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Research Output 1969 2019

2019

Analysis of crystalline and solution states of ligand-free spermidine N-acetyltransferase (SpeG) from escherichia coli

Filippova, E. V., Weigand, S., Kiryukhina, O., Wolfe, A. J. & Anderson, W. F., Jun 1 2019, In : Acta Crystallographica Section D: Structural Biology. 75, p. 545-553 9 p.

Research output: Contribution to journalArticle

Vibrio cholerae
Escherichia coli
Ligands
Spermidine
Acetyltransferases

A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction

Roy, S. M., Minasov, G., Arancio, O., Chico, L. W., Van Eldik, L. J., Anderson, W. F., Pelletier, J. C. & Watterson, D. M., Jun 13 2019, In : Journal of Medicinal Chemistry. 62, 11, p. 5298-5311 14 p.

Research output: Contribution to journalArticle

Open Access
Nervous System Diseases
Pharmacology
Crystallography
Protein-Serine-Threonine Kinases
Brain
Allosteric Site
Vibrio cholerae
Polyamines
Enzyme Assays
Molecular Biology
2018
7 Citations (Scopus)

An acetylatable lysine controls CRP function in E. coli

Davis, R., Écija-Conesa, A., Gallego-Jara, J., de Diego, T., Filippova, E. V., Kuffel, G., Anderson, W. F., Gibson, B. W., Schilling, B., Canovas, M. & Wolfe, A. J., Jan 1 2018, In : Molecular Microbiology. 107, 1, p. 116-131 16 p.

Research output: Contribution to journalArticle

Cyclic AMP Receptor Protein
Lysine
Escherichia coli
Acetylation
Carbon Cycle
2 Citations (Scopus)

CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in Toxoplasma gondii

Lykins, J. D., Filippova, E. V., Halavaty, A. S., Minasov, G., Zhou, Y., Dubrovska, I., Flores, K. J., Shuvalova, L. A., Ruan, J., El Bissati, K., Dovgin, S., Roberts, C. W., Woods, S., Moulton, J. D., Moulton, H., McPhillie, M. J., Muench, S. P., Fishwick, C. W. G., Sabini, E., Shanmugam, D. & 4 others, Roos, D. S., McLeod, R., Anderson, W. F. & Ngô, H. M., Jan 1 2018, In : Frontiers in Cellular and Infection Microbiology. 8, 1 p.

Research output: Contribution to journalArticle

Toxoplasma
Racemases and Epimerases
Parasites
Phenotype
Crystallography
1 Citation (Scopus)

Listeria monocytogenes InlP interacts with afadin and facilitates basement membrane crossing

Faralla, C., Bastounis, E. E., Ortega, F. E., Light, S. H., Rizzuto, G., Nocadello, S., Anderson, W. F., Robbins, J. R., Theriot, J. A. & Bakardjiev, A. I., May 1 2018, In : PLoS pathogens. 14, 5, e1007094.

Research output: Contribution to journalArticle

Listeria monocytogenes
Basement Membrane
Transcytosis
Madin Darby Canine Kidney Cells
Intercellular Junctions
8 Citations (Scopus)

Precision therapeutic targeting of human cancer cell motility

Xu, L., Gordon, R., Farmer, R., Pattanayak, A., Binkowski, A., Huang, X., Avram, M., Krishna, S., Voll, E., Pavese, J., Chavez, J., Bruce, J., Mazar, A., Nibbs, A., Anderson, W., Li, L., Jovanovic, B., Pruell, S., Valsecchi, M., Francia, G. & 3 others, Betori, R., Scheidt, K. & Bergan, R., Dec 1 2018, In : Nature communications. 9, 1, 2454.

Research output: Contribution to journalArticle

locomotion
Cell Movement
Toxicity
Assays
Carrier Proteins

Structural and immunological characterization of E. coli derived recombinant CRM197 protein used as carrier in conjugate vaccines

Mishra, R. P. N., Yadav, R. S. P., Jones, C., Nocadello, S., Minasov, G., Shuvalova, L. A., Anderson, W. F. & Goel, A., Sep 25 2018, In : Bioscience Reports. 38, 5, BSR20180238.

