Grants per year
Personal profile
Research Interests
Dr. Zhang's major research interests include the genetics and epigenetics of complex traits, such as risks for common diseases, drug response, and gene expression. Dr. Zhang is also developing novel epigenetics-based biomarkers for various human cancers and chronic diseases using liquid biopsy.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Microbiology, University of Vermont
… → 2004
Research interests keywords
- Bioinformatics
- Cancer Genetics
- Epigenetics
- Genomic Medicine/Personalized Medicine
- Health Disparities
- Microbiome
- Systems Biology
- Translational Research
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Collaborations and top research areas from the last five years
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Therapeutic Targeting in EGFR-amplified Glioblastoma
Cheng, S.-Y. (PD/PI), Hu, B. (Co-Investigator) & Zhang, W. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
4/16/24 → 3/31/29
Project: Research project
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RNA m6A modifications and treatment response in multiple myeloma
Zhang, W. (PD/PI)
The University of Chicago, National Cancer Institute
4/2/24 → 3/31/25
Project: Research project
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Heterozygous SERPINE1 Deficiency Confers Durable Cardiovascular Fitness in Humans
Vaughan, D. E. (PD/PI), Abdala-Valencia, H. (Co-Investigator), Burridge, P. (Co-Investigator), Cuda, C. M. (Co-Investigator), Eren, M. (Co-Investigator), Ghosh, A. K. (Co-Investigator), Hayes, M. G. (Co-Investigator), Kelleher, N. L. (Co-Investigator), Khan, S. S. (Co-Investigator), Stoeger, T. (Co-Investigator), Wilsbacher, L. D. (Co-Investigator) & Zhang, W. (Co-Investigator)
National Heart, Lung, and Blood Institute
1/1/24 → 12/31/30
Project: Research project
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Integrating liquid biopsy-based epigenetic and imaging modalities to evaluate disease response in multiple myeloma
Zhang, W. (PD/PI) & Zhang, W. (PD/PI)
The University of Chicago, National Cancer Institute
8/1/23 → 7/31/28
Project: Research project
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Targeting RNA Splicing in Glioma
Cheng, S.-Y. (PD/PI), Cheng, S.-Y. (PD/PI), Hu, B. (Co-Investigator), Hu, B. (Co-Investigator), Zhang, W. (Co-Investigator) & Zhang, W. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
7/1/22 → 4/30/27
Project: Research project
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Epigenomic exploration of disease status of EGFR-mutated non-small cell lung cancer using plasma cell-free DNA hydroxymethylomes
Peng, Y., Karpus, J., Patel, J. D., Vokes, E. E., Garassino, M. C., Lugtu, K., Zhang, Z., Zhang, W., Chen, M., He, C. & Bestvina, C. M., Jan 2025, In: Cancer Communications. 45, 1, p. 51-55 5 p.Research output: Contribution to journal › Letter › peer-review
Open Access -
LAMP-MS for Locus-Specific Visual Quantification of DNA 5 mC and RNA m6A Using Ultra-Low Input
Xie, R., Yang, X., He, W., Luo, Z., Li, W., Xu, C., Cui, X., Zhang, W., Wei, N., Wang, X., Shi, Y., He, C., Liu, J. & Hu, L., Jan 2 2025, In: Angewandte Chemie - International Edition. 64, 1, e202413872.Research output: Contribution to journal › Article › peer-review
Open Access -
5-Hydroxymethylated Biomarkers in Cell-Free DNA Predict Occult Colorectal Cancer up to 36 Months Before Diagnosis in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
West-Szymanski, D. C., Zhang, Z., Cui, X. L., Kowitwanich, K., Gao, L., Deng, Z., Dougherty, U., Williams, C., Merkle, S., He, C., Zhang, W. & Bissonnette, M., Oct 1 2024, In: JCO Precision Oncology. 8, e2400277.Research output: Contribution to journal › Article › peer-review
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A Highly Sensitive and Specific Non-Invasive Test through Genome-Wide 5-Hydroxymethylation Mapping for Early Detection of Lung Cancer
