Grants per year
Personal profile
Research Interests
Dr. Zhang's major research interests include the genetics and epigenetics of complex traits, such as risks for common diseases, drug response, and gene expression. Dr. Zhang is also developing novel epigenetics-based biomarkers for various human cancers and chronic diseases using liquid biopsy.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Microbiology, University of Vermont
… → 2004
Research interests keywords
- Bioinformatics
- Cancer Genetics
- Epigenetics
- Genomic Medicine/Personalized Medicine
- Health Disparities
- Microbiome
- Systems Biology
- Translational Research
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Therapeutic Targeting in EGFR-amplified Glioblastoma
Cheng, S.-Y. (PD/PI), Hu, B. (Co-Investigator) & Zhang, W. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
4/16/24 → 3/31/29
Project: Research project
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RNA m6A modifications and treatment response in multiple myeloma
Zhang, W. (PD/PI) & Zhang, W. (PD/PI)
The University of Chicago, National Cancer Institute
4/2/24 → 3/31/26
Project: Research project
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Heterozygous SERPINE1 Deficiency Confers Durable Cardiovascular Fitness in Humans
Vaughan, D. E. (PD/PI), Abdala-Valencia, H. (Co-Investigator), Burridge, P. (Co-Investigator), Cuda, C. M. (Co-Investigator), Eren, M. (Co-Investigator), Ghosh, A. K. (Co-Investigator), Hayes, M. G. (Co-Investigator), Kelleher, N. L. (Co-Investigator), Khan, S. S. (Co-Investigator), Stoeger, T. (Co-Investigator), Wilsbacher, L. D. (Co-Investigator) & Zhang, W. (Co-Investigator)
National Heart, Lung, and Blood Institute
1/1/24 → 12/31/30
Project: Research project
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Integrating liquid biopsy-based epigenetic and imaging modalities to evaluate disease response in multiple myeloma
Zhang, W. (PD/PI), Zhang, W. (PD/PI) & Zhang, W. (PD/PI)
The University of Chicago, National Cancer Institute
8/1/23 → 7/31/28
Project: Research project
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ATF Proposal: Development of 5hmc based plasma signatures (liquid biopsy) in the detection of patients with peritoneal metastases
Zhang, W. (PD/PI) & Zhang, W. (PD/PI)
Yale University, Gastro-Intestinal Research Foundation, Inc.
1/1/23 → 12/31/25
Project: Research project
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Epigenomic exploration of disease status of EGFR-mutated non-small cell lung cancer using plasma cell-free DNA hydroxymethylomes
Peng, Y., Karpus, J., Patel, J. D., Vokes, E. E., Garassino, M. C., Lugtu, K., Zhang, Z., Zhang, W., Chen, M., He, C. & Bestvina, C. M., Jan 2025, In: Cancer Communications. 45, 1, p. 51-55 5 p.Research output: Contribution to journal › Letter › peer-review
Open Access -
LAMP-MS for Locus-Specific Visual Quantification of DNA 5 mC and RNA m6A Using Ultra-Low Input
Xie, R., Yang, X., He, W., Luo, Z., Li, W., Xu, C., Cui, X., Zhang, W., Wei, N., Wang, X., Shi, Y., He, C., Liu, J. & Hu, L., Jan 2 2025, In: Angewandte Chemie - International Edition. 64, 1, e202413872.Research output: Contribution to journal › Article › peer-review
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5-Hydroxymethylated Biomarkers in Cell-Free DNA Predict Occult Colorectal Cancer up to 36 Months Before Diagnosis in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
West-Szymanski, D. C., Zhang, Z., Cui, X. L., Kowitwanich, K., Gao, L., Deng, Z., Dougherty, U., Williams, C., Merkle, S., He, C., Zhang, W. & Bissonnette, M., Oct 1 2024, In: JCO Precision Oncology. 8, e2400277.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