Research output: Contribution to journalArticle

Recombinant proteins
Conjugate Vaccines
Recombinant Proteins
Escherichia coli
Carrier Proteins
2 Citations (Scopus)

Structural basis for DNA recognition by the two-component response regulator RcsB

Filippova, E. V., Zemaitaitis, B., Aung, T., Wolfe, A. J. & Anderson, W. F., Jan 1 2018, In : mBio. 9, 1, e01993-17.

Research output: Contribution to journalArticle

Virulence
Bacterial Genes
Enterobacteriaceae
Biofilms
DNA

Structure of the Bacillus anthracis dTDP-L-rhamnose biosynthetic pathway enzyme: dTDP-α-D-glucose 4,6-dehydratase, RfbB

Gokey, T., Halavaty, A. S., Minasov, G., Anderson, W. F. & Kuhn, M. L., May 1 2018, In : Journal of Structural Biology. 202, 2, p. 175-181 7 p.

Research output: Contribution to journalArticle

Hydro-Lyases
Bacillus anthracis
Biosynthetic Pathways
Cell Wall
Glucose
3 Citations (Scopus)

The bacterial Ras/Rap1 site-specific endopeptidase RRSP cleaves Ras through an atypical mechanism to disrupt Ras-ERK signaling

Biancucci, M., Minasov, G., Banerjee, A., Herrera, A., Woida, P. J., Kieffer, M. B., Bindu, L., Abreu-Blanco, M., Anderson, W. F., Gaponenko, V., Stephen, A. G., Holderfield, M. & Satchell, K. J. F., Oct 2 2018, In : Science Signaling. 11, 550, eaat8335.

Research output: Contribution to journalArticle

Endopeptidases
Nucleotides
Pathogens
Peptide Hydrolases
Vibrio vulnificus
1 Citation (Scopus)

The spermidine acetyltransferase SpeG regulates transcription of the small RNA rprA

Hu, L. I., Filippova, E. V., Dang, J., Pshenychnyi, S., Ruan, J., Kiryukhina, O., Anderson, W. F., Kuhn, M. L. & Wolfe, A. J., Dec 1 2018, In : PloS one. 13, 12, e0207563.

Research output: Contribution to journalArticle

Acetylation
acetyltransferases
Polyamines
acetylation
spermidine
2017
58 Citations (Scopus)

Identification of novel small molecule inhibitors against NS2B/NS3 serine protease from Zika virus

Lee, H., Ren, J., Nocadello, S., Rice, A. J., Ojeda, I., Light, S., Minasov, G., Vargas, J., Nagarathnam, D., Anderson, W. F. & Johnson, M. E., Mar 1 2017, In : Antiviral Research. 139, p. 49-58 10 p.

Research output: Contribution to journalArticle

Serine Proteases
Peptide Hydrolases
Flavivirus Infections
Flavivirus
Central America
2 Citations (Scopus)

Insight into the 3D structure and substrate specificity of previously uncharacterized GNAT superfamily acetyltransferases from pathogenic bacteria

Majorek, K. A., Osinski, T., Tran, D. T., Revilla, A., Anderson, W. F., Minor, W. & Kuhn, M. L., Jan 1 2017, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1865, 1, p. 55-64 10 p.

Research output: Contribution to journalArticle

Acetyltransferases
Coenzyme A
Substrate Specificity
Bacteria
Substrates
2 Citations (Scopus)

New ligation independent cloning vectors for expression of recombinant proteins with a self-cleaving CPD/6xHis-tag

Biancucci, M., Dolores, J. S., Wong, J., Grimshaw, S., Anderson, W. F., Satchell, K. J. F. & Kwon, K., Jan 5 2017, In : BMC Biotechnology. 17, 1, 1.

Research output: Contribution to journalArticle

Genetic Vectors
Cysteine Proteases
Recombinant Proteins
Ligation
Solubility
8 Citations (Scopus)

Novel aldo-keto reductases for the biocatalytic conversion of 3- hydroxybutanal to 1,3-butanediol: Structural and biochemical studies

Kim, T., Flick, R., Brunzelle, J. S., Singer, A., Evdokimova, E., Brown, G., Joo, J. C., Minasov, G., Anderson, W. F., Mahadevan, R., Savchenko, A. & Yakunin, A. F., Apr 1 2017, In : Applied and Environmental Microbiology. 83, 7, e03172-16.

