muramatsu, M. & Kume, T., Jan 1 2019, In : Biological and Pharmaceutical Bulletin. 42, 10, p. 1609-1619 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells

Adane, B., Ye, H., Khan, N., Pei, S., Minhajuddin, M., Stevens, B. M., Jones, C. L., D'Alessandro, A., Reisz, J. A., Zaberezhnyy, V., Gasparetto, M., Ho, T. C., Kelly, K. K., Myers, J. R., Ashton, J. M., Siegenthaler, J., Kume, T., Campbell, E. L., Pollyea, D. A., Becker, M. W. & 1 others, Jordan, C. T., Apr 2 2019, In : Cell reports. 27, 1, p. 238-254.e6

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2018

Endothelial immune activation programmes cell-fate decisions and angiogenesis by inducing angiogenesis regulator DLL4 through TLR4-ERK-FOXC2 signalling

Xia, S., Menden, H. L., Korfhagen, T. R., Kume, T. & Sampath, V., Apr 15 2018, In : Journal of Physiology. 596, 8, p. 1397-1417 21 p.

Research output: Contribution to journalArticle

3 Scopus citations

Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion

Inman, K. E., Caiaffa, C. D., Melton, K. R., Sandell, L. L., Achilleos, A., Kume, T. & Trainor, P. A., Dec 2018, In : Developmental Dynamics. 247, 12, p. 1286-1296 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Meta-analysis of the likelihood of FOXC1 expression in early-and late-stage tumors

Kume, T. & Shackour, T., Nov 1 2018, In : Oncotarget. 9, 93, p. 36625-36630 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Meta-analysis of the likelihood of FOXC2 expression in earlyand late-stage tumors

Kume, T. & Shackour, T., Sep 1 2018, In : Oncotarget. 9, 70, p. 33396-33402 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Transcription factor Foxc1 is involved in anterior part of cranial base formation

Mya, N., Furutera, T., Okuhara, S., Kume, T., Takechi, M. & Iseki, S., Sep 1 2018, In : Congenital anomalies. 58, 5, p. 158-166 9 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Foxc1 Ablated Mice Are Anhidrotic and Recapitulate Features of Human Miliaria Sweat Retention Disorder

Cui, C. Y., Ishii, R., Campbell, D. P., Michel, M., Piao, Y., Kume, T. & Schlessinger, D., Jan 1 2017, In : Journal of Investigative Dermatology. 137, 1, p. 38-45 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Foxc1 and Foxc2 are necessary to maintain glomerular podocytes

Motojima, M., Kume, T. & Matsusaka, T., Mar 15 2017, In : Experimental Cell Research. 352, 2, p. 265-272 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Foxc1 and foxc2 in the neural crest are required for ocular anterior segment development

Seo, S., Chen, L., Liu, W., Zhao, D., Schultz, K. M., Sasman, A., Liu, T., Zhang, H. F., Gage, P. J. & Kume, T., Mar 2017, In : Investigative Ophthalmology and Visual Science. 58, 3, p. 1368-1377 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Foxc2CreERT2 knock-in mice mark stage-specific Foxc2-expressing cells during mouse organogenesis

Amin, M. B., Miura, N., Uddin, M. K. M., Islam, M. J., Yoshida, N., Iseki, S., Kume, T., Trainor, P. A., Saitsu, H. & Aoto, K., Jan 1 2017, In : Congenital anomalies. 57, 1, p. 24-31 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Human venous valve disease caused by mutations in FOXC2 and GJC2

Lyons, O., Saha, P., Seet, C., Kuchta, A., Arnold, A., Grover, S., Rashbrook, V., Sabine, A., Vizcay-Barrena, G., Patel, A., Ludwinski, F., Padayachee, S., Kume, T., Kwak, B. R., Brice, G., Mansour, S., Ostergaard, P., Mortimer, P., Jeffery, S., Brown, N. & 4 others, Makinen, T., Petrova, T. V., Modarai, B. & Smith, A., Aug 1 2017, In : Journal of Experimental Medicine. 214, 8, p. 2437-2452 16 p.