Ren, Y., Zhang, Z., She, Y., He, Y., Li, D., Shi, Y., He, C., Yang, Y., Zhang, W. & Chen, C., Mar 20 2024, In: Small Methods. 8, 3, 2300747.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Associations of Stool Metal Exposures with Childhood Gut Microbiome Multiomics Profiles in a Prospective Birth Cohort Study
Gao, F., Shen, Y., Wu, H., Laue, H. E., Lau, F. K., Gillet, V., Lai, Y., Shrubsole, M. J., Prada, D., Zhang, W., Liu, Z., Bellenger, J. P., Takser, L. & Baccarelli, A. A., Dec 17 2024, In: Environmental Science and Technology. 58, 50, p. 22053-22063 11 p.Research output: Contribution to journal › Article › peer-review
Datasets
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Genome-wide profiling of 5-hydroxymethylcytosines in circulating cell-free DNA reveals population-specific pathways in the development of multiple myeloma
Chiu, B.C.-H. (Creator), Zhang, Z. (Creator), Derman, B. A. (Creator), Karpus, J. (Creator), Luo, L. (Creator), Zhang, S. (Creator), Langerman, S. S. (Creator), Sukhanova, M. (Creator), Bhatti, P. (Creator), Jakubowiak, A. (Creator), He, C. (Creator) & Zhang, W. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.c.6151504, https://springernature.figshare.com/collections/Genome-wide_profiling_of_5-hydroxymethylcytosines_in_circulating_cell-free_DNA_reveals_population-specific_pathways_in_the_development_of_multiple_myeloma/6151504
Dataset
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Association of cardiovascular health and epigenetic age acceleration
Pottinger, T. D. (Creator), Khan, S. S. (Creator), Zheng, Y. (Creator), Zhang, W. (Creator), Tindle, H. A. (Creator), Allison, M. (Creator), Wells, G. (Creator), Shadyab, A. H. (Creator), Nassir, R. (Creator), Martin, L. W. (Creator), Manson, J. E. (Creator), Lloyd-Jones, D. M. (Creator), Greenland, P. (Creator), Baccarelli, A. A. (Creator), Whitsel, E. A. (Creator) & Hou, L. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.c.5319491.v1, https://springernature.figshare.com/collections/Association_of_cardiovascular_health_and_epigenetic_age_acceleration/5319491/1
Dataset
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Epigenetic Contribution of the Myosin Light Chain Kinase Gene to Acute Respiratory Distress Syndrome
Zhang, W. (Contributor), Gene Expression Omnibus, Apr 2 2015
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE67530
Dataset
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Additional file 3: Table S3. of Characterization of genome-wide H3K27ac profiles reveals a distinct PM2.5-associated histone modification signature
Liu, C. (Creator), Xu, J. (Contributor), Chen, Y. (Contributor), Guo, X. (Contributor), Zheng, Y. (Contributor), Wang, Q. (Contributor), Chen, Y. (Contributor), Ni, Y. (Creator), Zhu, Y. (Contributor), Joyce, B. T. (Creator), Baccarelli, A. (Creator), Deng, F. (Contributor), Zhang, W. (Creator) & Hou, L. (Contributor), figshare, 2015
DOI: 10.6084/m9.figshare.c.3610925_d1, https://springernature.figshare.com/articles/dataset/Additional_file_3_Table_S3_of_Characterization_of_genome-wide_H3K27ac_profiles_reveals_a_distinct_PM2_5-associated_histone_modification_signature/4361924
Dataset
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Additional file 4: Table S4. of Characterization of genome-wide H3K27ac profiles reveals a distinct PM2.5-associated histone modification signature
Liu, C. (Creator), Xu, J. (Contributor), Chen, Y. (Contributor), Guo, X. (Contributor), Zheng, Y. (Contributor), Wang, Q. (Contributor), Chen, Y. (Contributor), Ni, Y. (Creator), Zhu, Y. (Contributor), Joyce, B. T. (Creator), Baccarelli, A. (Creator), Deng, F. (Contributor), Zhang, W. (Creator) & Hou, L. (Contributor), figshare, 2015
DOI: 10.6084/m9.figshare.c.3610925_d2, https://springernature.figshare.com/articles/dataset/Additional_file_4_Table_S4_of_Characterization_of_genome-wide_H3K27ac_profiles_reveals_a_distinct_PM2_5-associated_histone_modification_signature/4361933
Dataset