• 5275 Citations
1969 …2020

Research output per year

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Research Output

2019

Analysis of crystalline and solution states of ligand-free spermidine N-acetyltransferase (SpeG) from escherichia coli

Filippova, E. V., Weigand, S., Kiryukhina, O., Wolfe, A. J. & Anderson, W. F., Jun 1 2019, In : Acta Crystallographica Section D: Structural Biology. 75, p. 545-553 9 p.

Research output: Contribution to journalArticle

A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction

Roy, S. M., Minasov, G., Arancio, O., Chico, L. W., Van Eldik, L. J., Anderson, W. F., Pelletier, J. C. & Watterson, D. M., Jun 13 2019, In : Journal of Medicinal Chemistry. 62, 11, p. 5298-5311 14 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Corrigendum to “A Novel Polyamine Allosteric Site of SpeG from Vibrio Cholerae is Revealed by its Dodecameric Structure” (Journal of Molecular Biology (2015) 427(6PB) (1316–1334), (S0022283615000303), (10.1016/j.jmb.2015.01.009))

Filippova, E. V., Kuhn, M. L., Osipiuk, J., Kiryukhina, O., Joachimiak, A., Ballicora, M. A. & Anderson, W. F., Nov 8 2019, In : Journal of Molecular Biology. 431, 22, 1 p.

Research output: Contribution to journalComment/debate

2018

An acetylatable lysine controls CRP function in E. coli

Davis, R., Écija-Conesa, A., Gallego-Jara, J., de Diego, T., Filippova, E. V., Kuffel, G., Anderson, W. F., Gibson, B. W., Schilling, B., Canovas, M. & Wolfe, A. J., Jan 2018, In : Molecular Microbiology. 107, 1, p. 116-131 16 p.

Research output: Contribution to journalArticle

9 Scopus citations

CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in Toxoplasma gondii

Lykins, J. D., Filippova, E. V., Halavaty, A. S., Minasov, G., Zhou, Y., Dubrovska, I., Flores, K. J., Shuvalova, L. A., Ruan, J., El Bissati, K., Dovgin, S., Roberts, C. W., Woods, S., Moulton, J. D., Moulton, H., McPhillie, M. J., Muench, S. P., Fishwick, C. W. G., Sabini, E., Shanmugam, D. & 4 others, Roos, D. S., McLeod, R., Anderson, W. F. & Ngô, H. M., Jan 1 2018, In : Frontiers in Cellular and Infection Microbiology. 8, 1 p.

Research output: Contribution to journalArticle

3 Scopus citations

Listeria monocytogenes InlP interacts with afadin and facilitates basement membrane crossing

Faralla, C., Bastounis, E. E., Ortega, F. E., Light, S. H., Rizzuto, G., Nocadello, S., Anderson, W. F., Robbins, J. R., Theriot, J. A. & Bakardjiev, A. I., May 2018, In : PLoS pathogens. 14, 5, e1007094.

Research output: Contribution to journalArticle

6 Scopus citations

Precision therapeutic targeting of human cancer cell motility

Xu, L., Gordon, R., Farmer, R., Pattanayak, A., Binkowski, A., Huang, X., Avram, M., Krishna, S., Voll, E., Pavese, J., Chavez, J., Bruce, J., Mazar, A., Nibbs, A., Anderson, W., Li, L., Jovanovic, B., Pruell, S., Valsecchi, M., Francia, G. & 3 others, Betori, R., Scheidt, K. & Bergan, R., Dec 1 2018, In : Nature communications. 9, 1, 2454.

Research output: Contribution to journalArticle

11 Scopus citations

Structural and immunological characterization of E. coli derived recombinant CRM197 protein used as carrier in conjugate vaccines

Mishra, R. P. N., Yadav, R. S. P., Jones, C., Nocadello, S., Minasov, G., Shuvalova, L. A., Anderson, W. F. & Goel, A., Sep 25 2018, In : Bioscience Reports. 38, 5, BSR20180238.