Research output: Contribution to journalArticle

butanediol
acetaldehyde
Acetaldehyde
crystal structure
NADP (coenzyme)
1 Citation (Scopus)

Structure of the Bacillus anthracis dTDP- l -rhamnose-biosynthetic enzyme dTDP-4-dehydrorhamnose 3,5-epimerase (RfbC)

Shornikov, A., Tran, H., Macias, J., Halavaty, A. S., Minasov, G., Anderson, W. F. & Kuhn, M. L., Dec 2017, In : Acta Crystallographica Section F:Structural Biology Communications. 73, 12, p. 664-671 8 p.

Research output: Contribution to journalArticle

Bacillus anthracis
Rhamnose
Bacillus
Bacilli
enzymes
1 Citation (Scopus)

Structure of the Bacillus anthracis dTDP- l -rhamnose-biosynthetic enzyme dTDP-4-dehydrorhamnose reductase (RfbD)

Law, A., Stergioulis, A., Halavaty, A. S., Minasov, G., Anderson, W. F. & Kuhn, M. L., Dec 2017, In : Acta Crystallographica Section F:Structural Biology Communications. 73, 12, p. 644-650 7 p.

Research output: Contribution to journalArticle

Bacillus anthracis
Rhamnose
Bacillus
Bacilli
enzymes
1 Citation (Scopus)

Structure of the Bacillus anthracis dTDP-l-rhamnose-biosynthetic enzyme glucose-1-phosphate thymidylyltransferase (RfbA)

Baumgartner, J., Lee, J., Halavaty, A. S., Minasov, G., Anderson, W. F. & Kuhn, M. L., Nov 2017, In : Acta Crystallographica Section F:Structural Biology Communications. 73, 11, p. 621-628 8 p.

Research output: Contribution to journalArticle

glucose-1-phosphate thymidylyltransferase
Bacillus anthracis
Rhamnose
Bacillus
Bacilli
5 Citations (Scopus)

Transferase Versus Hydrolase: The Role of Conformational Flexibility in Reaction Specificity

Light, S. H., Cahoon, L. A., Mahasenan, K. V., Lee, M., Boggess, B., Halavaty, A. S., Mobashery, S., Freitag, N. E. & Anderson, W. F., Feb 7 2017, In : Structure. 25, 2, p. 295-304 10 p.

Research output: Contribution to journalArticle

Hydrolases
Transferases
Hydrolysis
Catalytic Domain
Glucans
2016
6 Citations (Scopus)

An Unusual Cation-Binding Site and Distinct Domain-Domain Interactions Distinguish Class II Enolpyruvylshikimate-3-phosphate Synthases

Light, S. H., Krishna, S. N., Minasov, G. & Anderson, W. F., Mar 1 2016, In : Biochemistry. 55, 8, p. 1239-1245 7 p.

Research output: Contribution to journalArticle

Cations
glyphosate
Phosphates
Binding Sites
Coxiella burnetii
6 Citations (Scopus)

Crystal structure of nonphosphorylated receiver domain of the stress response regulator RcsB from Escherichia coli

Filippova, E. V., Wawrzak, Z., Ruan, J., Pshenychnyi, S., Schultz, R. M., Wolfe, A. J. & Anderson, W. F., Dec 1 2016, In : Protein Science. 25, 12, p. 2216-2224 9 p.

Research output: Contribution to journalArticle

Desiccation
Dimerization
Biofilms
Microbial Drug Resistance
Cell Division
5 Citations (Scopus)

Crystal structures of the components of the Staphylococcus aureus leukotoxin ED

Nocadello, S., Minasov, G., Shuvalova, L. A., Dubrovska, I., Sabini, E., Bagnoli, F., Grandi, G. & Anderson, W. F., Jan 1 2016, In : Acta Crystallographica Section D: Structural Biology. 72, 1, p. 113-120 8 p.

Research output: Contribution to journalArticle

Staphylococcus aureus
Leukocidins
Exotoxins
Protein Subunits
Methicillin-Resistant Staphylococcus aureus
11 Citations (Scopus)

Crystal structures of the spoiid lytic transglycosylases essential for bacterial sporulation

Nocadello, S., Minasov, G., Shuvalova, L. S., Dubrovska, I., Sabini, E. & Anderson, W. F., Jul 15 2016, In : Journal of Biological Chemistry. 291, 29, p. 14915-14926 12 p.