Research output: Contribution to journalArticle

10 Scopus citations

Regulation of Sema3c and the Interaction between Cardiac Neural Crest and Second Heart Field during Outflow Tract Development

Kodo, K., Shibata, S., Miyagawa-Tomita, S., Ong, S. G., Takahashi, H., Kume, T., Okano, H., Matsuoka, R. & Yamagishi, H., Dec 1 2017, In : Scientific reports. 7, 1, 6771.

Research output: Contribution to journalArticle

13 Scopus citations
2016

Characterization of kidney and skeleton phenotypes of mice double heterozygous for Foxc1 and Foxc2

Motojima, M., Tanimoto, S., Ohtsuka, M., Matsusaka, T., Kume, T. & Abe, K., Jun 9 2016, In : Cells Tissues Organs. 201, 5, p. 380-389 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Endothelial cell specification in the somite is compromised in Pax3-positive progenitors of Foxc1/2 conditional mutants, with loss of forelimb myogenesis

Mayeuf-Louchart, A., Montarras, D., Bodin, C., Kume, T., Vincent, S. D. & Buckingham, M., Mar 1 2016, In : Development (Cambridge). 143, 5, p. 872-879 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Foxc1 and Foxc2 deletion causes abnormal lymphangiogenesis and correlates with ERK hyperactivation

Fatima, A., Wang, Y., Uchida, Y., Norden, P., Liu, T., Culver, A., Dietz, W. H., Culver, F., Millay, M., Mukouyama, Y. S. & Kume, T., Jul 1 2016, In : Journal of Clinical Investigation. 126, 7, p. 2437-2451 15 p.

Research output: Contribution to journalArticle

26 Scopus citations
48 Scopus citations

Foxc1 Regulates Early Cardiomyogenesis and Functional Properties of Embryonic Stem Cell Derived Cardiomyocytes

Lambers, E., Arnone, B., Fatima, A., Qin, G., Andrew Wasserstrom, J. & Kume, T., Jun 1 2016, In : Stem Cells. 34, 6, p. 1487-1500 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Navigating the labyrinth of cardiac regeneration

Lambers, E. & Kume, T., Jul 1 2016, In : Developmental Dynamics. 245, 7, p. 751-761 11 p.

Research output: Contribution to journalReview article

6 Scopus citations
2015

Induction of hypoxia in vascular endothelial cell culture

Koo, H. Y., Millay, M. & Kume, T., Jan 1 2015, Handbook of Vascular Biology Techniques. Springer Netherlands, p. 23-27 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lymphatic vessel development: Fluid flow and valve-forming cells

Kume, T., Aug 3 2015, In : Journal of Clinical Investigation. 125, 8, p. 2924-2926 3 p.

Research output: Contribution to journalComment/debate

4 Scopus citations

Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium

Jang, I. H., Lu, Y. F., Zhao, L., Wenzel, P. L., Kume, T., Datta, S. M., Arora, N., Guiu, J., Lagha, M., Kim, P. G., Do, E. K., Kim, J. H., Schlaeger, T. M., Zon, L. I., Bigas, A., Burns, C. E. & Daley, G. Q., Jan 1 2015, In : Blood. 125, 9, p. 1418-1426 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Whole-mount immunostaining methods to study the blood and lymphatic vasculature in the embryonic mouse skin and adult mouse cornea

Fatima, A., Marie-Schultz, K., Seo, S., Culver, F., Culver, A. & Kume, T., Jan 1 2015, Handbook of Vascular Biology Techniques. Springer Netherlands, p. 245-253 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

A lymphatic defect causes ocular hypertension and glaucoma in mice

Thomson, B. R., Heinen, S., Jeansson, M., Ghosh, A. K., Fatima, A., Sung, H. K., Onay, T., Chen, H., Yamaguchi, S., Economides, A. N., Flenniken, A., Gale, N. W., Hong, Y. K., Fawzi, A., Liu, X., Kume, T. & Quaggin, S. E., Oct 1 2014, In : Journal of Clinical Investigation. 124, 10, p. 4320-4324 5 p.