Research output: Contribution to journalArticle

3 Scopus citations

Structural basis for DNA recognition by the two-component response regulator RcsB

Filippova, E. V., Zemaitaitis, B., Aung, T., Wolfe, A. J. & Anderson, W. F., Jan 1 2018, In : mBio. 9, 1, e01993-17.

Research output: Contribution to journalArticle

4 Scopus citations

Structure of the Bacillus anthracis dTDP-L-rhamnose biosynthetic pathway enzyme: dTDP-α-D-glucose 4,6-dehydratase, RfbB

Gokey, T., Halavaty, A. S., Minasov, G., Anderson, W. F. & Kuhn, M. L., May 2018, In : Journal of Structural Biology. 202, 2, p. 175-181 7 p.

Research output: Contribution to journalArticle

The bacterial Ras/Rap1 site-specific endopeptidase RRSP cleaves Ras through an atypical mechanism to disrupt Ras-ERK signaling

Biancucci, M., Minasov, G., Banerjee, A., Herrera, A., Woida, P. J., Kieffer, M. B., Bindu, L., Abreu-Blanco, M., Anderson, W. F., Gaponenko, V., Stephen, A. G., Holderfield, M. & Satchell, K. J. F., Oct 2 2018, In : Science Signaling. 11, 550, eaat8335.

Research output: Contribution to journalArticle

6 Scopus citations

The spermidine acetyltransferase SpeG regulates transcription of the small RNA rprA

Hu, L. I., Filippova, E. V., Dang, J., Pshenychnyi, S., Ruan, J., Kiryukhina, O., Anderson, W. F., Kuhn, M. L. & Wolfe, A. J., Dec 1 2018, In : PloS one. 13, 12, e0207563.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Identification of novel small molecule inhibitors against NS2B/NS3 serine protease from Zika virus

Lee, H., Ren, J., Nocadello, S., Rice, A. J., Ojeda, I., Light, S., Minasov, G., Vargas, J., Nagarathnam, D., Anderson, W. F. & Johnson, M. E., Mar 1 2017, In : Antiviral Research. 139, p. 49-58 10 p.

Research output: Contribution to journalArticle

70 Scopus citations

Insight into the 3D structure and substrate specificity of previously uncharacterized GNAT superfamily acetyltransferases from pathogenic bacteria

Majorek, K. A., Osinski, T., Tran, D. T., Revilla, A., Anderson, W. F., Minor, W. & Kuhn, M. L., Jan 1 2017, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1865, 1, p. 55-64 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

New ligation independent cloning vectors for expression of recombinant proteins with a self-cleaving CPD/6xHis-tag

Biancucci, M., Dolores, J. S., Wong, J., Grimshaw, S., Anderson, W. F., Satchell, K. J. F. & Kwon, K., Jan 5 2017, In : BMC Biotechnology. 17, 1, 1.

Research output: Contribution to journalArticle

4 Scopus citations

Novel aldo-keto reductases for the biocatalytic conversion of 3- hydroxybutanal to 1,3-butanediol: Structural and biochemical studies

Kim, T., Flick, R., Brunzelle, J. S., Singer, A., Evdokimova, E., Brown, G., Joo, J. C., Minasov, G., Anderson, W. F., Mahadevan, R., Savchenko, A. & Yakunin, A. F., Apr 1 2017, In : Applied and Environmental Microbiology. 83, 7, e03172-16.

Research output: Contribution to journalArticle

10 Scopus citations

Structure of the Bacillus anthracis dTDP- l -rhamnose-biosynthetic enzyme dTDP-4-dehydrorhamnose 3,5-epimerase (RfbC)

Shornikov, A., Tran, H., Macias, J., Halavaty, A. S., Minasov, G., Anderson, W. F. & Kuhn, M. L., Dec 2017, In : Acta Crystallographica Section F:Structural Biology Communications. 73, 12, p. 664-671 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Structure of the Bacillus anthracis dTDP- l -rhamnose-biosynthetic enzyme dTDP-4-dehydrorhamnose reductase (RfbD)

