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Research Output 1992 2019

2019

The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells

Adane, B., Ye, H., Khan, N., Pei, S., Minhajuddin, M., Stevens, B. M., Jones, C. L., D'Alessandro, A., Reisz, J. A., Zaberezhnyy, V., Gasparetto, M., Ho, T. C., Kelly, K. K., Myers, J. R., Ashton, J. M., Siegenthaler, J., Kume, T., Campbell, E. L., Pollyea, D. A., Becker, M. W. & 1 others, Jordan, C. T., Apr 2 2019, In : Cell reports. 27, 1, p. 238-254.e6

Research output: Contribution to journalArticle

Open Access
Stem cells
Oxidoreductases
NADPH Oxidase
NADP
Metabolism
2018
1 Citation (Scopus)

Endothelial immune activation programmes cell-fate decisions and angiogenesis by inducing angiogenesis regulator DLL4 through TLR4-ERK-FOXC2 signalling

Xia, S., Menden, H. L., Korfhagen, T. R., Kume, T. & Sampath, V., Apr 15 2018, In : Journal of Physiology. 596, 8, p. 1397-1417 21 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Extracellular Signal-Regulated MAP Kinases
Lipopolysaccharides
Endothelial Cells
Toll-Like Receptors
2 Citations (Scopus)

Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion

Inman, K. E., Caiaffa, C. D., Melton, K. R., Sandell, L. L., Achilleos, A., Kume, T. & Trainor, P. A., Dec 1 2018, In : Developmental Dynamics. 247, 12, p. 1286-1296 11 p.

Research output: Contribution to journalArticle

Neural Crest
Cell Movement
Persistent Truncus Arteriosus
Parasympathetic Ganglia
Forkhead Transcription Factors
1 Citation (Scopus)

Meta-analysis of the likelihood of FOXC1 expression in early-and late-stage tumors

Kume, T. & Shackour, T., Nov 1 2018, In : Oncotarget. 9, 93, p. 36625-36630 6 p.

Research output: Contribution to journalArticle

Meta-Analysis
Neoplasms
Forkhead Transcription Factors
Databases
Staining and Labeling
1 Citation (Scopus)

Meta-analysis of the likelihood of FOXC2 expression in earlyand late-stage tumors

Kume, T. & Shackour, T., Sep 1 2018, In : Oncotarget. 9, 70, p. 33396-33402 7 p.

Research output: Contribution to journalArticle

Meta-Analysis
Neoplasms
Forkhead Transcription Factors
Databases
Staining and Labeling
1 Citation (Scopus)

Transcription factor Foxc1 is involved in anterior part of cranial base formation

Mya, N., Furutera, T., Okuhara, S., Kume, T., Takechi, M. & Iseki, S., Sep 1 2018, In : Congenital Anomalies. 58, 5, p. 158-166 9 p.

Research output: Contribution to journalArticle

Skull Base
Cartilage
Transcription Factors
Osteogenesis
Chondrogenesis
2017
6 Citations (Scopus)

Foxc1 Ablated Mice Are Anhidrotic and Recapitulate Features of Human Miliaria Sweat Retention Disorder

Cui, C. Y., Ishii, R., Campbell, D. P., Michel, M., Piao, Y., Kume, T. & Schlessinger, D., Jan 1 2017, In : Journal of Investigative Dermatology. 137, 1, p. 38-45 8 p.

Research output: Contribution to journalArticle

Miliaria
Sweat Glands
Sweat
Ducts
Differentiation Antigens
6 Citations (Scopus)

Foxc1 and Foxc2 are necessary to maintain glomerular podocytes

Motojima, M., Kume, T. & Matsusaka, T., Mar 15 2017, In : Experimental Cell Research. 352, 2, p. 265-272 8 p.

