• 995 Citations
20032024

Research output per year

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Personal profile

Research Interests

The goal of our lab is to enhance functional recovery after spinal cord injury (SCI). Our approach to SCI research uses animal models to identify changes that occur within the spinal cord after injury. Specifically, we are interested in the changes that contribute to movement dysfunction. Once we have identified these changes, such as alterations in protein expression or neuronal excitability, we can create therapies that target them and produce a more functional motor output. We measure therapeutic effects not only in vitro on the local neuronal functions, but also in vivo on the overall behavior. We want to ensure that we are affecting the desired local neuronal target, and that this modification leads to overall improvements in function. In particular, we are focused on examining ventral motoneuronal and dorsal spinal interneuronal behavior, isolated spinal reflexes, single motor unit recordings, muscle activation and patterning during locomotion, and gross hyperreflexia.

Training Experience

2012Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine

Education/Academic qualification

PhD, Northwestern University

… → 2008

PT, University of Iowa

… → 1998

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Grants

  • Research Output

    • 995 Citations
    • 15 Article
    • 2 Chapter
    • 2 Review article
    • 1 Comment/debate

    Cortically Controlled FES for Restoration and Rehabilitation of Function Following SCI in Rats

    Barroso, F. O., Yoder, B., Wallner, J., Jantz, M., Tostado, P., Pei, E., Tysseling, V., Miller, L. E. & Tresch, M. C., Jan 1 2019, Biosystems and Biorobotics. Springer International Publishing, p. 931-934 4 p. (Biosystems and Biorobotics; vol. 21).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • Scaling of motor output, from mouse to humans

    Manuel, M., Chardon, M., Tysseling, V. & Heckman, C. J., Jan 1 2019, In : Physiology. 34, 1, p. 5-13 9 p.

    Research output: Contribution to journalReview article

  • 5 Scopus citations

    Ambulatory function in motor incomplete spinal cord injury: A magnetic resonance imaging study of spinal cord edema and lower extremity muscle morphometry

    Smith, A. C., Weber, K. A., Parrish, T. B., Hornby, T. G., Tysseling, V. M., McPherson, J. G., Wasielewski, M. & Elliott, J. M., Jul 1 2017, In : Spinal Cord. 55, 7, p. 672-678 7 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    Chronic electromyograms in treadmill running SOD1 mice reveal early changes in muscle activation

    Quinlan, K. A., Kajtaz, E., Ciolino, J. D., Imhoff-Manuel, R. D., Tresch, M. C., Heckman, C. J. & Tysseling, V. M., Aug 1 2017, In : Journal of Physiology. 595, 15, p. 5387-5400 14 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Constitutive activity of 5-HT2c receptors is present after incomplete spinal cord injury but is not modified after chronic SSRI or baclofen treatment

    Tysseling, V. M., Klein, D. A., Imhoff-Manuel, R., Manuel, M., Heckman, C. J. & Tresch, M. C., Nov 14 2017, In : Journal of neurophysiology. 118, 5, p. 2944-2952 9 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations