Grants per year
Personal profile
Research Interests
Primary research interest in using structural biology to further understanding of signaling systems.
Training Experience
| 1999 | Postdoctoral Fellowship, Northwestern University |
Education/Academic qualification
PhD, Northwestern University
… → 1998
Research interests
- Brain and Nervous System
- Cancer Biology
- Molecular Pharmacology
- Signal Transduction
- Structural Biology
- Viral Induced Pathology
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Dive into the research topics where Valerie L Tokars is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants
- 2 Finished
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Preclinical Alzheimers Disease Drug Development of Novel MAPK Inhibitors
Mesulam, M., Watterson, D. M. & Tokars, V. L.
9/1/16 → 5/31/18
Project: Research project
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Preclinical Alzheimer's Disease Drug Development of Novel MAPK Inhibitors
Mesulam, M., Watterson, D. M. & Tokars, V. L.
9/30/12 → 5/31/16
Project: Research project
Research Output
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Best practices for managing large CryoEM facilities
Alewijnse, B., Ashton, A. W., Chambers, M. G., Chen, S., Cheng, A., Ebrahim, M., Eng, E. T., Hagen, W. J. H., Koster, A. J., López, C. S., Lukoyanova, N., Ortega, J., Renault, L., Reyntjens, S., Rice, W. J., Scapin, G., Schrijver, R., Siebert, A., Stagg, S. M., Grum-Tokars, V. & 6 others, , Sep 1 2017, In: Journal of Structural Biology. 199, 3, p. 225-236 12 p.Research output: Contribution to journal › Review article › peer-review
12 Scopus citations -
Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer's Disease Mouse Models
Roy, S. M., Grum-Tokars, V. L., Schavocky, J. P., Saeed, F., Staniszewski, A., Teich, A. F., Arancio, O., Bachstetter, A. D., Webster, S. J., Van Eldik, L. J., Minasov, G., Anderson, W. F., Pelletier, J. C. & Watterson, D. M., Apr 15 2015, In: ACS Chemical Neuroscience. 6, 4, p. 666-680 15 p.Research output: Contribution to journal › Article › peer-review
47 Scopus citations -
Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction
Watterson, D. M., Grum-Tokars, V. L., Roy, S. M., Schavocky, J. P., de Bradaric, B., Bachstetter, A. D., Xing, B., Dimayuga, E., Saeed, F., Zhang, H., Staniszewski, A., Pelletier, J. C., Minasov, G., Anderson, W. F., Arancio, O. & van Eldik, L. J., Jun 26 2013, In: PloS one. 8, 6, e66226.Research output: Contribution to journal › Article › peer-review
51 Scopus citations -
Discovery, synthesis, and structure-based optimization of a series of N -(tert -Butyl)-2-(N -arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease
Jacobs, J., Grum-Tokars, V., Zhou, Y., Turlington, M., Saldanha, S. A., Chase, P., Eggler, A., Dawson, E. S., Baez-Santos, Y. M., Tomar, S., Mielech, A. M., Baker, S. C., Lindsley, C. W., Hodder, P., Mesecar, A. & Stauffer, S. R., Jan 24 2013, In: Journal of Medicinal Chemistry. 56, 2, p. 534-546 13 p.Research output: Contribution to journal › Article › peer-review
77 Scopus citations -
Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding
Turlington, M., Chun, A., Tomar, S., Eggler, A., Grum-Tokars, V., Jacobs, J., Daniels, J. S., Dawson, E., Saldanha, A., Chase, P., Baez-Santos, Y. M., Lindsley, C. W., Hodder, P., Mesecar, A. D. & Stauffer, S. R., Nov 15 2013, In: Bioorganic and Medicinal Chemistry Letters. 23, 22, p. 6172-6177 6 p.Research output: Contribution to journal › Article › peer-review
49 Scopus citations