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Personal profile

Research Interests

The goal of our lab is to enhance functional recovery after spinal cord injury (SCI). Our approach to SCI research uses animal models to identify changes that occur within the spinal cord after injury. Specifically, we are interested in the changes that contribute to movement dysfunction. Once we have identified these changes, such as alterations in protein expression or neuronal excitability, we can create therapies that target them and produce a more functional motor output. We measure therapeutic effects not only in vitro on the local neuronal functions, but also in vivo on the overall behavior. We want to ensure that we are affecting the desired local neuronal target, and that this modification leads to overall improvements in function. In particular, we are focused on examining ventral motoneuronal and dorsal spinal interneuronal behavior, isolated spinal reflexes, single motor unit recordings, muscle activation and patterning during locomotion, and gross hyperreflexia.

Training Experience

2012Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine

Education/Academic qualification

PhD, Northwestern University

… → 2008

PT, University of Iowa

… → 1998

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Grants 2010 2022

Spinal Cord Injuries
Spinal Cord Injuries
Wounds and Injuries
Calcium Channel Blockers
Spinal Cord Injuries
L-Type Calcium Channels
Muscle Contraction

Research Output 2003 2019

  • 861 Citations
  • 15 Article
  • 2 Chapter
  • 1 Comment/debate
  • 1 Review article

Cortically Controlled FES for Restoration and Rehabilitation of Function Following SCI in Rats

Barroso, F. O., Yoder, B., Wallner, J., Jantz, M., Tostado, P., Pei, E., Tysseling, V. M., Miller, L. E. & Tresch, M. C., Jan 1 2019, Biosystems and Biorobotics. Springer International Publishing, p. 931-934 4 p. (Biosystems and Biorobotics; vol. 21).

Research output: Chapter in Book/Report/Conference proceedingChapter

Patient rehabilitation
3 Citations

Ambulatory function in motor incomplete spinal cord injury: A magnetic resonance imaging study of spinal cord edema and lower extremity muscle morphometry

Smith, A. C., Weber, K. A., Parrish, T. B., Hornby, T. G., Tysseling, V. M., McPherson, J. G., Wasielewski, M. & Elliott, J. M., Jul 1 2017, In : Spinal Cord. 55, 7, p. 672-678 7 p.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Lower Extremity
Spinal Cord
Magnetic Resonance Imaging

Chronic electromyograms in treadmill running SOD1 mice reveal early changes in muscle activation

Quinlan, K. A., Kajtaz, E., Ciolino, J. D., Imhoff-Manuel, R. D., Tresch, M. C., Heckman, C. & Tysseling, V. M., Aug 1 2017, In : Journal of Physiology. 595, 15, p. 5387-5400 14 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis

Constitutive activity of 5-HT2c receptors is present after incomplete spinal cord injury but is not modified after chronic SSRI or baclofen treatment

Tysseling, V. M., Klein, D. A., Imhoff-Manuel, R., Manuel, M., Heckman, C. & Tresch, M. C., Nov 14 2017, In : Journal of Neurophysiology. 118, 5, p. 2944-2952 9 p.

Research output: Contribution to journalArticle

Serotonin Uptake Inhibitors
Spinal Cord Injuries
Receptor, Serotonin, 5-HT2C
Pyramidal Tracts
Spinal Cord Injuries
Cell Movement