A Highly Sensitive and Specific Non-Invasive Test through Genome-Wide 5-Hydroxymethylation Mapping for Early Detection of Lung Cancer
Ren, Y., Zhang, Z., She, Y., He, Y., Li, D., Shi, Y., He, C., Yang, Y., Zhang, W. & Chen, C., Mar 20 2024, In: Small Methods. 8, 3, 2300747.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Associations of Stool Metal Exposures with Childhood Gut Microbiome Multiomics Profiles in a Prospective Birth Cohort Study
Gao, F., Shen, Y., Wu, H., Laue, H. E., Lau, F. K., Gillet, V., Lai, Y., Shrubsole, M. J., Prada, D., Zhang, W., Liu, Z., Bellenger, J. P., Takser, L. & Baccarelli, A. A., Dec 17 2024, In: Environmental Science and Technology. 58, 50, p. 22053-22063 11 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Datasets
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Sprouty4 is epigenetically upregulated in human colorectal cancer
Stuckel, A. J. (Creator), Zeng, S. (Creator), Lyu, Z. (Creator), Zhang, W. (Creator), Zhang, X. (Creator), Dougherty, U. (Creator), Mustafi, R. (Creator), Khare, T. (Creator), Zhang, Q. (Creator), Joshi, T. (Creator), Bissonnette, M. (Creator) & Khare, S. (Creator), Taylor & Francis, 2022
DOI: 10.6084/m9.figshare.21571348.v1, https://tandf.figshare.com/articles/dataset/Sprouty4_is_epigenetically_upregulated_in_human_colorectal_cancer/21571348/1
Dataset
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MOESM1 of Associations of two-pore domain potassium channels and triple negative breast cancer subtype in The Cancer Genome Atlas: systematic evaluation of gene expression and methylation
Dookeran, K. A. (Creator), Zhang, W. (Creator), Stayner, L. (Creator) & Argos, M. (Creator), figshare, 2017
DOI: 10.6084/m9.figshare.c.3878248_d1, https://springernature.figshare.com/articles/dataset/MOESM1_of_Associations_of_two-pore_domain_potassium_channels_and_triple_negative_breast_cancer_subtype_in_The_Cancer_Genome_Atlas_systematic_evaluation_of_gene_expression_and_methylation/5401096
Dataset
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Associations of two-pore domain potassium channels and triple negative breast cancer subtype in The Cancer Genome Atlas: systematic evaluation of gene expression and methylation
Dookeran, K. A. (Creator), Zhang, W. (Creator), Stayner, L. (Creator) & Argos, M. (Creator), figshare, 2017
DOI: 10.6084/m9.figshare.c.3878248.v1, https://springernature.figshare.com/collections/Associations_of_two-pore_domain_potassium_channels_and_triple_negative_breast_cancer_subtype_in_The_Cancer_Genome_Atlas_systematic_evaluation_of_gene_expression_and_methylation/3878248/1
Dataset
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Additional file 3 of Genome-wide profiling of 5-hydroxymethylcytosines in circulating cell-free DNA reveals population-specific pathways in the development of multiple myeloma
Chiu, B.C.-H. (Creator), Zhang, Z. (Creator), Derman, B. A. (Creator), Karpus, J. (Creator), Luo, L. (Creator), Zhang, S. (Creator), Langerman, S. S. (Creator), Sukhanova, M. (Creator), Bhatti, P. (Creator), Jakubowiak, A. (Creator), He, C. (Creator) & Zhang, W. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.20499880, https://springernature.figshare.com/articles/dataset/Additional_file_3_of_Genome-wide_profiling_of_5-hydroxymethylcytosines_in_circulating_cell-free_DNA_reveals_population-specific_pathways_in_the_development_of_multiple_myeloma/20499880
Dataset
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Epigenetic Contribution of the Myosin Light Chain Kinase Gene to Acute Respiratory Distress Syndrome
Zhang, W. (Contributor), Gene Expression Omnibus, Apr 2 2015
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE67530
Dataset