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Personal profile

Research Interests

The goal of our lab is to enhance functional recovery after spinal cord injury (SCI). Our approach to SCI research uses animal models to identify changes that occur within the spinal cord after injury. Specifically, we are interested in the changes that contribute to movement dysfunction. Once we have identified these changes, such as alterations in protein expression or neuronal excitability, we can create therapies that target them and produce a more functional motor output. We measure therapeutic effects not only in vitro on the local neuronal functions, but also in vivo on the overall behavior. We want to ensure that we are affecting the desired local neuronal target, and that this modification leads to overall improvements in function. In particular, we are focused on examining ventral motoneuronal and dorsal spinal interneuronal behavior, isolated spinal reflexes, single motor unit recordings, muscle activation and patterning during locomotion, and gross hyperreflexia.

Training Experience

2012Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine

Education/Academic qualification

PhD, Northwestern University

… → 2008

PT, University of Iowa

… → 1998

Fingerprint Dive into the research topics where Vicki Maria Tysseling is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Grants 2010 2024

Spinal Cord Stimulation
Spinal Cord Injuries
Electric Stimulation
Spinal Cord Injuries
Wounds and Injuries
Spinal Cord Injuries
Calcium Channel Blockers
Spinal Cord Injuries
L-Type Calcium Channels
Muscle Contraction

Research Output 2003 2019

  • 958 Citations
  • 15 Article
  • 2 Chapter
  • 2 Review article
  • 1 Comment/debate

Cortically Controlled FES for Restoration and Rehabilitation of Function Following SCI in Rats

Barroso, F. O., Yoder, B., Wallner, J., Jantz, M., Tostado, P., Pei, E., Tysseling, V. M., Miller, L. E. & Tresch, M. C., Jan 1 2019, Biosystems and Biorobotics. Springer International Publishing, p. 931-934 4 p. (Biosystems and Biorobotics; vol. 21).

Research output: Chapter in Book/Report/Conference proceedingChapter

Patient rehabilitation
3 Citations (Scopus)

Scaling of motor output, from mouse to humans

Manuel, M., Chardon, M., Tysseling, V. & Heckman, C. J., Jan 1 2019, In : Physiology. 34, 1, p. 5-13 9 p.

Research output: Contribution to journalReview article

Motor Neurons
6 Citations (Scopus)

Ambulatory function in motor incomplete spinal cord injury: A magnetic resonance imaging study of spinal cord edema and lower extremity muscle morphometry

Smith, A. C., Weber, K. A., Parrish, T. B., Hornby, T. G., Tysseling, V. M., McPherson, J. G., Wasielewski, M. & Elliott, J. M., Jul 1 2017, In : Spinal Cord. 55, 7, p. 672-678 7 p.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Lower Extremity
Spinal Cord
Magnetic Resonance Imaging
3 Citations (Scopus)

Chronic electromyograms in treadmill running SOD1 mice reveal early changes in muscle activation

Quinlan, K. A., Kajtaz, E., Ciolino, J. D., Imhoff-Manuel, R. D., Tresch, M. C., Heckman, C. & Tysseling, V. M., Aug 1 2017, In : Journal of Physiology. 595, 15, p. 5387-5400 14 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
1 Citation (Scopus)

Constitutive activity of 5-HT2c receptors is present after incomplete spinal cord injury but is not modified after chronic SSRI or baclofen treatment

Tysseling, V. M., Klein, D. A., Imhoff-Manuel, R., Manuel, M., Heckman, C. & Tresch, M. C., Nov 14 2017, In : Journal of Neurophysiology. 118, 5, p. 2944-2952 9 p.

Research output: Contribution to journalArticle

Serotonin Uptake Inhibitors
Spinal Cord Injuries
Receptor, Serotonin, 5-HT2C