Vishal Kothari

  • Research Assistant Professor, Urology
  • 647 Citations
20102020

Research output per year

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Personal profile

Research Interests

The overall theme of my research is to identify, characterize and target the genes that help in the progression of aggressive prostate cancers. During my postdoctoral fellowship, I developed novel approaches to identify outlier kinases in breast and pancreatic cancer and studied the role of these kinases in oncogenic progression. I continued to apply this novel matrix to identify novel biomarkers to distinguish indolent from aggressive prostate cancer and to interrogate therapeutic targets in advanced prostate cancer. Apart from identifying biomarkers and therapeutic targets, I also have an expertise in delineating oncogenic signaling and resistance mechanisms and carry out translational research. My goal is to delineate the molecular and biological differences between the prostate cancers in African-American and Caucasian men, to help progress the field towards personalized medicine.

Education/Academic qualification

PhD, Advanced Center for Treatment Research and Education in Cancer (ACTREC)

… → 2009

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Research Output

  • 647 Citations
  • 18 Article
  • 2 Comment/debate

CDKN1B Deletions are Associated with Metastasis in African American Men with Clinically Localized, Surgically Treated Prostate Cancer

Faisal, F. A., Murali, S., Kaur, H., Vidotto, T., Guedes, L. B., Salles, D. C., Kothari, V., Tosoian, J. J., Han, S., Hovelson, D. H., Hu, K., Spratt, D. E., Baras, A. S., Tomlins, S. A., Schaeffer, E. M. & Lotan, T. L., Jun 1 2020, In : Clinical Cancer Research. 26, 11, p. 2595-2602 8 p.

Research output: Contribution to journalArticle

Open Access
  • A mouse model of prostate cancer bone metastasis in a syngeneic immunocompetent host

    Simons, B. W., Kothari, V., Benzon, B., Ghabili, K., Hughes, R., Zarif, J., Ross, A. E., Hurley, P. J. & Schaeffer, E. M., Jan 1 2019, In : Oncotarget. 10, 64, p. 6845-6854 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    DNA-dependent protein kinase drives prostate cancer progression through transcriptional regulation of the Wnt signaling pathway

    Kothari, V., Goodwin, J. F., Zhao, S. G., Drake, J. M., Yin, Y., Chang, S. L., Evans, J. R., Wilder-Romans, K., Gabbara, K., Dylgjeri, E., Chou, J., Sun, G., Tomlins, S. A., Mehra, R., Hege, K., Filvaroff, E. H., Schaeffer, E. M., Karnes, R. J., Quigley, D. A., Rathkopf, D. E. & 9 others, He, H. H., Speers, C., Spratt, D. E., Gilbert, L. A., Ashworth, A., Chinnaiyan, A. M., Raj, G. V., Knudsen, K. E. & Feng, F. Y., Sep 15 2019, In : Clinical Cancer Research. 25, 18, p. 5608-5622 15 p.

    Research output: Contribution to journalArticle

  • 5 Scopus citations

    Genomic Drivers of Poor Prognosis and Enzalutamide Resistance in Metastatic Castration-resistant Prostate Cancer(Figure presented.)

    Chen, W. S., Aggarwal, R., Zhang, L., Zhao, S. G., Thomas, G. V., Beer, T. M., Quigley, D. A., Foye, A., Playdle, D., Huang, J., Lloyd, P., Lu, E., Sun, D., Guan, X., Rettig, M., Gleave, M., Evans, C. P., Youngren, J., True, L., Lara, P. & 8 others, Kothari, V., Xia, Z., Chi, K. N., Reiter, R. E., Maher, C. A., Feng, F. Y., Small, E. J. & Alumkal, J. J., Nov 2019, In : European urology. 76, 5, p. 562-571 10 p.

    Research output: Contribution to journalArticle

  • 14 Scopus citations

    Pleiotropic impact of DNA-PK in cancer and implications for therapeutic strategies

    Dylgjeri, E., McNair, C., Goodwin, J. F., Raymon, H. K., McCue, P. A., Shafi, A. A., Leiby, B. E., De Leeuw, R., Kothari, V., McCann, J. J., Mandigo, A. C., Chand, S. N., Schiewer, M. J., Brand, L. J., Vasilevskaya, I., Gordon, N., Laufer, T. S., Gomella, L. G., Lallas, C. D., Trabulsi, E. J. & 5 others, Feng, F. Y., Filvaroff, E. H., Hege, K., Rathkopf, D. & Knudsen, K. E., Sep 15 2019, In : Clinical Cancer Research. 25, 18, p. 5623-5638 16 p.

    Research output: Contribution to journalArticle

  • 4 Scopus citations