Research output: Contribution to journalArticle

Podocytes
Tamoxifen
Kidney
Biological Phenomena
Gene Expression
13 Citations (Scopus)

Foxc1 and foxc2 in the neural crest are required for ocular anterior segment development

Seo, S., Chen, L., Liu, W., Zhao, D., Schultz, K. M., Sasman, A., Liu, T., Zhang, H. F., Gage, P. J. & Kume, T., Mar 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 3, p. 1368-1377 10 p.

Research output: Contribution to journalArticle

Neural Crest
Forkhead Transcription Factors
Mutation
Cornea
Limbus Corneae
2 Citations (Scopus)

Foxc2CreERT2 knock-in mice mark stage-specific Foxc2-expressing cells during mouse organogenesis

Amin, M. B., Miura, N., Uddin, M. K. M., Islam, M. J., Yoshida, N., Iseki, S., Kume, T., Trainor, P. A., Saitsu, H. & Aoto, K., Jan 1 2017, In : Congenital anomalies. 57, 1, p. 24-31 8 p.

Research output: Contribution to journalArticle

Organogenesis
Tamoxifen
Neural Crest
Embryonic Development
Winged-Helix Transcription Factors
7 Citations (Scopus)

Human venous valve disease caused by mutations in FOXC2 and GJC2

Lyons, O., Saha, P., Seet, C., Kuchta, A., Arnold, A., Grover, S., Rashbrook, V., Sabine, A., Vizcay-Barrena, G., Patel, A., Ludwinski, F., Padayachee, S., Kume, T., Kwak, B. R., Brice, G., Mansour, S., Ostergaard, P., Mortimer, P., Jeffery, S., Brown, N. & 4 others, Makinen, T., Petrova, T. V., Modarai, B. & Smith, A., Aug 1 2017, In : Journal of Experimental Medicine. 214, 8, p. 2437-2452 16 p.

Research output: Contribution to journalArticle

Venous Valves
Mutation
Calcineurin
Connexins
Transcription Factors
6 Citations (Scopus)

Regulation of Sema3c and the Interaction between Cardiac Neural Crest and Second Heart Field during Outflow Tract Development

Kodo, K., Shibata, S., Miyagawa-Tomita, S., Ong, S. G., Takahashi, H., Kume, T., Okano, H., Matsuoka, R. & Yamagishi, H., Dec 1 2017, In : Scientific Reports. 7, 1, 6771.

Research output: Contribution to journalArticle

Semaphorins
Neural Crest
Branchial Region
Pulmonary Circulation
Vertebrates
2016
7 Citations (Scopus)

Characterization of kidney and skeleton phenotypes of mice double heterozygous for Foxc1 and Foxc2

Motojima, M., Tanimoto, S., Ohtsuka, M., Matsusaka, T., Kume, T. & Abe, K., Jun 9 2016, In : Cells Tissues Organs. 201, 5, p. 380-389 10 p.

Research output: Contribution to journalArticle

Skeleton
Phenotype
Kidney
Heterozygote
Ureter
10 Citations (Scopus)

Endothelial cell specification in the somite is compromised in Pax3-positive progenitors of Foxc1/2 conditional mutants, with loss of forelimb myogenesis

Mayeuf-Louchart, A., Montarras, D., Bodin, C., Kume, T., Vincent, S. D. & Buckingham, M., Mar 1 2016, In : Development (Cambridge). 143, 5, p. 872-879 8 p.

Research output: Contribution to journalArticle

Somites
Forelimb
Muscle Development
Endothelial Cells
Extremities
18 Citations (Scopus)

Foxc1 and Foxc2 deletion causes abnormal lymphangiogenesis and correlates with ERK hyperactivation

Fatima, A., Wang, Y., Uchida, Y., Norden, P., Liu, T., Culver, A., Dietz, W. H., Culver, F., Millay, M., Mukouyama, Y. S. & Kume, T., Jul 1 2016, In : Journal of Clinical Investigation. 126, 7, p. 2437-2451 15 p.