Law, A., Stergioulis, A., Halavaty, A. S., Minasov, G., Anderson, W. F. & Kuhn, M. L., Dec 2017, In : Acta Crystallographica Section F:Structural Biology Communications. 73, 12, p. 644-650 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Structure of the Bacillus anthracis dTDP-l-rhamnose-biosynthetic enzyme glucose-1-phosphate thymidylyltransferase (RfbA)

Baumgartner, J., Lee, J., Halavaty, A. S., Minasov, G., Anderson, W. F. & Kuhn, M. L., Nov 2017, In : Acta Crystallographica Section F:Structural Biology Communications. 73, 11, p. 621-628 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Transferase Versus Hydrolase: The Role of Conformational Flexibility in Reaction Specificity

Light, S. H., Cahoon, L. A., Mahasenan, K. V., Lee, M., Boggess, B., Halavaty, A. S., Mobashery, S., Freitag, N. E. & Anderson, W. F., Feb 7 2017, In : Structure. 25, 2, p. 295-304 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
2016

An Unusual Cation-Binding Site and Distinct Domain-Domain Interactions Distinguish Class II Enolpyruvylshikimate-3-phosphate Synthases

Light, S. H., Krishna, S. N., Minasov, G. & Anderson, W. F., Mar 1 2016, In : Biochemistry. 55, 8, p. 1239-1245 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Crystal structure of nonphosphorylated receiver domain of the stress response regulator RcsB from Escherichia coli

Filippova, E. V., Wawrzak, Z., Ruan, J., Pshenychnyi, S., Schultz, R. M., Wolfe, A. J. & Anderson, W. F., Dec 1 2016, In : Protein Science. 25, 12, p. 2216-2224 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Crystal structures of the components of the Staphylococcus aureus leukotoxin ED

Nocadello, S., Minasov, G., Shuvalova, L., Dubrovska, I., Sabini, E., Bagnoli, F., Grandi, G. & Anderson, W. F., Jan 1 2016, In : Acta Crystallographica Section D: Structural Biology. 72, 1, p. 113-120 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Crystal structures of the spoiid lytic transglycosylases essential for bacterial sporulation

Nocadello, S., Minasov, G., Shuvalova, L. S., Dubrovska, I., Sabini, E. & Anderson, W. F., Jul 15 2016, In : Journal of Biological Chemistry. 291, 29, p. 14915-14926 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance

Filippova, E. V., Kieser, K. J., Luan, C. H., Wawrzak, Z., Kiryukhina, O., Rubin, E. J. & Anderson, W. F., Jun 1 2016, In : FEBS Journal. p. 2206-2218 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Fluorescence-based thermal shift data on multidrug regulator AcrR from Salmonella enterica subsp. entrica serovar Typhimurium str. LT2

Manjasetty, B. A., Halavaty, A. S., Luan, C. H., Osipiuk, J., Mulligan, R., Kwon, K., Anderson, W. F. & Joachimiak, A., Jun 1 2016, In : Data in Brief. 7, p. 537-539 3 p.

Research output: Contribution to journalArticle

Small angle X-ray scattering data and structure factor fitting for the study of the quaternary structure of the spermidine N-acetyltransferase SpeG

Weigand, S., Filippova, E. V., Kiryukhina, O. & Anderson, W. F., Mar 1 2016, In : Data in Brief. 6, p. 47-52 6 p.

Research output: Contribution to journalArticle

Structural Genomics Support for Infectious Disease Drug Design

Stacy, R., Anderson, W. F. & Myler, P. J., Jan 8 2016, In : ACS Infectious Diseases. 1, 3, p. 127-129 3 p.

