Valerie L Tokars

  • 980 Citations
19992017

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 980 Citations
  • 17 Article
  • 2 Review article
  • 1 Chapter
  • 1 Comment/debate
2017

Best practices for managing large CryoEM facilities

Alewijnse, B., Ashton, A. W., Chambers, M. G., Chen, S., Cheng, A., Ebrahim, M., Eng, E. T., Hagen, W. J. H., Koster, A. J., López, C. S., Lukoyanova, N., Ortega, J., Renault, L., Reyntjens, S., Rice, W. J., Scapin, G., Schrijver, R., Siebert, A., Stagg, S. M., Grum-Tokars, V. & 6 others, Wright, E. R., Wu, S., Yu, Z., Zhou, Z. H., Carragher, B. & Potter, C. S., Sep 1 2017, In : Journal of Structural Biology. 199, 3, p. 225-236 12 p.

Research output: Contribution to journalReview article

10 Scopus citations
2015

Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer's Disease Mouse Models

Roy, S. M., Grum-Tokars, V. L., Schavocky, J. P., Saeed, F., Staniszewski, A., Teich, A. F., Arancio, O., Bachstetter, A. D., Webster, S. J., Van Eldik, L. J., Minasov, G., Anderson, W. F., Pelletier, J. C. & Watterson, D. M., Apr 15 2015, In : ACS Chemical Neuroscience. 6, 4, p. 666-680 15 p.

Research output: Contribution to journalArticle

43 Scopus citations
2013

Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction

Watterson, D. M., Grum-Tokars, V. L., Roy, S. M., Schavocky, J. P., de Bradaric, B., Bachstetter, A. D., Xing, B., Dimayuga, E., Saeed, F., Zhang, H., Staniszewski, A., Pelletier, J. C., Minasov, G., Anderson, W. F., Arancio, O. & van Eldik, L. J., Jun 26 2013, In : PloS one. 8, 6, e66226.

Research output: Contribution to journalArticle

48 Scopus citations

Discovery, synthesis, and structure-based optimization of a series of N -(tert -Butyl)-2-(N -arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease

Jacobs, J., Grum-Tokars, V., Zhou, Y., Turlington, M., Saldanha, S. A., Chase, P., Eggler, A., Dawson, E. S., Baez-Santos, Y. M., Tomar, S., Mielech, A. M., Baker, S. C., Lindsley, C. W., Hodder, P., Mesecar, A. & Stauffer, S. R., Jan 24 2013, In : Journal of Medicinal Chemistry. 56, 2, p. 534-546 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding

Turlington, M., Chun, A., Tomar, S., Eggler, A., Grum-Tokars, V., Jacobs, J., Daniels, J. S., Dawson, E., Saldanha, A., Chase, P., Baez-Santos, Y. M., Lindsley, C. W., Hodder, P., Mesecar, A. D. & Stauffer, S. R., Nov 15 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 22, p. 6172-6177 6 p.

Research output: Contribution to journalArticle

24 Scopus citations
2012

Mutation of membrane type-1 metalloproteinase, MT1-MMP, causes the multicentric osteolysis and arthritis disease winchester syndrome

Evans, B. R., Mosig, R. A., Lobl, M., Martignetti, C. R., Camacho, C., Grum-Tokars, V., Glucksman, M. J. & Martignetti, J. A., Sep 7 2012, In : American journal of human genetics. 91, 3, p. 572-576 5 p.

Research output: Contribution to journalArticle

35 Scopus citations
2011
2 Scopus citations
2010

Discovery of non-covalent inhibitors of the SARS main proteinase 3CLpro

J, J., Information, N. C. F. B., S, Z., E, D. & Tokars, V. L., 2010, Probe Reports from the NIH Molecular Libraries Program [Internet].. Bethesda: http://www.ncbi.nlm.nih.gov/books/NBK133447/

Research output: Chapter in Book/Report/Conference proceedingChapter

2008

Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors

Ghosh, A. K., Gong, G., Grum-Tokars, V., Mulhearn, D. C., Baker, S. C., Coughlin, M., Prabhakar, B. S., Sleeman, K., Johnson, M. E. & Mesecar, A. D., Oct 15 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 20, p. 5684-5688 5 p.

Research output: Contribution to journalArticle

37 Scopus citations

Evaluating the 3C-like protease activity of SARS-Coronavirus: Recommendations for standardized assays for drug discovery

Grum-Tokars, V., Ratia, K., Begaye, A., Baker, S. C. & Mesecar, A. D., Apr 2008, In : Virus Research. 133, 1, p. 63-73 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Infantile systemic hyalinosis: Case report and review of the literature

Lindvall, L. E., Kormeili, T., Chen, E., Ramirez, M. C. M., Grum-Tokars, V., Glucksman, M. J., Martignetti, J. A., Zaragoza, M. V. & Dyson, S. W., Feb 1 2008, In : Journal of the American Academy of Dermatology. 58, 2, p. 303-307 5 p.