Research output: Contribution to journalArticle

Lymphangiogenesis
Lymphatic Vessels
Embryonic Structures
Endothelial Cells
Lymphatic System
40 Citations (Scopus)
Stem Cell Niche
Hair Follicle
Hair
Stem Cells
Homeostasis
10 Citations (Scopus)

Foxc1 Regulates Early Cardiomyogenesis and Functional Properties of Embryonic Stem Cell Derived Cardiomyocytes

Lambers, E., Arnone, B., Fatima, A., Qin, G., Andrew Wasserstrom, J. & Kume, T., Jun 1 2016, In : Stem Cells. 34, 6, p. 1487-1500 14 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Cardiac Myocytes
Cell Differentiation
Myocardium
RNA Sequence Analysis
6 Citations (Scopus)

Navigating the labyrinth of cardiac regeneration

Lambers, E. & Kume, T., Jul 1 2016, In : Developmental Dynamics. 245, 7, p. 751-761 11 p.

Research output: Contribution to journalReview article

Inner Ear
Cardiac Myocytes
Regeneration
Heart Diseases
Stem Cells
2015

Induction of hypoxia in vascular endothelial cell culture

Koo, H. Y., Millay, M. & Kume, T., Jan 1 2015, Handbook of Vascular Biology Techniques. Springer Netherlands, p. 23-27 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Endothelial cells
Human Umbilical Vein Endothelial Cells
angiogenesis
Cell culture
blood vessels
3 Citations (Scopus)

Lymphatic vessel development: Fluid flow and valve-forming cells

Kume, T., Aug 3 2015, In : Journal of Clinical Investigation. 125, 8, p. 2924-2926 3 p.

Research output: Contribution to journalComment/debate

Lymphatic Vessels
Blood Vessels
Lymphatic System
Lymphedema
Muscle Development
24 Citations (Scopus)

Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium

Jang, I. H., Lu, Y. F., Zhao, L., Wenzel, P. L., Kume, T., Datta, S. M., Arora, N., Guiu, J., Lagha, M., Kim, P. G., Do, E. K., Kim, J. H., Schlaeger, T. M., Zon, L. I., Bigas, A., Burns, C. E. & Daley, G. Q., Jan 1 2015, In : Blood. 125, 9, p. 1418-1426 9 p.

Research output: Contribution to journalArticle

Hemangioblasts
Endothelial cells
Hematopoiesis
Specifications
Hematopoietic Stem Cells

Whole-mount immunostaining methods to study the blood and lymphatic vasculature in the embryonic mouse skin and adult mouse cornea

Fatima, A., Marie-Schultz, K., Seo, S., Culver, F., Culver, A. & Kume, T., Jan 1 2015, Handbook of Vascular Biology Techniques. Springer Netherlands, p. 245-253 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

cornea
skin (animal)
Cornea
Skin
Blood
2014
57 Citations (Scopus)

A lymphatic defect causes ocular hypertension and glaucoma in mice

Thomson, B. R., Heinen, S., Jeansson, M., Ghosh, A. K., Fatima, A., Sung, H. K., Onay, T., Chen, H., Yamaguchi, S., Economides, A. N., Flenniken, A., Gale, N. W., Hong, Y. K., Fawzi, A., Liu, X., Kume, T. & Quaggin, S. E., Oct 1 2014, In : Journal of Clinical Investigation. 124, 10, p. 4320-4324 5 p.

Research output: Contribution to journalArticle

Ocular Hypertension
Glaucoma
Intraocular Pressure
Angiopoietins
Drainage
97 Citations (Scopus)

Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation

Omatsu, Y., Seike, M., Sugiyama, T., Kume, T. & Nagasawa, T., Jan 1 2014, In : Nature. 508, 7497, p. 536-540 5 p.

Research output: Contribution to journalArticle

Stem Cell Niche
Hematopoietic Stem Cells
Bone Marrow
Stem Cell Factor
Maintenance

In vitro differentiation and expansion of vascular endothelial cells derived from mouse embryonic stem cell.