Research output: Contribution to journalShort survey

2 Scopus citations

Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis

Kuhn, M. L., Alexander, E., Minasov, G., Page, H. J., Warwrzak, Z., Shuvalova, L., Flores, K. J., Wilson, D. J., Shi, C., Aldrich, C. C. & Anderson, W. F., Aug 12 2016, In : ACS Infectious Diseases. 2, 8, p. 579-591 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

Structure to function of an α-glucan metabolic pathway that promotes Listeria monocytogenes pathogenesis

Light, S. H., Cahoon, L. A., Halavaty, A. S., Freitag, N. E. & Anderson, W. F., Nov 7 2016, In : Nature Microbiology. 2, 16202.

Research output: Contribution to journalArticle

13 Scopus citations
2015

A novel phosphatidylinositol 4,5-bisphosphate binding domain mediates plasma membrane localization of ExoU and other patatin-like phospholipases

Tyson, G. H., Halavaty, A. S., Kim, H., Geissler, B., Agard, M., Satchell, K. J., Cho, W., Anderson, W. F. & Hauser, A. R., Jan 30 2015, In : Journal of Biological Chemistry. 290, 5, p. 2919-2937 19 p.

Research output: Contribution to journalArticle

18 Scopus citations

A Novel polyamine allosteric site of speg from vibrio cholerae is revealed by its dodecameric structure

Filippova, E. V., Kuhn, M. L., Osipiuk, J., Kiryukhina, O., Joachimiak, A., Ballicora, M. A. & Anderson, W. F., Mar 27 2015, In : Journal of Molecular Biology. 427, 6, p. 1316-1334 19 p.

Research output: Contribution to journalArticle

16 Scopus citations

Erratum: Insights into the mechanism of type I dehydroquinate dehydratases from structures of reaction intermediates

Light, S. H., Minasov, G., Shuvalova, L., Duban, M. E., Caffrey, M., Anderson, W. F. & Lavie, A., Jul 31 2015, In : Journal of Biological Chemistry. 290, 31, 1 p.

Research output: Contribution to journalComment/debate

Structural and functional analysis of betaine aldehyde dehydrogenase from Staphylococcus aureus

Halavaty, A. S., Rich, R. L., Chen, C., Joo, J. C., Minasov, G., Dubrovska, I., Winsor, J. R., Myszka, D. G., Duban, M., Shuvalova, L., Yakunin, A. F. & Anderson, W. F., May 1 2015, In : Acta Crystallographica Section D: Biological Crystallography. 71, p. 1159-1175 17 p.

Research output: Contribution to journalArticle

11 Scopus citations

Substrate-Induced Allosteric Change in the Quaternary Structure of the Spermidine N-Acetyltransferase SpeG

Filippova, E. V., Weigand, S., Osipiuk, J., Kiryukhina, O., Joachimiak, A. & Anderson, W. F., Jun 17 2015, In : Journal of Molecular Biology. 427, 22, p. 3538-3553 16 p.

Research output: Contribution to journalArticle

9 Scopus citations

Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer's Disease Mouse Models

Roy, S. M., Grum-Tokars, V. L., Schavocky, J. P., Saeed, F., Staniszewski, A., Teich, A. F., Arancio, O., Bachstetter, A. D., Webster, S. J., Van Eldik, L. J., Minasov, G., Anderson, W. F., Pelletier, J. C. & Watterson, D. M., Apr 15 2015, In : ACS Chemical Neuroscience. 6, 4, p. 666-680 15 p.

Research output: Contribution to journalArticle

41 Scopus citations

The E. coli sirtuin CobB shows no preference for enzymatic and nonenzymatic lysine acetylation substrate sites

Abouelfetouh, A., Kuhn, M. L., Hu, L. I., Scholle, M. D., Sorensen, D. J., Sahu, A. K., Becher, D., Antelmann, H., Mrksich, M., Anderson, W. F., Gibson, B. W., Schilling, B. & Wolfe, A. J., Feb 1 2015, In : MicrobiologyOpen. 4, 1, p. 66-83 18 p.

Research output: Contribution to journalArticle

46 Scopus citations

The structure of bradyzoite-specific enolase from Toxoplasma gondii reveals insights into its dual cytoplasmic and nuclear functions

Ruan, J., Mouveaux, T., Light, S. H., Minasov, G., Anderson, W. F., Tomavo, S. & Ngô, H. M., Mar 1 2015, In : Acta Crystallographica Section D: Biological Crystallography. 71, p. 417-426 10 p.