Research output: Contribution to journalArticle

71 Scopus citations

Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation

Omatsu, Y., Seike, M., Sugiyama, T., Kume, T. & Nagasawa, T., Jan 1 2014, In : Nature. 508, 7497, p. 536-540 5 p.

Research output: Contribution to journalArticle

111 Scopus citations

In vitro differentiation and expansion of vascular endothelial cells derived from mouse embryonic stem cell.

Bolli, R., Fatima, A., Nassano-Mille, C. & Kume, T., 2014, Manual of Research Techniques in Cardiovascular Medicine. New Jersey: Wiley-Blackwell

Research output: Chapter in Book/Report/Conference proceedingChapter

In vivo corneal neovascularization imaging by optical-resolution photoacoustic microscopy

Liu, W., Schultz, K. M., Zhang, K., Sasman, A., Gao, F., Kume, T. & Zhang, H. F., Jun 2014, In : Photoacoustics. 2, 2, p. 81-86 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Murine Notch1 is required for lymphatic vascular morphogenesis during development

Fatima, A., Culver, A., Culver, F., Liu, T., Dietz, W. H., Thomson, B. R., Hadjantonakis, A. K., Quaggin, S. E. & Kume, T., Jul 2014, In : Developmental Dynamics. 243, 7, p. 957-964 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Mutation of FOXC and PITX induces cerebral small-vessel disease

French, C. R., Seshadri, S., Destefano, A. L., Fornage, M., Arnold, C. R., Gage, P. J., Skarie, J. M., Dobyns, W. B., Millen, K. J., Liu, T., Dietz, W., Kume, T., Hofker, M., Emery, D. J., Childs, S. J., Waskiewicz, A. J. & Lehmann, O. J., Nov 3 2014, In : Journal of Clinical Investigation. 124, 11, p. 4877-4881 5 p.

Research output: Contribution to journalArticle

47 Scopus citations
2013

FoxC1-Dependent Regulation of Vascular Endothelial Growth Factor Signaling in Corneal Avascularity

Koo, H. Y. & Kume, T., Jan 2013, In : Trends in Cardiovascular Medicine. 23, 1, 1 p.

Research output: Contribution to journalReview article

7 Scopus citations

FOXC1 is enriched in the mammary luminal progenitor population, but is not necessary for mouse mammary ductal morphogenesis1

Sizemore, G. M., Sizemore, S. T., Pal, B., Booth, C. N., Seachrist, D. D., Abdul-Karim, F. W., Kume, T. & Keri, R. A., Dec 9 2013, In : Biology of reproduction. 89, 1, 10.

Research output: Contribution to journalArticle

8 Scopus citations

Foxc1 is required by pericytes during fetal brain angiogenesis

Siegenthaler, J. A., Choe, Y., Patterson, K. P., Hsieh, I., Li, D., Jaminet, S. C., Daneman, R., Kume, T., Huang, E. J. & Pleasure, S. J., Jul 15 2013, In : Biology Open. 2, 7, p. 647-659 13 p.

Research output: Contribution to journalArticle

36 Scopus citations

Hesr2 knockout mice develop aortic valve disease with advancing age

Kokubo, H., Miyagawa-Tomita, S., Nakashima, Y., Kume, T., Yoshizumi, M., Nakanishi, T. & Saga, Y., Mar 1 2013, In : Arteriosclerosis, thrombosis, and vascular biology. 33, 3, p. e84-e92

Research output: Contribution to journalArticle

9 Scopus citations

Interaction between Foxc1 and Fgf8 during Mammalian Jaw Patterning and in the Pathogenesis of Syngnathia

Inman, K. E., Purcell, P., Kume, T. & Trainor, P. A., Dec 1 2013, In : PLoS genetics. 9, 12, e1003949.

Research output: Contribution to journalArticle

29 Scopus citations
2012

Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth

Seo, S., Singh, H. P., Lacal, P. M., Sasman, A., Fatima, A., Liu, T., Schultz, K. M., Losordo, D. W., Lehmann, O. J. & Kume, T., Feb 7 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 6, p. 2015-2020 6 p.