Bolli, R., Fatima, A., Nassano-Mille, C. & Kume, T., 2014, Manual of Research Techniques in Cardiovascular Medicine. New Jersey: Wiley-Blackwell

Research output: Chapter in Book/Report/Conference proceedingChapter

23 Citations (Scopus)

In vivo corneal neovascularization imaging by optical-resolution photoacoustic microscopy

Liu, W., Schultz, K. M., Zhang, K., Sasman, A., Gao, F., Kume, T. & Zhang, H. F., Jan 1 2014, In : Photoacoustics. 2, 2, p. 81-86 6 p.

Research output: Contribution to journalArticle

photoacoustic microscopy
Corneal Neovascularization
angiogenesis
Optical Imaging
Microscopy
18 Citations (Scopus)

Murine Notch1 is required for lymphatic vascular morphogenesis during development

Fatima, A., Culver, A., Culver, F., Liu, T., Dietz, W. H., Thomson, B. R., Hadjantonakis, A. K., Quaggin, S. E. & Kume, T., Jan 1 2014, In : Developmental Dynamics. 243, 7, p. 957-964 8 p.

Research output: Contribution to journalArticle

Morphogenesis
Lymphatic Vessels
Blood Vessels
Endothelial Cells
Notch1 Receptor
40 Citations (Scopus)

Mutation of FOXC and PITX induces cerebral small-vessel disease

French, C. R., Seshadri, S., Destefano, A. L., Fornage, M., Arnold, C. R., Gage, P. J., Skarie, J. M., Dobyns, W. B., Millen, K. J., Liu, T., Dietz, W., Kume, T., Hofker, M., Emery, D. J., Childs, S. J., Waskiewicz, A. J. & Lehmann, O. J., Nov 3 2014, In : Journal of Clinical Investigation. 124, 11, p. 4877-4881 5 p.

Research output: Contribution to journalArticle

Cerebral Small Vessel Diseases
Mutation
Genome-Wide Association Study
Blood Vessels
Stroke
2013
4 Citations (Scopus)

FoxC1-Dependent Regulation of Vascular Endothelial Growth Factor Signaling in Corneal Avascularity

Koo, H. Y. & Kume, T., Jan 1 2013, In : Trends in Cardiovascular Medicine. 23, 1, 1 p.

Research output: Contribution to journalReview article

Metalloproteases
Vascular Endothelial Growth Factor A
Forkhead Transcription Factors
Neural Crest
Cornea
7 Citations (Scopus)

FOXC1 is enriched in the mammary luminal progenitor population, but is not necessary for mouse mammary ductal morphogenesis1

Sizemore, G. M., Sizemore, S. T., Pal, B., Booth, C. N., Seachrist, D. D., Abdul-Karim, F. W., Kume, T. & Keri, R. A., Dec 9 2013, In : Biology of reproduction. 89, 1, 10.

Research output: Contribution to journalArticle

Breast
Breast Neoplasms
Population
Human Mammary Glands
Morphogenesis
34 Citations (Scopus)

Foxc1 is required by pericytes during fetal brain angiogenesis

Siegenthaler, J. A., Choe, Y., Patterson, K. P., Hsieh, I., Li, D., Jaminet, S. C., Daneman, R., Kume, T., Huang, E. J. & Pleasure, S. J., Jul 15 2013, In : Biology Open. 2, 7, p. 647-659 13 p.

Research output: Contribution to journalArticle

Pericytes
angiogenesis
Brain
brain
blood vessels
9 Citations (Scopus)

Hesr2 knockout mice develop aortic valve disease with advancing age

Kokubo, H., Miyagawa-Tomita, S., Nakashima, Y., Kume, T., Yoshizumi, M., Nakanishi, T. & Saga, Y., Mar 1 2013, In : Arteriosclerosis, thrombosis, and vascular biology. 33, 3

Research output: Contribution to journalArticle

Aortic Diseases
Aortic Valve Insufficiency
Aortic Valve Stenosis
Aortic Valve
Knockout Mice
24 Citations (Scopus)

Interaction between Foxc1 and Fgf8 during Mammalian Jaw Patterning and in the Pathogenesis of Syngnathia

Inman, K. E., Purcell, P., Kume, T. & Trainor, P. A., Dec 1 2013, In : PLoS genetics. 9, 12, e1003949.