Research output: Contribution to journalArticle

12 Scopus citations
2014
11 Scopus citations

Arabinose 5-phosphate covalently inhibits transaldolase

Light, S. H. & Anderson, W. F., Mar 2014, In : Journal of Structural and Functional Genomics. 15, 1, p. 41-44 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Crystal structures of type i dehydroquinate dehydratase in complex with quinate and shikimate suggest a novel mechanism of schiff base formation

Light, S. H., Antanasijevic, A., Krishna, S. N., Caffrey, M., Anderson, W. F. & Lavie, A., Feb 11 2014, In : Biochemistry. 53, 5, p. 872-880 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Discovery of selective inhibitors of the Clostridium difficile dehydroquinate dehydratase

Ratia, K., Light, S. H., Antanasijevic, A., Anderson, W. F., Caffrey, M. & Lavie, A., Feb 21 2014, In : PloS one. 9, 2, e89356.

Research output: Contribution to journalArticle

10 Scopus citations

Double trouble - Buffer selection and his-tag presence may be responsible for nonreproducibility of biomedical experiments

Majorek, K. A., Kuhn, M. L., Chruszcz, M., Anderson, W. F. & Minor, W., Oct 1 2014, In : Protein Science. 23, 10, p. 1359-1368 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Ligand screening using fluorescence thermal shift analysis (FTS)

Luan, C. H., Light, S. H., Dunne, S. F. & Anderson, W. F., Jan 1 2014, In : Methods in Molecular Biology. 1140, p. 263-289 27 p.

Research output: Contribution to journalArticle

7 Scopus citations

Mechanisms of allosteric activation and inhibition of the deoxyribonucleoside triphosphate triphosphohydrolase from Enterococcus faecalis

Vorontsov, I. I., Wu, Y., Delucia, M., Minasov, G., Mehrens, J., Shuvalova, L., Anderson, W. F. & Ahn, J., Jan 31 2014, In : Journal of Biological Chemistry. 289, 5, p. 2815-2824 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Potential for reduction of streptogramin a resistance revealed by structural analysis of acetyltransferase VatA

Stogios, P. J., Kuhn, M. L., Evdokimova, E., Courvalin, P., Anderson, W. F. & Savchenko, A., Dec 1 2014, In : Antimicrobial agents and chemotherapy. 58, 12, p. 7083-7092 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Structural, kinetic and proteomic characterization of acetyl phosphate-dependent bacterial protein acetylation

Kuhn, M. L., Zemaitaitis, B., Hu, L. I., Sahu, A., Sorensen, D., Minasov, G., Lima, B. P., Scholle, M., Mrksich, M., Anderson, W. F., Gibson, B. W., Schilling, B. & Wolfe, A. J., Apr 22 2014, In : PloS one. 9, 4, e94816.

Research output: Contribution to journalArticle

138 Scopus citations
3 Scopus citations

Structure and protective efficacy of the Staphylococcus aureus autocleaving protease EpiP

Kuhn, M. L., Prachi, P., Minasov, G., Shuvalova, L., Ruan, J., Dubrovska, I., Winsor, J., Giraldi, M., Biagini, M., Liberatori, S., Savino, S., Bagnoli, F., Anderson, W. F. & Grandi, G., Apr 2014, In : FASEB Journal. 28, 4, p. 1780-1793 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Structure-based mutational studies of substrate inhibition of betaine aldehyde dehydrogenase BetB from staphylococcus aureus

Chen, C., Joo, J. C., Brown, G., Stolnikova, E., Halavaty, A. S., Savchenko, A., Anderson, W. F. & Yakunin, A. F., 2014, In : Applied and Environmental Microbiology. 80, 13, p. 3992-4002 11 p.

Research output: Contribution to journalArticle

22 Scopus citations