Research output: Contribution to journalArticle

Crystal structure
Pathogens
Bacterial Physiological Phenomena
Bioterrorism
Bacterial Spores
8 Citations (Scopus)

Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance

Filippova, E. V., Kieser, K. J., Luan, C. H., Wawrzak, Z., Kiryukhina, O., Rubin, E. J. & Anderson, W. F., Jun 1 2016, In : FEBS Journal. p. 2206-2218 13 p.

Research output: Contribution to journalArticle

Peptidyl Transferases
Penicillin-Binding Proteins
Microbial Drug Resistance
Mycobacterium tuberculosis
Penicillin V

Fluorescence-based thermal shift data on multidrug regulator AcrR from Salmonella enterica subsp. entrica serovar Typhimurium str. LT2

Manjasetty, B. A., Halavaty, A. S., Luan, C-H., Osipiuk, J., Mulligan, R., Kwon, K., Anderson, W. F. & Joachimiak, A., Jun 1 2016, In : Data in Brief. 7, p. 537-539 3 p.

Research output: Contribution to journalArticle

Salmonella enterica
Hot Temperature
Fluorescence
Ligands
Fluorescence Polarization

Small angle X-ray scattering data and structure factor fitting for the study of the quaternary structure of the spermidine N-acetyltransferase SpeG

Weigand, S., Filippova, E. V., Kiryukhina, O. & Anderson, W. F., Mar 1 2016, In : Data in Brief. 6, p. 47-52 6 p.

Research output: Contribution to journalArticle

biology
incident
2 Citations (Scopus)

Structural Genomics Support for Infectious Disease Drug Design

Stacy, R., Anderson, W. F. & Myler, P. J., Jan 8 2016, In : ACS Infectious Diseases. 1, 3, p. 127-129 3 p.

Research output: Contribution to journalShort survey

Drug Design
Genomics
Communicable Diseases
10 Citations (Scopus)

Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis

Kuhn, M. L., Alexander, E., Minasov, G., Page, H. J., Warwrzak, Z., Shuvalova, L. A., Flores, K. J., Wilson, D. J., Shi, C., Aldrich, C. C. & Anderson, W. F., Aug 12 2016, In : ACS Infectious Diseases. 2, 8, p. 579-591 13 p.

Research output: Contribution to journalArticle

Mycolic Acids
Adenosine Monophosphate
Ligases
Mycobacterium tuberculosis
Tuberculosis
8 Citations (Scopus)

Structure to function of an α-glucan metabolic pathway that promotes Listeria monocytogenes pathogenesis

Light, S. H., Cahoon, L. A., Halavaty, A. S., Freitag, N. E. & Anderson, W. F., Nov 7 2016, In : Nature Microbiology. 2, 16202.

Research output: Contribution to journalArticle

Glucans
Listeria monocytogenes
Metabolic Networks and Pathways
rho-Associated Kinases
Systems Biology
2015
14 Citations (Scopus)

A novel phosphatidylinositol 4,5-bisphosphate binding domain mediates plasma membrane localization of ExoU and other patatin-like phospholipases

Tyson, G. H., Halavaty, A. S., Kim, H., Geissler, B., Agard, M., Satchell, K. J., Cho, W., Anderson, W. F. & Hauser, A. R., Jan 30 2015, In : Journal of Biological Chemistry. 290, 5, p. 2919-2937 19 p.

Research output: Contribution to journalArticle

Phospholipases
Cell membranes
Phosphatidylinositols
Cell Membrane
Membranes
13 Citations (Scopus)

A Novel polyamine allosteric site of speg from vibrio cholerae is revealed by its dodecameric structure

Filippova, E. V., Kuhn, M. L., Osipiuk, J., Kiryukhina, O., Joachimiak, A., Ballicora, M. A. & Anderson, W. F., Mar 27 2015, In : Journal of Molecular Biology. 427, 6, p. 1316-1334 19 p.

Research output: Contribution to journalArticle

Allosteric Site
Vibrio cholerae
Polyamines
Spermidine
Enzymes

Erratum: Insights into the mechanism of type I dehydroquinate dehydratases from structures of reaction intermediates

Light, S. H., Minasov, G., Shuvalova, L., Duban, M. E., Caffrey, M., Anderson, W. F. & Lavie, A., Jul 31 2015, In : Journal of Biological Chemistry. 290, 31, 1 p.