Research output: Contribution to journalArticle

Neural Crest
Jaw
jaws
neural crest
pathogenesis
2012
55 Citations (Scopus)

Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth

Seo, S., Singh, H. P., Lacal, P. M., Sasman, A., Fatima, A., Liu, T., Schultz, K. M., Losordo, D. W., Lehmann, O. J. & Kume, T., Feb 7 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 6, p. 2015-2020 6 p.

Research output: Contribution to journalArticle

Forkhead Transcription Factors
Neural Crest
Blood Vessels
Corneal Neovascularization
Lymphatic Vessels
20 Citations (Scopus)

Generation of conditional alleles for Foxc1 and Foxc2 in mice

Sasman, A., Nassano-Miller, C., Shim, K. S., Koo, H. Y., Liu, T., Schultz, K. M., Millay, M., Nanano, A., Kang, M., Suzuki, T. & Kume, T., Oct 1 2012, In : Genesis. 50, 10, p. 766-774 9 p.

Research output: Contribution to journalArticle

Alleles
Embryonic Structures
Mutation
Forkhead Transcription Factors
Animal Diseases
45 Citations (Scopus)

Ligand-dependent notch signaling in vascular formation

Kume, T., Apr 19 2012, Notch Signaling in Embryology and Cancer. p. 210-222 13 p. (Advances in Experimental Medicine and Biology; vol. 727).

Research output: Chapter in Book/Report/Conference proceedingChapter

Blood Vessels
Ligands
Endothelial cells
Notch Receptors
Endothelial Cells

Reply to Chakrabarti et al. Corneal angiogenesis in patients with null FOXC1 variants

Seo, S., Singh, H. P., Lacal, P. M., Sasman, A., Fatima, A., Liu, T., Schultz, K. M., Losordo, D. W., Lehmann, O. J. & Kume, T., Jun 12 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 24

Research output: Contribution to journalLetter

31 Citations (Scopus)

The role of FoxC2 transcription factor in tumor angiogenesis

Kume, T., Jan 13 2012, In : Journal of Oncology. 204593.

Research output: Contribution to journalReview article

Transcription Factors
Neoplasms
Forkhead Transcription Factors
Disease Progression
Pathologic Neovascularization
2011
74 Citations (Scopus)

Angiopoietin-1/Tie2 signal augments basal notch signal controlling vascular quiescence by inducing delta-like 4 expression through AKT-mediated activation of β-catenin

Zhang, J., Fukuhara, S., Sako, K., Takenouchi, T., Kitani, H., Kume, T., Koh, G. Y. & Mochizuki, N., Mar 11 2011, In : Journal of Biological Chemistry. 286, 10, p. 8055-8066 12 p.

Research output: Contribution to journalArticle

Angiopoietin-1
Catenins
Blood Vessels
Chemical activation
Glycogen Synthase Kinase 3

Erratum: Retinoic acid from the meninges regulates cortical neuron generation (Cell (2009) 139 (597-609))

Siegenthaler, J. A., Ashique, A. M., Zarbalis, K., Patterson, K. P., Hecht, J. H., Kane, M. A., Folias, A. E., Choe, Y., May, S. R., Kume, T., Napoli, J. L., Peterson, A. S. & Pleasure, S. J., Aug 5 2011, In : Cell. 146, 3, 1 p.

Research output: Contribution to journalComment/debate

Tretinoin
Neurons
2010

Ligand-Dependent Notch Signaling in Vascular Formation

Kume, T., 2010, Notch Signaling in Embryology and Cancer. Reichrath, J. & Reichrath, S. (eds.). Austin: Landes Bioscience

Research output: Chapter in Book/Report/Conference proceedingChapter

68 Citations (Scopus)

Specification of arterial, venous, and lymphatic endothelial cells during embryonic development

Kume, T., May 1 2010, In : Histology and Histopathology. 25, 5, p. 637-646 10 p.