Research output: Contribution to journalReview article

33 Scopus citations
2007

Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors

Ghosh, A. K., Xi, K., Grum-Tokars, V., Xu, X., Ratia, K., Fu, W., Houser, K. V., Baker, S. C., Johnson, M. E. & Mesecar, A. D., Nov 1 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 21, p. 5876-5880 5 p.

Research output: Contribution to journalArticle

46 Scopus citations
2006

Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance

Ghosh, A. K., Sridhar, P. R., Leshchenko, S., Hussain, A. K., Li, J., Kovalevsky, A. Y., Walters, D. E., Wedekind, J. E., Grum-Tokars, V., Das, D., Koh, Y., Maeda, K., Gatanaga, H., Weber, I. T. & Mitsuya, H., Aug 24 2006, In : Journal of Medicinal Chemistry. 49, 17, p. 5252-5261 10 p.

Research output: Contribution to journalArticle

120 Scopus citations

Water in the active site of an All-RNA hairpin ribozyme and effects of Gua8 base variants on the geometry of phosphoryl transfer

Salter, J., Krucinska, J., Alam, S., Grum-Tokars, V. & Wedekind, J. E., Jan 24 2006, In : Biochemistry. 45, 3, p. 686-700 15 p.

Research output: Contribution to journalArticle

67 Scopus citations
2005

Calcium modulates endopeptidase 24.15 (EC 3.4.24.15) membrane association, secondary structure and substrate specificity

Oliveira, V., Garrido, P. A. G., Rodrigues, C. C., Colquhoun, A., Castro, L. M., Almeida, P. C., Shida, C. S., Juliano, M. A., Juliano, L., Camargo, A. C. M., Hyslop, S., Roberts, J. L., Grum-Tokars, V., Glucksman, M. J. & Ferro, E. S., Jun 2005, In : FEBS Journal. 272, 12, p. 2978-2992 15 p.

Research output: Contribution to journalArticle

15 Scopus citations

Conformational heterogeneity at position U37 of an all-RNA hairpin ribozyme with implications for metal binding and the catalytic structure of the S-turn

Alam, S., Grum-Tokars, V., Krucinska, J., Kundracik, M. L. & Wedekind, J. E., Nov 8 2005, In : Biochemistry. 44, 44, p. 14396-14408 13 p.

Research output: Contribution to journalArticle

38 Scopus citations
2003

Crystallization and X-ray diffraction analysis of an all-RNA U39C mutant of the minimal hairpin ribozyme

Grum-Tokars, V., Milovanovic, M. & Wedekind, J. E., Jan 1 2003, In : Acta Crystallographica - Section D Biological Crystallography. 59, 1, p. 142-145 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

Mutations in Capillary Morphogenesis Gene-2 Result in the Allelic Disorders Juvenile Hyaline Fibromatosis and Infantile Systemic Hyalinosis

Dowling, O., Difeo, A., Ramirez, M. C., Tukel, T., Narla, G., Bonafe, L., Kayserili, H., Yuksel-Apak, M., Paller, A. S., Norton, K., Teebi, A. S., Grum-Tokars, V., Martin, G. S., Davis, G. E., Glucksman, M. J. & Martignetti, J. A., Oct 1 2003, In : American journal of human genetics. 73, 4, p. 957-966 10 p.

Research output: Contribution to journalArticle

131 Scopus citations

Novel Roles of Neuropeptide Processing Enzymes: EC3.4.24.15 in the Neurome

Kim, S. I., Grum-Tokars, V., Swanson, T. A., Cotter, E. J., Cahill, P. A., Roberts, J. L., Cummins, P. M. & Glucksman, M. J., Nov 1 2003, In : Journal of Neuroscience Research. 74, 3, p. 456-467 12 p.

Research output: Contribution to journalArticle

21 Scopus citations
2001

Structural and thermodynamic studies of cloned fragments of spectrin

Li, D., MacDonald, R. I., Mondragón, A., Pozharski, E. V., Ruffatti, J. A. & Tokars, V. L., Jan 1 2001, In : Cellular and Molecular Biology Letters. 6, 2, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations
1999

Structures of two repeats of spectrin suggest models of flexibility

Grum, V. L., Li, D., MacDonald, R. I. & Mondragón, A., Aug 20 1999, In : Cell. 98, 4, p. 523-535 13 p.

Research output: Contribution to journalArticle

205 Scopus citations