Research output: Contribution to journalComment/debate

Hydro-Lyases
Reaction intermediates
8 Citations (Scopus)

Structural and functional analysis of betaine aldehyde dehydrogenase from Staphylococcus aureus

Halavaty, A. S., Rich, R. L., Chen, C., Joo, J. C., Minasov, G., Dubrovska, I., Winsor, J. R., Myszka, D. G., Duban, M., Shuvalova, L., Yakunin, A. F. & Anderson, W. F., May 1 2015, In : Acta Crystallographica Section D: Biological Crystallography. 71, p. 1159-1175 17 p.

Research output: Contribution to journalArticle

Betaine-Aldehyde Dehydrogenase
NAD
Staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus
Betaine
7 Citations (Scopus)

Substrate-Induced Allosteric Change in the Quaternary Structure of the Spermidine N-Acetyltransferase SpeG

Filippova, E. V., Weigand, S., Osipiuk, J., Kiryukhina, O., Joachimiak, A. & Anderson, W. F., Jun 17 2015, In : Journal of Molecular Biology. 427, 22, p. 3538-3553 16 p.

Research output: Contribution to journalArticle

Polyamines
Vibrio cholerae
Allosteric Site
Acetyl Coenzyme A
Spermidine
34 Citations (Scopus)

Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer's Disease Mouse Models

Roy, S. M., Tokars, V. L., Schavocky, J. P., Saeed, F., Staniszewski, A., Teich, A. F., Arancio, O., Bachstetter, A. D., Webster, S. J., Van Eldik, L. J., Minasov, G., Anderson, W. F., Pelletier, J. C. & Watterson, D. M., Apr 15 2015, In : ACS Chemical Neuroscience. 6, 4, p. 666-680 15 p.

Research output: Contribution to journalArticle

Neurology
Protein Kinases
Disease Progression
Alzheimer Disease
Protein Isoforms
43 Citations (Scopus)

The E. coli sirtuin CobB shows no preference for enzymatic and nonenzymatic lysine acetylation substrate sites

Abouelfetouh, A., Kuhn, M. L., Hu, L. I., Scholle, M. D., Sorensen, D. J., Sahu, A. K., Becher, D., Antelmann, H., Mrksich, M., Anderson, W. F., Gibson, B. W., Schilling, B. & Wolfe, A. J., Feb 1 2015, In : MicrobiologyOpen. 4, 1, p. 66-83 18 p.

Research output: Contribution to journalArticle

Acetylation
Lysine
Escherichia coli
Proteins
Acetyl-CoA C-Acetyltransferase
12 Citations (Scopus)

The structure of bradyzoite-specific enolase from Toxoplasma gondii reveals insights into its dual cytoplasmic and nuclear functions

Ruan, J., Mouveaux, T., Light, S. H., Minasov, G., Anderson, W. F., Tomavo, S. & Ngô, H. M., Mar 1 2015, In : Acta Crystallographica Section D: Biological Crystallography. 71, p. 417-426 10 p.

Research output: Contribution to journalArticle

Phosphopyruvate Hydratase
Toxoplasma
Cysts
Genes
Nucleotide Motifs
2014
10 Citations (Scopus)
Transaldolase
Fructose-Bisphosphate Aldolase
Schiff Bases
Catalysis
Biocatalysis
5 Citations (Scopus)

Arabinose 5-phosphate covalently inhibits transaldolase

Light, S. H. & Anderson, W. F., Jan 1 2014, In : Journal of Structural and Functional Genomics. 15, 1, p. 41-44 4 p.

Research output: Contribution to journalArticle

Transaldolase
Catalytic Domain
Francisella tularensis
Stereochemistry
Schiff Bases
7 Citations (Scopus)

Crystal structures of type i dehydroquinate dehydratase in complex with quinate and shikimate suggest a novel mechanism of schiff base formation

Light, S. H., Antanasijevic, A., Krishna, S. N., Caffrey, M., Anderson, W. F. & Lavie, A., Feb 11 2014, In : Biochemistry. 53, 5, p. 872-880 9 p.

Research output: Contribution to journalArticle

Quinic Acid
Hydro-Lyases
Schiff Bases
Crystal structure
Substrates
10 Citations (Scopus)

Discovery of selective inhibitors of the Clostridium difficile dehydroquinate dehydratase

Ratia, K., Light, S. H., Antanasijevic, A., Anderson, W. F., Caffrey, M. & Lavie, A., Feb 21 2014, In : PLoS One. 9, 2, e89356.