Research output: Contribution to journalArticle

60 Scopus citations

Generation of conditional alleles for Foxc1 and Foxc2 in mice

Sasman, A., Nassano-Miller, C., Shim, K. S., Koo, H. Y., Liu, T., Schultz, K. M., Millay, M., Nanano, A., Kang, M., Suzuki, T. & Kume, T., Oct 1 2012, In : Genesis. 50, 10, p. 766-774 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Ligand-dependent notch signaling in vascular formation

Kume, T., Apr 19 2012, Notch Signaling in Embryology and Cancer. p. 210-222 13 p. (Advances in Experimental Medicine and Biology; vol. 727).

Research output: Chapter in Book/Report/Conference proceedingChapter

48 Scopus citations

Reply to Chakrabarti et al. Corneal angiogenesis in patients with null FOXC1 variants

Seo, S., Singh, H. P., Lacal, P. M., Sasman, A., Fatima, A., Liu, T., Schultz, K. M., Losordo, D. W., Lehmann, O. J. & Kume, T., Jun 12 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 24

Research output: Contribution to journalLetter

The role of FoxC2 transcription factor in tumor angiogenesis

Kume, T., Jan 13 2012, In : Journal of Oncology. 204593.

Research output: Contribution to journalReview article

32 Scopus citations
2011

Angiopoietin-1/Tie2 signal augments basal notch signal controlling vascular quiescence by inducing delta-like 4 expression through AKT-mediated activation of β-catenin

Zhang, J., Fukuhara, S., Sako, K., Takenouchi, T., Kitani, H., Kume, T., Koh, G. Y. & Mochizuki, N., Mar 11 2011, In : Journal of Biological Chemistry. 286, 10, p. 8055-8066 12 p.

Research output: Contribution to journalArticle

80 Scopus citations

Erratum: Retinoic acid from the meninges regulates cortical neuron generation (Cell (2009) 139 (597-609))

Siegenthaler, J. A., Ashique, A. M., Zarbalis, K., Patterson, K. P., Hecht, J. H., Kane, M. A., Folias, A. E., Choe, Y., May, S. R., Kume, T., Napoli, J. L., Peterson, A. S. & Pleasure, S. J., Aug 5 2011, In : Cell. 146, 3, 1 p.

Research output: Contribution to journalComment/debate

2010

Specification of arterial, venous, and lymphatic endothelial cells during embryonic development

Kume, T., May 1 2010, In : Histology and histopathology. 25, 5, p. 637-646 10 p.

Research output: Contribution to journalReview article

73 Scopus citations

The cooperative roles of Foxc1 and Foxc2 in cardiovascular development

Kume, T., 2010, Forkhead Transcription Factors: Vital Elements in Biology and Medicine. Maiese, K. (ed.). New York: Springer Sciences

Research output: Chapter in Book/Report/Conference proceedingChapter

The Foxc2 transcription factor regulates tumor angiogenesis

Sano, H., LeBoeuf, J. P., Novitskiy, S. V., Seo, S., Zaja-Milatovic, S., Dikov, M. M. & Kume, T., Feb 5 2010, In : Biochemical and Biophysical Research Communications. 392, 2, p. 201-206 6 p.

Research output: Contribution to journalArticle

48 Scopus citations
2009

Foxc2 transcription factor as a regulator of angiogenesis via induction of integrin β3 expression

Hayashi, H. & Kume, T., Jan 1 2009, In : Cell Adhesion and Migration. 3, 1, p. 24-26 3 p.

Research output: Contribution to journalComment/debate

14 Scopus citations

Pax3:Foxc2 Reciprocal Repression in the Somite Modulates Muscular versus Vascular Cell Fate Choice in Multipotent Progenitors

Lagha, M., Brunelli, S., Messina, G., Cumano, A., Kume, T., Relaix, F. & Buckingham, M. E., Dec 15 2009, In : Developmental Cell. 17, 6, p. 892-899 8 p.

Research output: Contribution to journalArticle

63 Scopus citations