Research output: Contribution to journalReview article

Embryonic Development
Endothelial Cells
Transcription Factors
Orphan Nuclear Receptors
Genes

The cooperative roles of Foxc1 and Foxc2 in cardiovascular development

Kume, T., 2010, Forkhead Transcription Factors: Vital Elements in Biology and Medicine. Maiese, K. (ed.). New York: Springer Sciences

Research output: Chapter in Book/Report/Conference proceedingChapter

47 Citations (Scopus)

The Foxc2 transcription factor regulates tumor angiogenesis

Sano, H., LeBoeuf, J. P., Novitskiy, S. V., Seo, S., Zaja-Milatovic, S., Dikov, M. M. & Kume, T., Feb 5 2010, In : Biochemical and Biophysical Research Communications. 392, 2, p. 201-206 6 p.

Research output: Contribution to journalArticle

Tumors
Transcription Factors
Neoplasms
Vascular Tissue Neoplasms
Forkhead Transcription Factors
2009
13 Citations (Scopus)

Foxc2 transcription factor as a regulator of angiogenesis via induction of integrin β3 expression

Hayashi, H. & Kume, T., Jan 1 2009, In : Cell Adhesion and Migration. 3, 1, p. 24-26 3 p.

Research output: Contribution to journalComment/debate

Integrins
Transcription Factors
Endothelial Cells
Cell Adhesion
Cell Movement
60 Citations (Scopus)

Pax3:Foxc2 Reciprocal Repression in the Somite Modulates Muscular versus Vascular Cell Fate Choice in Multipotent Progenitors

Lagha, M., Brunelli, S., Messina, G., Cumano, A., Kume, T., Relaix, F. & Buckingham, M. E., Dec 15 2009, In : Developmental Cell. 17, 6, p. 892-899 8 p.

Research output: Contribution to journalArticle

Cytology
Somites
Stem cells
Blood Vessels
Muscle
239 Citations (Scopus)

Retinoic Acid from the Meninges Regulates Cortical Neuron Generation

Siegenthaler, J. A., Ashique, A. M., Zarbalis, K., Patterson, K. P., Hecht, J. H., Kane, M. A., Folias, A. E., Choe, Y., May, S. R., Kume, T., Napoli, J. L., Peterson, A. S. & Pleasure, S. J., Oct 30 2009, In : Cell. 139, 3, p. 597-609 13 p.

Research output: Contribution to journalArticle

Meninges
Tretinoin
Neurons
Phenotype
Prosencephalon
34 Citations (Scopus)

The cooperative roles of Foxcl and Foxc2 in cardiovascular development

Kume, T., Dec 1 2009, Forkhead Transcription Factors: Vital Elements in Biology and Medicine. p. 63-77 15 p. (Advances in Experimental Medicine and Biology; vol. 665).

Research output: Chapter in Book/Report/Conference proceedingChapter

Forkhead Transcription Factors
Genes
Overlapping Genes
Multiple Abnormalities
Lymphatic Vessels
2008
17 Citations (Scopus)

Endothelial Bmp4 Is Induced During Arterial Remodeling: Effects on Smooth Muscle Cell Migration and Proliferation

Corriere, M. A., Rogers, C. M., Eliason, J. L., Faulk, J., Kume, T., Hogan, B. L. M. & Guzman, R. J., Mar 1 2008, In : Journal of Surgical Research. 145, 1, p. 142-149 8 p.

Research output: Contribution to journalArticle

Smooth Muscle Myocytes
Cell Movement
Bone Morphogenetic Proteins
Cell Proliferation
Ligation
63 Citations (Scopus)
Forkhead Transcription Factors
CXC Chemokines
Chemokine Receptors
Endothelial cells
Cell Movement