Research output: Contribution to journalArticle

Hydro-Lyases
Clostridium difficile
Clostridium
Bacteria
Anti-Bacterial Agents
34 Citations (Scopus)

Double trouble - Buffer selection and his-tag presence may be responsible for nonreproducibility of biomedical experiments

Majorek, K. A., Kuhn, M. L., Chruszcz, M., Anderson, W. F. & Minor, W., Oct 1 2014, In : Protein Science. 23, 10, p. 1359-1368 10 p.

Research output: Contribution to journalArticle

Buffers
Acetyltransferases
HEPES
Proteins
Experiments
7 Citations (Scopus)

Ligand screening using fluorescence thermal shift analysis (FTS)

Luan, C-H., Light, S. H., Dunne, S. F. & Anderson, W. F., Jan 1 2014, In : Methods in Molecular Biology. 1140, p. 263-289 27 p.

Research output: Contribution to journalArticle

Hot Temperature
Fluorescence
Ligands
Genomics
Protein Unfolding
8 Citations (Scopus)

Mechanisms of allosteric activation and inhibition of the deoxyribonucleoside triphosphate triphosphohydrolase from Enterococcus faecalis

Vorontsov, I. I., Wu, Y., Delucia, M., Minasov, G., Mehrens, J., Shuvalova, L. A., Anderson, W. F. & Ahn, J., Jan 31 2014, In : Journal of Biological Chemistry. 289, 5, p. 2815-2824 10 p.

Research output: Contribution to journalArticle

Deoxyribonucleosides
Enterococcus faecalis
Allosteric Site
Chemical activation
Crystal structure
4 Citations (Scopus)

Potential for reduction of streptogramin a resistance revealed by structural analysis of acetyltransferase VatA

Stogios, P. J., Kuhn, M. L., Evdokimova, E., Courvalin, P., Anderson, W. F. & Savchenko, A., Dec 1 2014, In : Antimicrobial Agents and Chemotherapy. 58, 12, p. 7083-7092 10 p.

Research output: Contribution to journalArticle

Streptogramins
Virginiamycin
Acetyltransferases
Streptogramin A
Enzymes
132 Citations (Scopus)

Structural, kinetic and proteomic characterization of acetyl phosphate-dependent bacterial protein acetylation

Kuhn, M. L., Zemaitaitis, B., Hu, L. I., Sahu, A., Sorensen, D., Minasov, G., Lima, B. P., Scholle, M., Mrksich, M., Anderson, W. F., Gibson, B. W., Schilling, B. & Wolfe, A. J., Apr 22 2014, In : PLoS One. 9, 4, e94816.

Research output: Contribution to journalArticle

Acetylation
bacterial proteins
Bacterial Proteins
acetylation
Proteomics
2 Citations (Scopus)
Staphylococcal Protein A
Metabolism
Proteins
Actinobacteria
Protein Sequence Analysis
12 Citations (Scopus)

Structure and protective efficacy of the Staphylococcus aureus autocleaving protease EpiP

Kuhn, M. L., Prachi, P., Minasov, G., Shuvalova, L., Ruan, J., Dubrovska, I., Winsor, J., Giraldi, M., Biagini, M., Liberatori, S., Savino, S., Bagnoli, F., Anderson, W. F. & Grandi, G., Apr 2014, In : FASEB Journal. 28, 4, p. 1780-1793 14 p.

Research output: Contribution to journalArticle

Staphylococcus aureus
Peptide Hydrolases
Vaccines
Crystal structure
Proteins
18 Citations (Scopus)

Structure-based mutational studies of substrate inhibition of betaine aldehyde dehydrogenase BetB from staphylococcus aureus

Chen, C., Joo, J. C., Brown, G., Stolnikova, E., Halavaty, A. S., Savchenko, A., Anderson, W. F. & Yakunin, A. F., Jan 1 2014, In : Applied and Environmental Microbiology. 80, 13, p. 3992-4002 11 p.

Research output: Contribution to journalArticle

Betaine-Aldehyde Dehydrogenase
betaine
aldehyde
aldehydes
Staphylococcus aureus