Valerie L Tokars

  • 946 Citations

Research output per year

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Personal profile

Research Interests

Primary research interest in using structural biology to further understanding of signaling systems.

Training Experience

1999Postdoctoral Fellowship, Northwestern University

Education/Academic qualification

PhD, Northwestern University

… → 1998

Research interests

  • Brain and Nervous System
  • Cancer Biology
  • Molecular Pharmacology
  • Signal Transduction
  • Structural Biology
  • Viral Induced Pathology

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Research Output

  • 946 Citations
  • 17 Article
  • 2 Review article
  • 1 Chapter
  • 1 Comment/debate

Best practices for managing large CryoEM facilities

Alewijnse, B., Ashton, A. W., Chambers, M. G., Chen, S., Cheng, A., Ebrahim, M., Eng, E. T., Hagen, W. J. H., Koster, A. J., López, C. S., Lukoyanova, N., Ortega, J., Renault, L., Reyntjens, S., Rice, W. J., Scapin, G., Schrijver, R., Siebert, A., Stagg, S. M., Grum-Tokars, V. & 6 others, Wright, E. R., Wu, S., Yu, Z., Zhou, Z. H., Carragher, B. & Potter, C. S., Sep 1 2017, In : Journal of Structural Biology. 199, 3, p. 225-236 12 p.

Research output: Contribution to journalReview article

  • 10 Scopus citations

    Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer's Disease Mouse Models

    Roy, S. M., Grum-Tokars, V. L., Schavocky, J. P., Saeed, F., Staniszewski, A., Teich, A. F., Arancio, O., Bachstetter, A. D., Webster, S. J., Van Eldik, L. J., Minasov, G., Anderson, W. F., Pelletier, J. C. & Watterson, D. M., Apr 15 2015, In : ACS Chemical Neuroscience. 6, 4, p. 666-680 15 p.

    Research output: Contribution to journalArticle

  • 40 Scopus citations

    Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction

    Watterson, D. M., Grum-Tokars, V. L., Roy, S. M., Schavocky, J. P., de Bradaric, B., Bachstetter, A. D., Xing, B., Dimayuga, E., Saeed, F., Zhang, H., Staniszewski, A., Pelletier, J. C., Minasov, G., Anderson, W. F., Arancio, O. & van Eldik, L. J., Jun 26 2013, In : PloS one. 8, 6, e66226.

    Research output: Contribution to journalArticle

  • 45 Scopus citations

    Discovery, synthesis, and structure-based optimization of a series of N -(tert -Butyl)-2-(N -arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease

    Jacobs, J., Grum-Tokars, V., Zhou, Y., Turlington, M., Saldanha, S. A., Chase, P., Eggler, A., Dawson, E. S., Baez-Santos, Y. M., Tomar, S., Mielech, A. M., Baker, S. C., Lindsley, C. W., Hodder, P., Mesecar, A. & Stauffer, S. R., Jan 24 2013, In : Journal of Medicinal Chemistry. 56, 2, p. 534-546 13 p.

    Research output: Contribution to journalArticle

  • 40 Scopus citations

    Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding

    Turlington, M., Chun, A., Tomar, S., Eggler, A., Grum-Tokars, V., Jacobs, J., Daniels, J. S., Dawson, E., Saldanha, A., Chase, P., Baez-Santos, Y. M., Lindsley, C. W., Hodder, P., Mesecar, A. D. & Stauffer, S. R., Nov 15 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 22, p. 6172-6177 6 p.

    Research output: Contribution to journalArticle

  • 17 Scopus citations